Z-ligustilide attenuates lipopolysaccharide-induced proinflammatory response via inhibiting NF-κB pathway in primary rat microglia

[1]  H. Gendelman,et al.  Control of neuroinflammation as a therapeutic strategy for amyotrophic lateral sclerosis and other neurodegenerative disorders , 2010, Experimental Neurology.

[2]  Yu Yan.  Pharmacokinetic Profile of Z-ligustilide in Rat Plasma and Brain Following Oral Administration , 2010 .

[3]  S. Lakhan,et al.  Inflammatory mechanisms in ischemic stroke: therapeutic approaches , 2009, Journal of Translational Medicine.

[4]  Jun-Rong Du,et al.  Protective effect of Z-ligustilide against amyloid β-induced neurotoxicity is associated with decreased pro-inflammatory markers in rat brains , 2009, Pharmacology Biochemistry and Behavior.

[5]  G. Landreth,et al.  The Role of Peroxisome Proliferator-Activated Receptor-γ PPARγ) in Alzheimer’s Disease , 2012 .

[6]  K. Ono,et al.  Non-steroidal anti-inflammatory drugs as anti-amyloidogenic compounds. , 2008, Current pharmaceutical design.

[7]  S. Hickman,et al.  Microglial Dysfunction and Defective β-Amyloid Clearance Pathways in Aging Alzheimer's Disease Mice , 2008, The Journal of Neuroscience.

[8]  Jun-Rong Du,et al.  Postischemic administration of Z-Ligustilide ameliorates cognitive dysfunction and brain damage induced by permanent forebrain ischemia in rats , 2008, Pharmacology Biochemistry and Behavior.

[9]  Y. Ke,et al.  Ligustilide attenuates pain behavior induced by acetic acid or formalin. , 2007, Journal of ethnopharmacology.

[10]  Z. Qian,et al.  Neuroprotective effect of Z-ligustilide against permanent focal ischemic damage in rats. , 2007, Biological & pharmaceutical bulletin.

[11]  Z. Qian,et al.  Protection against hydrogen peroxide-induced injury by Z-ligustilide in PC12 cells , 2007, Experimental Brain Research.

[12]  Y. Ke,et al.  Ligustilide inhibits spontaneous and agonists- or K+ depolarization-induced contraction of rat uterus. , 2006, Journal of ethnopharmacology.

[13]  Tony Wyss-Coray,et al.  Inflammation in Alzheimer disease: driving force, bystander or beneficial response? , 2006, Nature Medicine.

[14]  Z. Qian,et al.  Neuroprotective role of Z-ligustilide against forebrain ischemic injury in ICR mice , 2006, Brain Research.

[15]  Michal Schwartz,et al.  Microglial phenotype: is the commitment reversible? , 2006, Trends in Neurosciences.

[16]  Kun Zhang,et al.  Phthalide Lactones from Ligusticum chuanxiong inhibit lipopolysaccharide-induced TNF-alpha production and TNF-alpha-mediated NF-kappaB Activation. , 2005, Planta medica.

[17]  M. Hüll,et al.  Signal transduction pathways regulating cyclooxygenase‐2 in lipopolysaccharide‐activated primary rat microglia , 2005, Glia.

[18]  M. Schwartz,et al.  Activation of microglia by aggregated β-amyloid or lipopolysaccharide impairs MHC-II expression and renders them cytotoxic whereas IFN-γ and IL-4 render them protective , 2005, Molecular and Cellular Neuroscience.

[19]  M. Block,et al.  Microglia and inflammation-mediated neurodegeneration: Multiple triggers with a common mechanism , 2005, Progress in Neurobiology.

[20]  T. Morgan,et al.  Peroxynitrite Mediates Neurotoxicity of Amyloid β-Peptide1–42- and Lipopolysaccharide-Activated Microglia , 2002, The Journal of Neuroscience.

[21]  S. Rivest,et al.  Regulation of the gene encoding the monocyte chemoattractant protein 1 (MCP‐1) in the mouse and rat brain in response to circulating LPS and proinflammatory cytokines , 2001, The Journal of comparative neurology.

[22]  T. Kameyama,et al.  Brain dysfunction associated with an induction of nitric oxide synthase following an intracerebral injection of lipopolysaccharide in rats , 1999, Neuroscience.

[23]  C. Janeway,et al.  A human homologue of the Drosophila Toll protein signals activation of adaptive immunity , 1997, Nature.

[24]  Q. Fang,et al.  [Chemical studies of Angelica sinensis (author's transl)]. , 1979, Yao xue xue bao = Acta pharmaceutica Sinica.