Disruption of BCATm in mice leads to increased energy expenditure associated with the activation of a futile protein turnover cycle.
暂无分享,去创建一个
Pengxiang She | C. Lynch | T. Vary | A. Hajnal | S. Bronson | S. Hutson | Tanya Reid
[1] G. Schwartz,et al. Increasing Dietary Leucine Intake Reduces Diet-Induced Obesity and Improves Glucose and Cholesterol Metabolism in Mice via Multimechanisms , 2007, Diabetes.
[2] R. Mattes,et al. Effects of Acute and Chronic Protein Intake on Metabolism, Appetite, and Ghrelin During Weight Loss , 2007, Obesity.
[3] C. Lynch,et al. Leucine in food mediates some of the postprandial rise in plasma leptin concentrations. , 2006, American journal of physiology. Endocrinology and metabolism.
[4] G. Thomas,et al. Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. , 2006, Cell metabolism.
[5] B. Spiegelman,et al. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. , 2006, Endocrine reviews.
[6] George Thomas,et al. Hypothalamic mTOR Signaling Regulates Food Intake , 2006, Science.
[7] V. Cruzat,et al. Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction. , 2006, Nutrition.
[8] H. Margolese,et al. Weight loss during prolonged branched-chain amino acid treatment for tardive dyskinesia in a patient with schizophrenia. , 2006, The Australian and New Zealand journal of psychiatry.
[9] S. Kimball,et al. Signaling pathways and molecular mechanisms through which branched-chain amino acids mediate translational control of protein synthesis. , 2006, The Journal of nutrition.
[10] D. Layman,et al. Potential importance of leucine in treatment of obesity and the metabolic syndrome. , 2006, The Journal of nutrition.
[11] M. Westerterp-Plantenga,et al. Ghrelin and glucagon-like peptide 1 concentrations, 24-h satiety, and energy and substrate metabolism during a high-protein diet and measured in a respiration chamber. , 2006, The American journal of clinical nutrition.
[12] M. Brand,et al. Physiological functions of the mitochondrial uncoupling proteins UCP2 and UCP3. , 2005, Cell metabolism.
[13] D. Baker. Tolerance for branched-chain amino acids in experimental animals and humans. , 2005, The Journal of nutrition.
[14] A. Bonen,et al. Constitutive UCP3 overexpression at physiological levels increases mouse skeletal muscle capacity for fatty acid transport and oxidation , 2005, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[15] J. Fernstrom. Branched-chain amino acids and brain function. , 2005, The Journal of nutrition.
[16] A. Marette,et al. Increased activation of the mammalian target of rapamycin pathway in liver and skeletal muscle of obese rats: possible involvement in obesity-linked insulin resistance. , 2005, Endocrinology.
[17] G. Marchesini,et al. Update on nutritional supplementation with branched-chain amino acids , 2005, Current opinion in clinical nutrition and metabolic care.
[18] Frank B. Hu,et al. The Effects of High Protein Diets on Thermogenesis, Satiety and Weight Loss: A Critical Review , 2004, Journal of the American College of Nutrition.
[19] J. Auwerx,et al. Corrigendum: Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity , 2004, Nature.
[20] K. Westerterp. Nutrition & Metabolism BioMed Central Review Diet induced thermogenesis , 2004 .
[21] M. Brosnan,et al. Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes. , 2004, Canadian journal of physiology and pharmacology.
[22] M. Willingham,et al. Branched-chain amino acid catabolism: unique segregation of pathway enzymes in organ systems and peripheral nerves. , 2004, American journal of physiology. Endocrinology and metabolism.
[23] T. Hasegawa,et al. Application of ultrafiltration method to measurement of catecholamines in plasma of human and rodents by high-performance liquid chromatography. , 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[24] C. Lynch,et al. Potential role of leucine metabolism in the leucine-signaling pathway involving mTOR. , 2003, American journal of physiology. Endocrinology and metabolism.
[25] B. Lowell,et al. β-Adrenergic Receptors, Diet-induced Thermogenesis, and Obesity* , 2003, Journal of Biological Chemistry.
[26] K. Nair,et al. Effect of insulin on human skeletal muscle mitochondrial ATP production, protein synthesis, and mRNA transcripts , 2003, Proceedings of the National Academy of Sciences of the United States of America.
[27] M. Rossmeisl,et al. Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. , 2003, The Journal of clinical investigation.
[28] B. Lowell,et al. Beta-Adrenergic receptors, diet-induced thermogenesis, and obesity. , 2003, The Journal of biological chemistry.
[29] C. Lynch,et al. Tissue-specific effects of chronic dietary leucine and norleucine supplementation on protein synthesis in rats. , 2002, American journal of physiology. Endocrinology and metabolism.
[30] G. Farber,et al. Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms. , 2002, Biochemistry.
[31] Pamela D. Swan,et al. Postprandial Thermogenesis Is Increased 100% on a High-Protein, Low-Fat Diet versus a High-Carbohydrate, Low-Fat Diet in Healthy, Young Women , 2002, Journal of the American College of Nutrition.
[32] C. G. van der Linden,et al. Mechanism of Thyroid-Hormone Regulated Expression of the SERCA Genes in Skeletal Muscle: Implications for Thermogenesis , 2001, Bioscience reports.
[33] S. Kimball,et al. Leucine stimulates translation initiation in skeletal muscle of postabsorptive rats via a rapamycin-sensitive pathway. , 2000, The Journal of nutrition.
[34] L. Cynober,et al. Branched-chain keto-acids and pyruvate in blood: measurement by HPLC with fluorimetric detection and changes in older subjects. , 2000, Clinical chemistry.
[35] D. Taylor,et al. Branched chain amino acids induce apoptosis in neural cells without mitochondrial membrane depolarization or cytochrome c release: implications for neurological impairment associated with maple syrup urine disease. , 2000, Molecular biology of the cell.
[36] Bruce M. Spiegelman,et al. Towards a molecular understanding of adaptive thermogenesis , 2000, Nature.
[37] P. R. Beckett. Spectrophotometric assay for measuring branched-chain amino acids. , 2000, Methods in enzymology.
[38] R. Harris,et al. A molecular model of human branched-chain amino acid metabolism. , 1998, The American journal of clinical nutrition.
[39] G. Reinhart,et al. Overexpression and Characterization of the Human Mitochondrial and Cytosolic Branched-chain Aminotransferases* , 1998, The Journal of Biological Chemistry.
[40] G. Brown,et al. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. , 1997, Physiological reviews.
[41] F. Yoshizawa,et al. Protein synthesis and degradation change rapidly in response to food intake in muscle of food-deprived mice. , 1997, The Journal of nutrition.
[42] Hitoshi Yamashita,et al. Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese , 1997, nature.
[43] Steven A. Thomas,et al. Thermoregulatory and metabolic phenotypes of mice lacking noradrenaline and adrenaline , 1997, nature.
[44] P. Dawson,et al. Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm). , 1997, Biochimica et biophysica acta.
[45] A. Bigard,et al. Combined effects of caloric restriction and branched-chain amino acid supplementation on body composition and exercise performance in elite wrestlers. , 1997, International journal of sports medicine.
[46] F. Buttgereit,et al. A hierarchy of ATP-consuming processes in mammalian cells. , 1995, The Biochemical journal.
[47] Guoyao Wu,et al. Free and protein-bound amino acids in sow's colostrum and milk. , 1994, The Journal of nutrition.
[48] G. Reinhart,et al. Branched chain aminotransferase isoenzymes. Purification and characterization of the rat brain isoenzyme. , 1993, The Journal of biological chemistry.
[49] S. Hutson,et al. Identification of mitochondrial branched chain aminotransferase and its isoforms in rat tissues. , 1992, Journal of Biological Chemistry.
[50] X. Remesar,et al. Plasma amino acids of lean and obese Zucker rats subjected to a cafeteria diet after weaning. , 1991, Biochemistry international.
[51] Y. Schutz,et al. Protein turnover and thermogenesis in response to high-protein and high-carbohydrate feeding in men. , 1990, The American journal of clinical nutrition.
[52] J. Peters,et al. Protein intake, brain amino acid and serotonin concentrations and protein self-selection. , 1989, The Journal of nutrition.
[53] S. Hutson,et al. Role of mitochondrial transamination in branched chain amino acid metabolism. , 1988, The Journal of biological chemistry.
[54] D. Sapir,et al. EFFECTS OF α-KETOISOCAPROATE AND OF LEUCINE ON NITROGEN METABOLISM IN POSTOPERATIVE PATIENTS , 1983, The Lancet.
[55] D. Sapir,et al. Effects of alpha-ketoisocaproate and of leucine on nitrogen metabolism in postoperative patients. , 1983, Lancet.
[56] P. Haggarty,et al. Energy costs of protein and fatty acid synthesis , 1982, Proceedings of the Nutrition Society.
[57] P. Haggarty,et al. Tissue and whole-body protein synthesis in immature Zucker rats and their relationship to protein deposition. , 1982, The Biochemical journal.
[58] A. Goldberg,et al. Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle? , 1982, The Journal of biological chemistry.
[59] W. Mitch,et al. Nitrogen sparing induced by leucine compared with that induced by its keto analogue, alpha-ketoisocaproate, in fasting obese man. , 1981, The Journal of clinical investigation.
[60] Young Vr,et al. Ntau-methylhistidine (3-methylhistidine) and muscle protein turnover: an overview. , 1978 .
[61] H. Munro,et al. Ntau-methylhistidine (3-methylhistidine) and muscle protein turnover: an overview. , 1978, Federation proceedings.
[62] M. Buse,et al. Leucine. A possible regulator of protein turnover in muscle. , 1975, The Journal of clinical investigation.
[63] A. Goldberg,et al. Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. , 1975, The Journal of biological chemistry.
[64] R. Winkelmann. The Metabolic Basis of Inherited Diseases , 1972 .
[65] P. Felig,et al. Plasma amino acid levels and insulin secretion in obesity. , 1970, The New England journal of medicine.
[66] H. Lardy,et al. INFLUENCE OF THYROID HORMONES ON L-ALPHA-GLYCEROPHOSPHATE DEHYDROGENASES AND OTHER DEHYDROGENASES IN VARIOUS ORGANS OF THE RAT. , 1965, The Journal of biological chemistry.
[67] R. Ramette. Benzene Extraction of Antimony Iodide , 1958 .
[68] S. Moore,et al. Chromatography of amino acids on sulfonated polystyrene resins. , 1951, The Journal of biological chemistry.