Introduction: Self-medication is defined as use of medicines by the individuals on their own without professional advice to treat self-diagnosed conditions. It is prevalent not only among general population but also among doctors including dentists. Aim: To assess the pattern of self-medication practice among students of a dental college of Bangalore city. Materials and Methods: A cross-sectional study was conducted among undergraduate dental students through convenience sampling. A questionnaire consisting of 20 close-ended questions related to various aspects of self-medication practice was handed to the students. Results: Among 165 students, 68.5% of the participants were females. The most common ailments responsible for usage of self-medication were cough, cold and sore throat (22.4%) followed by headache (6.7%). Antibiotics (34.2%) and analgesics (23.9%) were the most commonly used drug groups for self-medication. Old prescription (58.2%) was found as the most common source of information for encouraging this type of practice. Conclusion: Majority of the dental students self-medicate themselves. Measures should be adopted to reduce such type of practice by guiding the students about the pros and cons of using medicines without prescription.