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Penicillin remains a satisfactory main treatment for gonorrhea in Uganda, but evidence exists that its usefulness is declining. Consequently, the evaluation of other drugs must continue. Trimethoprim used in combination with sulphamethoxazole has given promising results, and because the Kampala population has a fairly high incidence of gonorrhea and a good record of cooperation in followup examinations, it was decided to conduct and evaluation of this form of treatment. 109 male college students suffered 154 attacks of acute urethritis, gonococcal and nongonococcal, between January 1 and May 31, 1969; 80 had urethritis once, 19 twice, 5 thrice, 4 four times, and 1 five times. Of the 154 attacks, 141 were seen and treated, and only these were included in the survey. Of the 141 attacks, 107 were diagnosed as cases of gonorrhea; 92 were seen 1 within 1 week of sexual contact and 15 later; 91 were seen within 2 days of the appearance of discharge, 10 within 3-6 days, and 6 after 7 or more days. The source of infection was a casual acquaintance or prostitute in 76 cases, a continuing acquaintance or friend in 30, and the wife in 1 case. 12 patients had received treatment elsewhere before coming to the Students' Clinic. Tests of minimum inhibitory concentration (MIC) and disc-diffusion sensitivity tests of trimethoprim and sulphamethoxazole were performed on lysed horse-blood agar. Trimethoprim/sulphamethoxazole was given by mouth as "Bactrim drapsules" (Roche) each containing trimethoprim 80 mg and sulphamethoxazole 400 mg. Each dose consisted of 4 drapsules, i.e., trimethprim 320 mg plus sulphamethoxazole 1600 mg. In each schedule the 1st dose was taken in the presence of the doctor. Later doses were taken unsupervised at 12 hour intervals. Patients were asked to return 3 days, 1 week, 2 weeks, and 3 weeks after the end of treatment. At each visit, they were examined clinically. If there was any urethral discharge, smears and cultures were taken. 2 doses gave the unsatisfactory cure rate of 65%. 3 or 4 doses cured 96% of cases compared to the 91% cured by procine penicillin 2-4 mega units. Although the 3-dose and 4-dose schedules were equally effective in the trial, it is recommended that 4 doses be used in practice. This new drug combination has no advantage over tetracycline except that it needs only 3 or 4 doses instead of the 8 of tetracycline foung effective by Arya and Phillips (1970).