2D Voxel-based Morphometry Shows Less White Matter Concentration in Autism

Autism is a neurodevelopmental disorder with the abnormal reduction in anterior, midbody and posterior part of the corpus callosum (CC) [2]. We applied 2D version of the voxel-based morphometry (VBM) in quantifying the dynamic pattern of the CC and show less white matter concentration in the high functioning autistic (HFA) group at the genu and spleninum removing the effect of age using the general linear model (GLM). Further it is shown that the less white matter concentration is due to hypoplasia rather than atrophy.