A Simple and Green Synthesis of Tetrahydrobenzo[α]-xanthen-11-one Using PEG-400 as Efficient and Recyclable Reaction Media

Multicomponent reactions (MCRs) have been emerged as an extremely powerful tool in combinatorial chemistry and drug discovery, since it offers sign ificant advantages over conven-tional linear step syntheses, in terms to improve classical organic reactions, promote new reactions and develop straightforward synthetic routes for bioactive heterocycles.

[1]  Hyo-Jun Lee,et al.  Organocatalytic asymmetric synthesis of chiral pyrrolizines by cascade conjugate addition-aldol reactions. , 2010, Organic letters.

[2]  Masami Tanaka,et al.  New eremophilanes from Farfugium japonicum , 2010 .

[3]  K. Row,et al.  Sesquiterpenoids and other constituents from Senecio argunensis. , 2010, Chemical & pharmaceutical bulletin.

[4]  P. Langer,et al.  Site-selective Suzuki cross-coupling reactions of 2,3-dibromobenzofuran , 2010 .

[5]  D. Park,et al.  Synthesis and Crystal Structure of the New Quaternary Subnitride, Sr2GeGaN. , 2009 .

[6]  G. Nandi,et al.  An efficient one-pot synthesis of tetrahydrobenzo[a]xanthene-11-one and diazabenzo[a]anthracene-9,11-dione derivatives under solvent free condition , 2009 .

[7]  N. Foroughifar,et al.  A Catalytic and Green Procedure for Synthesis of 12-Aryl- or 12-Alkyl-8,9,10,12-Tetrahydrobenzo[α]xanthen-11-one Derivatives under Solvent-Free Conditions , 2009 .

[8]  J. Khurana,et al.  pTSA-catalyzed one-pot synthesis of 12-aryl-8,9,10,12-tetrahydrobenzo[a]xanthen-11-ones in ionic liquid and neat conditions , 2009 .

[9]  O. Werz,et al.  Arylpyrrolizines as inhibitors of microsomal prostaglandin E2 synthase-1 (mPGES-1) or as dual inhibitors of mPGES-1 and 5-lipoxygenase (5-LOX). , 2009, Journal of medicinal chemistry.

[10]  P. Goekjian,et al.  Chemoselective functionalization of α-carbolines at the C-2, C-3, C-4, and C-6 positions using Suzuki–Miyaura reactions , 2009 .

[11]  Li-Feng Zhang,et al.  Iodine-Catalyzed Synthesis of 12-Aryl-8,9,10,12-tetrahydro-benzo[a]xanthen-11-one Derivatives via Multicomponent Reaction , 2009 .

[12]  W. Su,et al.  Strontium triflate catalyzed one-pot condensation of β-naphthol, aldehydes and cyclic 1,3-dicarbonyl compounds , 2008 .

[13]  D. Park,et al.  Sr(Mg3Ge)N4 and Sr(Mg2Ga2)N4: New isostructural Mg-containing quaternary nitrides with nitridometallate anions of [(Mg3Ge)N4]2−∞3 and [(Mg2Ga2)N4]2−∞3 in a 3D-network structure , 2008 .

[14]  Rafael C. Guadagnin,et al.  Chemoselective cross-coupling Suzuki–Miyaura reaction of (Z)-(2-chlorovinyl)tellurides and potassium aryltrifluoroborate salts , 2008 .

[15]  P. Langer,et al.  Regioselective Suzuki cross-coupling reactions of 2,3,4,5-tetrabromo-1-methylpyrrole , 2008 .

[16]  S. Purser,et al.  Fluorine in medicinal chemistry. , 2008, Chemical Society reviews.

[17]  D. Park,et al.  Ba9Ge3N10: A New Ternary Nitride Containing Isolated Planar Triangular Anions of [GeN3]5- , 2008 .

[18]  Xi‐Cun Wang,et al.  Michael additions of dihydropyrimidines and 2-amino-1,3,4-thiadiazoles to α,β-ethylenic compounds: using polyethylene glycols as a green reaction media , 2007 .

[19]  F. Felpin,et al.  Suzuki-Miyaura reactions of arenediazonium salts catalyzed by PD(0)/C. One-pot chemoselective double cross-coupling reactions. , 2007, Organic letters.

[20]  M. Krishnaiah,et al.  An efficient catalyst-free regio- and stereoselective ring-opening of epoxides with phenoxides using polyethylene glycol as the reaction medium ☆ , 2007 .

[21]  A. M. Demkin.  Determination of trace tin by stripping potentiostatic coulometry , 2006 .

[22]  S. Chandrasekhar,et al.  l-Proline catalysed asymmetric aldol reactions in PEG-400 as recyclable medium and transfer aldol reactions , 2006 .

[23]  Jin‐Heng Li,et al.  PEG-400 promoted Pd(OAc)2/DABCO-catalyzed cross-coupling reactions in aqueous media , 2006 .

[24]  P. Bernat,et al.  Acceleration of tributyltin chloride (TBT) degradation in liquid cultures of the filamentous fungus Cunninghamella elegans. , 2006, Chemosphere.

[25]  C. Stock,et al.  Regioselective Cross-Coupling Reactions of Multiple Halogenated Nitrogen-, Oxygen-, and Sulfur-Containing Heterocycles , 2005 .

[26]  D. Park,et al.  Synthesis and Structure of Sr 6 Ge 5 N 2 and Ba 6 Ge 5 N 2 , 2005 .

[27]  Carlos Kleber Z. Andrade and Luana M. Alves.  Environmentally Benign Solvents in Organic Synthesis: Current Topics , 2005 .

[28]  D. Park,et al.  Synthesis and Structure of a Second Polymorph of Strontium Germanium Nitride: β-Sr 2 GeN 2 , 2005 .

[29]  S. Bräse,et al.  A short, atom-economical entry to tetrahydroxanthenones. , 2004, Angewandte Chemie.

[30]  D. Park,et al.  Sr3GeMgN4: new quaternary nitride containing Mg , 2003 .

[31]  D. Park,et al.  Synthesis and structure of LiSrGaN2: a new quaternary nitride with interpenetrating two-dimensional networks , 2003 .

[32]  D. Park,et al.  Synthesis and structure of Li4Sr3Ge2N6: a new quaternary nitride containing Ge2N610− anions , 2003 .

[33]  D. Park,et al.  Synthesis and structure of Sr3GaN3 and Sr6GaN5: strontium gallium nitrides with isolated planar [GaN3]6- anions. , 2003, Inorganic chemistry.

[34]  U. Roy,et al.  Review: Biodegradation of tributyltins (organotins) by marine bacteria , 2003 .

[35]  N. Pope,et al.  Butyltin and phenyltin compounds in eels (Anguilla anguilla) , 2002, Journal of the Marine Biological Association of the United Kingdom.

[36]  T. King,et al.  Performance and photostability of xanthene and pyrromethene laser dyes in sol-gel phases , 2002 .

[37]  K. Gao,et al.  New eremophilenolides from Ligulariopsis shichuana. , 2002, Journal of natural products.

[38]  F. Disalvo,et al.  About Binary and Ternary Alkaline Earth Metal Nitrides , 2001 .

[39]  F. Disalvo,et al.  Magnesium nitride chemistry , 2001 .

[40]  G. Gadd.  Microbial interactions with tributyltin compounds: detoxification, accumulation, and environmental fate. , 2000, The Science of the total environment.

[41]  F. Disalvo,et al.  New calcium germanium nitrides: Ca2GeN2, Ca4GeN4, and Ca5Ge2N6. , 2000, Inorganic chemistry.

[42]  Masami Tanaka,et al.  Eremofarfugin A and eremopetasitenin B3, two new eremophilanolides from Farfugium japonicum , 2000 .

[43]  Louis J. Farrugia,et al.  WinGX suite for small-molecule single-crystal crystallography , 1999 .

[44]  W. Denny,et al.  DNA-Directed alkylating agents. 7. Synthesis, DNA interaction, and antitumor activity of bis(hydroxymethyl)- and bis(carbamate)-substituted pyrrolizines and imidazoles. , 1998, Journal of medicinal chemistry.

[45]  A. Pain,et al.  Characterization of Organotin-Resistant Bacteria from Boston Harbor Sediments , 1998, Archives of environmental contamination and toxicology.

[46]  H. Harino,et al.  Degradation of tributyltin by a bacterial strain isolated from polluted river water , 1998 .

[47]  F. Disalvo,et al.  Synthesis and structure of the subnitrides Ba2GeGaN and (BaxSr1−x)3Ge2N2; x≈0.7 , 1997 .

[48]  F. Disalvo,et al.  SYNTHESIS AND STRUCTURE OF ONE-, TWO-, AND THREE-DIMENSIONAL ALKALINE EARTH METAL GALLIUM NITRIDES : SR3GA2N4, CA3GA2N4, AND SR3GA3N5 , 1997 .

[49]  F. Disalvo,et al.  SYNTHESIS AND STRUCTURE OF TWO NEW STRONTIUM GERMANIUM NITRIDES : SR3GE2N2AND SR2GEN2 , 1996 .

[50]  F. Disalvo,et al.  A barium germanium nitride, Ba3Ge2N2, containingx1|Ge2− and GeN24− anions , 1996 .

[51]  S. Özkan,et al.  Determination of tin(II) in pharmaceuticals by amperometric oxidation after complexation with tropolone , 1996 .

[52]  S. Sander,et al.  Determination of tin traces in water samples by adsorptive stripping voltammetry , 1996 .

[53]  S. Laufer,et al.  (6,7-Diaryldihydropyrrolizin-5-yl)acetic acids, a novel class of potent dual inhibitors of both cyclooxygenase and 5-lipoxygenase. , 1994, Journal of medicinal chemistry.

[54]  H. Ploegh,et al.  Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase , 1987, Nature.

[55]  E. Parthé,et al.  STRUCTURE TIDY– a computer program to standardize crystal structure data , 1987 .

[56]  J. Gliński,et al.  Synthesis of pyrrolizidine alkaloids indicine, intermedine, lycopsamine, and analogues and their N-oxides. Potential antitumor agents. , 1985, Journal of medicinal chemistry.

[57]  T. Yamaji,et al.  Carcinogenic activity of Farfugium japonicum and Senecio cannabifolius. , 1983, Cancer letters.

[58]  T. Imagawa,et al.  The Photosensitized Oxygenation of Furanoeremophilanes. II. The Preparation and Stereochemistry of the Isomeric Hydroperoxides and the Corresponding Lactones from Furanofukinin and Furanoeremophilane , 1977 .

[59]  Takeyoshi Takahashi,et al.  New Sesquiterpene Lactones of Eremophilane-Type from Ligularia Fauriei (FR.) Koidz. , 1976 .

[60]  K. Naya,et al.  The Photosensitized Oxygenation of Furanoeremophilanes. I. The Isomeric Hydroperoxides from Petasalbin and Their Transformations to Lactones , 1975 .

[61]  K. Murakami,et al.  Senkirkine, a pyrrolizidine alkaloid from Farfugium japonicum , 1971 .