FT-INFRARED AND FT-RAMAN SPECTROSCOPY IN BIOMEDICAL RESEARCH

Recent efforts in the field of biomedical Fourier transform infrared (FTIR) and FT-Raman spectroscopy of disease states in humans have been published by various groups working on cells, tissues, and body fluids, and a number of excellent papers on the application of biomedical FT-IR and Raman spectroscopy has appeared in the literature (1–37). While FT-IR spectroscopy as a tool for biodiagnostic purposes seems to be established and the first dedicated instrumentation for routine biomedical characterizations has already appeared on the market, FT-Raman spectroscopy, though potentially even more versatile, has not yet reached the stage of development at which routine biomedical applications are possible. This paper will not review details of technological developments and experimental or theoretical progress achieved in biomedical FT-IR and FT-Raman spectroscopy. It will, rather, highlight some of the most important applications and experimental procedures in biomedical vibrational spectroscopy and possible future developments in this field. Emphasis will be put on the interpretation of spectra and the assignment of spectral features frequently observed in cells, tissues, and body fluids and on the discussion of acceptable standards for data acquisition and experimental protocols, the estab-

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