Differential mechanisms of asparaginase resistance in B-type acute lymphoblastic leukemia and malignant natural killer cell lines

[1]  K. Hagino-Yamagishi,et al.  [Oncogene]. , 2019, Gan to kagaku ryoho. Cancer & chemotherapy.

[2]  G. Salles,et al.  Pharmacology, immunogenicity, and efficacy of a novel pegylated recombinant Erwinia chrysanthemi-derived L-asparaginase , 2014, Investigational New Drugs.

[3]  M. Kilberg,et al.  Asparagine synthetase: regulation by cell stress and involvement in tumor biology. , 2013, American journal of physiology. Endocrinology and metabolism.

[4]  N. Richards,et al.  A sulfoximine-based inhibitor of human asparagine synthetase kills L-asparaginase-resistant leukemia cells. , 2012, Bioorganic & medicinal chemistry.

[5]  I. Heřmanová,et al.  Low expression of asparagine synthetase in lymphoid blasts precludes its role in sensitivity to L-asparaginase. , 2012, Experimental hematology.

[6]  V. Avramis.  Asparaginases: biochemical pharmacology and modes of drug resistance. , 2012, Anticancer research.

[7]  G. Gillet,et al.  µ-Calpain Conversion of Antiapoptotic Bfl-1 (BCL2A1) into a Prodeath Factor Reveals Two Distinct alpha-Helices Inducing Mitochondria-Mediated Apoptosis , 2012, PloS one.

[8]  V. Avramis.  Asparaginases: A Successful Class of Drugs Against Leukemias and Lymphomas , 2011, Journal of pediatric hematology/oncology.

[9]  G. Salles,et al.  Cyclin-dependent kinase 1 expression is inhibited by p16INK4a at the post-transcriptional level through the microRNA pathway , 2011, Oncogene.

[10]  Marc N. Offman,et al.  Rational engineering of L-asparaginase reveals importance of dual activity for cancer cell toxicity. , 2011, Blood.

[11]  C. Pui,et al.  L‐asparaginase treatment in acute lymphoblastic leukemia , 2011, Cancer.

[12]  Jiangbin Ye,et al.  The GCN2‐ATF4 pathway is critical for tumour cell survival and proliferation in response to nutrient deprivation , 2010, The EMBO journal.

[13]  K. Sugimoto,et al.  Suppression of eIF4E Expression by L-Asparaginase , 2010, Acta Haematologica.

[14]  T. Anthony,et al.  GCN2 Protein Kinase Is Required to Activate Amino Acid Deprivation Responses in Mice Treated with the Anti-cancer Agent l-Asparaginase* , 2009, The Journal of Biological Chemistry.

[15]  S. Kimball,et al.  ATF4 is necessary and sufficient for ER stress-induced upregulation of REDD1 expression. , 2009, Biochemical and biophysical research communications.

[16]  T. Okamura,et al.  Phase I study of dexamethasone, methotrexate, ifosfamide, l‐asparaginase, and etoposide (SMILE) chemotherapy for advanced‐stage, relapsed or refractory extranodal natural killer (NK)/T‐cell lymphoma and leukemia , 2008, Cancer science.

[17]  H. Aburatani,et al.  ATF4-mediated induction of 4E-BP1 contributes to pancreatic beta cell survival under endoplasmic reticulum stress. , 2008, Cell metabolism.

[18]  R. Kaufman,et al.  MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells* , 2008, Journal of Biological Chemistry.

[19]  C. Proud,et al.  Amino acids and mTOR signalling in anabolic function. , 2007, Biochemical Society transactions.

[20]  R. Gatti,et al.  The inhibition of glutamine synthetase sensitizes human sarcoma cells to l-asparaginase , 2007, Cancer Chemotherapy and Pharmacology.

[21]  B. Li,et al.  The downregulation of asparagine synthetase expression can increase the sensitivity of cells resistant to L-asparaginase , 2006, Leukemia.

[22]  N. Richards,et al.  An inhibitor of human asparagine synthetase suppresses proliferation of an L-asparaginase-resistant leukemia cell line. , 2006, Chemistry & biology.

[23]  D. Sabatini,et al.  Stress and mTORture signaling , 2006, Oncogene.

[24]  V. Avramis,et al.  Asparaginase (native ASNase or pegylated ASNase) in the treatment of acute lymphoblastic leukemia , 2006, International journal of nanomedicine.

[25]  Nigel G J Richards,et al.  Asparagine synthetase chemotherapy. , 2006, Annual review of biochemistry.

[26]  F. Natt,et al.  Amino acids mediate mTOR/raptor signaling through activation of class 3 phosphatidylinositol 3OH-kinase. , 2005, Proceedings of the National Academy of Sciences of the United States of America.

[27]  S. Schuster,et al.  Selective apoptosis of natural killer‐cell tumours by l‐asparaginase , 2005, British journal of haematology.

[28]  W. Evans,et al.  Asparagine synthetase expression is linked with L-asparaginase resistance in TEL-AML1-negative but not TEL-AML1-positive pediatric acute lymphoblastic leukemia. , 2005, Blood.

[29]  R. Gatti,et al.  Inhibition of Glutamine Synthetase Triggers Apoptosis in Asparaginase-Resistant Cells , 2005, Cellular Physiology and Biochemistry.

[30]  Z. Li,et al.  Epigenetic changes in the repression and induction of asparagine synthetase in human leukemic cell lines , 2005, Leukemia.

[31]  L. Boxer,et al.  A genome-wide view of the in vitro response to l-asparaginase in acute lymphoblastic leukemia. , 2005, Cancer research.

[32]  M. Scian,et al.  Modulation of Gene Expression by Tumor-Derived p53 Mutants , 2004, Cancer Research.

[33]  Cheng Cheng,et al.  Gene-expression patterns in drug-resistant acute lymphoblastic leukemia cells and response to treatment. , 2004, The New England journal of medicine.

[34]  Anindita Das,et al.  Tumor-derived p53 mutants induce oncogenesis by transactivating growth-promoting genes , 2004, Oncogene.

[35]  S. Roy,et al.  Methylation of the asparagine synthetase promoter in human leukemic cell lines is associated with a specific methyl binding protein , 2004, Oncogene.

[36]  P. Gaynon,et al.  Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961). , 2004, Anticancer research.

[37]  Jun Zhu,et al.  L-Asparaginase—Based Regimen in the Treatment of Refractory Midline Nasal/Nasal-Type T/NK-Cell Lymphoma , 2003, International journal of hematology.

[38]  M. D. Den Boer,et al.  Sensitivity to L-asparaginase is not associated with expression levels of asparagine synthetase in t(12;21)+ pediatric ALL. , 2003, Blood.

[39]  R. Paules,et al.  An integrated stress response regulates amino acid metabolism and resistance to oxidative stress. , 2003, Molecular cell.

[40]  M. Kilberg,et al.  Multiple adaptive mechanisms affect asparagine synthetase substrate availability in asparaginase-resistant MOLT-4 human leukaemia cells. , 2001, The Biochemical journal.

[41]  M. Kilberg,et al.  Asparagine synthetase expression alone is sufficient to induce l-asparaginase resistance in MOLT-4 human leukaemia cells. , 2001, The Biochemical journal.

[42]  M. Schapira,et al.  Regulated translation initiation controls stress-induced gene expression in mammalian cells. , 2000, Molecular cell.

[43]  Y. Matsuo,et al.  A novel natural killer cell line (KHYG-1) from a patient with aggressive natural killer cell leukemia carrying a p53 point mutation , 2000, Leukemia.

[44]  S. Schuster,et al.  Amino acid control of asparagine synthetase: relation to asparaginase resistance in human leukemia cells. , 1997, American Journal of Physiology.

[45]  B. M. Jackson,et al.  Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases , 1992, Molecular and cellular biology.

[46]  S. Sallan,et al.  In vitro and in vivo killing of acute lymphoblastic leukemia cells by L-asparaginase. , 1989, Cancer research.

[47]  C. Haskell,et al.  l-asparaginase resistance in human leukemia--asparagine synthetase. , 1969, Biochemical pharmacology.

[48]  J. Mitchell,et al.  Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR. , 2013, The Biochemical journal.

[49]  P. Gaulard,et al.  L-asparaginase-based treatment of 15 western patients with extranodal NK/T-cell lymphoma and leukemia and a review of the literature. , 2009, Annals of oncology : official journal of the European Society for Medical Oncology.

[50]  S. Kimball,et al.  ATF 4 is Necessary and Sufficient for ER Stress-induced Upregulation of REDD 1 Expression , 2009 .

[51]  I. Andrulis,et al.  Molecular and genetic characterization of human cell lines resistant tol-asparaginase and albizziin , 1990, Somatic cell and molecular genetics.