HC WM and MS NAWM and lesion tissue. Symbols highlight statistical significant differences (**p<0.01,*p<0.05). Fig. 2: Maps of NODDI and DTI parameters in a single MS subject. The MS lesion in the major white matter tracts is clearly marked in AD, MD and RD and NDI map (red arrow). NDI gives superior constrast over DTI metrics in periventricular lesion (green arrow) with CSF contribution. Application of multi-shell NODDI in Multiple Sclerosis Torben Schneider, Wallace Brownlee, Hui Zhang, Olga Ciccarelli, David H Miller, and Claudia A. M. Wheeler-Kingshott NMR Research Unit, Department of Neuroinflammation, Queen Square MS Centre, UCL Institute of Neurology, London, United Kingdom, Department of Computer Science & Centre for Medical Image Computing, UCL, London, United Kingdom, Department of Brain Repair and Rehabilitation, UCL Institute of Neurology, London, United Kingdom