Biochemical mechanisms of chromosomal translocations resulting from DNA double-strand breaks.

[1]  Y. Nikiforov,et al.  Interphase chromosome folding determines spatial proximity of genes participating in carcinogenic RET/PTC rearrangements , 2006, Oncogene.

[2]  D. Weinstock,et al.  A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. , 2006, Blood.

[3]  J. Gautier,et al.  Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11 , 2005, The Journal of cell biology.

[4]  T. Kunkel,et al.  A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. , 2005, Molecular cell.

[5]  D. L. Weeks,et al.  Triplex-induced recombination and repair in the pyrimidine motif , 2005, Nucleic acids research.

[6]  David J. Chen,et al.  Artemis deficiency confers a DNA double-strand break repair defect and Artemis phosphorylation status is altered by DNA damage and cell cycle progression. , 2005, DNA repair.

[7]  M. Segal,et al.  DNA topoisomerase II in therapy-related acute promyelocytic leukemia. , 2005, The New England journal of medicine.

[8]  M. Jasin,et al.  Chromosomal translocation mechanisms at intronic alu elements in mammalian cells. , 2005, Molecular cell.

[9]  J. Lupski,et al.  Defective DNA single-strand break repair in spinocerebellar ataxia with axonal neuropathy-1 , 2005, Nature.

[10]  J. Lupski,et al.  Deficiency in 3′-phosphoglycolate processing in human cells with a hereditary mutation in tyrosyl-DNA phosphodiesterase (TDP1) , 2005, Nucleic acids research.

[11]  K. Datta,et al.  Characterization of a complex 125I-induced DNA double-strand break: Implications for repair , 2005, International journal of radiation biology.

[12]  L. Povirk,et al.  Extreme cytotoxicity and susceptibility to hprt mutagenesis in Ku-deficient xrs-6 cells treated with bleomycin in plateau phase. , 2005, Mutagenesis.

[13]  Morten O. Christensen,et al.  TDP1 Overexpression in Human Cells Counteracts DNA Damage Mediated by Topoisomerases I and II* , 2004, Journal of Biological Chemistry.

[14]  P. Calsou,et al.  Involvement of Poly(ADP-ribose) Polymerase-1 and XRCC1/DNA Ligase III in an Alternative Route for DNA Double-strand Breaks Rejoining* , 2004, Journal of Biological Chemistry.

[15]  Yunmei Ma,et al.  A biochemically defined system for mammalian nonhomologous DNA end joining. , 2004, Molecular cell.

[16]  Martin Kühne,et al.  A pathway of double-strand break rejoining dependent upon ATM, Artemis, and proteins locating to gamma-H2AX foci. , 2004, Molecular cell.

[17]  Qi Ding,et al.  Non-homologous End Joining Requires That the DNA-PK Complex Undergo an Autophosphorylation-dependent Rearrangement at DNA Ends* , 2004, Journal of Biological Chemistry.

[18]  D. Ramsden,et al.  The DNA‐dependent protein kinase: the director at the end , 2004, Immunological reviews.

[19]  C. Desmaze,et al.  Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. , 2004, Molecular cell.

[20]  D. Roth,et al.  Distinct requirements for Ku in N nucleotide addition at V(D)J- and non-V(D)J-generated double-strand breaks. , 2004, Nucleic acids research.

[21]  D. van Heemst,et al.  End-joining of blunt DNA double-strand breaks in mammalian fibroblasts is precise and requires DNA-PK and XRCC4. , 2004, DNA repair.

[22]  T. Kunkel,et al.  Implication of DNA Polymerase λ in Alignment-based Gap Filling for Nonhomologous DNA End Joining in Human Nuclear Extracts* , 2004, Journal of Biological Chemistry.

[23]  N. Osheroff,et al.  Reciprocal DNA topoisomerase II cleavage events at 5′-TATTA-3′ sequences in MLL and AF-9 create homologous single-stranded overhangs that anneal to form der(11) and der(9) genomic breakpoint junctions in treatment-related AML without further processing , 2003, Oncogene.

[24]  Yves Pommier,et al.  Association of XRCC1 and tyrosyl DNA phosphodiesterase (Tdp1) for the repair of topoisomerase I-mediated DNA lesions. , 2003, DNA repair.

[25]  George Iliakis,et al.  Biochemical evidence for Ku-independent backup pathways of NHEJ. , 2003, Nucleic acids research.

[26]  K. Valerie,et al.  Regulation and mechanisms of mammalian double-strand break repair , 2003, Oncogene.

[27]  Timothy Woods,et al.  Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair , 2003, Molecular and Cellular Biology.

[28]  A. Borkhardt,et al.  Analysis of t(9;11) chromosomal breakpoint sequences in childhood acute leukemia: Almost identical MLL breakpoints in therapy‐related AML after treatment without etoposides , 2003, Genes, chromosomes & cancer.

[29]  David Lombard,et al.  Defective DNA Repair and Increased Genomic Instability in Artemis-deficient Murine Cells , 2003, The Journal of experimental medicine.

[30]  C. Delteil,et al.  Coordinated assembly of Ku and p460 subunits of the DNA-dependent protein kinase on DNA ends is necessary for XRCC4-ligase IV recruitment. , 2003, Journal of molecular biology.

[31]  M. Kastan,et al.  DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation , 2003, Nature.

[32]  L. Povirk,et al.  DNA end sequestration by DNA‐dependent protein kinase and end joining of sterically constrained substrates in whole‐cell extracts , 2003, Environmental and molecular mutagenesis.

[33]  David J. Chen,et al.  Requirement for XRCC4 and DNA ligase IV in alignment-based gap filling for nonhomologous DNA end joining in vitro. , 2003, Cancer research.

[34]  J. Thacker,et al.  Clustered DNA damage leads to complex genetic changes in irradiated human cells. , 2002, Cancer research.

[35]  J. Lupski,et al.  Mutation of TDP1, encoding a topoisomerase I–dependent DNA damage repair enzyme, in spinocerebellar ataxia with axonal neuropathy , 2002, Nature Genetics.

[36]  C. Jackson-Cook,et al.  Base Substitutions, Targeted Single-Base Deletions, and Chromosomal Translocations Induced by Bleomycin in Plateau-Phase Mammary Epithelial Cells , 2002, Radiation research.

[37]  L. Povirk,et al.  Conversion of Phosphoglycolate to Phosphate Termini on 3′ Overhangs of DNA Double Strand Breaks by the Human Tyrosyl-DNA Phosphodiesterase hTdp1* , 2002, The Journal of Biological Chemistry.

[38]  D. Ramsden,et al.  Association of DNA Polymerase μ (pol μ) with Ku and Ligase IV: Role for pol μ in End-Joining Double-Strand Break Repair , 2002, Molecular and Cellular Biology.

[39]  J. Griffith,et al.  Synapsis of DNA ends by DNA‐dependent protein kinase , 2002, The EMBO journal.

[40]  C. Jackson-Cook,et al.  Gene rearrangements induced by the DNA double-strand cleaving agent neocarzinostatin: conservative non-homologous reciprocal exchanges in an otherwise stable genome. , 2002, Nucleic acids research.

[41]  S. West,et al.  Involvement of human polynucleotide kinase in double‐strand break repair by non‐homologous end joining , 2002, The EMBO journal.

[42]  David J. Chen,et al.  Defining interactions between DNA-PK and ligase IV/XRCC4. , 2002, DNA repair.

[43]  Yunmei Ma,et al.  Hairpin Opening and Overhang Processing by an Artemis/DNA-Dependent Protein Kinase Complex in Nonhomologous End Joining and V(D)J Recombination , 2002, Cell.

[44]  L. Povirk,et al.  Resistance of 3′-Phosphoglycolate DNA Ends to Digestion by Mammalian DNase III , 2002, Radiation research.

[45]  J. Hoeijmakers,et al.  Different types of V(D)J recombination and end‐joining defects in DNA double‐strand break repair mutant mammalian cells , 2002, European journal of immunology.

[46]  W. Dynan,et al.  Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. , 2002, Nucleic acids research.

[47]  A. Tomkinson,et al.  Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. , 2001, Molecular cell.

[48]  D. Chan,et al.  Werner syndrome protein is regulated and phosphorylated by DNA-dependent protein kinase. , 2001, The Journal of biological chemistry.

[49]  J. Champoux,et al.  The tyrosyl-DNA phosphodiesterase Tdp1 is a member of the phospholipase D superfamily , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[50]  P. Nowell,et al.  Near-precise interchromosomal recombination and functional DNA topoisomerase II cleavage sites at MLL and AF-4 genomic breakpoints in treatment-related acute lymphoblastic leukemia with t(4;11) translocation , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[51]  L. Povirk,et al.  Accurate in Vitro End Joining of a DNA Double Strand Break with Partially Cohesive 3′-Overhangs and 3′-Phosphoglycolate Termini , 2001, The Journal of Biological Chemistry.

[52]  A. Fischer,et al.  Artemis, a Novel DNA Double-Strand Break Repair/V(D)J Recombination Protein, Is Mutated in Human Severe Combined Immune Deficiency , 2001, Cell.

[53]  C. Felix,et al.  Potential role for DNA topoisomerase II poisons in the generation of t(11;20)(p15;q11) translocations , 2000, Genes, chromosomes & cancer.

[54]  Elke Feldmann,et al.  DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining , 2000, Nucleic Acids Res..

[55]  Christine Richardson,et al.  Frequent chromosomal translocations induced by DNA double-strand breaks , 2000, Nature.

[56]  T. Paull,et al.  A mechanistic basis for Mre11-directed DNA joining at microhomologies. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[57]  F. Alt,et al.  Interplay of p53 and DNA-repair protein XRCC4 in tumorigenesis, genomic stability and development , 2000, Nature.

[58]  D. Ramsden,et al.  Ku complex interacts with and stimulates the Werner protein. , 2000, Genes & development.

[59]  Thomas Ried,et al.  DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation , 2000, Nature.

[60]  M. Lieber,et al.  The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts , 1999, Current Biology.

[61]  M. Nikiforova,et al.  Chromosomal breakpoint positions suggest a direct role for radiation in inducing illegitimate recombination between the ELE1 and RET genes in radiation-induced thyroid carcinomas , 1999, Oncogene.

[62]  S. Bacchetti,et al.  Construction of a recombinant adenovirus for efficient delivery of the I-SceI yeast endonuclease to human cells and its application in the in vivo cleavage of chromosomes to expose new potential telomeres. , 1999, Nucleic acids research.

[63]  J. Sgouros,et al.  Molecular Characterization of a Human DNA Kinase* , 1999, The Journal of Biological Chemistry.

[64]  S. Scherer,et al.  Molecular Cloning of the Human Gene, PNKP, Encoding a Polynucleotide Kinase 3′-Phosphatase and Evidence for Its Role in Repair of DNA Strand Breaks Caused by Oxidative Damage* , 1999, The Journal of Biological Chemistry.

[65]  R. Marschalek,et al.  Rapid isolation of chromosomal breakpoints from patients with t(4;11) acute lymphoblastic leukemia: implications for basic and clinical research. , 1999, Cancer research.

[66]  Dan J. Mazur,et al.  Identification and Expression of the TREX1 and TREX2 cDNA Sequences Encoding Mammalian 3′→5′ Exonucleases* , 1999, The Journal of Biological Chemistry.

[67]  J. Sgouros,et al.  A human DNA editing enzyme homologous to the Escherichia coli DnaQ/MutD protein , 1999, The EMBO journal.

[68]  David J. Chen,et al.  The DNA-dependent Protein Kinase Catalytic Activity Regulates DNA End Processing by Means of Ku Entry into DNA* , 1999, The Journal of Biological Chemistry.

[69]  M. Weinfeld,et al.  Removal by human apurinic/apyrimidinic endonuclease 1 (Ape 1) and Escherichia coli exonuclease III of 3'-phosphoglycolates from DNA treated with neocarzinostatin, calicheamicin, and gamma-radiation. , 1999, Biochemical pharmacology.

[70]  M. Jasin,et al.  Double-strand break repair by interchromosomal recombination: suppression of chromosomal translocations. , 1998, Genes & development.

[71]  L. Povirk A highly conservative, cyclically permuted, non-homologous exchange among three unrelated DNA sequences in bleomycin-treated CHO cells. , 1998, International journal of radiation biology.

[72]  C. Jackson-Cook,et al.  A precise interchromosomal reciprocal exchange between hot spots for cleavable complex formation by topoisomerase II in amsacrine-treated Chinese hamster ovary cells. , 1997, Cancer research.

[73]  C. Jackson-Cook,et al.  Highly conservative reciprocal translocations formed by apparent joining of exchanged DNA double-strand break ends. , 1997, Proceedings of the National Academy of Sciences of the United States of America.

[74]  B. Roe,et al.  Identification of complex genomic breakpoint junctions in the t(9;11) MLL‐AF9 fusion gene in acute leukemia , 1997 .

[75]  A. Pinchera,et al.  Comparison of the breakpoint regions of ELE1 and RET genes involved in the generation of RET/PTC3 oncogene in sporadic and in radiation-associated papillary thyroid carcinomas. , 1997, Genomics.

[76]  L. Povirk,et al.  3'-phosphodiesterase activity of human apurinic/apyrimidinic endonuclease at DNA double-strand break ends. , 1997, Nucleic acids research.

[77]  Y. Nikiforov,et al.  Distinct pattern of ret oncogene rearrangements in morphological variants of radiation-induced and sporadic thyroid papillary carcinomas in children. , 1997, Cancer research.

[78]  A. Burgin,et al.  A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[79]  L. Povirk,et al.  DNA damage and mutagenesis by radiomimetic DNA-cleaving agents: bleomycin, neocarzinostatin and other enediynes. , 1996, Mutation research.

[80]  L. Povirk,et al.  End-joining of Free Radical-mediated DNA Double-strand Breaks in Vitro Is Blocked by the Kinase Inhibitor Wortmannin at a Step Preceding Removal of Damaged 3′ Termini* , 1996, The Journal of Biological Chemistry.

[81]  J. Haber,et al.  Cell cycle and genetic requirements of two pathways of nonhomologous end-joining repair of double-strand breaks in Saccharomyces cerevisiae , 1996, Molecular and cellular biology.

[82]  M. Löbrich,et al.  Repair of x-ray-induced DNA double-strand breaks in specific Not I restriction fragments in human fibroblasts: joining of correct and incorrect ends. , 1995, Proceedings of the National Academy of Sciences of the United States of America.

[83]  C. Bertoncini,et al.  DNA strand breaks produced by oxidative stress in mammalian cells exhibit 3'-phosphoglycolate termini. , 1995, Nucleic acids research.

[84]  J. Schwartz,et al.  Multiplex polymerase chain reaction-based deletion analysis of spontaneous, gamma ray- and alpha-induced hprt mutants of CHO-K1 cells. , 1994, Mutagenesis.

[85]  W. Thilly,et al.  Resolution and conservation of mismatches in DNA end joining. , 1994, Mutagenesis.

[86]  L. Povirk,et al.  Single base-pair deletions induced by bleomycin at potential double-strand cleavage sites in the aprt gene of stationary phase Chinese hamster ovary D422 cells. , 1994, Journal of Molecular Biology.

[87]  R. D. Anderson,et al.  Mutagenicity and carcinogenicity of topoisomerase-interactive agents , 1994 .

[88]  J. Schwartz,et al.  Noninvolvement of the X chromosome in radiation-induced chromosome translocations in the human lymphoblastoid cell line TK6. , 1994, Radiation research.

[89]  S. Thode,et al.  Mechanisms of overlap formation in nonhomologous DNA end joining , 1994, Molecular and cellular biology.

[90]  B Demple,et al.  Repair of oxidative damage to DNA: enzymology and biology. , 1994, Annual review of biochemistry.

[91]  A. S. Waldman,et al.  Repair of a specific double-strand break generated within a mammalian chromosome by yeast endonuclease I-SceI. , 1994, Nucleic acids research.

[92]  N. Osheroff,et al.  When good enzymes go bad: conversion of topoisomerase II to a cellular toxin by antineoplastic drugs. , 1993, Chemical research in toxicology.

[93]  J. Thacker,et al.  High-resolution cytogenetic analysis of X-ray induced mutations of the HPRT gene of primary human fibroblasts. , 1993, Cytogenetics and cell genetics.

[94]  W. Morgan,et al.  Mechanisms involved in rejoining DNA double-strand breaks induced by ionizing radiation and restriction enzymes. , 1993, Mutation research.

[95]  J. Little,et al.  Cellular, molecular, and carcinogenic effects of radiation. , 1993, Hematology/oncology clinics of North America.

[96]  J. Thacker,et al.  Formation of large deletions by illegitimate recombination in the HPRT gene of primary human fibroblasts. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[97]  J. Fuscoe,et al.  Analysis of X-ray-induced HPRT mutations in CHO cells: insertion and deletions. , 1992, Mutation research.

[98]  N. Osheroff,et al.  Intrinsic intermolecular DNA ligation activity of eukaryotic topoisomerase II. Potential roles in recombination. , 1992, The Journal of biological chemistry.

[99]  P. Dedon,et al.  Free-radical mechanisms involved in the formation of sequence-dependent bistranded DNA lesions by the antitumor antibiotics bleomycin, neocarzinostatin, and calicheamicin. , 1992, Chemical research in toxicology.

[100]  K. Sankaranarayanan Ionizing radiation and genetic risks. III. Nature of spontaneous and radiation-induced mutations in mammalian in vitro systems and mechanisms of induction of mutations by radiation. , 1991, Mutation research.

[101]  H. Strutt,et al.  Camptothecin cytotoxicity in mammalian cells is associated with the induction of persistent double strand breaks in replicating DNA. , 1991, Nucleic acids research.

[102]  M. Meuth,et al.  DNA sequence analysis of gamma radiation—induced deletions and insertions at the APRT locus of hamster cells , 2006, Molecular carcinogenesis.

[103]  M. L. Le Beau,et al.  Implication of prior treatment with drug combinations including inhibitors of topoisomerase II in therapy‐related monocytic leukemia with a 9;11 translocation , 1990, Genes, chromosomes & cancer.

[104]  S. Thode,et al.  A novel pathway of DNA end-to-end joining , 1990, Cell.

[105]  L. Liu,et al.  Illegitimate recombination mediated by calf thymus DNA topoisomerase II in vitro. , 1988, Proceedings of the National Academy of Sciences of the United States of America.

[106]  P. Pfeiffer,et al.  Joining of nonhomologous DNA double strand breaks in vitro. , 1988, Nucleic acids research.

[107]  R. Hertzberg,et al.  Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I. , 1985, The Journal of biological chemistry.

[108]  F. Hutchinson,et al.  Chemical changes induced in DNA by ionizing radiation. , 1985, Progress in nucleic acid research and molecular biology.

[109]  L. Liu,et al.  Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II. , 1984, The Journal of biological chemistry.

[110]  W. Haseltine,et al.  gamma Ray induced deoxyribonucleic acid strand breaks. 3' Glycolate termini. , 1983, The Journal of biological chemistry.

[111]  M. Bender,et al.  Mechanisms of chromosomal aberration production. 3. Chemicals and ionizing radiation. , 1974, Mutation research.

[112]  M. Seabright Noninvolvement of the human X chromosome in X-ray induced exchanges. , 1973, Cytogenetics and cell genetics.

[113]  D. Lea Actions of Radiations on Living Cells , 1955 .