Antiparasitic activities of novel, orally available fumagillin analogs.

[1]  D. Ingber,et al.  Synthetic analogues of fumagillin that inhibit angiogenesis and suppress tumour growth , 1990, Nature.

[2]  J. Smith,et al.  Molecular cloning, sequencing, deletion, and overexpression of a methionine aminopeptidase gene from Saccharomyces cerevisiae. , 1992, The Journal of biological chemistry.

[3]  X Li,et al.  Amino-terminal protein processing in Saccharomyces cerevisiae is an essential function that requires two distinct methionine aminopeptidases. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[4]  Y. Chang,et al.  Evidence that the human homologue of a rat initiation factor-2 associated protein (p67) is a methionine aminopeptidase. , 1996, Biochemical and biophysical research communications.

[5]  K. Biemann,et al.  Methionine aminopeptidase (type 2) is the common target for angiogenesis inhibitors AGM-1470 and ovalicin. , 1997, Chemistry & biology.

[6]  W. Bornmann,et al.  The anti-angiogenic agent fumagillin covalently binds and inhibits the methionine aminopeptidase, MetAP-2. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[7]  J. Widom,et al.  Structure of human methionine aminopeptidase-2 complexed with fumagillin. , 1998, Science.

[8]  Eric C. Griffith,et al.  Molecular recognition of angiogenesis inhibitors fumagillin and ovalicin by methionine aminopeptidase 2. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[9]  G A Petsko,et al.  Chemistry and biology. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[10]  X. Su,et al.  Angiogenesis inhibitors specific for methionine aminopeptidase 2 as drugs for malaria and leishmaniasis. , 2002 .

[11]  C. D. Thompson,et al.  A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[12]  宁北芳,et al.  疟原虫var基因转换速率变化导致抗原变异[英]/Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A , 2005 .

[13]  Jun O. Liu,et al.  Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activity , 2006, Proceedings of the National Academy of Sciences.

[14]  B. Lefkove,et al.  Fumagillin: an anti-infective as a parent molecule for novel angiogenesis inhibitors , 2007, Expert review of anti-infective therapy.

[15]  P. Chiang,et al.  Total syntheses of (+/-)-ovalicin, C4(S *)-isomer, and its C5-analogs and anti-trypanosomal activities. , 2008, Bioorganic & medicinal chemistry.

[16]  Synthesis and evaluation of 2-pyridyl pyrimidines with in vitro antiplasmodial and antileishmanial activity. , 2009, Bioorganic & medicinal chemistry letters.

[17]  Jun O. Liu,et al.  Fumagillin and fumarranol interact with P. falciparum methionine aminopeptidase 2 and inhibit malaria parasite growth in vitro and in vivo. , 2009, Chemistry & biology.