Adherence to cardiovascular medications: lessons learned and future directions.

Approximately 50% of patients with cardiovascular disease and/or its major risk factors have poor adherence to their prescribed medications. Finding novel methods to help patients improve their adherence to existing evidence-based cardiovascular drug therapies has enormous potential to improve health outcomes while potentially reducing health care costs. The goal of this report is to provide a review of the current understanding of adherence to cardiovascular medications from the point of view of prescribing clinicians and cardiovascular researchers. Key topics addressed include: (1) definitions of medication adherence; (2) prevalence and impact of non-adherence; (3) methods for assessing medication adherence; 4) reasons for poor adherence; and 5) approaches to improving adherence to cardiovascular medications. For each of these topics, the report seeks to identify important gaps in knowledge and opportunities for advancing the field of cardiovascular adherence research.

[1]  C. Vogeli,et al.  Primary Medication Non-Adherence: Analysis of 195,930 Electronic Prescriptions , 2010, Journal of General Internal Medicine.

[2]  Dean Schillinger,et al.  Communication and medication refill adherence: the Diabetes Study of Northern California. , 2013, JAMA internal medicine.

[3]  …AND TRANSIENT ISCHEMIC ATTACKS , 1980 .

[4]  Ping Li,et al.  Prevalence, Predictors, and Outcomes of Primary Nonadherence After Acute Myocardial Infarction , 2008, Circulation.

[5]  Carol R Horowitz,et al.  Understanding Minority Patients’ Beliefs About Hypertension to Reduce Gaps in Communication Between Patients and Clinicians , 2012, Journal of clinical hypertension.

[6]  I. Wilson,et al.  Optimal Recall Period and Response Task for Self-Reported HIV Medication Adherence , 2007, AIDS and Behavior.

[7]  W. J. Elliott,et al.  Interventions to Enhance Medication Adherence in Chronic Medical Conditions: A Systematic Review , 2008 .

[8]  Harlan M. Krumholz,et al.  Prevalence, Predictors, and Outcomes of Premature Discontinuation of Thienopyridine Therapy After Drug-Eluting Stent Placement: Results From the PREMIER Registry , 2006, Circulation.

[9]  D. Asch,et al.  Automated hovering in health care--watching over the 5000 hours. , 2012, The New England journal of medicine.

[10]  E. Vittinghoff,et al.  Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. , 2008, JAMA.

[11]  J. Urquhart,et al.  Adherence to medications: insights arising from studies on the unreliable link between prescribed and actual drug dosing histories. , 2012, Annual review of pharmacology and toxicology.

[12]  Jeannie K. Lee,et al.  Effect of a pharmacy care program on medication adherence and persistence, blood pressure, and low-density lipoprotein cholesterol: a randomized controlled trial. , 2006, JAMA.

[13]  D. Wald,et al.  Adherence to drugs that prevent cardiovascular disease: meta-analysis on 376,162 patients. , 2012, The American journal of medicine.

[14]  David Bawden,et al.  The dark side of information: overload, anxiety and other paradoxes and pathologies , 2009, J. Inf. Sci..

[15]  W. Chaplin,et al.  Aspirin Adherence, Depression and One-Year Prognosis after Acute Coronary Syndrome , 2011, Psychotherapy and Psychosomatics.

[16]  L. Osterberg,et al.  Adherence to medication. , 2005, The New England journal of medicine.

[17]  J. Arndt,et al.  The implications of death for health: a terror management health model for behavioral health promotion. , 2008, Psychological review.

[18]  D. Sackett,et al.  RANDOMISED CLINICAL TRIAL OF STRATEGIES FOR IMPROVING MEDICATION COMPLIANCE IN PRIMARY HYPERTENSION , 1975, The Lancet.

[19]  A. Light,et al.  OPIUM ADDICTION: VI. THE EFFECTS OF ABRUPT WITHDRAWAL FOLLOWED BY READMINISTRATION OF MORPHINE IN HUMAN ADDICTS, WITH SPECIAL REFERENCE TO THE COMPOSITION OF THE BLOOD, THE CIRCULATION AND THE METABOLISM , 1929 .

[20]  C. Voils,et al.  Improving the measurement of self-reported medication nonadherence. , 2011, Journal of clinical epidemiology.

[21]  J. Stockman Patterns of Nonadherence to Antiepileptic Drug Therapy in Children With Newly Diagnosed Epilepsy , 2012 .

[22]  M. Woodward,et al.  Meta-Analysis: Impact of Drug Class on Adherence to Antihypertensives , 2011, Circulation.

[23]  B. Martina,et al.  Physicians' Ability to Predict Patients' Adherence to Antihypertensive Medication in Primary Care , 2008, Hypertension Research.

[24]  Lizheng Shi,et al.  Correlation between adherence rates measured by MEMS and self-reported questionnaires: a meta-analysis , 2010, Health and quality of life outcomes.

[25]  W. Spiering,et al.  The cardiovascular polypill in high-risk patients , 2012, European journal of preventive cardiology.

[26]  D. Alter,et al.  Relationship between adherence to evidence-based pharmacotherapy and long-term mortality after acute myocardial infarction. , 2007, JAMA.

[27]  C. Brensinger,et al.  Randomized trial of lottery-based incentives to improve warfarin adherence. , 2012, American heart journal.

[28]  D. Edmondson,et al.  Posttraumatic Stress Disorder and Adherence to Medications in Survivors of Strokes and Transient Ischemic Attacks , 2012, Stroke.

[29]  L. Green,et al.  Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence , 1986, Medical care.

[30]  Muhammad Mamdani,et al.  Adherence with statin therapy in elderly patients with and without acute coronary syndromes. , 2002, JAMA.

[31]  C. Viscoli,et al.  Treatment adherence and risk of death after a myocardial infarction , 1990, The Lancet.

[32]  B. Gersh,et al.  Prevalence, Predictors, and Outcomes of Premature Discontinuation of Thienopyridine Therapy After Drug-Eluting Stent Placement: Results From the PREMIER Registry , 2007 .

[33]  William H Shrank,et al.  Four-dollar generics--increased accessibility, impaired quality assurance. , 2010, The New England journal of medicine.

[34]  Kevin G Volpp,et al.  Can behavioural economics make us healthier? , 2012, BMJ : British Medical Journal.

[35]  G. Knafl,et al.  Secondary analysis of electronically monitored medication adherence data for a cohort of hypertensive African-Americans , 2012, Patient preference and adherence.

[36]  Nicholas A. Christakis,et al.  Social contagion theory: examining dynamic social networks and human behavior , 2011, Statistics in medicine.

[37]  R. Verbrugge,et al.  Impact of Medication Adherence on Hospitalization Risk and Healthcare Cost , 2005, Medical care.

[38]  Peter J. Neumann,et al.  Long-term persistence in use of statin therapy in elderly patients. , 2002, JAMA.

[39]  Cole Pv Treatment of Reflux Oesophagitis , 1964 .

[40]  E. Vittinghoff,et al.  Placebo adherence and mortality in the Heart and Estrogen/Progestin Replacement Study. , 2012, The American journal of medicine.

[41]  L. Køber,et al.  Persistent Use of Evidence-Based Pharmacotherapy in Heart Failure Is Associated With Improved Outcomes , 2007, Circulation.

[42]  D. Au,et al.  A Refill Adherence Algorithm for Multiple Short Intervals to Estimate Refill Compliance (ReComp) , 2007, Medical care.

[43]  Heather M. Tavel,et al.  Sociodemographic and Clinical Characteristics Are Not Clinically Useful Predictors of Refill Adherence in Patients With Hypertension , 2009, Circulation. Cardiovascular quality and outcomes.

[44]  J. McQuaid,et al.  A longitudinal investigation of the impact of life stress on HIV treatment adherence , 2010, Journal of Behavioral Medicine.

[45]  C. McKevitt,et al.  Lay perspectives on hypertension and drug adherence: systematic review of qualitative research , 2012, BMJ : British Medical Journal.

[46]  A. L. Dal-Fabbro,et al.  Adherence to long term therapies: evidence for action , 2005 .

[47]  Lonny Reisman,et al.  Full coverage for preventive medications after myocardial infarction. , 2011, The New England journal of medicine.

[48]  K. Lohr,et al.  Interventions to Improve Adherence to Self-administered Medications for Chronic Diseases in the United States , 2012, Annals of Internal Medicine.

[49]  Anuj K. Dalal,et al.  Effect of a Pharmacist Intervention on Clinically Important Medication Errors After Hospital Discharge , 2012, Annals of Internal Medicine.

[50]  Jane Wardle,et al.  Making health habitual: the psychology of 'habit-formation' and general practice. , 2012, The British journal of general practice : the journal of the Royal College of General Practitioners.

[51]  Anuja Roy,et al.  Medication compliance and persistence: terminology and definitions. , 2008, Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research.

[52]  M Christopher Roebuck,et al.  Medication adherence leads to lower health care use and costs despite increased drug spending. , 2011, Health affairs.

[53]  M. Woodward,et al.  Predictors of Nonadherence to Statins: A Systematic Review and Meta-Analysis , 2010, The Annals of pharmacotherapy.

[54]  T. Kaptchuk,et al.  Biological, clinical, and ethical advances of placebo effects , 2010, The Lancet.