Moxonidine : a second generation of centrally acting drugs : an appraisal of clinical experience

The multifactorial etiology of hypertension is reflected in the various possible sites of theropeutic attack in the treatment of high blood pressure. A selective modulation of the sites in the central nervous system responsible physiologically for the regulation of blood pressure sounds promising. Moxonidine, an imidazoline, represents a new class of antihypertensives that acts via a recently discovered receptor, the I 1 -imidazolin receptor