VEGFs and receptors involved in angiogenesis versus lymphangiogenesis.
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[1] Gavin Thurston,et al. Control of vascular morphogenesis and homeostasis through the angiopoietin–Tie system , 2009, Nature Reviews Molecular Cell Biology.
[2] P. Carmeliet,et al. Vascular Endothelial Growth Factor-B Induces Myocardium-Specific Angiogenesis and Arteriogenesis via Vascular Endothelial Growth Factor Receptor-1– and Neuropilin Receptor-1–Dependent Mechanisms , 2009, Circulation.
[3] K. Alitalo,et al. Transgenic induction of vascular endothelial growth factor-C is strongly angiogenic in mouse embryos but leads to persistent lymphatic hyperplasia in adult tissues. , 2008, The American journal of pathology.
[4] Christian Fischer,et al. FLT1 and its ligands VEGFB and PlGF: drug targets for anti-angiogenic therapy? , 2008, Nature Reviews Cancer.
[5] Seppo Ylä-Herttuala,et al. Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy , 2008, Circulation research.
[6] K. Alitalo,et al. Suppression of prostate cancer nodal and systemic metastasis by blockade of the lymphangiogenic axis. , 2008, Cancer research.
[7] E. Boscolo,et al. Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma , 2008, Nature Medicine.
[8] P. Carmeliet,et al. Reevaluation of the Role of VEGF-B Suggests a Restricted Role in the Revascularization of the Ischemic Myocardium , 2008, Arteriosclerosis, thrombosis, and vascular biology.
[9] Y. Funahashi,et al. Multi-Kinase Inhibitor E7080 Suppresses Lymph Node and Lung Metastases of Human Mammary Breast Tumor MDA-MB-231 via Inhibition of Vascular Endothelial Growth Factor-Receptor (VEGF-R) 2 and VEGF-R3 Kinase , 2008, Clinical Cancer Research.
[10] B. Garmy-Susini,et al. Integrins in angiogenesis and lymphangiogenesis , 2008, Nature Reviews Cancer.
[11] Gabriele Bergers,et al. Modes of resistance to anti-angiogenic therapy , 2008, Nature Reviews Cancer.
[12] Antonio Duarte,et al. Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation , 2008, Nature.
[13] K. Alitalo,et al. The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis. , 2008, Cancer research.
[14] E. Olson,et al. Control of endothelial cell proliferation and migration by VEGF signaling to histone deacetylase 7 , 2008, Proceedings of the National Academy of Sciences.
[15] Jussi Taipale,et al. Deletion of Vascular Endothelial Growth Factor C (VEGF-C) and VEGF-D Is Not Equivalent to VEGF Receptor 3 Deletion in Mouse Embryos , 2008, Molecular and Cellular Biology.
[16] Lauri Eklund,et al. Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell–cell and cell–matrix contacts , 2008, Nature Cell Biology.
[17] T. Kodama,et al. Differential function of Tie2 at cell–cell contacts and cell–substratum contacts regulated by angiopoietin-1 , 2008, Nature Cell Biology.
[18] S. Stacker,et al. Molecular Control of Lymphatic Metastasis , 2008, Annals of the New York Academy of Sciences.
[19] F. Peale,et al. Blocking neuropilin-2 function inhibits tumor cell metastasis. , 2008, Cancer cell.
[20] B. Spiegelman,et al. HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α , 2008, Nature.
[21] K. Alitalo,et al. Molecular biology and pathology of lymphangiogenesis. , 2008, Annual review of pathology.
[22] N. Ferrara,et al. VEGF inhibition: insights from preclinical and clinical studies , 2008, Cell and Tissue Research.
[23] K. Alitalo,et al. Therapeutic differentiation and maturation of lymphatic vessels after lymph node dissection and transplantation , 2007, Nature Medicine.
[24] M. Giacca,et al. Anti-PlGF Inhibits Growth of VEGF(R)-Inhibitor-Resistant Tumors without Affecting Healthy Vessels , 2007, Cell.
[25] Kenneth P. Roos,et al. Autocrine VEGF Signaling Is Required for Vascular Homeostasis , 2007, Cell.
[26] M. Shibuya,et al. Distinct vascular endothelial growth factor signals for lymphatic vessel enlargement and sprouting , 2007, The Journal of experimental medicine.
[27] T. Veikkola,et al. Distinct roles of vascular endothelial growth factor-D in lymphangiogenesis and metastasis. , 2007, The American journal of pathology.
[28] G. Thurston,et al. Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting , 2007, Proceedings of the National Academy of Sciences.
[29] Antonio Duarte,et al. The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching , 2007, Proceedings of the National Academy of Sciences.
[30] Nathan D. Lawson,et al. Notch signalling limits angiogenic cell behaviour in developing zebrafish arteries , 2007, Nature.
[31] Holger Gerhardt,et al. Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis , 2007, Nature.
[32] K. Alitalo,et al. VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. , 2007, Blood.
[33] K. Alitalo,et al. Vascular endothelial growth factor receptor 3 is involved in tumor angiogenesis and growth. , 2007, Cancer research.
[34] Franklin Peale,et al. Blocking neuropilin-1 function has an additive effect with anti-VEGF to inhibit tumor growth. , 2007, Cancer cell.
[35] Minhong Yan,et al. Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis , 2006, Nature.
[36] Gavin Thurston,et al. Blockade of Dll4 inhibits tumour growth by promoting non-productive angiogenesis , 2006, Nature.
[37] J. Gutkind,et al. VEGF controls endothelial-cell permeability by promoting the β-arrestin-dependent endocytosis of VE-cadherin , 2006, Nature Cell Biology.
[38] L. Damico,et al. DEVELOPMENT OF RANIBIZUMAB, AN ANTI–VASCULAR ENDOTHELIAL GROWTH FACTOR ANTIGEN BINDING FRAGMENT, AS THERAPY FOR NEOVASCULAR AGE-RELATED MACULAR DEGENERATION , 2006, Retina.
[39] A. Villemain,et al. The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. , 2006, Cancer research.
[40] T. Veikkola,et al. Lymphangiogenic growth factor responsiveness is modulated by postnatal lymphatic vessel maturation. , 2006, The American journal of pathology.
[41] Lena Claesson-Welsh,et al. Signal transduction by VEGF receptors in regulation of angiogenesis and lymphangiogenesis. , 2006, Experimental cell research.
[42] D. Shima,et al. VEGF function in vascular pathogenesis. , 2006, Experimental cell research.
[43] R. Avery,et al. Intravitreal bevacizumab (Avastin) for neovascular age-related macular degeneration. , 2006, Ophthalmology.
[44] M. Skobe,et al. Inhibition of VEGFR-3 activation with the antagonistic antibody more potently suppresses lymph node and distant metastases than inactivation of VEGFR-2. , 2006, Cancer research.
[45] A. Harris,et al. Up-regulation of the Notch ligand Delta-like 4 inhibits VEGF-induced endothelial cell function. , 2006, Blood.
[46] G. Davis,et al. Biosynthesis, Remodeling, and Functions During Vascular Morphogenesis and Neovessel Stabilization , 2005 .
[47] Napoleone Ferrara,et al. VEGF as a Therapeutic Target in Cancer , 2005, Oncology.
[48] W. Sessa,et al. Endothelial nitric oxide synthase is critical for ischemic remodeling, mural cell recruitment, and blood flow reserve. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[49] P. Carmeliet,et al. Common mechanisms of nerve and blood vessel wiring , 2005, Nature.
[50] C. Wernstedt,et al. VEGF receptor‐2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis , 2005, The EMBO journal.
[51] K. Alitalo,et al. Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. , 2005, Cancer research.
[52] Satoshi Hirakawa,et al. VEGF-A induces tumor and sentinel lymph node lymphangiogenesis and promotes lymphatic metastasis , 2005, The Journal of experimental medicine.
[53] M. Halford,et al. Vascular Endothelial Growth Factor D Is Dispensable for Development of the Lymphatic System , 2005, Molecular and Cellular Biology.
[54] B. Varnum,et al. Inhibition of vascular endothelial growth factor receptor 2-mediated endothelial cell activation by Axl tyrosine kinase receptor. , 2005, Blood.
[55] Seppo Ylä-Herttuala,et al. Pathogenesis of persistent lymphatic vessel hyperplasia in chronic airway inflammation. , 2005, The Journal of clinical investigation.
[56] M. Shibuya,et al. Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[57] R. Jain. Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy , 2005, Science.
[58] M. Skobe,et al. Complete and specific inhibition of adult lymphatic regeneration by a novel VEGFR-3 neutralizing antibody. , 2005, Journal of the National Cancer Institute.
[59] Kenji Nakamura,et al. Membrane Fixation of Vascular Endothelial Growth Factor Receptor 1 Ligand-Binding Domain Is Important for Vasculogenesis and Angiogenesis in Mice , 2005, Molecular and Cellular Biology.
[60] K. Alitalo,et al. Vascular endothelial growth factor‐C gene therapy restores lymphatic flow across incision wounds , 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[61] Napoleone Ferrara,et al. Vascular endothelial growth factor: basic science and clinical progress. , 2004, Endocrine reviews.
[62] P. Bohlen,et al. VEGF‐A promotes tissue repair‐associated lymphatic vessel formation via VEGFR‐2 and the α1β1 and α2β1 integrins , 2004 .
[63] J. Berlin,et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. , 2004, The New England journal of medicine.
[64] L. Claesson‐Welsh,et al. The Adaptor Protein Shb Binds to Tyrosine 1175 in Vascular Endothelial Growth Factor (VEGF) Receptor-2 and Regulates VEGF-dependent Cellular Migration* , 2004, Journal of Biological Chemistry.
[65] Y. Yamaoka,et al. Suppression of VEGFR‐3 signaling inhibits lymph node metastasis in gastric cancer , 2004, Cancer science.
[66] Jingtai Cao,et al. VEGF-A stimulates lymphangiogenesis and hemangiogenesis in inflammatory neovascularization via macrophage recruitment. , 2004, The Journal of clinical investigation.
[67] Rakesh K. Jain,et al. Pathology: Cancer cells compress intratumour vessels , 2004, Nature.
[68] K. Lim,et al. Circulating angiogenic factors and the risk of preeclampsia. , 2004, The New England journal of medicine.
[69] B. Christ,et al. The effects of growth factors on the day 13 chorioallantoic membrane (CAM): a study of VEGF165 and PDGF-BB , 1992, Anatomy and Embryology.
[70] J. Partanen,et al. Vascular endothelial growth factor C is required for sprouting of the first lymphatic vessels from embryonic veins , 2004, Nature Immunology.
[71] Lena Claesson-Welsh,et al. Ligand-induced Vascular Endothelial Growth Factor Receptor-3 (VEGFR-3) Heterodimerization with VEGFR-2 in Primary Lymphatic Endothelial Cells Regulates Tyrosine Phosphorylation Sites* , 2003, Journal of Biological Chemistry.
[72] G. Kay,et al. Vegfb gene knockout mice display reduced pathology and synovial angiogenesis in both antigen-induced and collagen-induced models of arthritis. , 2003, Arthritis and rheumatism.
[73] Christoph Dehio,et al. Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1 , 2003, Nature Medicine.
[74] K. Alitalo,et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia , 2003, The Journal of cell biology.
[75] P. Ratcliffe,et al. Regulation of angiogenesis by hypoxia: role of the HIF system , 2003, Nature Medicine.
[76] J. Sleeman,et al. Differential in vivo and in vitro expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in tumors and its relationship to lymphatic metastasis in immunocompetent rats. , 2003, Cancer research.
[77] E. Manseau,et al. Vascular Permeability Factor/Vascular Endothelial Growth Factor Induces Lymphangiogenesis as well as Angiogenesis , 2002, The Journal of experimental medicine.
[78] H. Dvorak. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. , 2002, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.
[79] Martin Friedlander,et al. Retinal vascular development is mediated by endothelial filopodia, a preexisting astrocytic template and specific R-cadherin adhesion. , 2002, Investigative ophthalmology & visual science.
[80] Holger Gerhardt,et al. Spatially restricted patterning cues provided by heparin-binding VEGF-A control blood vessel branching morphogenesis. , 2002, Genes & development.
[81] T. Veikkola,et al. Lymphangiogenic Gene Therapy With Minimal Blood Vascular Side Effects , 2002, The Journal of experimental medicine.
[82] K. Alitalo,et al. Tumor-associated macrophages express lymphatic endothelial growth factors and are related to peritumoral lymphangiogenesis. , 2002, The American journal of pathology.
[83] M. Siemionow,et al. Adenovirus encoding vascular endothelial growth factor-D induces tissue-specific vascular patterns in vivo. , 2002, Blood.
[84] K. Alitalo,et al. Suppression of tumor lymphangiogenesis and lymph node metastasis by blocking vascular endothelial growth factor receptor 3 signaling. , 2002, Journal of the National Cancer Institute.
[85] Rakesh K Jain,et al. Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics , 2002, Science.
[86] Z. Werb,et al. New functions for the matrix metalloproteinases in cancer progression , 2002, Nature Reviews Cancer.
[87] A. Luttun,et al. Revascularization of ischemic tissues by PlGF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1 , 2002, Nature Medicine.
[88] K. Alitalo,et al. Multiple Forms of Mouse Vascular Endothelial Growth Factor-D Are Generated by RNA Splicing and Proteolysis* , 2001, The Journal of Biological Chemistry.
[89] R. Kauppinen,et al. A model for gene therapy of human hereditary lymphedema , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[90] E C Nice,et al. Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF‐C/D receptor VEGFR‐3 , 2001, The EMBO journal.
[91] M. Karkkainen,et al. The Specificity of Receptor Binding by Vascular Endothelial Growth Factor-D Is Different in Mouse and Man* , 2001, The Journal of Biological Chemistry.
[92] M. Shibuya,et al. A single autophosphorylation site on KDR/Flk‐1 is essential for VEGF‐A‐dependent activation of PLC‐γ and DNA synthesis in vascular endothelial cells , 2001, The EMBO journal.
[93] N. Rahimi,et al. Identification of Tyrosine Residues in Vascular Endothelial Growth Factor Receptor-2/FLK-1 Involved in Activation of Phosphatidylinositol 3-Kinase and Cell Proliferation* , 2001, The Journal of Biological Chemistry.
[94] Till Acker,et al. Synergism between vascular endothelial growth factor and placental growth factor contributes to angiogenesis and plasma extravasation in pathological conditions , 2001, Nature Medicine.
[95] L Claesson-Welsh,et al. Signaling properties of VEGF receptor-1 and -2 homo- and heterodimers. , 2001, The international journal of biochemistry & cell biology.
[96] K. Alitalo,et al. Adenoviral Expression of Vascular Endothelial Growth Factor-C Induces Lymphangiogenesis in the Skin , 2001, Circulation research.
[97] T. Veikkola,et al. Signalling via vascular endothelial growth factor receptor‐3 is sufficient for lymphangiogenesis in transgenic mice , 2001, The EMBO journal.
[98] M. Karkkainen,et al. Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth. , 2001, Cancer research.
[99] R K Jain,et al. Predominant role of endothelial nitric oxide synthase in vascular endothelial growth factor-induced angiogenesis and vascular permeability , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[100] L. Orci,et al. Vascular endothelial growth factor‐C‐mediated lymphangiogenesis promotes tumour metastasis , 2001, The EMBO journal.
[101] Seppo Ylä-Herttuala,et al. Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3 , 2001, Nature Medicine.
[102] Thomas Hawighorst,et al. Induction of tumor lymphangiogenesis by VEGF-C promotes breast cancer metastasis , 2001, Nature Medicine.
[103] Steven A. Stacker,et al. VEGF-D promotes the metastatic spread of tumor cells via the lymphatics , 2001, Nature Medicine.
[104] K. Alitalo,et al. VEGF‐C and VEGF‐D expression in neuroendocrine cells and their receptor, VEGFR‐3, in fenestrated blood vessels in human tissues , 2000, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[105] L. Mayo,et al. Tumor Necrosis Factor Employs a Protein-tyrosine Phosphatase to Inhibit Activation of KDR and Vascular Endothelial Cell Growth Factor-induced Endothelial Cell Proliferation* , 2000, The Journal of Biological Chemistry.
[106] G. Kay,et al. Mice lacking the vascular endothelial growth factor-B gene (Vegfb) have smaller hearts, dysfunctional coronary vasculature, and impaired recovery from cardiac ischemia. , 2000, Circulation research.
[107] Dian Feng,et al. Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor , 2000, Laboratory Investigation.
[108] J. Peng,et al. Increased hemangioblast commitment, not vascular disorganization, is the primary defect in flt-1 knock-out mice. , 1999, Development.
[109] W. Sessa,et al. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt , 1999, Nature.
[110] B. Weinstein. What guides early embryonic blood vessel formation? , 1999, Developmental dynamics : an official publication of the American Association of Anatomists.
[111] B. Terman,et al. Autophosphorylation of KDR in the kinase domain is required for maximal VEGF-stimulated kinase activity and receptor internalization , 1999, Oncogene.
[112] Vishva Dixit,et al. Vascular Endothelial Growth Factor Regulates Endothelial Cell Survival through the Phosphatidylinositol 3′-Kinase/Akt Signal Transduction Pathway , 1998, The Journal of Biological Chemistry.
[113] K. Alitalo,et al. Cardiovascular failure in mouse embryos deficient in VEGF receptor-3. , 1998, Science.
[114] T. Noda,et al. Flt-1 lacking the tyrosine kinase domain is sufficient for normal development and angiogenesis in mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[115] F. Larcher,et al. VEGF/VPF overexpression in skin of transgenic mice induces angiogenesis, vascular hyperpermeability and accelerated tumor development , 1998, Oncogene.
[116] R K Jain,et al. Increased microvascular density and enhanced leukocyte rolling and adhesion in the skin of VEGF transgenic mice. , 1998, The Journal of investigative dermatology.
[117] Salvatore Oliviero,et al. Embryonic expression pattern of the murine figf gene, a growth factor belonging to platelet-derived growth factor/vascular endothelial growth factor family , 1998, Mechanisms of Development.
[118] K. Alitalo,et al. A Recombinant Mutant Vascular Endothelial Growth Factor-C that Has Lost Vascular Endothelial Growth Factor Receptor-2 Binding, Activation, and Vascular Permeability Activities* , 1998, The Journal of Biological Chemistry.
[119] K. Alitalo,et al. Vascular endothelial growth factor D (VEGF-D) is a ligand for the tyrosine kinases VEGF receptor 2 (Flk1) and VEGF receptor 3 (Flt4). , 1998, Proceedings of the National Academy of Sciences of the United States of America.
[120] Yihai Cao,et al. Proteolytic processing regulates receptor specificity and activity of VEGF‐C , 1997, The EMBO journal.
[121] R. Jain,et al. Hyperplasia of lymphatic vessels in VEGF-C transgenic mice. , 1997, Science.
[122] K. Alitalo,et al. VEGF-C receptor binding and pattern of expression with VEGFR-3 suggests a role in lymphatic vascular development. , 1996, Development.
[123] L. Aiello,et al. Characterization of vascular endothelial growth factor's effect on the activation of protein kinase C, its isoforms, and endothelial cell growth. , 1996, The Journal of clinical investigation.
[124] G. Breier,et al. The Vascular Endothelial Growth Factor Receptor Flt-1 Mediates Biological Activities , 1996, The Journal of Biological Chemistry.
[125] A. Mantovani,et al. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. , 1996, Blood.
[126] Lieve Moons,et al. Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele , 1996, Nature.
[127] Kenneth J. Hillan,et al. Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene , 1996, Nature.
[128] J. Rossant,et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium , 1995, Nature.
[129] Janet Rossant,et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice , 1995, Nature.
[130] K. Alitalo,et al. Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development. , 1995, Proceedings of the National Academy of Sciences of the United States of America.
[131] D. Donner,et al. Vascular Endothelial Cell Growth Factor Promotes Tyrosine Phosphorylation of Mediators of Signal Transduction That Contain SH2 Domains , 1995, The Journal of Biological Chemistry.
[132] K. Alitalo,et al. FLT4 receptor tyrosine kinase contains seven immunoglobulin-like loops and is expressed in multiple human tissues and cell lines. , 1992, Cancer research.
[133] D. Goeddel,et al. Vascular endothelial growth factor is a secreted angiogenic mitogen. , 1989, Science.
[134] D. Connolly,et al. Tumor vascular permeability factor stimulates endothelial cell growth and angiogenesis. , 1989, The Journal of clinical investigation.
[135] H. Dvorak,et al. Fibrin containing gels induce angiogenesis. Implications for tumor stroma generation and wound healing. , 1987, Laboratory investigation; a journal of technical methods and pathology.
[136] J. Folkman,et al. ISOLATION OF A TUMOR FACTOR RESPONSIBLE FOR ANGIOGENESIS , 1971, The Journal of experimental medicine.