Stability of amorphous drug, 2-benzyl-5-(4-chlorophenyl)-6-[4-(methylthio)phenyl]-2H-pyridazin-3-one, in silica mesopores and measurement of its molecular mobility by solid-state (13)C NMR spectroscopy.

[1]  K. Terada,et al.  Influence of particle design on oral absorption of poorly water-soluble drug in a silica particle-supercritical fluid system. , 2011, Chemical & pharmaceutical bulletin.

[2]  Hiroshi Nakao,et al.  Enhancement of dissolution rate and oral absorption of a poorly water-soluble drug, K-832, by adsorption onto porous silica using supercritical carbon dioxide. , 2010, European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V.

[3]  D. Norwood,et al.  Study and characterization of crystalline hydrate/polymorph forms of 5,11-dihydro-11-ethyl-5-methyl-8-(2-(1-oxido-4-quinolinyl)ethyl-6H-dipyrido(3,2-B:2',3'-E)(1,4)diazepin-6-one by solid-state NMR and solution NMR. , 2010, Journal of pharmaceutical and biomedical analysis.

[4]  David S. Jones,et al.  Physicochemical characterization of hot melt extruded bicalutamide-polyvinylpyrrolidone solid dispersions. , 2010, Journal of pharmaceutical sciences.

[5]  S. Ueda,et al.  Detection of lot-to-lot variations in the amorphous microstructure of lyophilized protein formulations. , 2007, International journal of pharmaceutics.

[6]  B. Segmuller,et al.  Investigation of the effects of pharmaceutical processing upon solid-state NMR relaxation times and implications to solid-state formulation stability. , 2007, Journal of pharmaceutical sciences.

[7]  A. Bansal,et al.  Analytical techniques for quantification of amorphous/crystalline phases in pharmaceutical solids. , 2006, Journal of pharmaceutical sciences.

[8]  E. Yonemochi,et al.  Comparison of Molecular Mobility in the Glassy State Between Amorphous Indomethacin and Salicin Based on Spin-Lattice Relaxation Times , 2005, Pharmaceutical Research.

[9]  E. Yonemochi,et al.  Microscopic molecular mobility of amorphous AG-041R measured by solid-state 13C NMR. , 2004, International journal of pharmaceutics.

[10]  Y Aso,et al.  Explanation of the crystallization rate of amorphous nifedipine and phenobarbital from their molecular mobility as measured by (13)C nuclear magnetic resonance relaxation time and the relaxation time obtained from the heating rate dependence of the glass transition temperature. , 2001, Journal of pharmaceutical sciences.

[11]  A. Serajuddin,et al.  Solid dispersion of poorly water-soluble drugs: early promises, subsequent problems, and recent breakthroughs. , 1999, Journal of pharmaceutical sciences.

[12]  G. Zografi,et al.  Effects of sorbed water on the crystallization of indomethacin from the amorphous state. , 1997, Journal of pharmaceutical sciences.

[13]  Bruno C. Hancock,et al.  Characteristics and significance of the amorphous state in pharmaceutical systems. , 1997, Journal of pharmaceutical sciences.