A Tetrachloro Polyketide Hexahydro-1H-isoindolone, Muironolide A from the Marine Sponge Phorbas sp. Natural Products at the Nanomole Scale.

Muironolide A, a new chemical entity with an unprecedented chlorinated hexahydro-1H-isoindolone skeleton, was isolated in only 90 μg yield from the same marine sponge, Phorbas sp. that also provide...