Heterogeneous Blood–Tumor Barrier Permeability Determines Drug Efficacy in Experimental Brain Metastases of Breast Cancer
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P. Steeg | B. Gril | D. Palmieri | Suyun Huang | P. Lockman | Q. Smith | Kunal S. Taskar | H. Thorsheim | R. K. Mittapalli | Julie A. Gaasch | C. Adkins | Vinay Rudraraju | K. A. Bohn | Amanda Roberts
[1] G. Kruh,et al. Influence of blood-brain barrier efflux pumps on the distribution of vincristine in brain and brain tumors. , 2010, Neuro-oncology.
[2] Dora Brites,et al. Looking at the blood–brain barrier: Molecular anatomy and possible investigation approaches , 2010, Brain Research Reviews.
[3] P. Erba,et al. Time Course of Paclitaxel-Induced Apoptosis in an Experimental Model of Virus-Induced Breast Cancer , 2010, Journal of Nuclear Medicine.
[4] Wolfgang M Kuebler,et al. Near-infrared spectroscopy and indocyanine green derived blood flow index for noninvasive measurement of muscle perfusion during exercise. , 2010, Journal of applied physiology.
[5] Wei Liu,et al. Rat model of metastatic breast cancer monitored by MRI at 3 tesla and bioluminescence imaging with histological correlation , 2009, Journal of Translational Medicine.
[6] P. Meltzer,et al. Vorinostat Inhibits Brain Metastatic Colonization in a Model of Triple-Negative Breast Cancer and Induces DNA Double-Strand Breaks , 2009, Clinical Cancer Research.
[7] P. Steeg,et al. Uptake of ANG1005, A Novel Paclitaxel Derivative, Through the Blood-Brain Barrier into Brain and Experimental Brain Metastases of Breast Cancer , 2009, Pharmaceutical Research.
[8] M. Gilbert,et al. The role of chemotherapy in the treatment of patients with brain metastases from solid tumors , 2009, International Journal of Clinical Oncology.
[9] R. Gabathuler. Blood-brain barrier transport of drugs for the treatment of brain diseases. , 2009, CNS & neurological disorders drug targets.
[10] N. Sibson,et al. The Vascular Basement Membrane as “Soil” in Brain Metastasis , 2009, PloS one.
[11] C. Arvanitis,et al. Dasatinib synergizes with doxorubicin to block growth, migration, and invasion of breast cancer cells , 2009, British Journal of Cancer.
[12] N. Ferrara. Vascular Endothelial Growth Factor , 2009, Arteriosclerosis, thrombosis, and vascular biology.
[13] W. Gerald,et al. Genes that mediate breast cancer metastasis to the brain , 2009, Nature.
[14] T. Nishioku,et al. Detachment of Brain Pericytes from the Basal Lamina is Involved in Disruption of the Blood–Brain Barrier Caused by Lipopolysaccharide-Induced Sepsis in Mice , 2009, Cellular and Molecular Neurobiology.
[15] M. Gassmann,et al. Maintaining blood–brain barrier integrity: Pericytes perform better than astrocytes during prolonged oxygen deprivation , 2009, Journal of cellular physiology.
[16] T. Mikkelsen,et al. Efficacy, safety and patterns of response and recurrence in patients with recurrent high-grade gliomas treated with bevacizumab plus irinotecan , 2009, Journal of Neuro-Oncology.
[17] Joseph,et al. Imagable 4T1 model for the study of late stage breast cancer , 2008, BMC Cancer.
[18] S. Steinberg,et al. Effect of lapatinib on the outgrowth of metastatic breast cancer cells to the brain. , 2008, Journal of the National Cancer Institute.
[19] A. Vortmeyer,et al. Reactive glia are recruited by highly proliferative brain metastases of breast cancer and promote tumor cell colonization , 2008, Clinical & Experimental Metastasis.
[20] S. Cross,et al. Differential Effect of Doxorubicin and Zoledronic Acid on Intraosseous versus Extraosseous Breast Tumor Growth In vivo , 2008, Clinical Cancer Research.
[21] H. Galla,et al. Pericyte–endothelial cell interaction increases MMP-9 secretion at the blood–brain barrier in vitro , 2008, Brain Research.
[22] A. Gregory Sorensen,et al. Angiogenesis in brain tumours , 2007, Nature Reviews Neuroscience.
[23] T. Terasaki,et al. Contribution of Carrier-Mediated Transport Systems to the Blood–Brain Barrier as a Supporting and Protecting Interface for the Brain; Importance for CNS Drug Discovery and Development , 2007, Pharmaceutical Research.
[24] K. Hynynen,et al. Chemotherapy delivery issues in central nervous system malignancy: a reality check. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[25] E. Gerstner,et al. Increased permeability of the blood-brain barrier to chemotherapy in metastatic brain tumors: establishing a treatment paradigm. , 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[26] S. Steinberg,et al. Her-2 overexpression increases the metastatic outgrowth of breast cancer cells in the brain. , 2007, Cancer research.
[27] P. Desai,et al. Pharmacokinetics of gemcitabine in tumor and non-tumor extracellular fluid of brain: an in vivo assessment in rats employing intracerebral microdialysis , 2007, Cancer Chemotherapy and Pharmacology.
[28] T. Maurer,et al. Use of Plasma and Brain Unbound Fractions to Assess the Extent of Brain Distribution of 34 Drugs: Comparison of Unbound Concentration Ratios to in Vivo P-Glycoprotein Efflux Ratios , 2007, Drug Metabolism and Disposition.
[29] M. Mayer. A Patient Perspective on Brain Metastases in Breast Cancer , 2007, Clinical Cancer Research.
[30] E. Winer,et al. Brain Metastases: The HER2 Paradigm , 2007, Clinical Cancer Research.
[31] W. Löscher,et al. The Blood-Brain Barrier and Cancer: Transporters, Treatment, and Trojan Horses , 2007, Clinical Cancer Research.
[32] C. Bucana,et al. Pathogenesis and vascular integrity of breast cancer brain metastasis , 2006, International journal of cancer.
[33] M. Desai,et al. Randomized Study of Paclitaxel and Tamoxifen Deposition into Human Brain Tumors: Implications for the Treatment of Metastatic Brain Tumors , 2006, Clinical Cancer Research.
[34] J. Beijnen,et al. Blood–brain barrier and chemotherapeutic treatment of brain tumors , 2006, Expert review of neurotherapeutics.
[35] R. Gelber,et al. Identifying breast cancer patients at risk for Central Nervous System (CNS) metastases in trials of the International Breast Cancer Study Group (IBCSG). , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.
[36] D. Peereboom. Chemotherapy in brain metastases. , 2005, Neurosurgery.
[37] C. B. Smith,et al. Resolution, sensitivity and precision with autoradiography and small animal positron emission tomography: implications for functional brain imaging in animal research. , 2005, Nuclear medicine and biology.
[38] R. Weil,et al. Breast cancer metastasis to the central nervous system. , 2005, The American journal of pathology.
[39] F. Parkinson,et al. Pericyte abundance affects sucrose permeability in cultures of rat brain microvascular endothelial cells , 2005, Brain Research.
[40] W. Lamph,et al. The selective retinoid X receptor agonist bexarotene (LGD1069, Targretin) prevents and overcomes multidrug resistance in advanced breast carcinoma , 2005, Molecular Cancer Therapeutics.
[41] E. Winer,et al. CNS metastases in breast cancer. , 2004, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[42] N. Wigler,et al. Central nervous system progression among patients with metastatic breast cancer responding to trastuzumab treatment. , 2004, European journal of cancer.
[43] R. Blasberg,et al. Assessment of treatment response by autoradiography with (14)C-aminocyclopentane carboxylic acid, (67)Ga-DTPA, and (18)F-FDG in a herpes simplex virus thymidine kinase/ganciclovir brain tumor model. , 2003, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.
[44] M. Bent. The role of chemotherapy in brain metastases , 2003 .
[45] J. Gallo,et al. The effect of P-glycoprotein on paclitaxel brain and brain tumor distribution in mice. , 2003, Cancer research.
[46] Willem Boogerd,et al. Increased penetration of paclitaxel into the brain by inhibition of P-Glycoprotein. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.
[47] E. Winer,et al. Central nervous system metastases in women who receive trastuzumab‐based therapy for metastatic breast carcinoma , 2003, Cancer.
[48] B. Chowbay,et al. Determination of doxorubicin and its metabolites in rat serum and bile by LC: application to preclinical pharmacokinetic studies. , 2002, Journal of pharmaceutical and biomedical analysis.
[49] Armin Buschauer,et al. Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo. , 2002, The Journal of clinical investigation.
[50] P. Wesseling,et al. Vascular endothelial growth factor-A(165) induces progression of melanoma brain metastases without induction of sprouting angiogenesis. , 2002, Cancer research.
[51] Paul J. Williams,et al. A Bone‐Seeking Clone Exhibits Different Biological Properties from the MDA‐MB‐231 Parental Human Breast Cancer Cells and a Brain‐Seeking Clone In Vivo and In Vitro , 2001, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.
[52] Claudio Cobelli,et al. Estimation of Blood Flow Heterogeneity in Human Skeletal Muscle Using Intravascular Tracer Data: Importance for Modeling Transcapillary Exchange , 1998, Annals of Biomedical Engineering.
[53] R. Blasberg,et al. Imaging Experimental Brain Tumors with 1-Aminocyclopentane Carboxylic Acid and Alpha-Aminoisobutyric Acid: Comparison to Fluorodeoxyglucose and Diethylenetriaminepentaacetic Acid in Morphologically Defined Tumor Regions , 1997, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[54] J. Beijnen,et al. The functional role of P-glycoprotein in the blood-brain barrier. , 1997, Journal of pharmaceutical sciences.
[55] J. Beijnen,et al. Tissue distribution, metabolism and excretion of paclitaxel in mice , 1996, Anti-cancer drugs.
[56] L. Deangelis,et al. Central nervous system progression of metastatic breast cancer in patients treated with paclitaxel , 1995, Cancer.
[57] M. Taphoorn,et al. Paclitaxel (Taxol) concentrations in brain tumor tissue. , 1994, Annals of oncology : official journal of the European Society for Medical Oncology.
[58] M. Zucchetti,et al. Cyclosporin A markedly changes the distribution of doxorubicin in mice and rats. , 1994, The Journal of pharmacology and experimental therapeutics.
[59] C. Bucana,et al. Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice. , 1992, The American journal of pathology.
[60] O. Dalesio,et al. Response of brain metastases from breast cancer to systemic chemotherapy , 1992, Cancer.
[61] P. Lønning,et al. Distribution of tamoxifen and metabolites into brain tissue and brain metastases in breast cancer patients. , 1991, British Journal of Cancer.
[62] V. P. Collins,et al. Uptake of Adriamycin in tumour and surrounding brain tissue in patients with malignant gliomas , 1990, Acta Neurochirurgica.
[63] N. Sposito,et al. Structural and Functional Variations in Capillary Systems within the Brain a , 1988, Annals of the New York Academy of Sciences.
[64] W. Lane,et al. Chemotherapy induces regression of brain metastases in breast carcinoma , 1986, Cancer.
[65] H Mogami,et al. Changes of the blood-brain barrier in experimental metastatic brain tumors. , 1983, Journal of neurosurgery.
[66] Ronald G. Blasberg,et al. Transport of α-Aminoisobutyric Acid across Brain Capillary and Cellular Membranes , 1983 .
[67] K D Pettigrew,et al. Local Cerebral Blood Flow in the Conscious Rat As Measured with 14C-Antipyrine, 14C-Iodoantipyrine and 3H-Nicotine , 1979, Stroke.
[68] D. Bigner,et al. Chemotherapy of Brain Tumors: The Blood-Brain Barrier Is Not a Factor , 1977 .
[69] Mellett Lb. Physicochemical considerations and pharmacokinetic behavior in delivery of drugs to the central nervous system. , 1977 .
[70] W. Walcher. [Chemotherapy of brain tumors]. , 1958, Der Krebsarzt.
[71] R. Shephard. Near-infrared spectroscopy and indocyanine green derived blood flow index for noninvasive measurement of muscle perfusion during exercise , 2011 .
[72] Jochen Herms,et al. Real-time imaging reveals the single steps of brain metastasis formation , 2010, Nature Medicine.
[73] G. Peters,et al. Gemcitabine uptake in glioblastoma multiforme: potential as a radiosensitizer. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.
[74] C. Waters,et al. Pharmacokinetic Considerations in the Treatment of CNS Tumours , 2006, Clinical pharmacokinetics.
[75] D. Stewart. A critique of the role of the blood-brain barrier in the chemotherapy of human brain tumors , 2005, Journal of Neuro-Oncology.
[76] M. Zucchetti,et al. Do anticancer agents reach the tumor target in the human brain? , 2004, Cancer Chemotherapy and Pharmacology.
[77] C. Patlak,et al. Local blood-to-tissue transport in Walker 256 metastatic brain tumors , 2004, Journal of Neuro-Oncology.
[78] M. Egorin,et al. Plasma pharmacokinetics and tissue distribution of paclitaxel in CD2F1 mice , 2004, Cancer Chemotherapy and Pharmacology.
[79] Suyun Huang,et al. Vascular endothelial growth factor expression promotes the growth of breast cancer brain metastases in nude mice , 2004, Clinical & Experimental Metastasis.
[80] K. Black,et al. Measurement of blood-brain and blood-tumor barrier permeabilities with [14C]-labeled tracers. , 2003, Methods in molecular medicine.
[81] Q. Smith,et al. A review of blood-brain barrier transport techniques. , 2003, Methods in molecular medicine.
[82] M. J. van den Bent. The role of chemotherapy in brain metastases. , 2003, European journal of cancer.
[83] C. Patlak,et al. Transport of alpha-aminoisobutyric acid across brain capillary and cellular membranes. , 1983, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.
[84] L. Mellett. Physicochemical considerations and pharmacokinetic behavior in delivery of drugs to the central nervous system. , 1977, Cancer treatment reports.