Left hemispheric reductions of regional cerebral blood flow (rCBF) correlate with measures of dementia severity in patients with Alzheimer's disease: a SPECT study

Regional cerebral blood flow (rCBF) values were measured by single photon emission computed tomography (SPECT) in different regions of the brain in 27 patients with DAT. Significant correlations were found between rCBF in left parieto-temporooccipital regions and psychometric test scores. Patients with hemisphere asymmetry in SPECT performed worse on psychometric tests. SPECT did not permit prediction of or differentiation between depressive and psychotic symptoms.

[1]  S. Eagger,et al.  Morphologic (CT) and functional (rCBF-SPECT) correlates in Alzheimer's disease. , 1992, Nuclear medicine communications.

[2]  H. Mayberg,et al.  Clinical correlates of PET- and SPECT-identified defects in dementia. , 1994, The Journal of clinical psychiatry.

[3]  B. Sahakian,et al.  A study of regional cerebral blood flow and cognitive performance in Alzheimer's disease. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[4]  R. Ihl,et al.  Differential validity of psychometric tests in dementia of the Alzheimer type , 1992, Psychiatry Research.

[5]  H S Markus,et al.  Alterations in regional cerebral blood flow, with increased temporal interhemispheric asymmetries, in the normal elderly: an HMPAO SPECT study. , 1993, Nuclear medicine communications.

[6]  F. Schmitt,et al.  Assessing Utility of Single Photon Emission Computed Tomography (SPECT) Scan in Alzheimer Disease: Correlation with Cognitive Severity , 1990, Alzheimer disease and associated disorders.

[7]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[8]  Jean-François Démonet,et al.  Lateral Asymmetries in Primary Degenerative Dementia of the Alzheimer Type. A Correlative Study of Cognitive, Haemodynamic and EEG Data, In Relation with Severity, Age of Onset and Sex , 1990, Cortex.

[9]  B. Reisberg,et al.  Diagnosis and Treatment of Senile Dementia , 1989, Springer Berlin Heidelberg.

[10]  B. Reisberg.  The Brief Cognitive Rating Scale (BCRS) : findings in primary degenerativ dementia (PDD) , 1983 .

[11]  R. Katzman.,et al.  Pathological verification of ischemic score in differentiation of dementias , 1980, Annals of neurology.

[12]  Klaus P. Ebmeier,et al.  Differential diagnosis in dementia using the cerebral blood flow agent 99mTc HM-PAO: a SPECT study. , 1987, Journal of computer assisted tomography.

[13]  H. Dilling,et al.  Internationale Klassifikation psychischer Störungen: ICD-10 Kapitel V (F), Klinisch-diagnostische Leitlinien, Weltgesundheitsorganisation , 1991 .

[14]  R. Ihl,et al.  Stage-dependent reductions of regional cerebral blood flow measured by HMPAO-SPECT in dementia of Alzheimer type , 1989, Psychiatry Research.

[15]  Jordan Grafman,et al.  Handbook of Neuropsychology , 1991 .

[16]  N. Lassen,et al.  99mTc-bicisate (neurolite) SPECT brain imaging and cognitive impairment in dementia of the Alzheimer type: a blinded read of image sets from a multicenter SPECT trial. , 1994, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

[17]  D Wyper,et al.  Measurements of regional cerebral blood flow and cognitive performance in Alzheimer's disease. , 1990, Journal of neurology, neurosurgery, and psychiatry.

[18]  H. Erzigkeit.  The SKT — A Short Cognitive Performance Test as an Instrument for the Assessment of Clinical Efficacy of Cognition Enhancers , 1989 .

[19]  W. Jagust,et al.  Functional imaging in dementia: an overview. , 1994, The Journal of clinical psychiatry.

[20]  R. Zec,et al.  Alzheimer Disease Assessment Scale: Useful for Both Early Detection and Staging of Dementia of the Alzheimer Type , 1992, Alzheimer disease and associated disorders.

[21]  S. Weintraub.  Four neuropsychological profiles in dementia , 1996 .

[22]  K. Davis,et al.  The Alzheimer's disease assessment scale: an instrument for assessing treatment efficacy. , 1983, Psychopharmacology bulletin.

[23]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[24]  Philip D. Harvey,et al.  Validity and utility of the ADAS-L for measurement of cognitive and functional impairment in geriatric schizophrenic inpatients. , 1995, The Journal of neuropsychiatry and clinical neurosciences.

[25]  S. Gupta,et al.  Toward a definite diagnosis of Alzheimer's disease. , 1992, Comprehensive psychiatry.