论文信息 - Successful Treatment of Pityriasis Rubra Pilaris with Ixekizumab

Successful Treatment of Pityriasis Rubra Pilaris with Ixekizumab

Pityriasis rubra pilaris is an inflammatory dermatologic disorder of unknown cause and often confounded with psoriasis. It is characterised by hyperkeratotic follicular papules, scaly erythematous plaques, palmoplantar keratoderma, and a progression to generalised erythroderma. Here, we report the case of a 68-year-old man with pityriasis rubra pilaris, who was successfully treated with ixekizumab, an interleukin-17A inhibitor.

E. Guenova | W. Hoetzenecker | Reinhard Motz | Á. Pekár-Lukacs | Kathrin Hanfstingl

[1] T. Biedermann,et al. Pityriasis rubra pilaris: algorithms for diagnosis and treatment , 2018, Journal of the European Academy of Dermatology and Venereology : JEADV.

[2] N. Maloney,et al. Refractory pityriasis rubra pilaris treated with etanercept, adalimumab, or ustekinumab: A retrospective investigation , 2017, Dermatologic therapy.

[3] D. Hohl,et al. Interleukin 23–Helper T Cell 17 Axis as a Treatment Target for Pityriasis Rubra Pilaris , 2017, JAMA dermatology.

[4] D. Schuster,et al. Successful Treatment of Refractory Pityriasis Rubra Pilaris With Secukinumab. , 2016, JAMA dermatology.

[5] J. Uitto,et al. Epidemiologic, Clinicopathologic, Diagnostic, and Management Challenges of Pityriasis Rubra Pilaris: A Case Series of 100 Patients. , 2016, JAMA dermatology.

[6] J. Wohlrab,et al. Treatment of pityriasis rubra pilaris with ustekinumab , 2010, The British journal of dermatology.

[7] B. Zelger,et al. Infliximab monotherapy as first-line treatment for adult-onset pityriasis rubra pilaris: case report and review of the literature on biologic therapy. , 2008, Journal of the American Academy of Dermatology.

[8] M. Landthaler,et al. Exacerbation of Pityriasis Rubra Pilaris under Efalizumab Therapy , 2007, Dermatology.

[9] A. B. Cannon. Pityriasis rubra pilaris. , 1947, Archives of dermatology and syphilology.