Immunologically specific antigens in leukemic tissues.

The injection of extracts of leukemic and Hodgkin’s disease tissues of man elicit an antibody reaction in both man and rabbit. This response is similar to that elicited by leukemic mouse tissues when injected into rabbits. The antibody reaction may be demonstrated by the technics of passive cutaneous anaphylaxis, immunodiffusion, microprecipitin and immunofluorescence. Tissue extracts from non-leukemic individuals do not elicit a similar response. Rabbits immune-tolerant to normal human tissues produce antibodies specific to leukemic human antigens. Antibodies develop in those individuals who are exposed for a long time to either human or mouse leukemia. These immunologic studies demonstrate specific antigenic differences between normal and leukemic tissue extracts. It is postulated that the difference between normal and leukemic extracts is the consequence of the presence of viruses or the alterations caused by them.

[1]  J. McKenna,et al.  Extraction of Distinctive Antigens from Neoplastic Tissue , 1962, Science.

[2]  A. Stein,et al.  The production of anti-human leukemic serum in rabbits. , 1962, Journal of immunology.

[3]  E. Brown,et al.  Adaptation of Fluorescent-Microscopy to Determination of Genetic Variations in Mouse Mammary Tumor Agent , 1961 .

[4]  C. Smith,et al.  Rapid identification of Neisseria meningitidis by fluorescent antibody technic. , 1960, United States Armed Forces medical journal.

[5]  S. Decarvalho.  Segregation of antigens from human leukemic and tumoral cells by fluorocarbon extraction. 1. Detection by a gel diffusion method. , 1960 .

[6]  H. Schoolman,et al.  Studies in Leukemia: XIV. Effect of Human Serum on Development of Leukemia in AKR Mice.† , 1960, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[7]  G. Cambrelin.  [Anaphylaxis and allergy]. , 1960, Acta oto-laryngologica.

[8]  H. Schoolman,et al.  Studies in leukemia. X. Passive immunization of C3H mice. , 1959, The Journal of laboratory and clinical medicine.

[9]  J. D. Marshall,et al.  Use of Contrasting Fluorescent Dye as Counterstain in Fixed Tissue Preparations , 1959, Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine.

[10]  D. Moore,et al.  Purification of the Mouse Mammary Carcinoma Agent by means of a Fluorocarbon , 1959, Nature.

[11]  F. Brandon,et al.  Complement-fixing antigens in neoplastic tissue extracts. , 1959, Virology.

[12]  H. Schoolman,et al.  The etiology of leukemia: the status of the virus as causative agent; a review. , 1959, Blood.

[13]  J. Riggs,et al.  Isothiocyanate compounds as fluorescent labeling agents for immune serum. , 1958, The American journal of pathology.

[14]  M. Mcentegart,et al.  Fluorescent protein tracers; a trial of new fluorochromes and the development of an alternative to fluorescein. , 1958, Immunology.

[15]  M. Mcentegart,et al.  Fluorescent protein tracers in the study of experimental liver damage. , 1958, The Journal of pathology and bacteriology.

[16]  P. Hughes.  The significance of staining reactions of preneoplastic rat liver with fluorescein-globulin complexes. , 1958, Cancer research.

[17]  Z. Óváry.  Immediate reactions in the skin of experimental animals provoked by antibody-antigen interaction. , 1958, Progress in allergy.

[18]  H. Schoolman,et al.  Studies in leukemia. I. Etiologic mechanism: antigen-antibody techniques. , 1955, Acta haematologica.

[19]  A. H. Coons,et al.  LOCALIZATION OF ANTIGEN IN TISSUE CELLS , 1950, The Journal of experimental medicine.

[20]  K. Landsteiner,et al.  Production of Local Skin Reactivity by Passive Transfer of Anti-Protein Sera , 1943 .