Training in Mammary Gland Biology and Breast Cancer

Abstract : The goal of the present proposal is to provide post-doctoral training opportunities in breast cancer research that focus on the role of microenvironment in mammary gland biology. Trainees will benefit from working in a dynamic interactive program under the guidance of the LBNL mentors to investigate the intersection of hormone action, growth factor activity and extracellular matrix remodeling during mammary gland development and carcinogenesis. In addition, trainees will be exposed to a variety of other topics related to breast cancer, as well as research ranging from molecular medicine to genomics, by their participation in working groups, lectures and scientific meetings with other Berkeley Lab and Bay Area researchers.

[1]  G. Shyamala.  Progesterone Signaling and Mammary Gland Morphogenesis , 1999, Journal of Mammary Gland Biology and Neoplasia.

[2]  C. Potten,et al.  Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. , 2001, Cancer research.

[3]  J. Campisi,et al.  Id-1, ITF-2, and Id-2 Comprise a Network of Helix-Loop-Helix Proteins That Regulate Mammary Epithelial Cell Proliferation, Differentiation, and Apoptosis* , 2001, The Journal of Biological Chemistry.

[4]  J D Norton,et al.  ID helix-loop-helix proteins in cell growth, differentiation and tumorigenesis. , 2000, Journal of cell science.

[5]  S. Nishikawa,et al.  Lactation defect in mice lacking the helix–loop–helix inhibitor Id2 , 2000, The EMBO journal.

[6]  C. Q. Lin,et al.  A role for Id-1 in the aggressive phenotype and steroid hormone response of human breast cancer cells. , 2000, Cancer research.

[7]  M J O'Hare,et al.  Proteomic definition of normal human luminal and myoepithelial breast cells purified from reduction mammoplasties. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[8]  W. Gerald,et al.  Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts , 1999, Nature.

[9]  M. Israel,et al.  Id gene expression as a key mediator of tumor cell biology. , 1999, Cancer research.

[10]  F. Sablitzky,et al.  Stage- and subcellular-specific expression of Id proteins in male germ and Sertoli cells implicates distinctive regulatory roles for Id proteins during meiosis, spermatogenesis, and Sertoli cell function. , 1998, Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research.

[11]  M. Bissell,et al.  Suppression of mammary epithelial cell differentiation by the helix-loop-helix protein Id-1 , 1995, Molecular and cellular biology.

[12]  J. Williams,et al.  Mammary ductal elongation: differentiation of myoepithelium and basal lamina during branching morphogenesis. , 1983, Developmental biology.