Monitoring total hemoglobin concentration changes across neoadjuvant chemotherapy in PgR-positive and PgR-negative breast cancer with diffuse optical tomography

The aim of this study was to investigate the optical chemotherapy changes induced by neoadjuvant chemotherapy (NAC) in PgR-positive and PgR-negative breast cancer subtypes using a diffuse optical tomographic breast imaging system (DOTBIS). ctTHb reduction in the tumor volume was greater for patients with PgR-negative, a statistically significant difference of 48.91μM, p = .022, which suggest that PgR-negative tumors are generally less resistant to NAC. These observations indicate that PgR negativity may be combined to optically derived biomarkers for predicting pCR during neoadjuvant chemotherapy.

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