Autoregulation of serotonin neurons: role in antidepressant drug action.

The existence of an endogenous vasoconstrictor in blood serum ([Stevens and Lee, 1984][1]; [Brodie, 1900][2]) and the presence in the gut of a substance that increases intestinal motility ([Vialli and Ersparmer, 1933][3]) had been known to scientists since the beginning of the century. However, it

[1]  J. Palacios,et al.  Localization of 5-HT1B, 5-HT1Dα, 5-HT1E and 5-HT1F receptor messenger RNA in rodent and primate brain , 1994, Neuropharmacology.

[2]  C. de Montigny,et al.  Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors: a single-cell study in the rat dorsal raphe nucleus. , 1989, Canadian journal of physiology and pharmacology.

[3]  S. Hjorth,et al.  The 5-HT1A receptor agonist, 8-OH-DPAT, preferentially activates cell body 5-HT autoreceptors in rat brain in vivo , 1988, Naunyn-Schmiedeberg's Archives of Pharmacology.

[4]  D. Rifkin,et al.  Basic fibroblast growth factor, a protein devoid of secretory signal sequence, is released by cells via a pathway independent of the endoplasmic reticulum‐Golgi complex , 1992, Journal of cellular physiology.

[5]  G. Aghajanian,et al.  Effects of ketanserin on neuronal responses to serotonin in the prefrontal cortex, lateral geniculate and dorsal raphe nucleus , 1985, Neuropharmacology.

[6]  M. Feany,et al.  The synaptic vesicle protein synaptotagmin promotes formation of filopodia in fibroblasts , 1993, Nature.

[7]  C. de Montigny,et al.  Effect of acute and repeated versus sustained administration of the 5-HT1A receptor agonist ipsapirone: electrophysiological studies in the rat hippocampus and dorsal raphe , 1997, Naunyn-Schmiedeberg's Archives of Pharmacology.

[8]  J. Raese,et al.  Identification of dopamine-containing cell bodies in the dorsal and median raphe nuclei of the rat brain using tyrosine hydroxylase immunochemistry , 1985, Brain Research Bulletin.

[9]  M. Millan,et al.  Agonist and Inverse Agonist Efficacy at Human Recombinant Serotonin 5-HT1A Receptors as a Function of Receptor:G-protein Stoichiometry , 1997, Neuropharmacology.

[10]  M. Millan,et al.  WAY 100,135 and (-)-tertatolol act as antagonists at both 5-HT1A autoreceptors and postsynaptic 5-HT1A receptors in vivo. , 1993, European journal of pharmacology.

[11]  M. Geffard,et al.  Identification of tryptamine and tryptamine‐serotonin neurons in the rat dorsal raphe nuclei using specific antibodies , 1993, Synapse.

[12]  P. Celada,et al.  The effects of brofaromine, a reversible MAO-A inhibitor, on extracellular serotonin in the raphe nuclei and frontal cortex of freely moving rats. , 1994, Journal of neural transmission. Supplementum.

[13]  S. Joseph,et al.  Immunocytochemical localization of ACTH1–39 in the brainstem of the rat , 1983, Brain Research.

[14]  H. Steinbusch,et al.  Distribution of serotonin-immunoreactivity in the central nervous system of the rat—Cell bodies and terminals , 1981, Neuroscience.

[15]  J. Terrón,et al.  Role of 5‐ht7 receptors in the long‐lasting hypotensive response induced by 5‐hydroxytryptamine in the rat , 1997, British journal of pharmacology.

[16]  C. de Montigny,et al.  Autoregulatory properties of dorsal raphe 5‐HT neurons: Possible role of electrotonic coupling and 5‐HT1D receptors in the rat brain , 1996, Synapse.

[17]  S. Haj-Dahmane,et al.  Alterations of central serotoninergic and dopaminergic neurotransmission in rats chronically treated with ipsapirone: biochemical and electrophysiological studies. , 1990, The Journal of pharmacology and experimental therapeutics.

[18]  Masaki Tanaka,et al.  differential expression of serotonin and [met]enkephalin-Arg6-Gly7-Leu8 in neurons of the rat brain stem , 1993, Brain Research Bulletin.

[19]  R. Rozmahel,et al.  Characterization of the human 5-hydroxytryptamine1B receptor. , 1992, The Journal of biological chemistry.

[20]  A. Basbaum,et al.  The peptidergic organization of the cat periaqueductal gray. I. The distribution of immunoreactive enkephalin-containing neurons and terminals , 1983, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[21]  M. Piercey,et al.  Characterization of U-92016A as a selective, orally active, high intrinsic activity 5-hydroxytryptamine1A agonist. , 1994, The Journal of pharmacology and experimental therapeutics.

[22]  G. Augustine,et al.  Calcium dependence of presynaptic calcium current and post‐synaptic response at the squid giant synapse. , 1986, The Journal of physiology.

[23]  C. de Montigny,et al.  Benzodiazepine receptors modulate 5-hydroxytryptamine neurotransmission in the rat hippocampus: in vivo electrophysiological evidence. , 1990, The Journal of pharmacology and experimental therapeutics.

[24]  J. Schwartz,et al.  Molecular cloning, characterization, and localization of a high-affinity serotonin receptor (5-HT7) activating cAMP formation. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[25]  A. Björklund,et al.  Endogenous Release of Neuronal Serotonin and 5‐Hydroxyindoleacetic Acid in the Caudate‐Putamen of the Rat as Revealed by Intracerebral Dialysis Coupled to High‐Performance Liquid Chromatography with Fluorimetric Detection , 1988, Journal of neurochemistry.

[26]  M. Millan,et al.  Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists. , 1994, The Journal of pharmacology and experimental therapeutics.

[27]  E. Esposito,et al.  Tertatolol, a new beta-blocker, is a serotonin (5-hydroxytryptamine1A) receptor antagonist in rat brain. , 1993, The Journal of pharmacology and experimental therapeutics.

[28]  T. Hökfelt,et al.  Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals , 1978, Neuroscience.

[29]  M. Raiteri,et al.  Fenfluramine Releases Serotonin from Human Brain Nerve Endings by a Dual Mechanism , 1994, Journal of neurochemistry.

[30]  R. Naylor,et al.  The profiles of interaction of yohimbine with anxiolytic and putative anxiolytic agents to modify 5‐HT release in the frontal cortex of freely‐moving rats , 1993, British journal of pharmacology.

[31]  A. Levey,et al.  Identification and characterization of antidepressant-sensitive serotonin transporter proteins using site-specific antibodies , 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[32]  P. H. Hutson,et al.  Hippocampal 5-HT synthesis and release in vivo is decreased by infusion of 8-OHDPAT into the nucleus raphe dorsalis , 1989, Neuroscience Letters.

[33]  T. Svensson,et al.  The novel 5-HT1A receptor antagonist (S)-UH-301 prevents (R)-8-OH-DPAT-induced decrease in interstitial concentrations of serotonin in the rat hippocampus. , 1992, European journal of pharmacology.

[34]  P. Blier,et al.  Differential responsiveness of the rat dorsal and median raphe 5‐HT systems to 5‐HT1 receptor agonists and p‐chloroamphetamine , 1990, Synapse.

[35]  G. Rudnick,et al.  p-Chloroamphetamine induces serotonin release through serotonin transporters. , 1992, Biochemistry.

[36]  D. Murphy,et al.  Regulation of G proteins by chronic antidepressant drug treatment in rat brain: tricyclics but not clorgyline increase Go alpha subunits. , 1991, European journal of pharmacology.

[37]  L. Descarries,et al.  Morphology of central serotonin neurons. Brief review of quantified aspects of their distribution and ultrastructural relationships. , 1990, Annals of the New York Academy of Sciences.

[38]  F. Artaud,et al.  Biochemical evidence for the 5-HT agonist properties of PAT (8-hydroxy-2-(di-n-propylamino)tetralin) in the rat brain. , 1984, European journal of pharmacology.

[39]  B. Jaffe,et al.  Localization and function of a 5-HT transporter in crypt epithelia of the gastrointestinal tract , 1996, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[40]  Acute depletion of serotonin down-regulates serotonin transporter mRNA in raphe neurons , 1995, Brain Research.

[41]  J. Glowinski,et al.  Identification of presynaptic serotonin autoreceptors using a new ligand: 3H-PAT , 1983, Nature.

[42]  C. Moret,et al.  Interaction between tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors and the presynaptic 5-hydroxytryptamine inhibitory autoreceptors in the rat hypothalamus. , 1985, The Journal of pharmacology and experimental therapeutics.

[43]  G. Aghajanian,et al.  Electrophysiological responses of serotoninergic dorsal raphe neurons to 5‐HT1A and 5‐HT1B agonists , 1987, Synapse.

[44]  H. Kimelberg,et al.  High-affinity uptake of serotonin into immunocytochemically identified astrocytes. , 1985, Science.

[45]  P. Celada,et al.  Reduction of in vivo striatal 5-hydroxytryptamine release by 8-OH-DPAT after inactivation of Gi/G(o) proteins in dorsal raphe nucleus. , 1994, European journal of pharmacology.

[46]  J. Hubbard,et al.  Fluorescence histochemistry of monoamine‐containing cell bodies in the brain stem of the squirrel monkey (Saimiri sciureus). IV. An atlas , 1973, The Journal of comparative neurology.

[47]  B. Renaud,et al.  Increased serotonin platelet uptake after tianeptine administration in depressed patients , 1991, Biological Psychiatry.

[48]  H. Vaudry,et al.  Effect of the antidepressant tianeptine on the activity of the hypothalamo-pituitary-adrenal axis , 1993, European Psychiatry.

[49]  J. Greuel,et al.  The putative 5-HT1A receptor antagonists NAN-190 and BMY 7378 are partial agonists in the rat dorsal raphe nucleus in vitro. , 1992, European journal of pharmacology.

[50]  N. Kamalakannan,et al.  TFMPP and RU24969 enhance serotonin release from rat hippocampus. , 1990, European journal of pharmacology.

[51]  R. Blakely,et al.  Regulation of the human serotonin transporter. Cholera toxin-induced stimulation of serotonin uptake in human placental choriocarcinoma cells is accompanied by increased serotonin transporter mRNA levels and serotonin transporter-specific ligand binding. , 1993, The Journal of biological chemistry.

[52]  F. Artigas,et al.  Dopamine D2 receptor-mediated regulation of serotonin extracellular concentration in the dorsal raphe nucleus of freely moving rats. , 2006, Journal of neurochemistry.

[53]  Ronald M. Harper,et al.  Dorsal raphe neurons: depression of firing during sleep in cats , 1976, Brain Research.

[54]  T. Branchek,et al.  Human serotonin 1D receptor is encoded by a subfamily of two distinct genes: 5-HT1D alpha and 5-HT1D beta. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[55]  G. Aghajanian,et al.  Physiological evidence for habenula as major link between forebrain and midbrain raphe. , 1977, Science.

[56]  Yan-ying Cui,et al.  Species difference in the modulatory effect of κ agonist on 5-HT release from ground squirrel and rat hippocampus , 1994, Neuroscience Letters.

[57]  M. Maitre,et al.  γ-Aminobutyric acid and 5-hydroxytryptamine interrelationship in the rat nucleus raphe dorsalis: Combination of radioautographic and immunocytochemical techniques at light and electron microscopy levels , 1987, Neuroscience.

[58]  G. Higgins,et al.  Evidence that the unilateral activation of 5‐HT1D receptors in the substantia nigra of the guinea‐pig elicits contralateral rotation , 1991, British journal of pharmacology.

[59]  M. Piercey,et al.  Electrophysiological evidence that spiperone is an antagonist of 5-HT1A receptors in the dorsal raphe nucleus. , 1988, European journal of pharmacology.

[60]  T. Kojima,et al.  Anxiolytic 5-hydroxytryptamine1A agonists suppress firing activity of dorsal hippocampus CA1 pyramidal neurons through a postsynaptic mechanism: single-unit study in unanesthetized, unrestrained rats. , 1999, The Journal of pharmacology and experimental therapeutics.

[61]  E. Azmitia,et al.  The substituted amphetamines 3,4-methylenedioxymethamphetamine, methamphetamine, p-chloroamphetamine and fenfluramine induce 5-hydroxytryptamine release via a common mechanism blocked by fluoxetine and cocaine. , 1992, European journal of pharmacology.

[62]  G. Chiara,et al.  Serotonin release estimated by transcortical dialysis in freely-moving rats , 1989, Neuroscience.

[63]  R. Blakely,et al.  Cloning, expression, and localization of a chloride-facilitated, cocaine-sensitive serotonin transporter from Drosophila melanogaster. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[64]  R. M. Rose,et al.  Localization of distinct monoamine oxidase a and monoamine oxidase b cell populations in human brainstem , 1988, Neuroscience.

[65]  B. Jacobs,et al.  Serotonergic afferents to the dorsal raphe nucleus: Evidence from HRP and synaptosomal uptake studies , 1977, Brain Research.

[66]  J. Kelly,et al.  Serotonin receptor activation reduces calcium current in an acutely dissociated adult central neuron , 1990, Neuron.

[67]  G. M. Halliday,et al.  Distribution, morphology and number of monoamine-synthesizing and substance P-containing neurons in the human dorsal raphe nucleus , 1991, Neuroscience.

[68]  V. D. Carlo,et al.  Fluorescence histochemistry of monoamine‐containing cell bodies in the brain stem of the squirrel monkey (Saimiri sciureus). II. Catecholamine‐containing groups , 1974, The Journal of comparative neurology.

[69]  G. Aghajanian,et al.  Collateral inhibition of serotonergic neurones in the rat dorsal raphe nucleus: Pharmacological evidence , 1978, Neuropharmacology.

[70]  G. Aghajanian,et al.  Pertussis toxin blocks 5-HT1A and GABAB receptor-mediated inhibition of serotonergic neurons. , 1987, European journal of pharmacology.

[71]  M. Reith,et al.  Uptake of [3H]serotonin into plasma membrane vesicles from mouse cerebral cortex. , 1988, The Journal of biological chemistry.

[72]  C. Lamotte,et al.  Immunocytochemical and electron microscopic study of serotonin neuronal organization in the dorsal raphe nucleus of the monkey , 1985, Neuroscience.

[73]  S. Haj-Dahmane,et al.  Central pre- and postsynaptic 5-HT1A receptors in rats treated chronically with a novel antidepressant, cericlamine. , 1994, The Journal of pharmacology and experimental therapeutics.

[74]  G. Rudnick Active transport of 5-hydroxytryptamine by plasma membrane vesicles isolated from human blood platelets. , 1977, The Journal of biological chemistry.

[75]  A. Biegon Effect of Chronic Desipramine Treatment on Dihydroalprenolol, Imipramine, and Desipramine Binding Sites: A Quantitative Autoradiographic Study in the Rat Brain , 1986, Journal of neurochemistry.

[76]  S. Hjorth,et al.  Sustained 5-hydroxytryptamine release-inhibitory and anxiolytic-like action of the partial 5-HT1A receptor agonist, buspirone, after prolonged chronic administration. , 1993, European journal of pharmacology.

[77]  B. Jacobs,et al.  Effects of adrenergic drugs on raphe unit activity in freely moving cats. , 1981, European journal of pharmacology.

[78]  R. Summers,et al.  Antidepressant binding sites in brain: autoradiographic comparison of [3H]paroxetine and [3H]imipramine localization and relationship to serotonin transporter. , 1990, The Journal of pharmacology and experimental therapeutics.

[79]  C. Marsden,et al.  Effects of a selective 5‐HT2 agonist, DOI, on 5‐HT neuronal firing in the dorsal raphe nucleus and 5‐HT release and metabolism in the frontal cortex , 1990, British journal of pharmacology.

[80]  R. Lefkowitz,et al.  A mutation-induced activated state of the beta 2-adrenergic receptor. Extending the ternary complex model. , 1993, The Journal of biological chemistry.

[81]  M. Erlander,et al.  Two members of a distinct subfamily of 5-hydroxytryptamine receptors differentially expressed in rat brain. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[82]  L. Descarries,et al.  Morphology of Central Serotonin Neurons , 1990 .

[83]  M. Gobbi,et al.  Effect of acute and chronic administration of buspirone on serotonin and benzodiazepine receptor subtypes in the rat brain: An autoradiographic study , 1991, Neuropharmacology.

[84]  S. Cheetham,et al.  [3H]Paroxetine binding in rat frontal cortex strongly correlates with [3H]5-HT uptake: Effect of administration of various antidepressant treatments , 1993, Neuropharmacology.

[85]  R. Pinnock Activation of κ-opioid receptors depresses electrically evoked excitatory postsynaptic potentials on 5-HT-sensitive neurones in the rat dorsal raphé nucleus in vitro , 1992, Brain Research.

[86]  E. Levine,et al.  Neurochemical afferents controlling the activity of serotonergic neurons in the dorsal raphe nucleus: microiontophoretic studies in the awake cat , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[87]  E. Azmitia The Serotonin-Producing Neurons of the Midbrain Median and Dorsal Raphe Nuclei , 1978 .

[88]  H. Rollema,et al.  Do 5-HT1B/1D Autoreceptors Modulate Dorsal Raphe Cell Firing? In Vivo Electrophysiological Studies in Guinea Pigs with GR127935 , 1997, Neuropharmacology.

[89]  S. Z. Langer,et al.  Effect of chronic treatment with selective monoamine oxidase inhibitors and specific 5-hydroxytryptamine uptake inhibitors on [3h]paroxetine binding to cerebral cortical membranes of the rat , 1987, Neuropharmacology.

[90]  I. Lucki,et al.  Differential regulation of serotonin (5-HT) release in the striatum and hippocampus by 5-HT1A autoreceptors of the dorsal and median raphe nuclei. , 1994, The Journal of pharmacology and experimental therapeutics.

[91]  M. Briley,et al.  Specific tricyclic antidepressant binding sites in rat brain , 1979, Nature.

[92]  R. Horton,et al.  The distribution of 5-HT1D and 5-HT1E binding sites in human brain. , 1992, European journal of pharmacology.

[93]  L. Descarries,et al.  Validation of the transporter ligand cyanoimipramine as a marker of serotonin innervation density in brain. , 1994, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[94]  M. Grönblad,et al.  Serotonin-like immunoreactivity in rat carotid body , 1983, Brain Research.

[95]  T. Kenakin,et al.  The cubic ternary complex receptor-occupancy model. III. resurrecting efficacy. , 1996, Journal of theoretical biology.

[96]  J. Bolam,et al.  Facilitation of a dendritic calcium conductance by 5-hydroxytryptamine in the substantia nigra , 1988, Nature.

[97]  A. Beaudet,et al.  Dopaminergic projection from nucleus raphe dorsalis to neostriatum in the rat , 1986, The Journal of comparative neurology.

[98]  B. Fanburg,et al.  8-hydroxy-2-(di-n-propylamino)tetralin-responsive 5-hydroxytryptamine4-like receptor expressed in bovine pulmonary artery smooth muscle cells. , 1992, Molecular pharmacology.

[99]  F. Artigas,et al.  Chronic treatment with fluvoxamine increases extracellular serotonin in frontal cortex but not in raphe nuclei , 1993, Synapse.

[100]  C. de Montigny,et al.  Electrophysiological assessment of the effects of antidepressant treatments on the efficacy of 5-HT neurotransmission. , 1988, Clinical neuropharmacology.

[101]  M. Teitler,et al.  Quantitative autoradiography of 5-CT-sensitive (5-HT1D) and 5-CT-insensitive (5-HT1E) serotonin receptors in human brain , 1992, Neuroscience Letters.

[102]  Z. Kruk,et al.  Effects of 21 days treatment with fluoxetine on stimulated endogenous 5-hydroxytryptamine overflow in the rat dorsal raphe and suprachiasmatic nucleus studies using fast cyclic voltammetry in vitro , 1994, Brain Research.

[103]  D. Hoyer Serotonin 5-HT3, 5-HT4, and 5-HT-M receptors. , 1990, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[104]  M. Wood,et al.  Identification of Multiple Binding Sites for [3H]5‐Hydroxytryptamine in the Rat CNS , 1986, Journal of neurochemistry.

[105]  R. Vertes,et al.  Projections of the dorsal raphe nucleus to the brainstem: PHA‐L analysis in the rat , 1994, The Journal of comparative neurology.

[106]  A. Fox,et al.  Effects of LSD on Ca++ currents in central 5-HT-containing neurons: 5-HT1A receptors may play a role in hallucinogenesis. , 1994, Journal of Pharmacology and Experimental Therapeutics.

[107]  C. Surridge,et al.  The phosphatidylinositol-binding site of microtubule-associated protein MAP2. , 1995, Biochemical Society transactions.

[108]  A. Sleight,et al.  In vivo evidence that 5-hydroxytryptamine (5-HT) neuronal firing and release are not necessarily correlated with 5-HT metabolism , 1990, Neuroscience.

[109]  S. Nakanishi,et al.  Regulation of Neuropeptide Expression in Cultured Cerebral Cortical Neurons by Brain‐Derived Neurotrophic Factor , 1993, Journal of neurochemistry.

[110]  D. Middlemiss,et al.  [3H]L-694,247 labels the 5-HT1Dβ receptor in pig caudate membranes , 1994 .

[111]  G. Aghajanian,et al.  Habenular and other midbrain raphe afferents demonstrated by a modified retrograde tracing technique , 1977, Brain Research.

[112]  E. Callaway Psychopharmacology's need for linking variables , 1992, Biological Psychiatry.

[113]  R. Lefkowitz,et al.  A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor. , 1980, The Journal of biological chemistry.

[114]  Z. Kruk,et al.  Frequency dependence of 5-HT autoreceptor function in rat dorsal raphe and suprachiasmatic nuclei studied using fast cyclic voltammetry , 1991, Brain Research.

[115]  S. Soinila,et al.  Colocalization of dopamine and serotonin in the rat pituitary gland and in the nuclei innervating it , 1995, Brain Research.

[116]  S. Garattini,et al.  Effects of short- and long-term administration of fluoxetine on the monoamine content of rat brain , 1992, Neuropharmacology.

[117]  V. Ganapathy,et al.  Expression and cyclic AMP-dependent regulation of a high affinity serotonin transporter in the human placental choriocarcinoma cell line (JAR). , 1991, The Journal of biological chemistry.

[118]  F. Artigas 5-HT and antidepressants: new views from microdialysis studies. , 1993, Trends in pharmacological sciences.

[119]  J. Ieni,et al.  The 5-HT1A receptor probe [3H]8-OH-DPAT labels the 5-HT transporter in human platelets. , 1988, Life sciences.

[120]  C. McKittrick,et al.  Tianeptine treatment induces regionally specific changes in monoamines , 1995, Brain Research.

[121]  J. Ochi,et al.  Occurrence of dopamine-containing neurons in the midbrain raphe nuclei of the rat , 1978, Neuroscience Letters.

[122]  J. Marcusson,et al.  Single-site model of the neuronal 5-hydroxytryptamine uptake and imipramine-binding site. , 1986, Molecular pharmacology.

[123]  P. Blier,et al.  Modulation of 5‐HT release in the guinea‐pig brain following long‐term administration of antidepressant drugs , 1994, British journal of pharmacology.

[124]  Y. Watanabe,et al.  Tianeptine decreases both serotonin transporter mRNA and binding sites in rat brain. , 1994, European journal of pharmacology.

[125]  A. Galzin,et al.  Interaction between neuronal uptake inhibitors and presynaptic serotonin autoreceptors in rat hypothalamic slices: comparison of K+ and electrical depolarization. , 1987, The Journal of pharmacology and experimental therapeutics.

[126]  F. Artigas,et al.  Fluvoxamine preferentially increases extracellular 5-hydroxytryptamine in the raphe nuclei: an in vivo microdialysis study. , 1992, European journal of pharmacology.

[127]  T. Takahashi,et al.  Serotonin enhances a low-voltage-activated calcium current in rat spinal motoneurons , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[128]  O. Inoue,et al.  Synthesis and evaluation of [11C]cyanoimipramine. , 1987, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

[129]  M. Jouvet,et al.  Afferent connections of the nucleus raphe dorsalis in the cat as visualized by the horseradish peroxidase technique , 1977, Brain Research.

[130]  S. Schuldiner,et al.  Mechanism of Transport and Storage of Neurotransmitter , 1987 .

[131]  R. M. Rose,et al.  Distinct monoamine oxidase A and B populations in primate brain. , 1985, Science.

[132]  L. Descarries,et al.  Ultrastructural relationships of serotonin axon terminals in the cerebral cortex of the adult rat , 1989, The Journal of comparative neurology.

[133]  J. Fritschy,et al.  Neuron-specific expression of GABAA-receptor subtypes: Differential association of theα1- andα3-subunits with serotonergic and gabaergic neurons , 1993, Neuroscience.

[134]  M. Millan,et al.  Modulation of the activity of central serotoninergic neurons by novel serotonin1A receptor agonists and antagonists: a comparison to adrenergic and dopaminergic neurons in rats. , 1995, The Journal of pharmacology and experimental therapeutics.

[135]  B. O'dowd,et al.  A single amino-acid difference confers major pharmacological variation between human and rodent 5-HT1B receptors , 1992, Nature.

[136]  M. Briley,et al.  High‐ and Low‐Affinity Binding of [3H]Imipramine in Rat Hypothalamus , 1986, Journal of neurochemistry.

[137]  V. Pérez,et al.  Pindolol induces a rapid improvement of depressed patients treated with serotonin reuptake inhibitors. , 1994, Archives of general psychiatry.

[138]  F. Bloom,et al.  Neurons containing beta-endorphin in rat brain exist separately from those containing enkephalin: immunocytochemical studies. , 1978, Proceedings of the National Academy of Sciences of the United States of America.

[139]  C. Dourish,et al.  EFFECTS OF THE PUTATIVE 5-HT1A RECEPTOR ANTAGONIST SDZ-216,525 IN 2 MODELS OF SOMATODENDRITIC 5-HT1A AUTORECEPTOR FUNCTION , 1993 .

[140]  B. Scatton,et al.  Inhibitory influence of GABA on central serotonergic transmission. Involvement of the habenulo-raphe´pathways in the GABAergic inhibition of ascending cerebral serotonergic neurons , 1985, Brain Research.

[141]  G. Rudnick,et al.  Binding of the cocaine analog 2 beta-[3H] carboxymethoxy-3 beta-(4-fluorophenyl)tropane to the serotonin transporter. , 1991, Molecular pharmacology.

[142]  N. Newberry,et al.  WAY-100635 and GR127935: effects on 5-hydroxytryptamine-containing neurones. , 1994, European journal of pharmacology.

[143]  B. Lerer,et al.  5-HT-1A receptor-mediated effects of antidepressants , 1993, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[144]  J. Palacios,et al.  A comparative autoradiographic study of 5-HT1D binding sites in human and guinea-pig brain using different radioligands. , 1994, Brain research. Molecular brain research.

[145]  J. Scuvée-Moreau,et al.  Electrophysiological effects of tianeptine on rat locus coeruleus, raphe dorsalis, and hippocampus activity. , 1988, Clinical neuropharmacology.

[146]  H. Schoemaker,et al.  [3H]8-OH-DPAT labels the serotonin transporter in the rat striatum. , 1986, European journal of pharmacology.

[147]  A. Beaudet,et al.  Organization of ascending serotonin systems in the adult rat brain. A radioautographic study after intraventricular administration of [3h]5-hydroxytryptamine , 1981, Neuroscience.

[148]  S. Hjorth,et al.  Serotonin 5‐HT1A Autoreceptor Blockade Potentiates the Ability of the 5‐HT Reuptake Inhibitor Citalopram to Increase Nerve Terminal Output of 5‐HT In Vivo: A Microdialysis Study , 1993, Journal of neurochemistry.

[149]  J. Marcusson,et al.  Characterization of [3H]Paroxetine Binding in Rat Brain , 1988, Journal of neurochemistry.

[150]  B. Jacobs,et al.  Raphe unit activity during REM sleep in normal cats and in pontine lesioned cats displaying REM sleep without atonia , 1981, Brain Research.

[151]  M. Hamon,et al.  SR 57227A: a potent and selective agonist at central and peripheral 5-HT3 receptors in vitro and in vivo. , 1993, European journal of pharmacology.

[152]  Carol A. Tamminga Images in neuroscience , 1999 .

[153]  A. Barkai Interactions of Drugs and Electroshock Treatment on Cerebral Monoaminergic Systems a , 1986, Annals of the New York Academy of Sciences.

[154]  R. Buijs,et al.  Light and electron microscopic immunocytochemical analysis of the serotonin innervation of the rat visual cortex , 1987, Journal of neurocytology.

[155]  S. Amara,et al.  Neurotransmitter transporters: recent progress. , 1993, Annual review of neuroscience.

[156]  H N Wagner,et al.  A PET radiotracer for studying serotonin uptake sites: carbon-11-McN-5652Z. , 1993, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

[157]  D. Felten,et al.  The raphe nuclei of the rabbit brain stem , 1979, The Journal of comparative neurology.

[158]  D. Middlemiss,et al.  8-Hydroxy-2-(di-n-propylamino)-tetralin discriminates between subtypes of the 5-HT1 recognition site. , 1983, European journal of pharmacology.

[159]  J. Burn THE ACTION OF NICOTINE ON THE PERIPHERAL CIRCULATION , 1960, Annals of the New York Academy of Sciences.

[160]  G. Rudnick,et al.  Zwitterionic and anionic forms of a serotonin analog as transport substrates. , 1989, The Journal of biological chemistry.

[161]  T. Dawson,et al.  Autoradiographic localization of [3H]-imipramine binding sites: Association with serotonergic neurons , 1983, Brain Research Bulletin.

[162]  C. de Montigny,et al.  Long-Term Antidepressant Treatments Result in a Tonic Activation of Forebrain 5-HT1A Receptors , 1998, The Journal of Neuroscience.

[163]  P. Hrdina Differentiation of two components of specific [3H]imipramine binding in rat brain. , 1984, European journal of pharmacology.

[164]  T. R. Stratford,et al.  Ascending dopaminergic projections from the dorsal raphe nucleus in the rat , 1990, Brain Research.

[165]  H. Westenberg,et al.  Effects of single and repeated oral administration of fluvoxamine on extracellular serotonin in the median raphe nucleus and dorsal hippocampus of the rat , 1995, Neuropharmacology.

[166]  E. Richelson,et al.  Blockade by newly-developed antidepressants of biogenic amine uptake into rat brain synaptosomes. , 1993, Life sciences.

[167]  G. Aghajanian,et al.  Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices , 1983, Brain Research.

[168]  R. Roth,et al.  Synaptosomes from forebrains of rats with midbrain raphe lesions: selective reduction of serotonin uptake. , 1972, The Journal of pharmacology and experimental therapeutics.

[169]  T. Branchek,et al.  Receptor reserve masks partial agonist activity of drugs in a cloned rat 5-hydroxytryptamine1B receptor expression system. , 1993, Molecular pharmacology.

[170]  T. Kemper,et al.  Nucleus raphe dorsalis: A morphometric golgi study in rats of three age groups , 1981, Brain Research.

[171]  J. Palacios,et al.  Homogeneous 5-HT1D recognition sites in the human substantia nigra identified with a new iodinated radioligand. , 1991, European journal of pharmacology.

[172]  V. Pérez,et al.  Randomised, double-blind, placebo-controlled trial of pindolol in combination with fluoxetine antidepressant treatment , 1997, The Lancet.

[173]  G. Halliday,et al.  Cytoarchitecture of the human dorsal raphe nucleus , 1990, The Journal of comparative neurology.

[174]  T. Branchek,et al.  The rat 5-hydroxytryptamine1B receptor is the species homologue of the human 5-hydroxytryptamine1D beta receptor. , 1992, Molecular pharmacology.

[175]  R. McCarley,et al.  Behavioral state-related changes of extracellular serotonin concentration in the dorsal raphe nucleus: a microdialysis study in the freely moving cat , 1994, Brain Research.

[176]  J. Fozard,et al.  The involvement of subtypes of the 5-HT1 receptor and of catecholaminergic systems in the behavioural response to 8-hydroxy-2-(di-n-propylamino)tetralin in the rat. , 1984, European journal of pharmacology.

[177]  A. S. Chang,et al.  Differential regulation of the imipramine-sensitive serotonin transporter by cAMP in human JAr choriocarcinoma cells, rat PC12 pheochromocytoma cells, and C33-14-B1 transgenic mouse fibroblast cells. , 1992, Biochemical and biophysical research communications.

[178]  J. Besson,et al.  Effects of tianeptine on 5-hydroxyindoles and on the morphine-induced increase in 5-HT metabolism at the medullary dorsal horn level as measured by in vivo voltammetry in freely moving rats , 1993, Brain Research.

[179]  H. Ladinsky,et al.  The orphan receptor cDNA RDC4 encodes a 5-HT1D serotonin receptor. , 1991, Biochemical and biophysical research communications.

[180]  M. Tome,et al.  Paroxetine and pindolol: a randomized trial of serotonergic autoreceptor blockade in the reduction of antidepressant latency , 1997, International clinical psychopharmacology.

[181]  C. Montigny,et al.  Electrophysiological investigations on the effect of repeated zimelidine administration on serotonergic neurotransmission in the rat , 1983, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[182]  D. Mckenna,et al.  3,4-Methylenedioxyamphetamine (MDA) analogues exhibit differential effects on synaptosomal release of 3H-dopamine and 3H-5-hydroxytryptamine , 1991, Pharmacology Biochemistry and Behavior.

[183]  E. Wright,et al.  Intestinal brush border membrane Na+/glucose cotransporter functions in situ as a homotetramer. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[184]  P. Blier,et al.  Pre‐ and post‐synaptic effects of the 5‐HT3 agonist 2‐Methyl‐5‐HT on the 5‐HT system in the rat brain , 1995, Synapse.

[185]  B. Waszczak,et al.  Electrophysiological evidence for a large receptor reserve for inhibition of dorsal raphe neuronal firing by 5‐HT1A agonists , 1993, Synapse.

[186]  G. Woodruff,et al.  Pharmacology of a cholecystokinin receptor on 5‐hydroxytryptamine neurones in the dorsal raphe of the rat brain , 1991, British journal of pharmacology.

[187]  G. Griebel 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. , 1995, Pharmacology & therapeutics.

[188]  M. Ohayon,et al.  [3H]paroxetine binding and serotonin content of rat brain: absence of changes following antidepressant treatments. , 1993, European journal of pharmacology.

[189]  Mark D. Johnson,et al.  Localization of NADPH diaphorase activity in monoaminergic neurons of the rat brain , 1993, The Journal of comparative neurology.

[190]  C. Montigny,et al.  Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine—II. Effects of acute administration of 1-PP and long-term adminstration of tandospirone on noradrenergic neurotransmission , 1991, Neuropharmacology.

[191]  J. Villalobos,et al.  The differential descending projections from the anterior, central and posterior regions of the lateral hypothalamic area: An autoradiographic study , 1987, Neuroscience Letters.

[192]  P. Hrdina Inhibition of sodium-dependent [3H]imipramine binding in rat brain by serotonin and serotonin uptake inhibitors. , 1988, European journal of pharmacology.

[193]  K. Fuxe,et al.  Basic fibroblast growth factor (bFGF, FGF-2) immunoreactivity exists in the noradrenaline, adrenaline and 5-HT nerve cells of the rat brain , 1993, Neuroscience Letters.

[194]  A. Calas,et al.  Direct electron microscopic evidence for the coexistence of GABA uptake and endogenous serotonin in the same rat central neurons by coupled radioautographic and immunocytochemical procedures , 1984, Neuroscience Letters.

[195]  D. Hoyer,et al.  Characterization of the 5-HT1B recognition site in rat brain: binding studies with (-)[125I]iodocyanopindolol. , 1985, European journal of pharmacology.

[196]  L. Wennogle,et al.  Serotonin uptake inhibitors differentially modulate high affinity imipramine dissociation in human platelet membranes. , 1985, Life sciences.

[197]  P. McGuffin,et al.  Lack of effect of antidepressant drugs on the levels of mRNAs encoding serotonergic receptors, synthetic enzymes and 5HT transporter , 1994, Neuropharmacology.

[198]  L. Lanfumey,et al.  Antagonist properties of (−)‐pindolol and WAY 100635 at somatodendritic and postsynaptic 5‐HT1A receptors in the rat brain , 1998, British journal of pharmacology.

[199]  C. de Montigny,et al.  Effect of Pindolol on the Function of Pre- and Postsynaptic 5-HT1A Receptors: In Vivo Microdialysis and Electrophysiological Studies in the Rat Brain , 1996, Neuropsychopharmacology.

[200]  K. Semba,et al.  A direct retinal projection to the dorsal raphe nucleus in the rat , 1994, Brain Research.

[201]  M. Molliver,et al.  The locus coeruleus in the rat: An immunohistochemical delineation , 1980, Neuroscience.

[202]  C. de Montigny,et al.  Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: II. Effect of pertussis and cholera toxins. , 1993, The Journal of pharmacology and experimental therapeutics.

[203]  T. Gudermann,et al.  Molecular cloning of a human serotonin receptor (S12) with a pharmacological profile resembling that of the 5-HT1D subtype. , 1992, The Journal of biological chemistry.

[204]  C. P. Vandermaelen,et al.  Inhibition of serotonergic dorsal raphe neurons by systemic and iontophoretic administration of buspirone, a non-benzodiazepine anxiolytic drug. , 1986, European journal of pharmacology.

[205]  N. Mizuno,et al.  Identification of periaqueductal gray and dorsal raphe nucleus neurons projecting to both the trigeminal sensory complex and forebrain structures: a fluorescent retrograde double-labeling study in the rat , 1993, Brain Research.

[206]  X. Breakefield,et al.  Immunocytochemical demonstration of monoamine oxidase B in brain astrocytes and serotonergic neurons. , 1982, Proceedings of the National Academy of Sciences of the United States of America.

[207]  E. Parker,et al.  A Single Amino Acid Difference Accounts for the Pharmacological Distinctions Between the Rat and Human 5‐Hydroxytryptamine1B Receptors , 1993, Journal of neurochemistry.

[208]  K. Fuxe,et al.  EVIDENCE FOR THE EXISTENCE OF MONOAMINE-CONTAINING NEURONS IN THE CENTRAL NERVOUS SYSTEM. I. DEMONSTRATION OF MONOAMINES IN THE CELL BODIES OF BRAIN STEM NEURONS. , 1964, Acta physiologica Scandinavica. Supplementum.

[209]  B. Jacobs,et al.  Atlas of serotonergic cell bodies in the cat brainstem: An immunocytochemical analysis , 1984, Brain Research Bulletin.

[210]  R. Innis,et al.  Binding of the cocaine analog 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane to serotonin and dopamine transporters: different ionic requirements for substrate and 2 beta-carbomethoxy-3 beta-(4-[125I]iodophenyl)tropane binding. , 1993, Molecular pharmacology.

[211]  C. de Montigny,et al.  Effect of short‐term serotonin depletion on the efficacy of serotonin neurotransmission: Electrophysiological Studies in the Rat central Nervous System , 1990 .

[212]  J. Lazo,et al.  Translocation of protein kinase C is associated with inhibition of 5-HT uptake by cultured endothelial cells. , 1989, The American journal of physiology.

[213]  G. Rudnick,et al.  The molecular mechanism of "ecstasy" [3,4-methylenedioxy-methamphetamine (MDMA)]: serotonin transporters are targets for MDMA-induced serotonin release. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[214]  A. Frazer,et al.  Quantitative autoradiography of serotonin uptake sites in rat brain using [3H]cyanoimipramine , 1988, Brain Research.

[215]  K F Martin,et al.  Opposing roles for 5‐HT1B and 5‐HT3 receptors in the control of 5‐HT release in rat hippocampus in vivo , 1992, British journal of pharmacology.

[216]  U. Boschert,et al.  Mouse 5HT1B serotonin receptor: cloning, functional expression, and localization in motor control centers. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[217]  P. Leff,et al.  A three-state receptor model of agonist action. , 1997, Trends in pharmacological sciences.

[218]  D. Middlemiss,et al.  Serotonin-5-O-carboxymethyl-glycyl[125I]tyrosinamide labels the 5-HT1D beta receptor subtype in human cortex. , 1993, European journal of pharmacology.

[219]  S. Ross,et al.  Tricyclic antidepressant agents. I. Comparison of the inhibition of the uptake of 3-H-noradrenaline and 14-C-5-hydroxytryptamine in slices and crude synaptosome preparations of the midbrain-hypothalamus region of the rat brain. , 2009, Acta pharmacologica et toxicologica.

[220]  J W Dailey,et al.  Effects of fluoxetine on convulsions and on brain serotonin as detected by microdialysis in genetically epilepsy-prone rats. , 1992, The Journal of pharmacology and experimental therapeutics.

[221]  G. Aghajanian Modulation of a transient outward current in serotonergic neurones by α1-adrenoceptors , 1985, Nature.

[222]  J. Raymond,et al.  Protein kinase C induces phosphorylation and desensitization of the human 5-HT1A receptor. , 1991, The Journal of biological chemistry.

[223]  W. Cruce,et al.  Distribution of tyrosine hydroxylase, serotonin, and leu-enkephalin immunoreactive cells in the brainstem of a shark, Squalus acanthias. , 1992, Brain, behavior and evolution.

[224]  M. Raiteri,et al.  5‐Hydroxytryptamine3 Receptors Sited on Cholinergic Axon Terminals of Human Cerebral Cortex Mediate Inhibition of Acetylcholine Release , 1992, Journal of neurochemistry.

[225]  M. Rapport,et al.  Serum vasoconstrictor, serotonin; isolation and characterization. , 1948, The Journal of biological chemistry.

[226]  M. Molliver,et al.  Dual serotoninergic projections to forebrain in the rat: Morphologically distinct 5‐HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives , 1991, The Journal of comparative neurology.

[227]  J. Pujol,et al.  Immunocytochemical evidence for the existence of GABAergic neurons in the nucleus raphe dorsalis. possible existence of neurons containing serotonin and GABA , 1982, Brain Research.

[228]  M. Briley,et al.  Specific tricyclic antidepressant binding sites in rat brain characterised by high-affinity 3H-imipramine binding. , 1980, European journal of pharmacology.

[229]  T. O'donohue,et al.  A comparison of the anatomical distribution of substance P and substance P receptors in the rat central nervous system , 1984, Peptides.

[230]  J. Williams,et al.  5-HT-mediated synaptic potentials in the dorsal raphe nucleus: interactions with excitatory amino acid and GABA neurotransmission. , 1989, Journal of neurophysiology.

[231]  C. de Montigny,et al.  Full agonistic properties of BAY x 3702 on presynaptic and postsynaptic 5-HT1A receptors electrophysiological studies in the rat hippocampus and dorsal raphe. , 1998, The Journal of pharmacology and experimental therapeutics.

[232]  M. Raiteri,et al.  Functional evidence for two stereochemically different alpha-2 adrenoceptors regulating central norepinephrine and serotonin release. , 1983, The Journal of pharmacology and experimental therapeutics.

[233]  D. Middlemiss Stereoselective blockade at [3H]5-HT binding sites and at the 5-HT autoreceptor by propranolol. , 1984, European journal of pharmacology.

[234]  H. Schoemaker,et al.  Effects of antidepressants on monoamine transporters , 1988, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[235]  A. Brusco,et al.  Serotonin-like immunoreactivity and anti-5-hydroxytryptamine (5-HT) antibodies: ultrastructural application in the central nervous system. , 1983, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[236]  K. Starke,et al.  Species differences in presynaptic serotonin autoreceptors: mainly 5-HT1B but possibly in addition 5-HT1D in the rat, 5-HT1D in the rabbit and guinea-pig brain cortex , 1991, Naunyn-Schmiedeberg's Archives of Pharmacology.

[237]  A. Schoups,et al.  Species dependence of adaptations at the pre- and postsynaptic serotonergic receptors following long-term antidepressant drug treatment. , 1988, Biochemical pharmacology.

[238]  J. Pujol,et al.  High resolution radioautographic identification of [3H]GABA labeled neurons in the rat nucleus raphe dorsalis , 1979, Neuroscience Letters.

[239]  M. Reith,et al.  Role of ions and membrane potential in uptake of serotonin into plasma membrane vesicles from mouse brain. , 1989, Biochemical pharmacology.

[240]  S. J. Smith,et al.  Calcium entry and transmitter release at voltage‐clamped nerve terminals of squid. , 1985, The Journal of physiology.

[241]  J. Hornung,et al.  Serotoninergic system in the brainstem of the marmoset: A combined immunocytochemical and three‐dimensional reconstruction study , 1988, The Journal of comparative neurology.

[242]  C. Montigny,et al.  Autoradiographic quantification of serotonin1A receptors in rat brain following antidepressant drug treatment , 1989, Synapse.

[243]  G. Rudnick,et al.  From synapse to vesicle: the reuptake and storage of biogenic amine neurotransmitters. , 1993, Biochimica et biophysica acta.

[244]  J. Villalobos,et al.  The differential ascending projections from the anterior, central and posterior regions of the lateral hypothalamic area: An autoradiographic study , 1987, Neuroscience Letters.

[245]  F. Yocca Neurochemistry and Neurophysiology of Buspirone and Gepirone: Interactions at Presynaptic and Postsynaptic 5‐HT1A Receptors , 1990, Journal of clinical psychopharmacology.

[246]  P. Pauwels,et al.  Functional effects of the 5-HT1D receptor antagonist GR 127,935 at human 5-HT1Dα, 5-HT1Dβ, 5-HT1A and opposum 5-HT1B receptors , 1995 .

[247]  S. Siegelbaum,et al.  Up- and down-modulation of single K+ channel function by distinct second messengers , 1988, Trends in Neurosciences.

[248]  V. Pike,et al.  The radiosynthesis of [N-methyl-11C]-sertraline. , 1989, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

[249]  R. Strecker,et al.  Regulation of striatal serotonin release by the lateral habenula-dorsal raphe pathway in the rat as demonstrated by in vivo microdialysis: role of excitatory amino acids and GABA , 1989, Brain Research.

[250]  Y. Reilly,et al.  WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. , 1993, European journal of pharmacology.

[251]  H. Kao,et al.  Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[252]  D. Middlemiss,et al.  An investigation of the 5-HT1D receptor binding affinity of 5-hydroxytryptamine, 5-carboxyamidotryptamine and sumatriptan in the central nervous system of seven species. , 1992, European journal of pharmacology.

[253]  E. Kidd,et al.  Effects of repeated treatment with 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) on the autoregulatory control of dorsal raphe 5-HT neuronal firing and cortical 5-HT release. , 1991, European journal of pharmacology.

[254]  M. Barbaccia,et al.  Modulation of neuronal serotonin uptake by a putative endogenous ligand of imipramine recognition sites. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[255]  C. Marsden,et al.  Effect of the putative 5-HT1A antagonists WAY100135 and SDZ 216—525 on 5-HT neuronal firing in the guinea-pig dorsal raphe nucleus , 1994, Neuropharmacology.

[256]  D. Dorsa,et al.  Distinct 5-HT1B and 5-HT1D serotonin receptors in rat: Structural and pharmacological comparison of the two cloned receptors , 1992, Molecular and Cellular Neuroscience.

[257]  Antidepressant binding to the porcine and human platelet serotonin transporters. , 1988, Molecular pharmacology.

[258]  D. Murphy,et al.  Primary Structure of the Human Platelet Serotonin Uptake Site: Identity with the Brain Serotonin Transporter , 1993, Journal of neurochemistry.

[259]  Marc Laruelle,et al.  SPECT imaging of dopamine and serotonin transporters with [123I]β‐CIT: Pharmacological characterization of brain uptake in nonhuman primates , 1993, Synapse.

[260]  Rex Y. Wang,et al.  Antidromically identified serotonergic neurons in the rat midbrain raphe: evidence for collateral inhibition , 1977, Brain Research.

[261]  P. Seeburg,et al.  Molecular cloning and characterization of a rat brain cDNA encoding a 5‐hydroxytryptamine1B receptor. , 1991, The EMBO journal.

[262]  L. Descarries,et al.  Ultrastructural features of the serotonin innervation in adult rat hippocampus: An immunocytochemical description in single and serial thin sections , 1991, Neuroscience.

[263]  P. Hrdina Regulation of high- and low-affinity [3H]imipramine recognition sites in rat brain by chronic treatment with antidepressants. , 1987, European journal of pharmacology.

[264]  A. Basbaum,et al.  Enkephalin-immunoreactive perikarya in the cat raphe dorsalis , 1981, Neuroscience Letters.

[265]  E. Smeraldi,et al.  Faster onset of action of fluvoxamine in combination with pindolol in the treatment of delusional depression: a controlled study. , 1998, Journal of clinical psychopharmacology.

[266]  M. Minchin,et al.  Characterisation of the Binding of [3H]WAY‐100635, a Novel 5‐Hydroxytryptamine1A Receptor Antagonist, to Rat Brain , 1995, Journal of neurochemistry.

[267]  A. Sleight,et al.  In vivo effects of sumatriptan (GR 43175) on extracellular levels of 5-HT in the guinea pig , 1990, Neuropharmacology.

[268]  H. Niznik,et al.  Agonist activity of sumatriptan and metergoline at the human 5-HT1D beta receptor: further evidence for a role of the 5-HT1D receptor in the action of sumatriptan. , 1992, European journal of pharmacology.

[269]  M. Goldstein,et al.  Receptor reserve for 5-hydroxytryptamine1A-mediated inhibition of serotonin synthesis: possible relationship to anxiolytic properties of 5-hydroxytryptamine1A agonists. , 1990, Molecular pharmacology.

[270]  J. Mann,et al.  Studies of selective and reversible monoamine oxidase inhibitors. , 1984, The Journal of clinical psychiatry.

[271]  C. de Montigny,et al.  Effects of the 5-hydroxytryptamine receptor antagonist, BMY 7378, on 5-hydroxytryptamine neurotransmission: electrophysiological studies in the rat central nervous system. , 1988, The Journal of pharmacology and experimental therapeutics.

[272]  M. Raiteri,et al.  Release‐Regulating Serotonin 5‐HT1D Autoreceptors in Human Cerebral Cortex , 1993, Journal of neurochemistry.

[273]  T. Kenakin The classification of seven transmembrane receptors in recombinant expression systems. , 1996, Pharmacological reviews.

[274]  J. D. De Mey,et al.  Immunohistochemical localization of cholecystokinin- and gastrin-like peptides in the brain and hypophysis of the rat. , 1980, Proceedings of the National Academy of Sciences of the United States of America.

[275]  S. Z. Langer,et al.  Complex Inhibition of [3H]Imipramine Binding by Serotonin and Nontricyclic Serotonin Uptake Blockers , 1983, Journal of neurochemistry.

[276]  T. Hökfelt,et al.  Serotonin-, substance P- and glutamate/aspartate-like immunoreactivities in medullo-spinal pathways of rat and primate , 1992, Neuroscience.

[277]  B. Everitt,et al.  The organization of indoleamine neurons in the brain of the rhesus monkey (Macaca mulatta) , 1981, The Journal of comparative neurology.

[278]  F. Fonnum,et al.  An estimation of the concentration of y-aminobutyric acid and glutamate decarboxylase in the inhibitory Purkinje axon terminals in the cat. , 1973, Brain research.

[279]  G. Breese,et al.  Autoradiographic characterization of [3H]imipramine and [3H]citalopram binding in rat and human brain: species differences and relationships to serotonin innervation patterns , 1992, Brain Research.

[280]  P. Blier,et al.  Functional characterization of a 5‐HT3 receptor which modulates the release of 5‐HT in the guinea‐pig brain , 1993, British journal of pharmacology.

[281]  R. Blakely,et al.  Expression of Serotonin Transporter Messenger RNA in the Human Brain , 1994, Journal of neurochemistry.

[282]  E. Vergani,et al.  LSD-25 and carbohydrate metabolism. , 1969, Brain research.

[283]  J. Gripenberg Inhibition of reserpine, guanethidine and imiparmine of the uptake of 5-hydroxytryptamine by rat peritoneal mast cells in vitro. , 1976, Acta physiologica Scandinavica.

[284]  Melburn R. Park Monosynaptic inhibitory postsynaptic potentials from lateral habenula recorded in dorsal raphe neurons , 1987, Brain Research Bulletin.

[285]  Warren C. Stern,et al.  Neuropharmacology of the afferent projections from the lateral habenula and substantia nigra to the anterior raphe in the rat , 1981, Neuropharmacology.

[286]  R. Blakely,et al.  Cloning and expression of a functional serotonin transporter from rat brain , 1991, Nature.

[287]  K. Lesch,et al.  Signal-transducing G proteins and antidepressant Drugs: Evidence for modulation of α subunit gene expression in rat brain , 1992, Biological Psychiatry.

[288]  M. Rettori,et al.  Pharmacological antidepressive effects and tianeptine-induced 5-HT uptake increase. , 1988, Clinical neuropharmacology.

[289]  B. Kosofsky,et al.  The serotoninergic innervation of cerebral cortex: Different classes of axon terminals arise from dorsal and median raphe nuclei , 1987, Synapse.

[290]  G. Kato,et al.  Neurochemical profile of tianeptine, a new antidepressant drug. , 1988, Clinical neuropharmacology.

[291]  J. Fritschy,et al.  Neuron-specific expression of GABAA-receptor subtypes: differential association of the alpha 1- and alpha 3-subunits with serotonergic and GABAergic neurons. , 1993, Neuroscience.

[292]  M. Rasenick,et al.  Chronic Treatment of C6 Glioma Cells with Antidepressant Drugs Increases Functional Coupling Between a G Protein (GS) and Adenylyl Cyclase , 1995, Journal of neurochemistry.

[293]  E. sanders-Bush,et al.  Constitutively active 5-hydroxytryptamine2C receptors reveal novel inverse agonist activity of receptor ligands. , 1994, The Journal of biological chemistry.

[294]  R. Glennon,et al.  5-(Nonyloxy)tryptamine: a novel high-affinity 5-HT1D beta serotonin receptor agonist. , 1994, Journal of medicinal chemistry.

[295]  P. Soubrié,et al.  Involvement of lateral habenula-dorsal raphe neurons in the differential regulation of striatal and nigral serotonergic transmission cats , 1982, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[296]  D. Hoyer,et al.  Molecular pharmacology of 5-HT1 and 5-HT2 recognition sites in rat and pig brain membranes: radioligand binding studies with [3H]5-HT, [3H]8-OH-DPAT, (-)[125I]iodocyanopindolol, [3H]mesulergine and [3H]ketanserin. , 1985, European journal of pharmacology.

[297]  H. Lôo,et al.  Association of [3H]-imipramine and [3H]-paroxetine binding with the 5HT transporter in brain and platelets: relevance to studies in depression. , 1987, Journal of receptor research.

[298]  P. Goldman-Rakic,et al.  Selective prefrontal cortical projections to the region of the locus coeruleus and raphe nuclei in the rhesus monkey , 1984, Brain Research.

[299]  X. Khawaja,et al.  Quantitative autoradiographic characterisation of the binding of [3H]WAY-100635, a selective 5-HT1A receptor antagonist , 1995, Brain Research.

[300]  V. D. Carlo,et al.  Fluorescence histochemistry of monoamine‐containing cell bodies in the brain stem of the squirrel monkey (Saimiri sciureus). III. Serotonin‐containing groups , 2004 .

[301]  P. Pauwels,et al.  The 5-HT1Dreceptor antagonist GR 127,935 is an agonist at cloned human 5-HT1Dα receptor sites , 1995, Neuropharmacology.

[302]  V. Ganapathy,et al.  Modulation of serotonin uptake kinetics by ions and ion gradients in human placental brush-border membrane vesicles. , 1990, Biochemistry.

[303]  J. Stamford,et al.  The effect of paroxetine on 5-HT efflux in the rat dorsal raphe nucleus is potentiated by both 5-HT1A and 5-HT 1B D receptor antagonists , 1995, Neuroscience Letters.

[304]  G. Aghajanian,et al.  Stimulation of pontine reticular formation suppresses firing of serotonergic neurones in the dorsal raphe , 1976, Nature.

[305]  L. Wiklund,et al.  Afferents to the median raphe nucleus of the rat: Retrograde cholera toxin and wheat germ conjugated horseradish peroxidase tracing, and selectived-[3H]aspartate labelling of possible excitatory amino acid inputs , 1990, Neuroscience.

[306]  M. Gobbi,et al.  Acute noise stress reduces [3H]5-hydroxytryptamine uptake in rat brain synaptosomes: protective effects of buspirone and tianeptine. , 1993, European journal of pharmacology.

[307]  E. Smeraldi,et al.  How long should pindolol be associated with paroxetine to improve the antidepressant response? , 1997, Journal of clinical psychopharmacology.

[308]  C. Montigny,et al.  Serotoninergic but not noradrenergic neurons in rat central nervous system adapt to long-term treatment with monoamine oxidase inhibitors , 1985, Neuroscience.

[309]  L. Pozzi,et al.  Tianeptine increases the extracellular concentrations of dopamine in the nucleus accumbens by a serotonin-independent mechanism , 1992, Neuropharmacology.

[310]  G. Higgins,et al.  Stimulation of central 5-HT1D receptors causes hypothermia in the guinea-pig , 1994, Journal of psychopharmacology.

[311]  R. Fontanges,et al.  Effect of tianeptine on neuroendocrine, enzyme and behavioral responses to restraint stress in male rats , 1993, European Psychiatry.

[312]  W. Horne,et al.  Activators of protein kinase C decrease serotonin transport in human platelets. , 1992, Biochimica et biophysica acta.

[313]  G. Battaglia,et al.  Methylenedioxyamphetamine (MDA) and methylenedioxymethamphetamine (MDMA) cause selective ablation of serotonergic axon terminals in forebrain: immunocytochemical evidence for neurotoxicity , 1988, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[314]  M. Titeler,et al.  Detection and Characterization of the Serotonin 5‐HT1D Receptor in Rat and Human Brain , 1988 .

[315]  G. Rudnick,et al.  Mechanism of imipramine inhibition of platelet 5-hydroxytryptamine transport. , 1979, The Journal of biological chemistry.

[316]  D. Middlemiss,et al.  Species differences in the pharmacology of terminal 5-HT autoreceptors in mammalian brain. , 1989, Trends in pharmacological sciences.

[317]  M. Raiteri,et al.  (−)-Propranolol and (±)-cyanopindolol are mixed agonists-antagonists at serotonin autoreceptors in the hippocampus of the rat brain , 1987, Neuropharmacology.

[318]  C. Marsden,et al.  Measurement of extracellular basal levels of serotonin in vivo using nafion-coated carbon fibre electrodes combined with differential pulse voltammetry , 1988, Neuroscience.

[319]  J. E. Vaughn,et al.  Immunocytochemical localization of glutamate decarboxylase in rat substantia nigra , 1976, Brain Research.

[320]  E. Azmitia,et al.  The ultrastructural localization of serotonin immunoreactivity in myelinated and unmyelinated axons within the medial forebrain bundle of rat and monkey , 1983, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[321]  G. Aghajanian,et al.  (-)-Propranolol blocks the inhibition of serotonergic dorsal raphe cell firing by 5-HT1A selective agonists. , 1986, European journal of pharmacology.

[322]  S. Peroutka,et al.  Pharmacological Differentiation and Characterization of 5‐HT1A, 5‐HT1B, and 5‐HT1C Binding Sites in Rat Frontal Cortex , 1986, Journal of neurochemistry.

[323]  T. Feuerstein,et al.  The serotonin (5-HT) autoreceptor in the hippocampus of the rabbit: Role of 5-HT biophase concentration , 1987, Neuropharmacology.

[324]  P. Hrdina,et al.  Chronic fluoxetine treatment upregulates 5‐HT uptake sites and 5‐HT2 receptors in rat brain: An autoradiographic study , 1993, Synapse.

[325]  J. Kennedy,et al.  A human serotonin 1D receptor variant (5HT1D beta) encoded by an intronless gene on chromosome 6. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[326]  A. Anand,et al.  Effect of pindolol in hastening response to fluoxetine in the treatment of major depression: a double-blind, placebo-controlled trial. , 1997, The American journal of psychiatry.

[327]  R. Tao,et al.  The putative 5-HT1B receptor agonist CP-93,129 suppresses rat hippocampal 5-HT release in vivo: comparison with RU 24969. , 1991, European journal of pharmacology.

[328]  D. Salvert,et al.  Differential projections of the nucleus raphe dorsalis and nucleus raphe centralis as revealed by autoradiography , 1975, Brain Research.

[329]  R. Myers,et al.  Citalopram: labelling with carbon-11 and evaluation in rat as a potential radioligand for in vivo PET studies of 5-HT re-uptake sites. , 1991, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

[330]  Y. Claustre,et al.  Characterization of [3H]paroxetine binding to rat cortical membranes. , 1985, European journal of pharmacology.

[331]  J. Priestley,et al.  Serotonin and NADPH-diaphorase in the dorsal raphe nucleus of the adult rat , 1994, Neuroscience Letters.

[332]  A. Cesura,et al.  Quantitative enzyme radioautography with [3H]Ro 19-6327: Localization of MAO-B in rat CNS, peripheral organs and human brain , 1988 .

[333]  H. Steinbusch,et al.  Serotonin-immunoreactive neurons and their projections in the CNS , 1984 .

[334]  M. Hamon,et al.  Tianeptine stimulates uptake of 5-hydroxytryptamine in vivo in the rat brain , 1990, Neuropharmacology.

[335]  F. Hery,et al.  Release of serotonin from perikarya in cat nodose ganglia , 1984, Brain Research.

[336]  M. Langlois,et al.  Structural analysis by the comparative molecular field analysis method of the affinity of beta-adrenoreceptor blocking agents for 5-HT1A and 5-HT1B receptors. , 1993, European journal of pharmacology.

[337]  G. Ricaurte,et al.  Paroxetine as an in vivo indicator of 3,4-methylenedioxymethamphetamine neurotoxicity: a presynaptic serotonergic positron emission tomography ligand? , 1990, Brain Research.

[338]  K. Datla,et al.  Behavioural and neurochemical evidence for the decrease of brain extracellular 5-HT by the antidepressant drug tianeptine , 1993, Neuropharmacology.

[339]  J. Fozard,et al.  The novel 5‐HT1A receptor antagonist, SDZ 216–525, decreases 5‐HT release in rat hippocampus in vivo , 1993, British journal of pharmacology.

[340]  M. Maes,et al.  Efficacy of treatment with trazodone in combination with pindolol or fluoxetine in major depression. , 1996, Journal of affective disorders.

[341]  W. Foote,et al.  Evidence for a retinal projection to the midbrain raphe of the cat , 1978, Brain Research.

[342]  D. Jacobowitz,et al.  Studies on the origin of innervation of the noradrenergic area bordering on the nucleus raphe dorsalis , 1976, Brain Research.

[343]  L. D. van de Kar,et al.  Attenuation of hormone responses to the 5-HT1A agonist ipsapirone by long-term treatment with fluoxetine, but not desipramine, in male rats , 1994, Biological Psychiatry.

[344]  J. Richards,et al.  Evidence against a neurotoxic action of halogenated amphetamines on serotoninergic B9 cells. A morphometric fluorescence histochemical study , 1978, Brain Research.

[345]  T. Costa,et al.  Mu and delta opioid receptors inhibit serotonin release in rat hippocampus. , 1989, The Journal of pharmacology and experimental therapeutics.

[346]  P. Plenge,et al.  Affinity modulation of [3H]imipramine, [3H]paroxetine and [3H]citalopram binding to the 5-HT transporter from brain and platelets. , 1991, European journal of pharmacology.

[347]  M. Briley,et al.  Stereoselective inhibition of 3H-imipramine binding by antidepressant drugs and their derivatives. , 1980, European journal of pharmacology.

[348]  A. Fox,et al.  Whole‐cell recordings of inwardly rectifying K+ currents activated by 5‐HT1A receptors on dorsal raphe neurones of the adult rat. , 1993, The Journal of physiology.

[349]  James H. Fallon,et al.  Monoamine innervation of the forebrain: Collateralization , 1982, Brain Research Bulletin.

[350]  S. T. Kitai,et al.  The organization of divergent axonal projections from the midbrain raphe nuclei in the rat , 1986, The Journal of comparative neurology.

[351]  D. Jacobowitz,et al.  Distribution of glutamic acid decar☐ylase in certain rhombencephalic and thalamic nuclei of the rat , 1976, Brain Research.

[352]  P. Blier,et al.  Functional characterization of 5‐HT1D autoreceptors on the modulation of 5‐HT release in guinea‐pig mesencephalic raphe, hippocampus and frontal cortex , 1996, British journal of pharmacology.

[353]  E. Kidd,et al.  Inhibition of 5-hydroxytryptamine neuronal activity by the 5-HT agonist, DOI. , 1991, European journal of pharmacology.

[354]  E. Zimmerman,et al.  Vasoactive intestinal polypeptide (VIP) in mouse and rat brain: An immunocytochemical study , 1980, Brain Research.

[355]  T. Kenakin,et al.  Agonist-receptor efficacy. I: Mechanisms of efficacy and receptor promiscuity. , 1995, Trends in pharmacological sciences.

[356]  C. de Montigny,et al.  Modification of serotonergic and noradrenergic neurotransmissions by repeated administration of monoamine oxidase inhibitors: electrophysiological studies in the rat central nervous system. , 1986, The Journal of pharmacology and experimental therapeutics.

[357]  J. Palacios,et al.  Visualization of a novel serotonin recognition site (5-HT1D) in the human brain by autoradiography , 1988, Neuroscience Letters.

[358]  H. Akil,et al.  Serotonin transporter mRNA in rat brain is regulated by classical antidepressants , 1994, Biological Psychiatry.

[359]  M. Molliver,et al.  Organization of raphe-cortical projections in rat: A quantitative retrograde study , 1984, Brain Research Bulletin.

[360]  M. Johnson Electrophysiological and histochemical properties of postnatal rat serotonergic neurons in dissociated cell culture , 1994, Neuroscience.

[361]  P. Greengard,et al.  Synapsin I bundles F-actin in a phosphorylation-dependent manner , 1987, Nature.

[362]  E. Azmitia,et al.  The primate serotonergic system: a review of human and animal studies and a report on Macaca fascicularis. , 1986, Advances in neurology.

[363]  M. Wood,et al.  Stereoselective blockade of central [3H]5‐hydroxytryptamine binding to multiple sites (5‐HT1A, 5‐HT1B and 5‐HT1C) by mianserin and propranolol , 1987, The Journal of pharmacy and pharmacology.

[364]  S. J. Starkey,et al.  5-HT1D as well as 5-HT1A autoreceptors modulate 5-HT release in the guinea-pig dorsal raphénucleus , 1994, Neuropharmacology.

[365]  Extracellular 5‐Hydroxytryptamine in Median Raphe Nucleus of the Conscious Rat Is Decreased by Nanomolar Concentrations of 8‐Hydroxy‐2‐(Di‐n‐Propylamino)tetralin and Is Sensitive to Tetrodotoxin , 1994, Journal of neurochemistry.

[366]  M. J. Sumner,et al.  5‐HT1D binding sites in porcine brain can be sub‐divided by GR43175 , 1989, British journal of pharmacology.

[367]  A. Oblin,et al.  Inter- and intracellular relationship of substance P-containing neurons with serotonin and GABA in the dorsal raphe nucleus: combination of autoradiographic and immunocytochemical techniques. , 1986, The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society.

[368]  F. Artigas,et al.  In Vivo Brain Dialysis Study of the Somatodendritic Release of Serotonin in the Raphe Nuclei of the Rat: Effects of 8‐Hydroxy‐2‐(Di‐n‐Propylamino)tetralin , 1993, Journal of neurochemistry.

[369]  M. Göthert Presynaptic Serotonin Receptors in the Central Nervous System , 1990, Annals of the New York Academy of Sciences.

[370]  B. Jacobs,et al.  SINGLE-UNIT RECORDINGS FROM FREELY-MOVING ANIMALS PROVIDE EVIDENCE THAT WAY-100635, BUT NOT (S)-WAY-100135, BLOCKS THE ACTION OF ENDOGENOUS SEROTONIN AT THE 5-HT AUTORECEPTOR , 1994 .

[371]  S. Joseph,et al.  Opiocortin and catecholamine projections to raphe nuclei , 1989, Peptides.

[372]  P. Whitton,et al.  The effect of the novel antidepressant tianeptine on the concentration of 5-hydroxytryptamine in rat hippocampal dialysates in vivo , 1991, Neuropharmacology.

[373]  P. Plenge,et al.  [3H]Citalopram Binding to Brain and Platelet Membranes of Human and Rat , 1991, Journal of neurochemistry.

[374]  J. Mulheron,et al.  Agonist-induced desensitization and phosphorylation of human 5-HT1A receptor expressed in Sf9 insect cells. , 1995, Biochemistry.

[375]  A. Björklund,et al.  Topography of the monoamine neuron systems in the human brain as revealed in fetuses. , 1973, Acta physiologica Scandinavica. Supplementum.

[376]  S. Maayani,et al.  Buspirone and gepirone: partial agonists at the 5HT/sub 1/A receptor linked to adenylate cyclase (AC) in rat and guinea pig hippocampal preparations , 1986 .

[377]  M. Fache,et al.  Glutamate, GABA, glycine and taurine modulate serotonin synthesis and release in rostral and caudal rhombencephalic raphe cells in primary cultures , 1993, Neurochemistry International.

[378]  I. Page,et al.  Serotonin content of some mammalian tissues and urine and a method for its determination. , 1953, The American journal of physiology.

[379]  M. Molliver,et al.  Anatomic evidence for a neurotoxic effect of (±)-fenfluramine upon serotonergic projections in the rat , 1990, Brain Research.

[380]  C. de Montigny,et al.  Differential Effect of Gepirone on Presynaptic and Postsynaptic Serotonin Receptors: Single‐Cell Recording Studies , 1990, Journal of clinical psychopharmacology.

[381]  C. de Montigny,et al.  Short‐term lithium treatment enhances responsiveness of postsynaptic 5‐HT1A receptors without altering 5‐HT autoreceptor sensitivity: An electrophysiological study in the rat brain , 1987, Synapse.

[382]  M. Metcalf,et al.  Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. , 1991, Molecular pharmacology.

[383]  J. Hensler,et al.  A quantitative autoradiographic study of serotonin1A receptor regulation. Effect of 5,7-dihydroxytryptamine and antidepressant treatments. , 1991, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[384]  T. Campbell,et al.  Effects of hyperkalaemia on the depression of maximum rate of depolarization by class I antiarrhythmic agents in guinea‐pig myocardium , 1993, British journal of pharmacology.

[385]  L. Descarries,et al.  Serotonin innervation in adult rat neostriatum. I. Quantified regional distribution , 1987, Brain Research.

[386]  R. Eglen,et al.  Characterization and distribution of putative 5‐ht7 receptors in guinea‐pig brain , 1995, British journal of pharmacology.

[387]  R. Nicoll,et al.  Pharmacologically distinct actions of serotonin on single pyramidal neurones of the rat hippocampus recorded in vitro. , 1987, The Journal of physiology.

[388]  M. P. Johnson,et al.  Combined administration of a non-neurotoxic 3,4-methylenedioxymethamphetamine analogue with amphetamine produces serotonin neurotoxicity in rats , 1991, Neuropharmacology.

[389]  R. Anwyl,et al.  Modulation of vertebrate neuronal calcium channels by transmitters , 1991, Brain Research Reviews.

[390]  J. Macor,et al.  Biochemical and behavioral studies of the 5‐HT1B receptor agonist, CP‐94,253 , 1992 .

[391]  M. Hamon,et al.  Differential effects of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ) on various 5-HT receptor binding sites in the rat brain , 1994, Neuropharmacology.

[392]  D G Grahame-Smith,et al.  In Vivo Measurement of Extracellular 5‐Hydroxytryptamine in Hippocampus of the Anaesthetized Rat Using Microdialysis: Changes in Relation to 5‐Hydroxytryptaminergic Neuronal Activity , 1989, Journal of neurochemistry.

[393]  M. Wood,et al.  Examination of the relationship between the uptake system for 5-hydroxytryptamine and the high-affinity [3H]imipramine binding site—I Inhibition by drugs , 1986, Neuropharmacology.

[394]  Gilles Bonvento,et al.  Effect of local injection of 8-OH-DPAT into the dorsal or median raphe nuclei on extracellular levels of serotonin in serotonergic projection areas in the rat brain , 1992, Neuroscience Letters.

[395]  A. Kamoun,et al.  Structure-activity relationships of tricyclic antidepressants, with special reference to tianeptine. , 1988, Clinical neuropharmacology.

[396]  D. Sibley,et al.  Molecular cloning and expression of a 5-hydroxytryptamine7 serotonin receptor subtype. , 1993, The Journal of biological chemistry.

[397]  M. L. Berk,et al.  Efferent connections of the lateral hypothalamic area of the rat: An autoradiographic investigation , 1982, Brain Research Bulletin.

[398]  M. Dubocovich,et al.  High-affinity [3H]imipramine binding in rat hypothalamus: association with uptake of serotonin but not of norepinephrine. , 1980, Science.

[399]  H. Y. Yang,et al.  The monoamine oxidases of brain: selective inhibition with drugs and the consequences for the metabolism of the biogenic amines. , 1974, The Journal of pharmacology and experimental therapeutics.

[400]  G. Aghajanian,et al.  Hyperpolarization of serotonergic neurons by serotonin and LSD: Studies in brain slices showing increased K+ conductance , 1984, Brain Research.

[401]  C. J. Schmidt,et al.  Antagonism of the neurotoxicity due to a single administration of methylenedioxymethamphetamine. , 1990, European journal of pharmacology.

[402]  E. Azmitia,et al.  Integrative transporter-mediated release from cytoplasmic and vesicular 5-hydroxytryptamine stores in cultured neurons. , 1993, European journal of pharmacology.

[403]  S. Peroutka,et al.  Species variations in RU 24969 interactions with non-5-HT1A binding sites. , 1986, European journal of pharmacology.

[404]  S. Hjorth,et al.  Application of brain microdialysis to study the pharmacology of the 5-HT1A autoreceptor , 1990, Journal of Neuroscience Methods.

[405]  J. Krystal,et al.  Serotonin-specific drugs for anxiety and depressive disorders. , 1990, Annual review of medicine.

[406]  M. Wilson,et al.  Distinct morphologic classes of serotonergic axons in primates exhibit differential vulnerability to the psychotropic drug 3,4-methylenedioxymethamphetamine , 1989, Neuroscience.

[407]  M. Pranzatelli,et al.  Plasticity and ontogeny of the central 5-HT transporter: effect of neonatal 5,7-dihydroxytryptamine lesions in the rat. , 1992, Brain research. Developmental brain research.

[408]  L. Descarries,et al.  Serotonin‐immunoreactive neurons in the cnidarian Renilla koellikeri , 1990, The Journal of comparative neurology.

[409]  C. Montigny,et al.  Selective Activation of Postsynaptic 5-HT1A Receptors Induces Rapid Antidepressant Response , 1997, Neuropsychopharmacology.

[410]  F. Borsini,et al.  The inhibitory effect of 8-OH-DPAT on the firing activity of dorsal raphe serotoninergic neurons in rats is attenuated by lesion of the frontal cortex , 1994, Neuropharmacology.

[411]  T. Hökfelt,et al.  On the functional role of coexistence of 5-HT and substance P in bulbospinal 5-HT neurons. Substance P reduces affinity and increases density of 3H-5-HT binding sites. , 1983, Acta physiologica Scandinavica.

[412]  P. Blier,et al.  Effectiveness of pindolol with selected antidepressant drugs in the treatment of major depression. , 1995, Journal of clinical psychopharmacology.

[413]  F. Hery,et al.  The role of serotonin release and autoreceptors in the dorsalis raphe nucleus in the control of serotonin release in the cat caudate nucleus , 1990, Neuroscience.

[414]  M. Hamon,et al.  Quantitative autoradiographic mapping of 5‐HT3 receptors in the rat CNS using [125I]iodo‐zacopride and [3H]zacopride as radioligands , 1992, Synapse.

[415]  G. Fillion,et al.  Antagonism by citalopram and tianeptine of presynaptic 5-HT1B heteroreceptors inhibiting acetylcholine release. , 1993, European journal of pharmacology.

[416]  Mary Ann Moran,et al.  Synthesis and Evaluation , 1986 .

[417]  D. Middlemiss,et al.  A pharmacological analysis of the 5-HT receptor mediating inhibition of 5-HT release in the guinea-pig frontal cortex. , 1988, European journal of pharmacology.

[418]  D. Middlemiss,et al.  Stereoselective actions of the isomers of metitepine at 5-HT1D receptors in the guinea pig brain , 1993, Neuropharmacology.

[419]  R. Glennon,et al.  NAN-190: agonist and antagonist interactions with brain 5-HT1A receptors , 1990, Brain Research.

[420]  W. Harris Neural activity and development. , 1981, Annual review of physiology.

[421]  M. Kuhar,et al.  [123/125I]RTI‐55, an in vivo label for the serotonin transporter , 1992, Synapse.

[422]  T. G. Brodie The immediate action of an intravenous injection of blood‐serum , 1900, The Journal of physiology.

[423]  P. Blier,et al.  Regulation of 5-hydroxytryptamine release from rat midbrain raphe nuclei by 5-hydroxytryptamine1D receptors: effect of tetrodotoxin, G protein inactivation and long-term antidepressant administration. , 1996, The Journal of pharmacology and experimental therapeutics.

[424]  S. Snyder,et al.  Selective labeling of serotonin uptake sites in rat brain by [3H]citalopram contrasted to labeling of multiple sites by [3H]imipramine. , 1987, The Journal of pharmacology and experimental therapeutics.

[425]  G. Rudnick,et al.  The role of chloride ion in platelet serotonin transport. , 1982, The Journal of biological chemistry.

[426]  C. Montigny,et al.  Current advances and trends in the treatment of depression. , 1994, Trends in pharmacological sciences.

[427]  C. Montigny,et al.  Desensitization of the neuronal 5-HT carrier following its long-term blockade , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[428]  I A Cliffe,et al.  A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. , 1995, European journal of pharmacology.

[429]  T. Branchek,et al.  Cloning of a novel human serotonin receptor (5-HT7) positively linked to adenylate cyclase. , 1993, The Journal of biological chemistry.

[430]  D. Brunswick,et al.  Labeling in vivo of serotonin uptake sites in rat brain after administration of [3H]cyanoimipramine. , 1987, The Journal of pharmacology and experimental therapeutics.

[431]  J. C. Vuletin,et al.  A Light and Electron Microscopic Study , 1976 .

[432]  B. Jacobs,et al.  Effects of the putative 5-hydroxytryptamine1A antagonists BMY 7378, NAN 190 and (-)-propranolol on serotonergic dorsal raphe unit activity in behaving cats. , 1994, The Journal of pharmacology and experimental therapeutics.

[433]  G. Aghajanian,et al.  Noradrenergic innervation of serotonergic neurons in the dorsal raphe: Demonstration by electron microscopic autoradiography , 1981, Brain Research.

[434]  G. C. Ormandy Increased cyclic AMP reduces 5-HT1D receptor-mediated inhibition of [3H]5-hydroxytryptamine release from guinea-pig cortical slices. , 1993, European journal of pharmacology.

[435]  B. Jacobs,et al.  Structure and function of the brain serotonin system. , 1992, Physiological reviews.

[436]  T. Svensson,et al.  Substance P injection into the dorsal raphe increases blood pressure and serotonin release in hippocampus of conscious rats. , 1992, European journal of pharmacology.

[437]  F. Bloom,et al.  Differential projections of neurons within the dorsal raphe nucleus of the rat: a horseradish peroxidase (HRP) study , 1978, Brain Research.

[438]  C. Saper,et al.  Organization of medullary adrenergic and noradrenergic projections to the periaqueductal gray matter in the rat , 1992, The Journal of comparative neurology.

[439]  M. Molliver,et al.  Immunohistochemical study of the development of serotonergic neurons in the rat CNS , 1982, Brain Research Bulletin.

[440]  F. Artigas,et al.  Dopaminergic regulation of the serotonergic raphe-striatal pathway: microdialysis studies in freely moving rats , 1994, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[441]  D. Roberts,et al.  Relationship between levels and uptake of serotonin and high affinity [3H]imipramine recognition sites in the rat brain. , 1985, Canadian Journal of Physiology and Pharmacology.

[442]  M. Fillenz,et al.  Both systemic and local administration of benzodiazepine agonists inhibit the in vivo release of 5-HT from ventral hippocampus , 1989, Neuropharmacology.

[443]  Images in neuroscience. Molecular biology, II. A dopamine transporter mouse knockout. , 1996, The American journal of psychiatry.

[444]  E. Azmitia Bilateral serotonergic projections to the dorsal hippocampus of the rat: Simultaneous localization of 3H‐5HT and HRP after retrograde transport , 1981, The Journal of comparative neurology.

[445]  E. Hamel,et al.  Contractile 5‐HT1 receptors in human isolated pial arterioles: correlation with 5‐HT1D binding sites , 1991, British journal of pharmacology.

[446]  F. Bloom,et al.  Lysergic acid diethylamide and serotonin: direct actions on serotonin-containing neurons in rat brain. , 1972, Life sciences. Pt. 1: Physiology and pharmacology.

[447]  G. Aghajanian,et al.  Effect of antipsychotic drugs on the firing of dorsal raphe cells. II. Reversal by picrotoxin. , 1976, European journal of pharmacology.

[448]  F. Artigas,et al.  Effects of the antidepressant drug tianeptine on plasma and platelet serotonin concentrations in the rat. , 1991, European journal of pharmacology.

[449]  M. Buckle,et al.  One-step purification of the serotonin transporter located at the human platelet plasma membrane. , 1992, The Journal of biological chemistry.

[450]  P. Hrdina,et al.  Sodium Dependence of [3H]]Paroxetine Binding and 5‐ [3H]]Hydroxytryptamine Uptake in Rat Diencephalon , 1992, Journal of neurochemistry.

[451]  S. Hjorth,et al.  Mixed agonist/antagonist properties of NAN-190 at 5-HT1A receptors: behavioural and in vivo brain microdialysis studies. , 1990, Life sciences.

[452]  B. Brodie,et al.  Identification and assay of serotonin in brain. , 1956, The Journal of pharmacology and experimental therapeutics.

[453]  H. Yamamura,et al.  Discrimination of Multiple [3H]5‐Hydroxytryptamine Binding Sites by the Neuroleptic Spiperone in Rat Brain , 1981, Journal of neurochemistry.

[454]  J. Chodkiewicz,et al.  Characterization of the 5‐Hydroxytryptamine Receptor Modulating the Release of 5‐[3H]Hydroxytryptamine in Slices of the Human Neocortex , 1992, Journal of neurochemistry.

[455]  M. Villar,et al.  Dorsal raphe serotonergic projection to the retina. A combined peroxidase tracing-neurochemical/high-performance liquid chromatography study in the rat , 1987, Neuroscience.

[456]  S. Peroutka,et al.  Characterization of a novel 3H-5-hydroxytryptamine binding site subtype in bovine brain membranes , 1987, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[457]  F. Fonnum,et al.  QUANTITATIVE HISTOCHEMISTRY OF GLUTAMATE DECARBOXYLASE IN THE RAT HIPPOCAMPAL REGION , 1971, Journal of neurochemistry.

[458]  D. Brunswick,et al.  Effect of repeated administration of antidepressants on serotonin uptake sites in limbic and neocortical structures of rat brain determined by quantitative autoradiography. , 1992, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[459]  B. Jacobs,et al.  Raphe unit activity in freely moving cats is altered by manipulations of central but not peripheral motor systems , 1983, Brain Research.

[460]  C. de Montigny,et al.  In vivo electrophysiological evidence for the regulatory role of autoreceptors on serotonergic terminals , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[461]  W. Nauta,et al.  Efferent connections of the habenular nuclei in the rat , 1979, The Journal of comparative neurology.

[462]  M. Mattei,et al.  Mouse 5-hydroxytryptamine5A and 5-hydroxytryptamine5B receptors define a new family of serotonin receptors: cloning, functional expression, and chromosomal localization. , 1993, Molecular pharmacology.

[463]  C. Montigny,et al.  Presynaptic and postsynaptic modifications of the serotonin system by long-term administration of antidepressant treatments. An in vivo electrophysiologic study in the rat. , 1991, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

[464]  L. Lanfumey,et al.  Biochemical and electrophysiological evidence for an agonist action of CM 57493 at pre- and postsynaptic 5-hydroxytryptamine1A receptors in brain. , 1989, The Journal of pharmacology and experimental therapeutics.

[465]  A. Manfridi,et al.  In vivo studies on the enhancement of serotonin reuptake by tianeptine , 1992, Brain Research.

[466]  T. Bártfai,et al.  Substance P and neurokinin A, two coexisting tachykinins stimulating the release of [3H]5-HT from rat cerebral cortical slices , 1990, Brain Research.

[467]  M. Brownstein,et al.  Cloning of a serotonin transporter affected by antidepressants. , 1991, Science.

[468]  J. Richards,et al.  Fluoxetine attenuates the dl-fenfluramine-induced increase in extracellular serotonin as measured by in vivo dialysis , 1992, Brain Research.

[469]  S. Z. Langer,et al.  A common binding site for tricyclic and nontricyclic 5-hydroxytryptamine uptake inhibitors at the substrate recognition site of the neuronal sodium-dependent 5-hydroxytryptamine transporter. , 1989, Biochemical pharmacology.

[470]  S. Haj-Dahmane,et al.  Further assessment of the antagonist properties of the novel and selective 5-HT1A receptor ligands (+)-WAY 100 135 and SDZ 216-525. , 1993, European journal of pharmacology.

[471]  R. Samanin,et al.  Chronic treatment with citalopram facilitates the effect of a challenge dose on cortical serotonin output: role of presynaptic 5-HT1A receptors. , 1994, European journal of pharmacology.

[472]  C. Lévêque,et al.  The synaptic vesicle protein synaptotagmin associates with calcium channels and is a putative Lambert-Eaton myasthenic syndrome antigen. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[473]  T. Branchek,et al.  A subfamily of 5-HT1D receptor genes. , 1992, Trends in pharmacological sciences.

[474]  J. Catravas,et al.  Cyclic AMP-independent Up-regulation of the Human Serotonin Transporter by Staurosporine in Choriocarcinoma Cells (*) , 1995, The Journal of Biological Chemistry.

[475]  J. Marcusson,et al.  Inhibition of [3H]paroxetine binding by various serotonin uptake inhibitors: structure-activity relationships. , 1992, European journal of pharmacology.

[476]  D G Grahame-Smith,et al.  Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378. , 1990, European journal of pharmacology.

[477]  R. Hen,et al.  New players in the 5-HT receptor field: genes and knockouts. , 1995, Trends in pharmacological sciences.

[478]  J. Pujol,et al.  Identification of catecholamine cell bodies in the pons and pons-mesencephalon junction of the cat brain, using tyrosine hydroxylase and dopamine-β-hydroxylase immunohistochemistry , 1984, Brain Research.

[479]  K. Starke,et al.  Modulation of neurotransmitter release by presynaptic autoreceptors. , 1989, Physiological reviews.

[480]  S. Hjorth,et al.  In vivo microdialysis evidence for central serotonin1A and serotonin1B autoreceptor blocking properties of the beta adrenoceptor antagonist (-)penbutolol. , 1993, The Journal of pharmacology and experimental therapeutics.

[481]  D. Murphy,et al.  Fluoxetine modulates G protein αs, αq and α12 subunit mRNA expression in rat brain , 1992 .

[482]  Roberto Invernizzi,et al.  Citalopram's ability to increase the extracellular concentrations of serotonin in the dorsal raphe prevents the drug's effect in the frontal cortex , 1992, Brain Research.

[483]  S. Whittemore,et al.  Adrenocorticotropic hormone activation of adenylate cyclase in raphe neurons: multiple regulatory pathways control serotonergic neuronal differentiation. , 1995, Journal of neurobiology.

[484]  E. Anderson,et al.  Serotonin uptake by astrocytes in situ , 1992, Glia.

[485]  A. Björklund,et al.  Topographic principles in the spinal projections of serotonergic and non-serotonergic brainstem neurons in the rat , 1985, Neuroscience.

[486]  D. Laude,et al.  Influence of the novel antidepressant tianeptine on neurochemical, neuroendocrinological, and behavioral effects of stress in rats , 1992, Biological Psychiatry.

[487]  Mark D. Johnson Synaptic glutamate release by postnatal rat serotonergic neurons in microculture , 1994, Neuron.

[488]  J. Chauveau,et al.  Pharmacological characterization of serotonin-O-carboxymethyl-glycyl-tyrosinamide, a new selective indolic ligand for 5-hydroxytryptamine (5-HT)1B and 5-HT1D binding sites. , 1991, The Journal of pharmacology and experimental therapeutics.

[489]  R. Shank,et al.  McN-5652: a highly potent inhibitor of serotonin uptake. , 1988, The Journal of pharmacology and experimental therapeutics.

[490]  R. Vertes,et al.  Autoradiographic analysis of ascending projections from the pontine and mesencephalic reticular formation and the median raphe nucleus in the rat , 1988, The Journal of comparative neurology.

[491]  S. Keyes,et al.  Coupling of transmembrane proton gradients to platelet serotonin transport. , 1982, The Journal of biological chemistry.

[492]  J. Saura,et al.  Quantitative enzyme radioautography with 3H-Ro 41-1049 and 3H-Ro 19- 6327 in vitro: localization and abundance of MAO-A and MAO-B in rat CNS, peripheral organs, and human brain , 1992, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[493]  T. Reynolds,et al.  Different types of bombesin receptors on neurons in the dorsal raphe nucleus and the rostral hypothalamus in rat brain slices in vitro , 1994, Brain Research.

[494]  I. Törk Anatomy of the Serotonergic System a , 1990, Annals of the New York Academy of Sciences.

[495]  G. Rudnick,et al.  Coupling between platelet 5-hydroxytryptamine and potassium transport. , 1979, The Journal of biological chemistry.

[496]  D. Sibley,et al.  Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. , 1993, Molecular pharmacology.

[497]  H. Lester,et al.  Conducting states of a mammalian serotonin transporter , 1994, Neuron.

[498]  B. Costall,et al.  Differential modulation of extracellular levels of 5‐hydroxytryptamine in the rat frontal cortex by (R)‐ and (S)‐zacopride , 1992, British journal of pharmacology.

[499]  S. Snyder,et al.  Neurotensin-containing cell bodies, fibers and nerve terminals in the brain stem of the rat: Immunohistochemical mapping , 1979, Brain Research.

[500]  M. Raiteri,et al.  Is there a functional linkage between neurotransmitter uptake mechanisms and presynaptic receptors? , 1984, The Journal of pharmacology and experimental therapeutics.

[501]  L. Wiklund,et al.  Possible excitatory amino acid afferents to nucleus raphe dorsalis of the rat investigated with retrograde wheat germ agglutinin and d-[3H]aspartate tracing , 1985, Brain Research.

[502]  H. Vaudry,et al.  Effect of chronic treatment with the antidepressant tianeptine on the hypothalamo-pituitary-adrenal axis. , 1994, European Journal of Pharmacology.

[503]  D. Bylund,et al.  The cloning and expression of an OK cell cDNA encoding a 5-hydroxytryptamine1B receptor. , 1994, Molecular pharmacology.

[504]  P. Plenge,et al.  Lithium treatment: Are the present schedules optimal? , 1988, Acta Psychiatrica Scandinavica Supplementum.

[505]  C. Montigny,et al.  Electrophysiologic Evidence for Desensitization of α2-Adrenoceptors on Serotonin Terminals Following Long-Term Treatment with Drugs Increasing Norepinephrine Synaptic Concentration , 1994, Neuropsychopharmacology.

[506]  P. Chidiac,et al.  Inverse agonist activity of beta-adrenergic antagonists. , 1994, Molecular pharmacology.

[507]  P. Greengard,et al.  Structure and function of the synapsins. , 1992, The Journal of biological chemistry.

[508]  J. Hyttel,et al.  Citalopram — Pharmacological profile of a specific serotonin uptake inhibitor with antidepressant activity , 1982, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[509]  C. Dourish,et al.  Neurochemical profile of the selective and silent 5-HT1A receptor antagonist WAY100135: an in vivo microdialysis study. , 1993, European journal of pharmacology.

[510]  G. Rudnick,et al.  Stable expression of biogenic amine transporters reveals differences in inhibitor sensitivity, kinetics, and ion dependence. , 1994, The Journal of biological chemistry.

[511]  L. Descarries,et al.  Serotonin nerve terminals in adult rat neocortex , 1975, Brain Research.

[512]  B. Ulfhake,et al.  Increased expression of serotonin transporter messenger RNA in raphe neurons of the aged rat. , 1995, Brain research. Molecular brain research.

[513]  M Briley,et al.  Serotonin autoreceptor subsensitivity and antidepressant activity. , 1990, European journal of pharmacology.

[514]  J. Chauveau,et al.  Biochemical and Pharmacological Characterization of Serotonin‐O‐Carboxymethylglycyl[125I]Iodotyrosinamide5 a New Radioiodinated Probe for 5‐HT1B and 5‐HT1D Binding Sites , 1992, Journal of Neurochemistry.

[515]  G. Hanson,et al.  Role of endogenous dopamine in the central serotonergic deficits induced by 3,4-methylenedioxymethamphetamine. , 1988, The Journal of pharmacology and experimental therapeutics.

[516]  G. Rudnick,et al.  The serotonin transporter-imipramine "receptor". , 1983, The Journal of biological chemistry.

[517]  D. Hoyer,et al.  5-HT receptors: subtypes and second messengers. , 1991, Journal of receptor research.

[518]  J. Bockaert,et al.  A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. , 1988, Molecular pharmacology.

[519]  M. Briley,et al.  Sensitivity of the response of 5-HT autoreceptors to drugs modifying synaptic availability of 5-HT , 1988, Neuropharmacology.

[520]  D. Woodward,et al.  Topographical distribution of dorsal and median raphe neurons projecting to motor, sensorimotor, and visual cortical areas in the rat , 1986, The Journal of comparative neurology.

[521]  D M Katz,et al.  Kinetics and autoradiography of high affinity uptake of serotonin by primary astrocyte cultures , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[522]  R. Fuller Uptake inhibitors increase extracellular serotonin concentration measured by brain microdialysis. , 1994, Life sciences.

[523]  S. Haj-Dahmane,et al.  Central action of 5-HT3 receptor ligands in the regulation of sleep-wakefulness and raphe neuronal activity in the rat , 1992, Neuropharmacology.

[524]  B. Jacobs,et al.  5-HT and motor control: a hypothesis , 1993, Trends in Neurosciences.

[525]  M. Hamon,et al.  Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats , 1986, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[526]  P. Benfield,et al.  Tianeptine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in depression and coexisting anxiety and depression. , 1995, Drugs.

[527]  H. Tamir,et al.  Multiple signal transduction mechanisms leading to the secretion of 5- hydroxytryptamine by MTC cells, a neurectodermally derived cell line , 1990, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[528]  B. McEwen,et al.  The Vulnerability of the Hippocampus to Protective and Destructive Effects of Glucocorticoids in Relation to Stress , 1992, British Journal of Psychiatry.

[529]  C. Montigny,et al.  Modulation of the firing activity of rat serotonin and noradrenaline neurons by (±)pindolol , 1999, Biological Psychiatry.

[530]  J. Williams,et al.  GABA- and glutamate-mediated synaptic potentials in rat dorsal raphe neurons in vitro. , 1989, Journal of neurophysiology.

[531]  K. Semba,et al.  Extent of colocalization of serotonin and GABA in the neurons of the rat raphe nuclei , 1995, Brain Research.

[532]  S. Haj-Dahmane,et al.  New methoxy-chroman derivatives, 4[N-(5-methoxy-chroman-3-yl)N- propylamino]butyl-8-azaspiro-(4,5)-decane-7,9-dione [(+/-)-S 20244] and its enantiomers, (+)-S 20499 and (-)-S 20500, with potent agonist properties at central 5-hydroxytryptamine1A receptors. , 1993, The Journal of pharmacology and experimental therapeutics.

[533]  H. Steinbusch,et al.  Identification of serotonin and non-serotonin-containing neurons of the mid-brain raphe projecting to the entorhinal area and the hippocampal formation. A combined immunohistochemical and fluorescent retrograde tracing study in the rat brain , 1982, Neuroscience.

[534]  F. Walberg,et al.  The raphe nuclei of the brain stem in the cat. II. Efferent connections , 1960 .

[535]  J. Palacios,et al.  Direct visualization of serotonin1D receptors in the human brain using a new iodinated radioligand. , 1992, Brain research. Molecular brain research.

[536]  M W Quick,et al.  Permeation properties of neurotransmitter transporters. , 1994, Annual review of pharmacology and toxicology.

[537]  F. Hery,et al.  Release of Serotonin in Structures Containing Serotoninergic Nerve Cell Bodies: Dorsalis Raphe Nucleus and Nodose Ganglia of the Cat a , 1986, Annals of the New York Academy of Sciences.

[538]  L. Grégoire,et al.  5-HT1 receptors mediating contraction in bovine cerebral arteries: a model for human cerebrovascular '5-HT1D beta' receptors. , 1993, European journal of pharmacology.

[539]  T. R. Stratford,et al.  Evidence for a projection from the B9 serotonergic cell group to the median raphe nucleus , 1988, Brain Research Bulletin.

[540]  M. Molliver,et al.  Evidence for dual serotonergic projections to neocortex: Axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA) , 1988, Experimental Neurology.

[541]  C. Pycock,et al.  The effect of some putative neurotransmitters on the release of 5-hydroxytryptamine and γ-aminobutyric acid from slices of the rat midbrain raphe area , 1979, Neuroscience.

[542]  M. Le Moal,et al.  Difference in the effects of the antidepressant tianeptine on dopaminergic metabolism in the prefrontal cortex and the nucleus accumbens of the rat. A voltammetric study. , 1990, Life sciences.

[543]  M. Fache,et al.  N‐Methyl‐d‐Aspartic Acid/Glycine Interactions on the Control of 5‐Hydroxytryptamine Release in Raphe Primary Cultures , 1993, Journal of neurochemistry.

[544]  I. Lucki,et al.  Desensitization of 5-HT1A autoreceptors by chronic administration of 8-OH-DPAT , 1992, Neuropharmacology.

[545]  R. Fuller,et al.  Pharmacological characterization of LY293284: A 5-HT1A receptor agonist with high potency and selectivity. , 1994, The Journal of pharmacology and experimental therapeutics.

[546]  Immunocytochemical study of the CLIP/ACTH-immunoreactive nerve fibres in the dorsal raphe nucleus of the rat , 1994, Neuroscience Letters.

[547]  B. W. Logan,et al.  Further studies on the inhibition of monoamine oxidase by M and B 9302 (clorgyline). I. Substrate specificity in various mammalian species. , 1969, Biochemical pharmacology.

[548]  G. Rudnick,et al.  The Platelet Plasma Membrane Serotonin Transporter Catalyzes Exchange between Neurotoxic Amphetamines and Serotonin , 1992, Annals of the New York Academy of Sciences.

[549]  R. Mccall,et al.  Characterization of the serotonin1A receptor antagonist activity of WAY-100135 and spiperone. , 1994, The Journal of pharmacology and experimental therapeutics.

[550]  D. Murphy,et al.  Regional brain expression of serotonin transporter mRNA and its regulation by reuptake inhibiting antidepressants. , 1993, Brain research. Molecular brain research.

[551]  J. Palacios,et al.  β-Adrenoceptor blocking agents recognize a subpopulation of serotonin receptors in brain , 1985, Brain Research.

[552]  K. Fuxe,et al.  EVIDENCE FOR THE EXISTENCE OF MONOAMINE NEURONS IN THE CENTRAL NERVOUS SYSTEM. IV. DISTRIBUTION OF MONOAMINE NERVE TERMINALS IN THE CENTRAL NERVOUS SYSTEM. , 1965, Acta physiologica Scandinavica. Supplementum.

[553]  D. Middlemiss,et al.  The 5‐HT1B Receptors , 1990, Annals of the New York Academy of Sciences.

[554]  H. Higashi,et al.  5-Hydroxytryptamine mediates inhibitory postsynaptic potentials in rat dorsal raphe neurons , 1985, Neuroscience Letters.

[555]  K. Lesch,et al.  Neurotransmitter Reuptake Mechanisms , 1995 .

[556]  M. Hamon,et al.  In situ hybridization evidence for the synthesis of 5‐HT1B receptor in serotoninergic neurons of anterior raphe nuclei in the rat brain , 1995, Synapse.

[557]  C. de Montigny,et al.  Blockade of the serotonin and norepinephrine uptake processes by duloxetine: in vitro and in vivo studies in the rat brain. , 1996, The Journal of pharmacology and experimental therapeutics.

[558]  L. Wiklund,et al.  Monoamine cell distribution in the cat brain stem. A fluorescence histochemical study with quantification of indolaminergic and locus coeruleus cell groups , 1981, The Journal of comparative neurology.

[559]  L. Descarries,et al.  Evaluation of three transporter ligands as quantitative markers of serotonin innervation density in rat brain , 1995, Synapse.

[560]  P. Hrdina Sodium-dependent [3H]imipramine binding in rat hippocampus and its relationship to serotonin uptake. , 1987, Canadian journal of physiology and pharmacology.

[561]  P. Broderick Adinazolam affects biogenic amine release in hippocampal CA1 neuronal circuitry , 1991, Brain Research Bulletin.

[562]  L. Arvidsson,et al.  Intrinsic activity of enantiomers of 8-hydroxy-2-(di-n-propylamino)tetralin and its analogs at 5-hydroxytryptamine1A receptors that are negatively coupled to adenylate cyclase. , 1991, Molecular pharmacology.

[563]  T. Yamamura,et al.  The Effect of Fentanyl and Morphine on Neurons in the Dorsal Raphe Nucleus in the Rat: An In Vitro Study , 1994, Anesthesia and analgesia.

[564]  M. Neal,et al.  Chronic diazepam treatment in rats causes long‐lasting changes in central [3H]‐5‐hydroxytryptamine and [14C]‐γ‐aminobutyric acid release , 1990, British journal of pharmacology.

[565]  A. Beaudet,et al.  The fine structure of central serotonin neurons. , 1981, Journal de physiologie.

[566]  M. Hajós,et al.  Interaction between a selective 5‐HT1A receptor antagonist and an SSRI in vivo: effects on 5‐HT cell firing and extracellular 5‐HT , 1995, British journal of pharmacology.

[567]  T. Branchek,et al.  Dual coupling of cloned human 5-hydroxytryptamine1D alpha and 5-hydroxytryptamine1D beta receptors stably expressed in murine fibroblasts: inhibition of adenylate cyclase and elevation of intracellular calcium concentrations via pertussis toxin-sensitive G protein(s). , 1993, Molecular pharmacology.

[568]  D. Middlemiss Blockade of the central 5-HT autoreceptor by β-adrenoceptor antagonists☆ , 1986 .

[569]  P. Maclean,et al.  A brainstem atlas of catecholaminergic neurons and serotonergic perikarya in a pygmy primate (Cebuella pygmaea) , 1978, The Journal of comparative neurology.

[570]  M. Marcinkiewicz,et al.  CNS connections with the median raphe nucleus: Retrograde tracing with WGA‐apoHRP‐gold complex in the rat , 1989, The Journal of comparative neurology.

[571]  M. Jouvet,et al.  Is the nucleus raphe dorsalis a target for the peptides possessing hypnogenic properties? , 1994, Brain Research.

[572]  M. Fujita,et al.  Cellular localization of serotonin transporter mRNA in the rat brain , 1993, Neuroscience Letters.

[573]  E. D. De Souza,et al.  Autoradiographic localization of 3H‐paroxetine‐labeled serotonin uptake sites in rat brain , 1987, Synapse.

[574]  V. Ganapathy,et al.  Partial purification and characterization of the human placental serotonin transporter. , 1993, Placenta.

[575]  E. Biessen,et al.  Evidence for the existence of at least two different binding sites for 5HT-reuptake inhibitors within the 5HT-reuptake system from human platelets. , 1988, Biochemical pharmacology.

[576]  E. Azmitia,et al.  ACTH neuropeptide stimulation of serotonergic neuronal maturation in tissue culture: modulation by hippocampal cells. , 1987, Progress in brain research.

[577]  R. Bordet,et al.  Effect of pindolol on onset of action of paroxetine in the treatment of major depression: intermediate analysis of a double-blind, placebo-controlled trial. Réseau de Recherche et d'Expérimentation Psychopharmacologique. , 1998, The American journal of psychiatry.

[578]  J S Kelly,et al.  A study of the mechanism of Ca2+ current inhibition produced by serotonin in rat dorsal raphe neurons , 1991, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[579]  R. McGuffin,et al.  Molecular cloning and functional characterization of a human 5-HT1B serotonin receptor: a homologue of the rat 5-HT1B receptor with 5-HT1D-like pharmacological specificity. , 1992, Biochemical and biophysical research communications.

[580]  Y. Okamoto,et al.  Single or repeated treatment with electroconvulsive shock increases number of serotonin uptake binding sites in the frontal cortex. , 1995, Neuropsychobiology.

[581]  V. Ganapathy,et al.  Regulation of the human serotonin transporter by interleukin-1 beta. , 1995, Biochemical and Biophysical Research Communications - BBRC.

[582]  J. Stamford,et al.  Evidence that 5‐hydroxytryptamine release in rat dorsal raphé nucleus is controlled by 5‐HT1A, 5‐HT1B and 5‐HT1D autoreceptors , 1995, British journal of pharmacology.

[583]  B. Jacobs,et al.  Single-unit responses of serotonergic dorsal raphe neurons to 5-HT1A agonist and antagonist drug administration in behaving cats. , 1994, The Journal of pharmacology and experimental therapeutics.

[584]  D. Chuang,et al.  Down regulation of dihydroalprenolol and imipramine binding sites in brain of rats repeatedly treated with imipramine. , 1980, European journal of pharmacology.

[585]  R. Blakely,et al.  Antidepressant- and cocaine-sensitive human serotonin transporter: molecular cloning, expression, and chromosomal localization. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[586]  Stephen J. Smith,et al.  Calcium ions, active zones and synaptic transmitter release , 1988, Trends in Neurosciences.

[587]  N. Kamalakannan,et al.  TFMPP and RU24969 enhance serotonin release rat hipocampus , 1990 .

[588]  G. Rudnick,et al.  Non-neurotoxic amphetamine derivatives release serotonin through serotonin transporters. , 1993, Molecular pharmacology.

[589]  G. Rudnick ATP-driven H+ pumping into intracellular organelles. , 1986, Annual review of physiology.

[590]  R. Hen,et al.  Regulation of [3H]5-HT release in raphe, frontal cortex and hippocampus of 5-HT1B knock-out mice , 1995, Neuroreport.

[591]  S. Paul,et al.  Inhibition of synaptosomal 5‐[3H]hydroxytryptamine uptake by endogenous factor(s) in human blood , 1984, FEBS letters.

[592]  S B Auerbach,et al.  Acute uptake inhibition increases extracellular serotonin in the rat forebrain. , 1993, The Journal of pharmacology and experimental therapeutics.

[593]  J. Marcusson,et al.  Dissociation Kinetics of [3H]Paroxetine Binding to Rat Brain Consistent with a Single‐Site Model of the Antidepressant Binding/5‐Hydroxytryptamine Uptake Site , 1988, Journal of neurochemistry.

[594]  M. Titeler,et al.  Detection of a Novel Serotonin Receptor Subtype (5‐HT1E) in Human Brain: Interaction with a GTP‐Binding Protein , 1989, Journal of neurochemistry.

[595]  G. Uhl,et al.  Transporter explosion: update on uptake. , 1992, Trends in pharmacological sciences.

[596]  F. van Huizen,et al.  Agonist-induced down-regulation of human 5-HT1A and 5-HT2 receptors in Swiss 3T3 cells. , 1993, Neuroreport.

[597]  I. Törk,et al.  Serotoninergic innervation of the cat cerebral cortex , 1988, The Journal of comparative neurology.

[598]  M. Raiteri,et al.  Carrier-mediated release of neurotransmitters , 1993, Trends in Neurosciences.

[599]  P. Hartig,et al.  125I-lysergic acid diethylamide binds to a novel serotonergic site on rat choroid plexus epithelial cells , 1985, The Journal of neuroscience : the official journal of the Society for Neuroscience.

[600]  M. Briley,et al.  The unique effect of methiothepin on the terminal serotonin autoreceptor in the rat hypothalamus could be an example of inverse agonism , 1993, Journal of psychopharmacology.

[601]  B. Bean Neurotransmitter inhibition of neuronal calcium currents by changes in channel voltage dependence , 1989, Nature.

[602]  J. Palacios,et al.  Non 5‐HT1A/5‐HT1C[3H]5‐HT binding sites in the hamster, opossum, and rabbit brain show similar regional distribution but different sensitivity to β‐adrenoceptor antagonists , 1992, Synapse.

[603]  G. Aghajanian,et al.  Suppression of firing activity of 5-HT neurons in the dorsal raphe by alpha-adrenoceptor antagonists , 1980, Neuropharmacology.

[604]  K. Perry,et al.  Effect of fluoxetine on serotonin and dopamine concentration in microdialysis fluid from rat striatum. , 1992, Life sciences.

[605]  N. Davidson,et al.  A cocaine-sensitive Drosophila serotonin transporter: cloning, expression, and electrophysiological characterization. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[606]  M. Barbaccia,et al.  (-)-Deprenyl a selective MAO "B' inhibitor, increases [3H]imipramine binding and decreases beta-adrenergic receptor function. , 1983, European journal of pharmacology.

[607]  C. de Montigny,et al.  Modification of 5‐HT neuron properties by sustained administration of the 5‐HT1A agonist gepirone: Electrophysiological studies in the rat brain , 1987, Synapse.

[608]  E. sanders-Bush 5-HT Receptors Coupled to Phosphoinositide Hydrolysis , 1988 .

[609]  M. Wood,et al.  [3H]8‐OH‐DPAT labels the 5‐Hydroxytryptamine uptake recognition site and the 5‐HT1A binding site in the rat striatum , 1988, The Journal of pharmacy and pharmacology.

[610]  B. Leonard,et al.  The chronic effects of desipramine and sertraline on platelet and synaptosomal 5HT uptake in olfactory bulbectomised rats , 1988, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[611]  R. Tao,et al.  Increased Extracellular Serotonin in Rat Brain After Systemic or Intraraphe Administration of Morphine , 1994, Journal of neurochemistry.

[612]  P. Plenge,et al.  Inhibitory and regulatory binding sites on the rat brain serotonin transporter: molecular weight of the [3H]paroxetine and [3H]citalopram binding proteins. , 1990, European journal of pharmacology.

[613]  W. Nauta,et al.  Afferent connections of the habenular nuclei in the rat. A horseradish peroxidase study, with a note on the fiber‐of‐passage problem , 1977, The Journal of comparative neurology.

[614]  D. Gemsa,et al.  The effect of adrenergic drugs on serotonin metabolism in the nucleus raphe dorsalis of the rat, studied by in vivo voltammetry. , 1992, European journal of pharmacology.

[615]  A. Beitz The organization of afferent projections to the midbrain periaqueductal gray of the rat , 1982, Neuroscience.

[616]  S. Hjorth,et al.  Effect of the 5-HT1A receptor agonist 8-OH-DPAT on the release of 5-HT in dorsal and median raphe-innervated rat brain regions as measured by in vivo microdialysis. , 1991, Life sciences.

[617]  W. Soudijn,et al.  The concept of selectivity in 5-HT receptor research. , 1990, European journal of pharmacology.

[618]  P. Leff,et al.  The two-state model of receptor activation. , 1995, Trends in pharmacological sciences.

[619]  S. Z. Langer,et al.  Binding of [3H]imimipramine and [3H]desipramine as biochemical tools for studies in depression , 1983, Neuropharmacology.

[620]  P. Blier,et al.  Alteration of Serotonin Release in the Guinea Pig Orbito-Frontal Cortex by Selective Serotonin Reuptake Inhibitors , 1995, Neuropsychopharmacology.

[621]  A. Sleight,et al.  Effects of the 5-HT1D receptor antagonist GR127935 on extracellular levels of 5-HT in the guinea-pig frontal cortex as measured by microdialysis , 1995, Neuropharmacology.

[622]  L. Heimer,et al.  Double and triple labeling of neurons with fluorescent substances; The study of collateral pathways in the ascending raphe system , 1980, Neuroscience Letters.

[623]  C. Montigny,et al.  5-HT1D Receptors Regulate 5-HT Release in the Rat Raphe Nuclei , 1995, Neuropsychopharmacology.

[624]  J. Pujol,et al.  GABA-accumulating neurons in the nucleus raphe dorsalis and periaqueductal gray in the rat: A biochemical and radioautographic study , 1979, Brain Research.

[625]  D. Felten,et al.  Dendrite bundles in nuclei raphe dorsalis and centralis superior of the rabbit: A possible substrate for local control of serotonergic neurons , 1980, Neuroscience Letters.

[626]  E. Azmitia,et al.  An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat , 1978, The Journal of comparative neurology.

[627]  Richard J. Miller Receptor‐mediated regulation of calcium channels and neurotransmitter release , 1990, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[628]  R. McGuffin,et al.  Conversion of the human 5-HT1D beta serotonin receptor to the rat 5-HT1B ligand-binding phenotype by Thr355Asn site directed mutagenesis. , 1992, Biochemical pharmacology.

[629]  J. Palacios,et al.  Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors , 1985, Brain Research.

[630]  R. Hen,et al.  The mouse 5-hydroxytryptamine 1B receptor is localized predominantly on axon terminals , 1994, Neuroscience.

[631]  B. Hoffman,et al.  Adenosine A3 receptors regulate serotonin transport via nitric oxide and cGMP. , 1994, The Journal of biological chemistry.

[632]  J. Lauder,et al.  Development of the serotonergic system in the rat embryo: An immunocytochemical study , 1983, Brain Research Bulletin.

[633]  B. McEwen,et al.  Stress and antidepressant effects on hippocampal and cortical 5-HT1A and 5-HT2 receptors and transport sites for serotonin , 1993, Brain Research.

[634]  A. Beaudet,et al.  The serotonin neurons in nucleus raphe dorsalis of adult rat: A light and electron microscope radioautographic study , 1982, The Journal of comparative neurology.

[635]  B. Scatton,et al.  GABA mimetics decrease extracellular concentrations of 5-HIAA (as measured by in vivo voltammetry) in the dorsal raphe of the rat , 1985, Brain Research.

[636]  C. de Montigny,et al.  Effect of the alpha-2 adrenoceptor antagonist mirtazapine on the 5-hydroxytryptamine system in the rat brain. , 1996, The Journal of pharmacology and experimental therapeutics.

[637]  C. Montigny,et al.  Characterization of 5-hydroxytryptamine1A properties of flesinoxan: In Vivo electrophysiology and hypothermia study , 1995, Neuropharmacology.

[638]  V. Ganapathy,et al.  Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. , 1994, The Journal of biological chemistry.

[639]  A. Gardier,et al.  Time course of brain serotonin metabolism after cessation of long-term fluoxetine treatment in the rat. , 1993, Life sciences.

[640]  H. Ralston,et al.  Serotonin‐containing structures in the nucleus raphe dorsalis of the cat: An ultrastructural analysis of dendrites, presynaptic dendrites, and axon terminals , 1987, The Journal of comparative neurology.

[641]  F. Artigas,et al.  Effects of single and chronic treatment with tranylcypromine on extracellular serotonin in rat brain. , 1994, European journal of pharmacology.

[642]  Y. Watanabe,et al.  Tianeptine attenuates stress-induced morphological changes in the hippocampus. , 1992, European journal of pharmacology.

[643]  T. Kitazawa,et al.  Involvement of 5‐hydroxytryptamine7 receptors in inhibition of porcine myometrial contractility by 5‐hydroxytryptamine , 1998, British journal of pharmacology.

[644]  A. Bendahan,et al.  Transport of 5-hydroxytryptamine in membrane vesicles from rat basophilic leukemia cells. , 1985, Biochimica et biophysica acta.

[645]  G. Aghajanian,et al.  Intracellular recordings from serotonergic dorsal raphe neurons: pacemaker potentials and the effects of LSD , 1982, Brain Research.

[646]  L. Descarries,et al.  Quantified distribution of the serotonin innervation in adult rat hippocampus , 1990, Neuroscience.

[647]  T. Branchek,et al.  A single point mutation increases the affinity of serotonin 5-HT1Dα, 5-HT1Dβ, 5-HT1E and 5-HT1F receptors for β-adrenergic antagonists , 1994, Neuropharmacology.

[648]  A. Björklund,et al.  Mechanisms of regrowth in the bulbospinal serotonin system following 5,6-dihydroxytryptamine induced axotomy. II. Fluorescence histochemical observations , 1980, Brain Research.

[649]  J. Glowinski,et al.  Dendritic release of dopamine in the substantia nigra , 1981, Nature.

[650]  M. Hamon,et al.  Electrophysiological activity of raphe dorsalis serotoninergic neurones in a possible model of endogenous depression. , 1995, Neuroreport.

[651]  C. Moret,et al.  Citalopram antagonizes the stimulation by lysergic acid diethylamide of presynaptic inhibitory serotonin autoreceptors in the rat hypothalamus. , 1982, The Journal of pharmacology and experimental therapeutics.

[652]  C. de Montigny,et al.  Differential properties of pre- and postsynaptic 5-hydroxytryptamine1A receptors in the dorsal raphe and hippocampus: I. Effect of spiperone. , 1993, The Journal of pharmacology and experimental therapeutics.

[653]  M. Jouvet,et al.  Distribution of the pro-opiomelanocortin-immunoreactive axons in relation to the serotoninergic neurons in the dorsal raphe nucleus of the rat , 1991, Neuroscience Letters.

[654]  R. Godbout,et al.  Tandospirone and its metabolite, 1-(2-pyrimidinyl)-piperazine—I. Effects of acute and long-term administration of tandospirone on serotonin neurotransmission , 1991, Neuropharmacology.

[655]  McEwen Bs Stress and hippocampus. An update on current knowledge , 1991 .

[656]  H. Imai,et al.  Morphology and intracellular responses of an identified dorsal raphe projection neuron , 1982, Brain Research.

[657]  C. Sinton,et al.  Electrophysiological evidence for a functional differentiation between subtypes of the 5-HT1 receptor. , 1988, European journal of pharmacology.