MUC1 Oncoprotein Stabilizes and Activates Estrogen Receptor α

[1]  L. Yin,et al.  MUC1 Oncoprotein Blocks Glycogen Synthase Kinase 3β–Mediated Phosphorylation and Degradation of β-Catenin , 2005 .

[2]  R. Gaynor,et al.  Formation of an IKKalpha-dependent transcription complex is required for estrogen receptor-mediated gene activation. , 2005, Molecular cell.

[3]  Xiaolong Wei,et al.  Human MUC1 oncoprotein regulates p53-responsive gene transcription in the genotoxic stress response. , 2005, Cancer cell.

[4]  Y. Kawasaki,et al.  Wnt/β-Catenin and Estrogen Signaling Converge in Vivo* , 2004, Journal of Biological Chemistry.

[5]  W. Shao,et al.  Coactivator AIB1 links estrogen receptor transcriptional activity and stability. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[6]  S. Gendler,et al.  MUC1 overexpression results in mammary gland tumorigenesis and prolonged alveolar differentiation , 2004, Oncogene.

[7]  Jeong Hoon Kim,et al.  Synergistic effects of coactivators GRIP1 and beta-catenin on gene activation: cross-talk between androgen receptor and Wnt signaling pathways. , 2004, The Journal of biological chemistry.

[8]  D. Kufe,et al.  Human MUC1 carcinoma-associated protein confers resistance to genotoxic anticancer agents. , 2004, Cancer cell.

[9]  Heike Brand,et al.  Estrogen Receptor-α Directs Ordered, Cyclical, and Combinatorial Recruitment of Cofactors on a Natural Target Promoter , 2003, Cell.

[10]  Jeong Hoon Kim,et al.  CoCoA, a nuclear receptor coactivator which acts through an N-terminal activation domain of p160 coactivators. , 2003, Molecular cell.

[11]  D. Kufe,et al.  MUC1 Cytoplasmic Domain Coactivates Wnt Target Gene Transcription and Confers Transformation , 2003, Cancer biology & therapy.

[12]  M. Hollingsworth,et al.  Nuclear Association of the Cytoplasmic Tail of MUC1 and β-Catenin* , 2003, Journal of Biological Chemistry.

[13]  L. Yin,et al.  Human MUC1 Carcinoma Antigen Regulates Intracellular Oxidant Levels and the Apoptotic Response to Oxidative Stress* , 2003, Journal of Biological Chemistry.

[14]  D. Kufe,et al.  Human DF3/MUC1 carcinoma-associated protein functions as an oncogene , 2003, Oncogene.

[15]  M. Loda,et al.  Heregulin targets gamma-catenin to the nucleolus by a mechanism dependent on the DF3/MUC1 oncoprotein. , 2003, Molecular cancer research : MCR.

[16]  S. Grossman,et al.  Physical and Functional Interactions between PML and MDM2* , 2003, Journal of Biological Chemistry.

[17]  M. Welsh,et al.  Segregation of receptor and ligand regulates activation of epithelial growth factor receptor , 2003, Nature.

[18]  D. Kufe,et al.  DF3/MUC1 Signaling In Multiple Myeloma Cells Is Regulated by Interleukin-7 , 2003, Cancer biology & therapy.

[19]  J. Ellenberg,et al.  Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling. , 2003, Molecular cell.

[20]  R. Russell,et al.  A dynamic structural model for estrogen receptor-alpha activation by ligands, emphasizing the role of interactions between distant A and E domains. , 2002, Molecular cell.

[21]  W. Shao,et al.  ERAP140, a Conserved Tissue-Specific Nuclear Receptor Coactivator , 2002, Molecular and Cellular Biology.

[22]  Simak Ali,et al.  Endocrine-responsive breast cancer and strategies for combating resistance , 2002, Nature Reviews Cancer.

[23]  L. Yin,et al.  The Epidermal Growth Factor Receptor Regulates Interaction of the Human DF3/MUC1 Carcinoma Antigen with c-Src and β-Catenin* , 2001, The Journal of Biological Chemistry.

[24]  Xinli Hu,et al.  Ligand-dependent Formation of Retinoid Receptors, Receptor-interacting Protein 140 (RIP140), and Histone Deacetylase Complex Is Mediated by a Novel Receptor-interacting Motif of RIP140* , 2001, The Journal of Biological Chemistry.

[25]  S. Gendler,et al.  Transgenic MUC1 Interacts with Epidermal Growth Factor Receptor and Correlates with Mitogen-activated Protein Kinase Activation in the Mouse Mammary Gland* , 2001, The Journal of Biological Chemistry.

[26]  D. Kufe,et al.  The c-Src Tyrosine Kinase Regulates Signaling of the Human DF3/MUC1 Carcinoma-associated Antigen with GSK3β and β-Catenin* , 2001, The Journal of Biological Chemistry.

[27]  D. Kufe,et al.  The Human DF3/MUC1 carcinoma-associated antigen signals nuclear localization of the catenin p120(ctn). , 2001, Biochemical and biophysical research communications.

[28]  Myles Brown,et al.  Cofactor Dynamics and Sufficiency in Estrogen Receptor–Regulated Transcription , 2000, Cell.

[29]  B. O’Malley,et al.  The 26S Proteasome Is Required for Estrogen Receptor-α and Coactivator Turnover and for Efficient Estrogen Receptor-α Transactivation , 2000 .

[30]  D. Aswad,et al.  Regulation of transcription by a protein methyltransferase. , 1999, Science.

[31]  Paul Tempst,et al.  Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex , 1999, Nature.

[32]  B. O’Malley,et al.  Proteasome-dependent degradation of the human estrogen receptor. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[33]  H. Richard-Foy,et al.  Chromatin structure of the regulatory regions of pS2 and cathepsin D genes in hormone-dependent and -independent breast cancer cell lines , 1999, Oncogene.

[34]  David A. Agard,et al.  The Structural Basis of Estrogen Receptor/Coactivator Recognition and the Antagonism of This Interaction by Tamoxifen , 1998, Cell.

[35]  D. Kufe,et al.  Interaction of Glycogen Synthase Kinase 3β with the DF3/MUC1 Carcinoma-Associated Antigen and β-Catenin , 1998, Molecular and Cellular Biology.

[36]  R. Roeder,et al.  The TRAP220 component of a thyroid hormone receptor- associated protein (TRAP) coactivator complex interacts directly with nuclear receptors in a ligand-dependent fashion. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[37]  Zbigniew Dauter,et al.  Molecular basis of agonism and antagonism in the oestrogen receptor , 1997, Nature.

[38]  C. Allis,et al.  Steroid receptor coactivator-1 is a histone acetyltransferase , 1997, Nature.

[39]  D. Kufe,et al.  Interaction of the DF3/MUC1 Breast Carcinoma-associated Antigen and β-Catenin in Cell Adhesion* , 1997, The Journal of Biological Chemistry.

[40]  M. Garabedian,et al.  GRIP1, a transcriptional coactivator for the AF-2 transactivation domain of steroid, thyroid, retinoid, and vitamin D receptors , 1997, Molecular and cellular biology.

[41]  Daniel Metzger,et al.  Activation of the Estrogen Receptor Through Phosphorylation by Mitogen-Activated Protein Kinase , 1995, Science.

[42]  B. O’Malley,et al.  Sequence and Characterization of a Coactivator for the Steroid Hormone Receptor Superfamily , 1995, Science.

[43]  William Bourguet,et al.  Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-α , 1995, Nature.

[44]  F. Miralles,et al.  Characterization of the proximal estrogen-responsive element of human cathepsin D gene. , 1994, Molecular endocrinology.

[45]  L. Perey,et al.  Tumor selective reactivity of a monoclonal antibody prepared against a recombinant peptide derived from the DF3 human breast carcinoma-associated antigen. , 1992, Cancer research.

[46]  M. Parker,et al.  Antiestrogen ICI 164,384 reduces cellular estrogen receptor content by increasing its turnover. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[47]  M. Ligtenberg,et al.  Cell-associated episialin is a complex containing two proteins derived from a common precursor. , 1992, The Journal of biological chemistry.

[48]  G. Merlo,et al.  Frequent alteration of the DF3 tumor-associated antigen gene in primary human breast carcinomas. , 1989, Cancer research.

[49]  J. Rothbard,et al.  A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. , 1988, The Journal of biological chemistry.

[50]  D. Hayes,et al.  Isolation and sequencing of a cDNA coding for the human DF3 breast carcinoma-associated antigen. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[51]  J. Lundy,et al.  Monoclonal antibody DF3 correlates with tumor differentiation and hormone receptor status in breast cancer patients , 2005, Breast Cancer Research and Treatment.

[52]  B. O’Malley,et al.  The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. , 2000, Molecular cell.

[53]  J. Schlom,et al.  Differential reactivity of a novel monoclonal antibody (DF3) with human malignant versus benign breast tumors. , 1984, Hybridoma.