Bioenergetics and kinetics of microtubule and actin filament assembly-disassembly.

Publisher Summary This chapter discusses the bioenergetics and kinetics of microtubule and actin filament assembly–disassembly. The chapter focuses on an important property of actin filaments and microtubules: their utilization of the free energy of adenosine triphosphate (ATP) or guanosine triphosphate (GTP) hydrolysis. To interpret the function of nucleoside triphosphate hydrolysis, a number of other properties are considered that include the structural and kinetic polarity of the filaments; their interaction at the ends with specific components; and the action of forces on the filaments. The important boundary conditions, such as forces acting in various ways on the filaments and the effect of materials that interact at the ends of filaments, are discussed in the chapter. The chapter also focuses on the biological implications of these properties in terms of capacity to do work, regulate length, and regulate spatial distribution.

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