The miR‐139‐5p regulates proliferation of supratentorial paediatric low‐grade gliomas by targeting the PI3K/AKT/mTORC1 signalling

Paediatric low‐grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease recurrence. Our aim was to shed light on the biology of pLGGs.

[1]  F. Boop,et al.  Mortality in children with low‐grade glioma or glioneuronal tumors: A single‐institution study , 2018, Pediatric blood & cancer.

[2]  David T. W. Jones,et al.  Pediatric Gliomas: Current Concepts on Diagnosis, Biology, and Clinical Management. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[3]  M. Todaro,et al.  Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma , 2017, Oncogene.

[4]  David T. W. Jones,et al.  Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing , 2016, Oncotarget.

[5]  K. Ligon,et al.  Pediatric low-grade gliomas: implications of the biologic era , 2016, Neuro-oncology.

[6]  F. Rodriguez,et al.  MicroRNA profiling of low grade glial and glioneuronal tumors shows an independent role for cluster 14q32.31 member miR-487b , 2016, Modern Pathology.

[7]  Gregory J. Goodall,et al.  A network-biology perspective of microRNA function and dysfunction in cancer , 2016, Nature Reviews Genetics.

[8]  G. Reifenberger,et al.  The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary , 2016, Acta Neuropathologica.

[9]  D. Haas-Kogan,et al.  Exploiting molecular biology for diagnosis and targeted management of pediatric low-grade gliomas. , 2016, Future oncology.

[10]  Roland Eils,et al.  New Brain Tumor Entities Emerge from Molecular Classification of CNS-PNETs , 2016, Cell.

[11]  Heather L. Mulder,et al.  Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology , 2016, Acta Neuropathologica.

[12]  D. Ellison,et al.  Pediatric gliomas as neurodevelopmental disorders , 2015, Glia.

[13]  Hsien-Da Huang,et al.  miRTarBase 2016: updates to the experimentally validated miRNA-target interactions database , 2015, Nucleic Acids Res..

[14]  G. Lambrou,et al.  MicroRNA expression profiles in pediatric dysembryoplastic neuroepithelial tumors , 2016, Medical Oncology.

[15]  T. Jacques,et al.  Molecular analysis of pediatric brain tumors identifies microRNAs in pilocytic astrocytomas that target the MAPK and NF-κB pathways , 2015, Acta Neuropathologica Communications.

[16]  Jianwen Liu,et al.  The loss of MiR-139-5p promotes colitis-associated tumorigenesis by mediating PI3K/AKT/Wnt signaling. , 2015, The international journal of biochemistry & cell biology.

[17]  Pankaj Pathak,et al.  Genome‐wide small noncoding RNA profiling of pediatric high‐grade gliomas reveals deregulation of several miRNAs, identifies downregulation of snoRNA cluster HBII‐52 and delineates H3F3A and TP53 mutant‐specific miRNAs and snoRNAs , 2015, International journal of cancer.

[18]  Xianjun Wang,et al.  MicroRNA-139-5p acts as a tumor suppressor by targeting ELTD1 and regulating cell cycle in glioblastoma multiforme. , 2015, Biochemical and biophysical research communications.

[19]  Y. Suh Dysembryoplastic Neuroepithelial Tumors , 2015, Journal of pathology and translational medicine.

[20]  W. Yeh,et al.  Migration-prone glioma cells show curcumin resistance associated with enhanced expression of miR-21 and invasion/anti-apoptosis-related proteins , 2015, Oncotarget.

[21]  Dequan Wu,et al.  miR-139-5p inhibits epithelial-mesenchymal transition, migration and invasion of hepatocellular carcinoma cells by targeting ZEB1 and ZEB2. , 2015, Biochemical and biophysical research communications.

[22]  I. Screpanti,et al.  Proteomic analysis of human Sonic Hedgehog (SHH) medulloblastoma stem-like cells. , 2015, Molecular bioSystems.

[23]  Artemis G. Hatzigeorgiou,et al.  DIANA-miRPath v3.0: deciphering microRNA function with experimental support , 2015, Nucleic Acids Res..

[24]  Hui Zhang,et al.  miR-139-5p suppresses cancer cell migration and invasion through targeting ZEB1 and ZEB2 in GBM , 2015, Tumor Biology.

[25]  S. Khatua,et al.  Review of low-grade gliomas in children—evolving molecular era and therapeutic insights , 2015, Child's Nervous System.

[26]  He-da Zhang,et al.  MiR-139-5p: promising biomarker for cancer , 2015, Tumor Biology.

[27]  C. Gomes,et al.  Assessment of BRAFV600E and SMOF412E mutations in epithelial odontogenic tumours , 2015, Tumor Biology.

[28]  L. Marchionni,et al.  Notch Signaling Activation in Pediatric Low-Grade Astrocytoma , 2015, Journal of neuropathology and experimental neurology.

[29]  Yuan Yin,et al.  MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1 , 2014, Protein & Cell.

[30]  S. Lawler,et al.  MicroRNAs in cancer: biomarkers, functions and therapy. , 2014, Trends in molecular medicine.

[31]  A. Gulino,et al.  High-throughput microRNA profiling of pediatric high-grade gliomas , 2013, Neuro-oncology.

[32]  Jun Yu,et al.  microRNA-139-5p exerts tumor suppressor function by targeting NOTCH1 in colorectal cancer , 2014, Molecular Cancer.

[33]  F. Zindy,et al.  Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression. , 2013, Cancer Research.

[34]  J. D. Cameron,et al.  Activation of mTORC1/mTORC2 signaling in pediatric low-grade glioma and pilocytic astrocytoma reveals mTOR as a therapeutic target. , 2013, Neuro-oncology.

[35]  Keerthana Krishnan,et al.  miR-139-5p is a regulator of metastatic pathways in breast cancer , 2013, RNA.

[36]  Shengying Qin,et al.  Identification of aberrant microRNA expression pattern in pediatric gliomas by microarray , 2013, Diagnostic Pathology.

[37]  Richard G Grundy,et al.  Comparative expression analysis reveals lineage relationships between human and murine gliomas and a dominance of glial signatures during tumor propagation in vitro. , 2013, Cancer research.

[38]  Chris Jones,et al.  Preclinical evaluation of dipotassium bisperoxo (picolinato) oxovanadate V for the treatment of pediatric low-grade gliomas. , 2013, Future oncology.

[39]  Ying Sun,et al.  MiR‐139 Inhibits Mcl‐1 Expression and Potentiates TMZ‐Induced Apoptosis in Glioma , 2013, CNS neuroscience & therapeutics.

[40]  W. Wu,et al.  Derepression of c‐Fos caused by MicroRNA‐139 down‐regulation contributes to the metastasis of human hepatocellular carcinoma , 2013, Cell biochemistry and function.

[41]  Volker Hovestadt,et al.  Robust molecular subgrouping and copy-number profiling of medulloblastoma from small amounts of archival tumour material using high-density DNA methylation arrays , 2013, Acta Neuropathologica.

[42]  Volker Hovestadt,et al.  Differential expression and methylation of brain developmental genes define location-specific subsets of pilocytic astrocytoma , 2013, Acta Neuropathologica.

[43]  Heather L. Mulder,et al.  Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas , 2013, Nature Genetics.

[44]  Chris Jones,et al.  Viability screen on pediatric low grade glioma cell lines unveils a novel anti-cancer drug of the steroid biosynthesis inhibitor family. , 2013, Cancer letters.

[45]  Caterina Giannini,et al.  MicroRNA profiling in pediatric pilocytic astrocytoma reveals biologically relevant targets, including PBX3, NFIB, and METAP2. , 2013, Neuro-oncology.

[46]  Arijit Mukhopadhyay,et al.  Genome-wide analysis reveals downregulation of miR-379/miR-656 cluster in human cancers , 2013, Biology Direct.

[47]  David T. W. Jones,et al.  Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. , 2012, Cancer cell.

[48]  Jianjun Zhang,et al.  Regulation of RAP1B by miR-139 suppresses human colorectal carcinoma cell proliferation. , 2012, The international journal of biochemistry & cell biology.

[49]  M. Berger,et al.  PTEN promoter methylation and activation of the PI3K/Akt/mTOR pathway in pediatric gliomas and influence on clinical outcome. , 2012, Neuro-oncology.

[50]  Tao Wang,et al.  HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells. , 2011, Gastroenterology.

[51]  H. Ohgaki,et al.  MicroRNA-21 suppression impedes medulloblastoma cell migration. , 2011, European journal of cancer.

[52]  L. Garraway,et al.  Detection of KIAA1549-BRAF fusion transcripts in formalin-fixed paraffin-embedded pediatric low-grade gliomas. , 2011, The Journal of molecular diagnostics : JMD.

[53]  Bryan R. Cullen,et al.  Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene , 2011, PloS one.

[54]  S. Pfister,et al.  Genetic Aberrations Leading to MAPK Pathway Activation Mediate Oncogene-Induced Senescence in Sporadic Pilocytic Astrocytomas , 2011, Clinical Cancer Research.

[55]  G. Nikkhah,et al.  BRAF Activation Induces Transformation and Then Senescence in Human Neural Stem Cells: A Pilocytic Astrocytoma Model , 2011, Clinical Cancer Research.

[56]  Michael H Handler,et al.  Survey of MicroRNA expression in pediatric brain tumors , 2011, Pediatric blood & cancer.

[57]  I. Ng,et al.  The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2. , 2011, Gastroenterology.

[58]  J. Campisi,et al.  Protocols to detect senescence-associated beta-galactosidase (SA-βgal) activity, a biomarker of senescent cells in culture and in vivo , 2009, Nature Protocols.

[59]  Richard Grundy,et al.  The miR-17/92 polycistron is up-regulated in sonic hedgehog-driven medulloblastomas and induced by N-myc in sonic hedgehog-treated cerebellar neural precursors. , 2009, Cancer research.

[60]  Paul Workman,et al.  Molecular and Phenotypic Characterisation of Paediatric Glioma Cell Lines as Models for Preclinical Drug Development , 2009, PloS one.

[61]  S. Pfister,et al.  Pediatric gliomas. , 2009, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

[62]  David T. W. Jones,et al.  Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas. , 2008, Cancer research.

[63]  Stijn van Dongen,et al.  miRBase: tools for microRNA genomics , 2007, Nucleic Acids Res..

[64]  B. Scheithauer,et al.  The 2007 WHO classification of tumours of the central nervous system , 2007, Acta Neuropathologica.

[65]  M. Berger,et al.  Methylation of the PTEN promoter defines low-grade gliomas and secondary glioblastoma. , 2007, Neuro-oncology.

[66]  Hidetoshi Shimodaira,et al.  Pvclust: an R package for assessing the uncertainty in hierarchical clustering , 2006, Bioinform..

[67]  R. Fimmers,et al.  Supratentorial gangliogliomas: Histopathologic grading and tumor recurrence in 184 patients with a median follow‐up of 8 years , 2004, Cancer.

[68]  J. Xavier,et al.  [Dysembryoplastic neuroepithelial tumors]. , 2000, Revista de neurologia.