Chapter 6 Bioanalytical microsystems: technology and applications

Publisher Summary This chapter focuses on miniaturization techniques that are applied in the fabrication of novel biosensing systems. Novel immobilization procedures of biorecognition elements and sensing layers are described and the effect of miniaturization on the biosensor performance is discussed in the chapter. The chapter illustrates various examples of successfully miniaturized biosensors and fabrication of miniaturized biosensors. A distinction in miniaturized biosensors has to be made between a miniaturized flow system and the use of a miniaturized transducer. The integration of both can result in a microbiosensor with advantages over other analytical and bioanalytical methods. Research and development are necessary for the miniaturized biosensor part of these bioanalytical microsystems as well as for miniaturized sample pretreatment steps.

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