Proton and carbon-13 nuclear magnetic resonance studies of the effects of retinal on the dynamic structure and stability of lipid bilayer.

The effects of retinal and vitamin A on the dynamic structure and stability of hen egg yolk lecithin bilayers have been studied by means of carbon-13 and proton NMR spectroscopies. 13C spin-lattice relaxation and paramagnetic ion permeability studies on lecithin bilayers indicate a marked decrease in flexibility of the lipid acyl chain and a breakdown of membrane impermeableness to ion by the intercalated all-trans- and 11-cis-retinal, whereas the effect of incorporated vitamin A on the fluidity of bilayers is small and its impermeableness to ion remains effective even in the presence of higher concentration of vitamin A. The experimental results are discussed in connection with the mechanism of the permeability change in photoreceptive disk membrane.

[1]  G. Groenendijk,et al.  Dark isomerization of retinals in the presence of phosphatidylethanolamine. , 2005, European journal of biochemistry.

[2]  N. Zumbulyadis,et al.  Proton and carbon-13 nuclear magnetic resonance studies of rhodopsin-phospholipid interactions. , 1979, Biochemistry.

[3]  R. Strasser,et al.  Rhodopsin--phospholipid complexes in apolar environments: photochemical characterization. , 1979, Biochemistry.

[4]  E. Dratz,et al.  Thermal lateral phase separations in bovine retinal rod outer segment membranes and phospholipids as evidenced by parinaric acid fluorescence polarization and energy transfer. , 1979, The Journal of biological chemistry.

[5]  A. Watts,et al.  Rhodopsin-lipid associations in bovine rod outer segment membranes. Identification of immobilized lipid by spin-labels. , 1979, Biochemistry.

[6]  A. J. Adams,et al.  SPATIAL ARRANGEMENT OF RHODOPSIN IN THE DISK MEMBRANE AS STUDIED BY ENZYMATIC LABELING * , 1979, Photochemistry and photobiology.

[7]  B. Litman.  RHODOPSIN: ITS MOLECULAR SUBSTRUCTURE AND PHOSPHOLIPID INTERACTIONS * , 1979, Photochemistry and photobiology.

[8]  B. Rabinovitch.  A POSSIBLE MECHANISM FOR THE ROLE OF N‐RETINYLIDENE PHOSPHATIDYL ETHANOLAMINE IN THE REGENERATION OF RHODOPSIN , 1979 .

[9]  Y. Inoue,et al.  Carbon-13 Chemical Shifts of Retinal Isomers and Their Schiff Bases as Models of Visual Chromophores , 1979 .

[10]  N. Zumbulyadis,et al.  Light-regulated permeability of rhodopsin:egg phosphatidylcholine recombinant membranes. , 1977, Proceedings of the National Academy of Sciences of the United States of America.

[11]  Y. Inoue,et al.  A study of pi-electron delocalization in model compounds of visual pigment by UV and carbon-13 NMR spectra. , 1977, Journal of the American Chemical Society.

[12]  S. E. Ostroy.  Rhodopsin and the visual process. , 1977, Biochimica et biophysica acta.

[13]  D. O'Brien,et al.  Photochemical functionality of rhodopsin-phospholipid recombinant membranes. , 1977, Biochemistry.

[14]  C. Polnaszek,et al.  Molecular motion and order in single-bilayer vesicles and multilamellar dispersions of egg lecithin and lecithin-cholesterol mixtures. A deuterium nuclear magnetic resonance study of specifically labeled lipids. , 1976, Biochemistry.

[15]  R. Somers,et al.  EFFECT OF THE PHYSICAL STATE OF PHOSPHOLIPID ON RHODOPSIN REGENERATION FROM RETINYLIDENE PHOSPHOLIPID , 1975, Photochemistry and photobiology.

[16]  P. E. Godici,et al.  Carbon-13 nuclear magnetic resonance study of the dynamic structure of lecithin-cholesterol membranes and the position of stearic acid spin-labels , 1975 .

[17]  I. R. Peat,et al.  Time saving in 13C spin-lattice relaxation measurements by inversion-recovery , 1975 .

[18]  W. Hubbell.  Characterization of rhodopsin in synthetic systems , 1975 .

[19]  G. Radda,et al.  NMR studies on phospholipid bilayers. Some factors affecting lipid distribution. , 1975, Biochimica et biophysica acta.

[20]  R. Somers,et al.  Possible involvement of retinylidene phospholipid in photoisomerization of all-trans-retinal to 11-cis-retinal. , 1974, The Journal of biological chemistry.

[21]  T. Jovin,et al.  Rhodopsin. Purification and recombination with phospholipids assayed by the metarhodopsin I leads to metarhodopsin II transition. , 1974, Biochemistry.

[22]  L. Pinto,et al.  Ionic mechanism for the photoreceptor potential of the retina of Bufo marinus , 1974, The Journal of physiology.

[23]  P. E. Godici,et al.  The dynamic structure of lipid membranes. A 13C nuclear magnetic resonance study using spin labels. , 1974, Biochemistry.

[24]  H. Hauser,et al.  Effect of chain length on the stability of lecithin bilayers. , 1973, Biochemical and biophysical research communications.

[25]  R. Barrnett,et al.  Lanthanide ion-induced isotropic shifts and broadening for nuclear magnetic resonance structural analysis of model membranes. , 1973, Proceedings of the National Academy of Sciences of the United States of America.

[26]  M. Akhtar,et al.  The regeneration of rhodopsin from all-trans-retinal: solubilization of an enzyme system involved in the completion of the visual cycle. , 1972, The Biochemical journal.

[27]  R. Cone,et al.  Dark Ionic Flux and the Effects of Light in Isolated Rod Outer Segments , 1972, The Journal of general physiology.

[28]  D. Papahadjopoulos,et al.  Permeability properties of phospholipid membranes: effect of cholesterol and temperature. , 1972, Biochimica et biophysica acta.

[29]  N. Birdsall,et al.  13 C nuclear magnetic resonance relaxation measurements of synthetic lecithins and the effect of spin-labeled lipids. , 1972, Biochemistry.

[30]  H. Shichi.  Biochemistry of visual pigments. II. Phospholipid requirement and opsin conformation for regeneration of bovine rhodopsin. , 1971, The Journal of biological chemistry.

[31]  T. Yoshizawa,et al.  The effects of all-trans- and II-cis-retinal on the erythrocyte membrane. , 1971, Biochimica et biophysica acta.

[32]  R. Kornberg,et al.  Inside-outside transitions of phospholipids in vesicle membranes. , 1971, Biochemistry.

[33]  R. E. Anderson,et al.  Phospholipids of bovine outer segments. , 1970, Biochemistry.

[34]  S. Fleischer,et al.  Lipid composition of bovine retinal outer segment fragments. , 1970, Biochimica et biophysica acta.

[35]  T. Tomita.  Electrical activity of vertebrate photoreceptors , 1970, Quarterly Reviews of Biophysics.

[36]  T. Tomita,et al.  Studies on the mass receptor potential of the isolated frog retina. II. On the basis of the ionic mechanism. , 1969, Vision research.

[37]  F. Daemen,et al.  Internal Protonation in Retinylidene Phosphatidylethanolamine and the Red-shift in Rhodopsin , 1969, Nature.

[38]  R. P. Poincelot,et al.  Lipid to Protein Chromophore Transfer in the Photolysis of Visual Pigments , 1969, Nature.

[39]  N. Tattrie,et al.  Maximum and minimum values for lecithin classes from various biological sources. , 1968, Canadian journal of biochemistry.

[40]  W. S. Singleton,et al.  Chromatographically homogeneous lecithin from egg phospholipids , 1965, Journal of the American Oil Chemists' Society.

[41]  J. Lucy,et al.  Studies on the mode of action of excess of vitamin A. 5. The effect of vitamin A on the stability of the erythrocyte membrane. , 1962, The Biochemical journal.

[42]  J. Dingle,et al.  Studies on the mode of action of excess of vitamin A. 3. Release of a bound protease by the action of vitamin A. , 1961, The Biochemical journal.

[43]  G. Wald,et al.  The neo-b isomer of vitamin A and retinene. , 1956, The Journal of biological chemistry.