Inside the human cancer tyrosine phosphatome

[1]  M. Lacroix-Triki,et al.  PTPL1/PTPN13 regulates breast cancer cell aggressiveness through direct inactivation of Src kinase. , 2010, Cancer research.

[2]  G. Coetzee,et al.  8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC , 2010, Proceedings of the National Academy of Sciences.

[3]  A. Combs Recent advances in the discovery of competitive protein tyrosine phosphatase 1B inhibitors for the treatment of diabetes, obesity, and cancer. , 2010, Journal of medicinal chemistry.

[4]  Joshua F. McMichael,et al.  Genome Remodeling in a Basal-like Breast Cancer Metastasis and Xenograft , 2010, Nature.

[5]  S. Croft,et al.  In vitro activity of anti-leishmanial drugs against Leishmania donovani is host cell dependent. , 2010, The Journal of antimicrobial chemotherapy.

[6]  S. Toyooka,et al.  Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers , 2010, Journal of Cancer Research and Clinical Oncology.

[7]  Kishore Guda,et al.  Identification and functional characterization of paxillin as a target of protein tyrosine phosphatase receptor T , 2010, Proceedings of the National Academy of Sciences.

[8]  P. Kohonen,et al.  Inhibition of receptor tyrosine kinase signalling by small molecule agonist of T-cell protein tyrosine phosphatase , 2010, BMC Cancer.

[9]  A. Sloan,et al.  PTPmu suppresses glioma cell migration and dispersal. , 2009, Neuro-oncology.

[10]  A. Ferrando,et al.  Deletion of the protein tyrosine phosphatase gene PTPN2 in T-cell acute lymphoblastic leukemia , 2009, Nature Genetics.

[11]  P. Mischel,et al.  An Unbiased Screen Identifies DEP-1 Tumor Suppressor as a Phosphatase Controlling EGFR Endocytosis , 2009, Current Biology.

[12]  D. Lawrence,et al.  Acquisition of a potent and selective TC-PTP inhibitor via a stepwise fluorophore-tagged combinatorial synthesis and screening strategy. , 2009, Journal of the American Chemical Society.

[13]  J. Bixby,et al.  Dimerization of tyrosine phosphatase PTPRO decreases its activity and ability to inactivate TrkC , 2009, Journal of neurochemistry.

[14]  A. Sloan,et al.  Proteolytic cleavage of protein tyrosine phosphatase mu regulates glioblastoma cell migration. , 2009, Cancer research.

[15]  K. Amara,et al.  Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma. , 2009, Clinica chimica acta; international journal of clinical chemistry.

[16]  Chris Sander,et al.  The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers , 2009, Proceedings of the National Academy of Sciences.

[17]  L. Castagnoli,et al.  Tumor Suppressor Density-enhanced Phosphatase-1 (DEP-1) Inhibits the RAS Pathway by Direct Dephosphorylation of ERK1/2 Kinases* , 2009, The Journal of Biological Chemistry.

[18]  M. Blaskovich Drug discovery and protein tyrosine phosphatases. , 2009, Current medicinal chemistry.

[19]  Beatriz Bellosillo,et al.  Mitogen-Activated Protein Kinase Phosphatase-1 in Human Breast Cancer Independently Predicts Prognosis and Is Repressed by Doxorubicin , 2009, Clinical Cancer Research.

[20]  Jian-ming Li,et al.  Over‐expression of phosphatase of regenerating liver‐3 correlates with tumor progression and poor prognosis in nasopharyngeal carcinoma , 2009, International journal of cancer.

[21]  P. Zapata,et al.  Tumoral Prostate Shows Different Expression Pattern of Somatostatin Receptor 2 (SSTR2) and Phosphotyrosine Phosphatase SHP-1 (PTPN6) According to Tumor Progression , 2009, Advances in urology.

[22]  T. Hunter Tyrosine phosphorylation: thirty years and counting. , 2009, Current opinion in cell biology.

[23]  C. Shou,et al.  Expression of phosphatase regenerating liver 3 is an independent prognostic indicator for gastric cancer. , 2009, World journal of gastroenterology.

[24]  F. J. Luque,et al.  Binding site detection and druggability index from first principles. , 2009, Journal of medicinal chemistry.

[25]  A. Harada,et al.  SAP‐1 is a microvillus‐specific protein tyrosine phosphatase that modulates intestinal tumorigenesis , 2009, Genes to cells : devoted to molecular & cellular mechanisms.

[26]  E. Tajara,et al.  Gene expression profiling reveals molecular marker candidates of laryngeal squamous cell carcinoma. , 2009, Oncology reports.

[27]  C. Shou,et al.  Prognostic Significance of Phosphatase of Regenerating Liver-3 Expression in Ovarian Cancer , 2009, Pathology & Oncology Research.

[28]  K. Takagaki,et al.  Protein phosphatase Dusp26 associates with KIF3 motor and promotes N-cadherin-mediated cell–cell adhesion , 2009, Oncogene.

[29]  X. Qiu,et al.  PRL‐3 facilitates angiogenesis and metastasis by increasing ERK phosphorylation and up‐regulating the levels and activities of Rho‐A/C in lung cancer , 2009, Pathology.

[30]  K. Ghoshal,et al.  Estrogen-mediated suppression of the gene encoding protein tyrosine phosphatase PTPRO in human breast cancer: mechanism and role in tamoxifen sensitivity. , 2009, Molecular endocrinology.

[31]  F. Révillion,et al.  Expression of the putative tumor suppressor gene PTPN13/PTPL1 is an independent prognostic marker for overall survival in breast cancer , 2009, International journal of cancer.

[32]  C. Shou,et al.  Prognostic value of PRL‐3 overexpression in early stages of colonic cancer , 2009, Histopathology.

[33]  P. Heneberg Use of protein tyrosine phosphatase inhibitors as promising targeted therapeutic drugs. , 2009, Current medicinal chemistry.

[34]  M. Tremblay The PTP Family Photo Album , 2009, Cell.

[35]  Wen Hwa Lee,et al.  Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome , 2009, Cell.

[36]  S. Cai,et al.  Elevated PRL-3 expression was more frequently detected in the large primary gastric cancer and exhibits a poor prognostic impact on the patients , 2009, Journal of Cancer Research and Clinical Oncology.

[37]  K. Ghoshal,et al.  PTPROt Inactivates the Oncogenic Fusion Protein BCR/ABL and Suppresses Transformation of K562 Cells* , 2009, Journal of Biological Chemistry.

[38]  B. Sander,et al.  EXPRESSION OF PTEN AND SHP1, INVESTIGATED FROM TISSUE MICROARRAYS IN PEDIATRIC ACUTE LYMPHOBLASTIC, LEUKEMIA , 2009, Pediatric hematology and oncology.

[39]  T. Ryken,et al.  Mutational inactivation of PTPRD in glioblastoma multiforme and malignant melanoma. , 2008, Cancer research.

[40]  I. Lossos,et al.  PTP1B is a negative regulator of interleukin 4-induced STAT6 signaling. , 2008, Blood.

[41]  Yan P. Yuan,et al.  Frameshift mutations in coding repeats of protein tyrosine phosphatase genes in colorectal tumors with microsatellite instability , 2008, BMC Cancer.

[42]  G. Capellá,et al.  PRL-3 is essentially overexpressed in primary colorectal tumours and associates with tumour aggressiveness , 2008, British Journal of Cancer.

[43]  E. Liu,et al.  Functional analysis of a cell cycle-associated, tumor-suppressive gene, protein tyrosine phosphatase receptor type G, in nasopharyngeal carcinoma. , 2008, Cancer research.

[44]  S. Cai,et al.  Expression and prognostic impact of PRL‐3 in lymph node metastasis of gastric cancer: Its molecular mechanism was investigated using artificial microRNA interference , 2008, International journal of cancer.

[45]  T. Furukawa,et al.  Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells. , 2008, Carcinogenesis.

[46]  L. Tan,et al.  Potential Molecular Mechanism for c-Src Kinase-mediated Regulation of Intestinal Cell Migration* , 2008, Journal of Biological Chemistry.

[47]  Keun Woo Lee,et al.  Molecular dynamics simulation study of PTP1B with allosteric inhibitor and its application in receptor based pharmacophore modeling , 2008, J. Comput. Aided Mol. Des..

[48]  J. Lei,et al.  Expression of phosphatase of regenerating liver 1 and 3 mRNA in esophageal squamous cell carcinoma. , 2008, Archives of pathology & laboratory medicine.

[49]  P. Delvenne,et al.  Cervix carcinoma is associated with an up-regulation and nuclear localization of the dual-specificity protein phosphatase VHR , 2008, BMC Cancer.

[50]  S. Pilotti,et al.  PTPRK negatively regulates transcriptional activity of wild type and mutated oncogenic beta-catenin and affects membrane distribution of beta-catenin/E-cadherin complexes in cancer cells. , 2008, Cellular signalling.

[51]  Q. Zeng,et al.  Monoclonal antibodies target intracellular PRL phosphatases to inhibit cancer metastases in mice , 2008, Cancer biology & therapy.

[52]  Zhon-Yin Zhang,et al.  Translational Control of C-terminal Src Kinase (Csk) Expression by PRL3 Phosphatase* , 2008, Journal of Biological Chemistry.

[53]  R. Stallings,et al.  Aberrant splicing of the PTPRD gene mimics microdeletions identified at this locus in neuroblastomas , 2008, Genes, chromosomes & cancer.

[54]  A. Elson,et al.  Protein tyrosine phosphatases: functional inferences from mouse models and human diseases , 2008, The FEBS journal.

[55]  B. Neel,et al.  The tyrosine phosphatase Shp2 (PTPN11) in cancer , 2008, Cancer and Metastasis Reviews.

[56]  N. Fotouhi,et al.  A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage. , 2008, Cancer research.

[57]  O. Abaan,et al.  PTPL1: a large phosphatase with a split personality , 2008, Cancer and Metastasis Reviews.

[58]  Zhon-Yin Zhang,et al.  Targeting PTPs with small molecule inhibitors in cancer treatment , 2008, Cancer and Metastasis Reviews.

[59]  M. Nistér,et al.  Gene expression analyses of grade II gliomas and identification of rPTPβ/ζ as a candidate oligodendroglioma marker , 2008 .

[60]  F. Zhan,et al.  Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. , 2008, Blood.

[61]  G. Hostetter,et al.  Small interfering RNA-mediated knockdown of PRL phosphatases results in altered Akt phosphorylation and reduced clonogenicity of pancreatic cancer cells , 2008, Molecular Cancer Therapeutics.

[62]  T. Mustelin,et al.  IMMUNOHISTOCHEMICAL ANALYSES OF PHOSPHATASES IN CHILDHOOD B-CELL LYMPHOMA: Lower Expression of PTEN and HePTP and Higher Number of Positive Cells for Nuclear SHP2 in B-Cell Lymphoma Cases Compared to Controls , 2008, Pediatric hematology and oncology.

[63]  L. Kong,et al.  The value and correlation between PRL‐3 expression and matrix metalloproteinase activity and expression in human gliomas , 2007, Neuropathology : official journal of the Japanese Society of Neuropathology.

[64]  Jian-Feng Wang,et al.  Metastatic suppressor genes inactivated by aberrant methylation in gastric cancer. , 2007, World journal of gastroenterology.

[65]  E. Jones,et al.  Immunoglobulin superfamily cell adhesion molecules: zippers and signals. , 2007, Current opinion in cell biology.

[66]  G. Garcia-Manero,et al.  Decreased expression level of SH2 domain‐containing protein tyrosine phosphatase‐1 (Shp1) is associated with progression of chronic myeloid leukaemia , 2007, The Journal of pathology.

[67]  S. Cai,et al.  Association of Tyrosine PRL-3 Phosphatase Protein Expression with Peritoneal Metastasis of Gastric Carcinoma and Prognosis , 2007, Surgery Today.

[68]  M. Grever,et al.  Methylation and Silencing of Protein Tyrosine Phosphatase Receptor Type O in Chronic Lymphocytic Leukemia , 2007, Clinical Cancer Research.

[69]  S. Sahu,et al.  Interaction of Pyk2 and PTP-PEST with leupaxin in prostate cancer cells. , 2007, American journal of physiology. Cell physiology.

[70]  Ying Wang,et al.  Expression of the human phosphatases of regenerating liver (PRLs) in colonic adenocarcinoma and its correlation with lymph node metastasis , 2007, International Journal of Colorectal Disease.

[71]  A. Scarpa,et al.  Expression of transmembrane protein tyrosine phosphatase gamma (PTPγ) in normal and neoplastic human tissues , 2007, Histopathology.

[72]  B. Neel,et al.  Protein-tyrosine phosphatase 1B is required for HER2/Neu-induced breast cancer. , 2007, Cancer research.

[73]  K. Kinzler,et al.  Identification of STAT3 as a substrate of receptor protein tyrosine phosphatase T , 2007, Proceedings of the National Academy of Sciences.

[74]  B. Kennedy,et al.  Protein tyrosine phosphatase 1B deficiency or inhibition delays ErbB2-induced mammary tumorigenesis and protects from lung metastasis , 2007, Nature Genetics.

[75]  J. Inazawa,et al.  A novel amplification target, DUSP26, promotes anaplastic thyroid cancer cell growth by inhibiting p38 MAPK activity , 2007, Oncogene.

[76]  B. Neel,et al.  The role of Shp2 (PTPN11) in cancer. , 2007, Current opinion in genetics & development.

[77]  K. Yanagihara,et al.  High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study , 2007, Virchows Archiv.

[78]  Y. Kwong,et al.  Aberrant gene methylation implicated in the progression of monoclonal gammopathy of undetermined significance to multiple myeloma , 2007, Journal of Clinical Pathology.

[79]  C. Chi,et al.  Protein tyrosine-phosphatase expression profiling in gastric cancer tissues. , 2006, Cancer letters.

[80]  A. Ullrich,et al.  PTP-PEST phosphatase variations in human cancer. , 2006, Cancer genetics and cytogenetics.

[81]  B. Dong,et al.  Overexpression of phosphatase of regenerating liver-3 in breast cancer: association with a poor clinical outcome. , 2006, Annals of oncology : official journal of the European Society for Medical Oncology.

[82]  L. Kiesel,et al.  Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer , 2006, British Journal of Cancer.

[83]  C. Croce,et al.  Genetic ablation of Ptprj, a mouse cancer susceptibility gene, results in normal growth and development and does not predispose to spontaneous tumorigenesis. , 2006, DNA and cell biology.

[84]  K. Burridge,et al.  Regulation of Cell Adhesion by Protein-tyrosine Phosphatases , 2006, Journal of Biological Chemistry.

[85]  Q. Tao,et al.  Epigenetic disruption of two proapoptotic genes MAPK10/JNK3 and PTPN13/FAP-1 in multiple lymphomas and carcinomas through hypermethylation of a common bidirectional promoter , 2006, Leukemia.

[86]  Emmanuel Dias-Neto,et al.  Identification of candidates for tumor‐specific alternative splicing in the thyroid , 2006, Genes, chromosomes & cancer.

[87]  A. Ullrich,et al.  Furin-, ADAM 10-, and γ-Secretase-Mediated Cleavage of a Receptor Tyrosine Phosphatase and Regulation of β-Catenin's Transcriptional Activity , 2006, Molecular and Cellular Biology.

[88]  P. di Sant'Agnese,et al.  Protein tyrosine phosphatase PTP1B is involved in neuroendocrine differentiation of prostate cancer , 2006, The Prostate.

[89]  K. Omura,et al.  Gene expression analysis by cDNA microarray in oral squamous cell carcinoma. , 2006, Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology.

[90]  C. Hellberg,et al.  Protein-tyrosine phosphatases and cancer , 2006, Nature Reviews Cancer.

[91]  C. Desponts,et al.  Conformation-assisted Inhibition of Protein-tyrosine Phosphatase-1B Elicits Inhibitor Selectivity over T-cell Protein-tyrosine Phosphatase* , 2006, Journal of Biological Chemistry.

[92]  A. Cox,et al.  PRL tyrosine phosphatases regulate rho family GTPases to promote invasion and motility. , 2006, Cancer research.

[93]  S. Polo,et al.  Endocytosis Conducts the Cell Signaling Orchestra , 2006, Cell.

[94]  C. Chi,et al.  PTPN3 and PTPN4 tyrosine phosphatase expression in human gastric adenocarcinoma. , 2006, Anticancer research.

[95]  E. Asante-Appiah,et al.  Residues Distant from the Active Site Influence Protein-tyrosine Phosphatase 1B Inhibitor Binding* , 2006, Journal of Biological Chemistry.

[96]  Jane Kuo,et al.  Targeting of the receptor protein tyrosine phosphatase beta with a monoclonal antibody delays tumor growth in a glioblastoma model. , 2006, Cancer research.

[97]  Ding‐Shinn Chen,et al.  Genetic characterization of fas-associated phosphatase-1 as a putative tumor suppressor gene on chromosome 4q21.3 in hepatocellular carcinoma. , 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.

[98]  T. Tammela,et al.  Dual‐specificity phosphatase 1 and serum/glucocorticoid‐regulated kinase are downregulated in prostate cancer , 2005, International journal of cancer.

[99]  M. Tremblay,et al.  Genetic ablation of protein tyrosine phosphatase 1B accelerates lymphomagenesis of p53-null mice through the regulation of B-cell development. , 2005, Cancer research.

[100]  Y. Maehara,et al.  Suppressed MKP-1 Is an Independent Predictor of Outcome in Patients with Hepatocellular Carcinoma , 2005, Oncology.

[101]  A. Bardelli,et al.  PRL-3 Phosphatase Is Implicated in Ovarian Cancer Growth , 2005, Clinical Cancer Research.

[102]  S. Jacob,et al.  Epigenetic regulation of protein tyrosine phosphatases: potential molecular targets for cancer therapy , 2005, Cancer Gene Therapy.

[103]  Neil O. Carragher,et al.  The role of focal-adhesion kinase in cancer — a new therapeutic opportunity , 2005, Nature Reviews Cancer.

[104]  Remco Dijkman,et al.  Epigenetic profiling of cutaneous T-cell lymphoma: promoter hypermethylation of multiple tumor suppressor genes including BCL7a, PTPRG, and p73. , 2005, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[105]  T. Furukawa,et al.  Abrogation of DUSP6 by hypermethylation in human pancreatic cancer , 2005, Journal of Human Genetics.

[106]  A. Gazdar,et al.  Differential methylation of genes that regulate cytokine signaling in lymphoid and hematopoietic tumors , 2005, Oncogene.

[107]  H. Chung,et al.  Gene copy number change events at chromosome 20 and their association with recurrence in gastric cancer patients. , 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

[108]  A. Fusco,et al.  The tyrosine phosphatase PTPRJ/DEP-1 genotype affects thyroid carcinogenesis , 2004, Oncogene.

[109]  E. Song,et al.  Expression of FAP-1 by human colon adenocarcinoma: implication for resistance against Fas-mediated apoptosis in cancer , 2004, British Journal of Cancer.

[110]  C. Morrison,et al.  Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[111]  J. Li,et al.  Catalytic domain of PRL-3 plays an essential role in tumor metastasis: Formation of PRL-3 tumors inside the blood vessels , 2004, Cancer biology & therapy.

[112]  K. Gish,et al.  Candidate tumor-suppressor genes on chromosome arm 8p in early-onset and high-grade breast cancers , 2004, Oncogene.

[113]  S. Semba,et al.  Expression of PRL-3 Phosphatase in Human Gastric Carcinomas: Close Correlation with Invasion and Metastasis , 2004, Pathobiology.

[114]  Y. Kwong,et al.  SOCS1 and SHP1 hypermethylation in multiple myeloma: implications for epigenetic activation of the Jak/STAT pathway. , 2004, Blood.

[115]  Joanna M. Sasin,et al.  Protein Tyrosine Phosphatases in the Human Genome , 2004, Cell.

[116]  Gang Liu Technology evaluation: ISIS-113715, Isis. , 2004, Current opinion in molecular therapeutics.

[117]  S. Vicent,et al.  Mitogen-Activated Protein Kinase Phosphatase-1 Is Overexpressed in Non-Small Cell Lung Cancer and Is an Independent Predictor of Outcome in Patients , 2004, Clinical Cancer Research.

[118]  Giovanni Parmigiani,et al.  Mutational Analysis of the Tyrosine Phosphatome in Colorectal Cancers , 2004, Science.

[119]  C. Shou,et al.  The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal cancer , 2004, Journal of Cancer Research and Clinical Oncology.

[120]  K. Pienta,et al.  Expression mapping at 12p12‐13 in advanced prostate carcinoma , 2004, International journal of cancer.

[121]  J. Nesland,et al.  The PAC-1 dual specificity phosphatase predicts poor outcome in serous ovarian carcinoma. , 2004, Gynecologic oncology.

[122]  B. Leggett,et al.  Identification of Genes Uniquely Involved in Frequent Microsatellite Instability Colon Carcinogenesis by Expression Profiling Combined with Epigenetic Scanning , 2004, Cancer Research.

[123]  Toshiyuki Fukada,et al.  A genomic perspective on protein tyrosine phosphatases: gene structure, pseudogenes, and genetic disease linkage , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[124]  K. Hayashi,et al.  Activated Proliferation of B-Cell Lymphomas/Leukemias with the SHP1 Gene Silencing by Aberrant CpG Methylation , 2003, Laboratory Investigation.

[125]  M. Westphal,et al.  Expression and Function of the Receptor Protein Tyrosine Phosphatase ζ and Its Ligand Pleiotrophin in Human Astrocytomas , 2003, Journal of neuropathology and experimental neurology.

[126]  K. Kinzler,et al.  PRL-3 expression in metastatic cancers. , 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

[127]  O. Sagi-Assif,et al.  Dual-specificity phosphatase Pyst2-L is constitutively highly expressed in myeloid leukemia and other malignant cells , 2003, Oncogene.

[128]  M. Westphal,et al.  A role for receptor tyrosine phosphataseζ in glioma cell migration , 2003, Oncogene.

[129]  O. Sagi-Assif,et al.  Overexpression of the dual-specificity MAPK phosphatase PYST2 in acute leukemia. , 2003, Cancer letters.

[130]  Kenneth M. Yamada,et al.  Phosphatases in cell–matrix adhesion and migration , 2003, Nature Reviews Molecular Cell Biology.

[131]  M. Kasuga,et al.  Downregulation of stomach cancer-associated protein tyrosine phosphatase-1 (SAP-1) in advanced human hepatocellular carcinoma , 2003, Oncogene.

[132]  V. Vasioukhin Faculty Opinions recommendation of Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148. , 2003 .

[133]  J. Li,et al.  PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. , 2003, Cancer research.

[134]  F. Motoi,et al.  Potential tumor suppressive pathway involving DUSP6/MKP-3 in pancreatic cancer. , 2003, The American journal of pathology.

[135]  M. Kruhøffer,et al.  The resistance of B-CLL cells to DNA damage-induced apoptosis defined by DNA microarrays. , 2003, Blood.

[136]  H. Friess,et al.  Down-regulation of the dual-specificity phosphatase MKP-1 suppresses tumorigenicity of pancreatic cancer cells. , 2003, Gastroenterology.

[137]  M. Corada,et al.  Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, β-catenin, and the phosphatase DEP-1/CD148 , 2003, The Journal of cell biology.

[138]  Mitsutoshi Nakamura,et al.  Overexpression of leucocyte common antigen (LAR) P-subunit in thyroid carcinomas , 2003, British Journal of Cancer.

[139]  Hsien-yu Wang,et al.  Overexpression of mitogen-activated protein kinase phosphatases MKP1, MKP2 in human breast cancer. , 2003, Cancer letters.

[140]  Mitsutoshi Nakamura,et al.  Novel tumor suppressor loci on 6q22-23 in primary central nervous system lymphomas. , 2003, Cancer research.

[141]  Steffen Hauptmann,et al.  Expression of mitogen‐activated protein kinase phosphatase‐1 (MKP‐1) in primary human ovarian carcinoma , 2002, International journal of cancer.

[142]  Mattias Höglund,et al.  Frequent amplification of 8q24, 11q, 17q, and 20q‐specific genes in pancreatic cancer , 2002, Genes, chromosomes & cancer.

[143]  K. Hayashi,et al.  Gene silencing of the tyrosine phosphatase SHP1 gene by aberrant methylation in leukemias/lymphomas. , 2002, Cancer research.

[144]  E. Borden,et al.  Anticancer Activity of Sodium Stibogluconate in Synergy with IFNs1 , 2002, The Journal of Immunology.

[145]  S. Vicent,et al.  CL100 expression is down-regulated in advanced epithelial ovarian cancer and its re-expression decreases its malignant potential , 2002, Oncogene.

[146]  Cestmir Vlcek,et al.  Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers , 2002, Nature Genetics.

[147]  S. M. Burden-Gulley,et al.  Expression of the Receptor Protein-tyrosine Phosphatase, PTPμ, Restores E-cadherin-dependent Adhesion in Human Prostate Carcinoma Cells* , 2002, The Journal of Biological Chemistry.

[148]  W. Birchmeier,et al.  Hakai, a c-Cbl-like protein, ubiquitinates and induces endocytosis of the E-cadherin complex , 2002, Nature Cell Biology.

[149]  L. Buscail,et al.  Autocrine regulation of human prostate carcinoma cell proliferation by somatostatin through the modulation of the SH2 domain containing protein tyrosine phosphatase (SHP)-1. , 2002, The Journal of clinical endocrinology and metabolism.

[150]  M. Herlyn,et al.  Protein tyrosine phosphatase genes downregulated in melanoma. , 2001, The Journal of investigative dermatology.

[151]  Michael A. Choti,et al.  A Phosphatase Associated with Metastasis of Colorectal Cancer , 2001, Science.

[152]  B. Kennedy,et al.  Attenuation of Adhesion-dependent Signaling and Cell Spreading in Transformed Fibroblasts Lacking Protein Tyrosine Phosphatase-1B , 2001, The Journal of Biological Chemistry.

[153]  J. Bjorge,et al.  Identification of Protein-tyrosine Phosphatase 1B as the Major Tyrosine Phosphatase Activity Capable of Dephosphorylating and Activating c-Src in Several Human Breast Cancer Cell Lines* , 2000, The Journal of Biological Chemistry.

[154]  C. LeVea,et al.  PTP LAR Expression Compared to Prognostic Indices in Metastatic and Non-Metastatic Breast Cancer , 2000, Breast Cancer Research and Treatment.

[155]  S. Ménard,et al.  Expression of protein tyrosine phosphatase alpha (RPTPα) in human breast cancer correlates with low tumor grade, and inhibits tumor cell growth in vitro and in vivo , 2000, Oncogene.

[156]  M. Wasik,et al.  Lack of phosphotyrosine phosphatase SHP-1 expression in malignant T-cell lymphoma cells results from methylation of the SHP-1 promoter. , 2000, The American journal of pathology.

[157]  Y. Liaw,et al.  Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma. , 2000, Cancer research.

[158]  K. Mikoshiba,et al.  Impaired learning with enhanced hippocampal long‐term potentiation in PTPδ‐deficient mice , 2000 .

[159]  K. Hirokawa,et al.  Expression of protein tyrosine phosphatases and its significance in esophageal cancer. , 2000, Experimental and molecular pathology.

[160]  R. Vilella,et al.  Site-selective Dephosphorylation of the Platelet-derived Growth Factor β-Receptor by the Receptor-like Protein-tyrosine Phosphatase DEP-1* , 2000, The Journal of Biological Chemistry.

[161]  Stuart A. Aaronson,et al.  Overexpression of Kinase-Associated Phosphatase (KAP) in Breast and Prostate Cancer and Inhibition of the Transformed Phenotype by Antisense KAP Expression , 2000, Molecular and Cellular Biology.

[162]  M. Camps,et al.  Dual specificity phosphatases: a gene family for control of MAP kinase function , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[163]  S. H. Kim,et al.  In vivo expression of soluble Fas and FAP‐1: possible mechanisms of Fas resistance in human hepatoblastomas , 1999, The Journal of pathology.

[164]  J. Hahn,et al.  Constitutive activation of extracellular signal-regulated kinase in human acute leukemias: combined role of activation of MEK, hyperexpression of extracellular signal-regulated kinase, and downregulation of a phosphatase, PAC1. , 1999, Blood.

[165]  Tao Yang,et al.  Leukocyte common antigen–related tyrosine phosphatase receptor: Increased expression and neuronal‐type splicing in breast cancer cells and tissue , 1999, Molecular carcinogenesis.

[166]  H. Kosmehl,et al.  Expression of the transmembrane protein tyrosine phosphatase RPTPα in human oral squamous cell carcinoma , 1999, Histochemistry and Cell Biology.

[167]  L. Poels,et al.  Reduced expression of protein tyrosine phosphatase gamma in lung and ovarian tumors. , 1999, Cancer letters.

[168]  J. Peacock,et al.  Protein-tyrosine Phosphatase α Regulates Src Family Kinases and Alters Cell-Substratum Adhesion* , 1998, The Journal of Biological Chemistry.

[169]  Y. Bang,et al.  Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma. , 1998, Biochemical and biophysical research communications.

[170]  R. Siebert,et al.  Cytogenetical assignment and physical mapping of the human R-PTP-kappa gene (PTPRK) to the putative tumor suppressor gene region 6q22.2-q22.3. , 1998, Genomics.

[171]  Bert Vogelstein,et al.  Mutational Analysis of the APC/β-Catenin/Tcf Pathway in Colorectal Cancer , 1998 .

[172]  M. Kasuga,et al.  Overexpression of SAP-1, a transmembrane-type protein tyrosine phosphatase, in human colorectal cancers. , 1997, Biochemical and biophysical research communications.

[173]  M. Loda,et al.  Expression of mitogen-activated protein kinase phosphatase-1 in the early phases of human epithelial carcinogenesis. , 1996, The American journal of pathology.

[174]  D. Smith,et al.  Increased mRNA expression of the receptor-like protein tyrosine phosphatase α in late stage colon carcinomas , 1995 .

[175]  R. Berkowitz,et al.  Overexpression of the protein tyrosine phosphatase, nonreceptor type 6 (PTPN6), in human epithelial ovarian cancer. , 1995, Gynecologic oncology.

[176]  R. Bast,et al.  Overexpression of the tyrosine phosphatase PTP1B is associated with human ovarian carcinomas. , 1994, American journal of obstetrics and gynecology.

[177]  R. Bast,et al.  Overexpression of the protein tyrosine phosphatase PTP1B in human breast cancer: association with p185c-erbB-2 protein expression. , 1994, Journal of the National Cancer Institute.

[178]  H. Griesser,et al.  A hematopoietic protein tyrosine phosphatase (HePTP) gene that is amplified and overexpressed in myeloid malignancies maps to chromosome 1q32.1. , 1994, Leukemia.

[179]  J. Inazawa,et al.  Molecular cloning of a human transmembrane-type protein tyrosine phosphatase and its expression in gastrointestinal cancers. , 1994, The Journal of biological chemistry.

[180]  N. Tonks,et al.  Purification of the major protein-tyrosine-phosphatases of human placenta. , 1988, The Journal of biological chemistry.

[181]  Peter A. Jones,et al.  Epigenetics in cancer. , 2010, Carcinogenesis.

[182]  K. Burridge,et al.  Chapter 1. Focal adhesions: new angles on an old structure. , 2009, International review of cell and molecular biology.

[183]  Y. Li,et al.  Evaluation of PRL-3 expression, and its correlation with angiogenesis and invasion in hepatocellular carcinoma. , 2008, International journal of molecular medicine.

[184]  S. Cai,et al.  High Expression of PRL-3 can Promote Growth of Gastric Cancer and Exhibits a Poor Prognostic Impact on Patients , 2008, Annals of Surgical Oncology.

[185]  M. Nistér,et al.  Gene expression analyses of grade II gliomas and identification of rPTPbeta/zeta as a candidate oligodendroglioma marker. , 2008, Neuro-oncology.

[186]  Xiuli Jiang,et al.  Aberrant splicing of cyclin-dependent kinase-associated protein phosphatase KAP increases proliferation and migration in glioblastoma. , 2007, Cancer research.

[187]  Charis Eng,et al.  Cancer phenomics: RET and PTEN as illustrative models , 2007, Nature Reviews Cancer.

[188]  Nunzio Bottini,et al.  Protein tyrosine phosphatases and the immune response , 2005, Nature Reviews Immunology.

[189]  M. Sibony,et al.  An In Situ Hybridization Study , 2005 .

[190]  加藤 洋隆 High expression of PRL-3 promotes cancer cell motility and liver metastasis in human colorectal cancer : a predictive molecular marker of metachronous liver and lung metastases , 2005 .

[191]  S. Kulp,et al.  Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-γ (PTPγ) mRNA expression by estrogenically active agents , 2004, Breast Cancer Research and Treatment.

[192]  M. Westphal,et al.  A role for receptor tyrosine phosphatase zeta in glioma cell migration. , 2003, Oncogene.

[193]  S. Kulp,et al.  Involvement of breast epithelial-stromal interactions in the regulation of protein tyrosine phosphatase-gamma (PTPgamma) mRNA expression by estrogenically active agents. , 2002, Breast Cancer Research and Treatment.

[194]  B. Alberts,et al.  Cell-Cell Adhesion , 2002 .

[195]  T. Goldmann,et al.  A receptor-type protein tyrosine phosphatase PTP zeta is expressed in human cutaneous melanomas. , 2000, Folia histochemica et cytobiologica.

[196]  A. Sparks,et al.  Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. , 1998, Cancer research.

[197]  M. Loda,et al.  Mitogen-activated protein kinase phosphatase 1 is overexpressed in prostate cancers and is inversely related to apoptosis. , 1997, Laboratory investigation; a journal of technical methods and pathology.