论文信息 - Sulphasalazine induced renal failure.

Sulphasalazine induced renal failure.

Two men with longstanding ulcerative colitis who were treated with sulphasalazine for several years and who developed chronic renal failure are reported. Renal biopsy specimens showed histological changes consistent with drug induced chronic intestinal nephritis. Extensive investigation made other causes of chronic renal failure unlikely. One of these patients underwent renal transplantation, the other has impaired but stable renal function.

R. Allan | A. Dwarakanath | J. Michael

[1] P. Williams,et al. Nephrotic syndrome associated with sulphasalazine. , 1990, BMJ.

[2] D. Jewell,et al. Acetylation of 5-aminosalicylic acid by isolated human colonic epithelial cells. , 1990, Clinical science.

[3] H. Gröne,et al. [Chronic interstitial nephritis after treatment with 5-aminosalicylic acid]. , 1989, Deutsche medizinische Wochenschrift.

[4] F. Hofstädter,et al. [Acute interstitial nephritis caused by 5-aminosalicylic acid?]. , 1989, Der Internist.

[5] F. Müller. [Suspicion of syphilis from cross reactions in Borrelia infection]. , 1989, Deutsche medizinische Wochenschrift.

[6] J. Bernheim,et al. Nephrotic syndrome after treatment with 5-aminosalicylic acid , 1988, British medical journal.

[7] H. Pieniaszek,et al. Capacity-limited gut wall metabolism of 5-aminosalicylic acid, a therapeutically active metabolite of sulfasalazine, in rats. , 1979, Journal of pharmaceutical sciences.

[8] J. McManus,et al. Adverse reactions during salicylazosulfapyridine therapy and the relation with drug metabolism and acetylator phenotype. , 1973, The New England journal of medicine.

[9] I. Calder,et al. Comparative Nephrotoxicity of Aspirin and Phenacetin Derivatives , 1971, British medical journal.

[10] Kirk Ts. A Case of Paraplegia Due to Spinal Caries: Ménard's Operation. , 1896 .