An Electromagnetic Microvalve for Pneumatic Control of Microfluidic Systems

An electromagnetic microvalve for pneumatic control of microfluidic devices has been designed, fabricated, and tested. The microvalve is composed of two parts: a miniature electromagnetic actuator and a valve body. The electromagnetic actuator consists mainly of a thin polydimethylsiloxane (PDMS)–based elastomer, which acts as the valve diaphragm. The diaphragm, used as a solid hydraulic medium, converts the large contact area of a valve core into a small contact area of valve head while maintaining a large stroking force. This microvalve remains closed because of a compressed mechanical spring force generated by the actuator. On the other hand, when a voltage is applied, the valve core moves up, relaxing the thin PDMS membrane, opening the microvalve. The fast open response (~17 ms) of the valve was achieved with a leak rate as low as 0.026 sccm at 200 KPa (N2) pressure. We tested the pertinent dynamic parameters such as flow rate in on/off mode, flow rate of duty cycles, and actuated frequencies in pulse width modulation (PWM) mode. Our method provides a simple, cheap, and small microvalve that avoids the bulky and expensive external pressure control solenoid manifold. This allows it to be easily integrated into portable and disposable devices.

[1]  G. Whitesides,et al.  Torque-actuated valves for microfluidics. , 2005, Analytical chemistry.

[2]  Werner Karl Schomburg,et al.  Polymer micro valve with a hydraulic piezo-drive fabricated by the AMANDA process , 2004 .

[3]  Chang-Hyeon Ji,et al.  A solid hydraulically amplified piezoelectric microvalve , 2011 .

[4]  C. A. Rich A thermopneumatically -actuated silicon microvalve and integrated microflow controller. , 2000 .

[5]  Bo Yang Yu Microfluidic Large Scale Integration and its Application in Image Based Microflow Cytometry , 2010 .

[6]  G. Whitesides,et al.  Fabrication of microfluidic systems in poly(dimethylsiloxane) , 2000, Electrophoresis.

[7]  Vincent Studer,et al.  Scaling properties of a low-actuation pressure microfluidic valve , 2004 .

[9]  S Elizabeth Hulme,et al.  Incorporation of prefabricated screw, pneumatic, and solenoid valves into microfluidic devices. , 2009, Lab on a chip.

[10]  J. Mueller,et al.  Leak-tight piezoelectric microvalve for high-pressure gas micropropulsion , 2004, Journal of Microelectromechanical Systems.

[11]  Bruce K. Gale,et al.  An electrostatic microvalve for pneumatic control of microfluidic systems , 2012 .

[12]  Peter J. Hesketh,et al.  An electromagnetic actuated on/off microvalve fabricated on top of a single wafer , 2005 .

[13]  Hongkai Wu,et al.  A screw-actuated pneumatic valve for portable, disposable microfluidics. , 2009, Lab on a chip.

[14]  Shuichi Takayama,et al.  Multiplexed hydraulic valve actuation using ionic liquid filled soft channels and Braille displays , 2007 .

[15]  F. T. Degasperi,et al.  Fabrication and testing of a poly(vinylidene fluoride) (PVDF) microvalve for gas flow control , 2007 .

[16]  Lin Gui,et al.  Microfluidic phase change valve with a two-level cooling/heating system , 2011 .

[17]  Bruce K. Gale,et al.  A PDMS-based gas permeation pump for on-chip fluid handling in microfluidic devices , 2006 .

[18]  G. Whitesides,et al.  Rapid Prototyping of Microfluidic Systems in Poly(dimethylsiloxane). , 1998, Analytical chemistry.

[19]  Werner Karl Schomburg,et al.  Polymer micro piezo valve with a small dead volume , 2004 .

[20]  Samuel K Sia,et al.  Actuation of elastomeric microvalves in point-of-care settings using handheld, battery-powered instrumentation. , 2010, Lab on a chip.

[21]  R. Pal,et al.  Phase change microvalve for integrated devices. , 2004, Analytical chemistry.

[22]  C. Malek,et al.  Development of a low cost hybrid Si/PDMS multi-layered pneumatic microvalve , 2005 .

[23]  G. Thornell,et al.  A solder sealing method for paraffin-filled microcavities , 2006 .

[24]  A. Neogi,et al.  Oscillating magnetic field-actuated microvalves for micro- and nanofluidics , 2009 .

[25]  Shuichi Takayama,et al.  Computerized microfluidic cell culture using elastomeric channels and Braille displays. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Capanu,et al.  Design, fabrication, and testing of a bistable electromagnetically actuated microvalve , 2000, Journal of Microelectromechanical Systems.

[27]  G. Whitesides,et al.  Poly(dimethylsiloxane) as a material for fabricating microfluidic devices. , 2002, Accounts of chemical research.

[28]  Jong Wook Hong,et al.  Integrated nanoliter systems , 2003, Nature Biotechnology.