Characterization of rofecoxib as a cyclooxygenase‐2 isoform inhibitor and demonstration of analgesia in the dental pain model

[1]  S. Abramson,et al.  Selective cyclooxygenase-2 inhibitors. , 1999, Rheumatic diseases clinics of North America.

[2]  K. Hargreaves,et al.  Effect of NSAID administration on tissue levels of immunoreactive prostaglandin E2, leukotriene B4, and (S)-flurbiprofen following extraction of impacted third molars , 1997, Pain.

[3]  A. Bodenteich,et al.  Isoenzyme-specific cyclooxygenase inhibitors: a whole cell assay system using the human erythroleukemic cell line HEL and the human monocytic cell line Mono Mac 6. , 1997, Journal of pharmacological and toxicological methods.

[4]  J. López-Belmonte,et al.  Selective induction of cyclo‐oxygenase‐2 activity in the permanent human endothelial cell line HUV‐EC‐C: biochemical and pharmacological characterization , 1997, British journal of pharmacology.

[5]  J. Falgueyret,et al.  Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX‐2 inhibitor , 1997, British journal of pharmacology.

[6]  D. Riendeau,et al.  Characterization of autocrine inducible prostaglandin H synthase-2 (PGHS-2) in human osteosarcoma cells , 1997, Inflammation Research.

[7]  William L. Smith,et al.  Prostaglandin Endoperoxide H Synthases (Cyclooxygenases)-1 and −2* , 1996, The Journal of Biological Chemistry.

[8]  Jilly F. Evans,et al.  Mechanism of selective inhibition of human prostaglandin G/H synthase-1 and -2 in intact cells. , 1996, Biochemical pharmacology.

[9]  R. Botting,et al.  Cyclooxygenase-2 and its regulation in inflammation , 1996, Mediators of inflammation.

[10]  D. Riendeau,et al.  Characterization of Prostaglandin G/H Synthase 1 and 2 in rat, dog, monkey, and human gastrointestinal tracts. , 1996, Gastroenterology.

[11]  P. Worley,et al.  COX-2, a synaptically induced enzyme, is expressed by excitatory neurons at postsynaptic sites in rat cerebral cortex. , 1996, Proceedings of the National Academy of Sciences of the United States of America.

[12]  J. Adams,et al.  Constitutive cyclooxygenase (COX‐1) and inducible cyclooxygenase (COX‐2): Rationale for selective inhibition and progress to date , 1996, Medicinal research reviews.

[13]  J. de Belleroche,et al.  Cyclooxygenase‐2 Induction in Cerebral Cortex: An Intracellular Response to Synaptic Excitation , 1996, Journal of neurochemistry.

[14]  S. Boyce,et al.  Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. , 1995, The Journal of pharmacology and experimental therapeutics.

[15]  M. Percival,et al.  Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. , 1995, The Biochemical journal.

[16]  J. Gierse,et al.  Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. , 1995, The Biochemical journal.

[17]  K. Seibert,et al.  Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[18]  H. Jacobson,et al.  Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. , 1994, The Journal of clinical investigation.

[19]  S. Iacobelli,et al.  Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. , 1994, The Journal of pharmacology and experimental therapeutics.

[20]  R. Copeland,et al.  Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[21]  D. Breuer,et al.  Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. , 1994, The Journal of pharmacology and experimental therapeutics.

[22]  D. Willoughby,et al.  Inducible cyclooxygenase (COX-2): a safer therapeutic target? , 1994, British journal of rheumatology.

[23]  K. Seibert,et al.  Selective inhibition of inducible cyclooxygenase 2 in vivo is antiinflammatory and nonulcerogenic. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[24]  U. Sinterhauf,et al.  A Placebo‐Controlled Comparative Evaluation of Diclofenac Dispersible Versus Ibuprofen in Postoperative Pain After Third Molar Surgery , 1994, Journal of clinical pharmacology.

[25]  J. Falgueyret,et al.  Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. , 1994, Molecular pharmacology.

[26]  C. Thiemermann,et al.  Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[27]  D. Dewitt,et al.  Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. , 1993, The Journal of biological chemistry.

[28]  S. Hart,et al.  Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. , 1992, The Journal of biological chemistry.

[29]  R. Seymour,et al.  The efficacy of locally applied aspirin and acetaminophen in postoperative pain after third molar surgery , 1992, Clinical pharmacology and therapeutics.

[30]  T. Hla,et al.  Human cyclooxygenase-2 cDNA. , 1992, Proceedings of the National Academy of Sciences of the United States of America.

[31]  J. Richards,et al.  Hormonal regulation of messenger ribonucleic acid encoding a novel isoform of prostaglandin endoperoxide H synthase in rat preovulatory follicles. Induction in vivo and in vitro. , 1992, The Journal of biological chemistry.

[32]  H. Herschman,et al.  Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. , 1992, The Journal of biological chemistry.

[33]  V. Winn,et al.  A serum- and glucocorticoid-regulated 4-kilobase mRNA encodes a cyclooxygenase-related protein. , 1991, The Journal of biological chemistry.

[34]  R. Erikson,et al.  Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing. , 1991, Proceedings of the National Academy of Sciences of the United States of America.

[35]  J. Fries.  NSAID gastropathy: the second most deadly rheumatic disease? Epidemiology and risk appraisal. , 1991, The Journal of rheumatology. Supplement.

[36]  J. Helfrick,et al.  Multicenter clinical trial of ibuprofen and acetaminophen in the treatment of postoperative dental pain. , 1990, Journal of the American Dental Association.

[37]  B. Schachtel,et al.  Ibuprofen and Acetaminophen in the Relief of Acute Pain: A Randomized, Double‐Blind, Placebo‐Controlled Study , 1989, Journal of clinical pharmacology.

[38]  E. Laska,et al.  The correlation between blood levels of ibuprofen and clinical analgesic response , 1986, Clinical pharmacology and therapeutics.

[39]  S. Cooper.  Five studies on ibuprofen for postsurgical dental pain. , 1984, The American journal of medicine.

[40]  S. Cooper,et al.  A model to evaluate mild analgesics in oral surgery outpatients , 1976, Clinical pharmacology and therapeutics.

[41]  J. Vane,et al.  Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. , 1971, Nature: New biology.

[42]  D. Riendeau,et al.  Chapter 21. Selective Cyclooxygenase-2 Inhibitors , 1997 .