Substituted 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]thiophene derivatives as potent tubulin polymerization inhibitors.

[1]  A. Brancale,et al.  Design, synthesis and structure-activity relationship of 2-(3',4',5'-trimethoxybenzoyl)-benzo[b]furan derivatives as a novel class of inhibitors of tubulin polymerization. , 2009, Bioorganic & medicinal chemistry.

[2]  S. Ducki Antimitotic chalcones and related compounds as inhibitors of tubulin assembly. , 2009, Anti-cancer agents in medicinal chemistry.

[3]  R. Gambari,et al.  Induction of gamma-globin mRNA, erythroid differentiation and apoptosis in UVA-irradiated human erythroid cells in the presence of furocumarin derivatives. , 2008, Biochemical pharmacology.

[4]  Anurag Chaudhary,et al.  Combretastatin a-4 analogs as anticancer agents. , 2007, Mini reviews in medicinal chemistry.

[5]  N. André,et al.  Targeting microtubules to inhibit angiogenesis and disrupt tumour vasculature: implications for cancer treatment. , 2007, Current cancer drug targets.

[6]  Jan Balzarini,et al.  Synthesis and biological evaluation of 2- and 3-aminobenzo[b]thiophene derivatives as antimitotic agents and inhibitors of tubulin polymerization. , 2007, Journal of medicinal chemistry.

[7]  K. Balakin,et al.  Recent progress in discovery and development of antimitotic agents. , 2007, Anti-cancer agents in medicinal chemistry.

[8]  E. Hamel Evaluation of antimitotic agents by quantitative comparisons of their effects on the polymerization of purified tubulin , 2007, Cell Biochemistry and Biophysics.

[9]  Giovanni Sorba,et al.  Medicinal chemistry of combretastatin A4: present and future directions. , 2006, Journal of medicinal chemistry.

[10]  H. Hsieh,et al.  Antitubulin agents for the treatment of cancer – a medicinal chemistry update , 2006 .

[11]  E. De Clercq,et al.  Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles. , 2005, Bioorganic & medicinal chemistry letters.

[12]  H. Hsieh,et al.  Pharmaceutical design of antimitotic agents based on combretastatins. , 2005, Current pharmaceutical design.

[13]  D. Budman,et al.  Review: Tubulin Function, Action of Antitubulin Drugs, and New Drug Development , 2005, Cancer investigation.

[14]  D. Alberts,et al.  Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4 , 1989, Experientia.

[15]  Patrick A. Curmi,et al.  Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain , 2004, Nature.

[16]  John A Hadfield,et al.  Tubulin and microtubules as targets for anticancer drugs. , 2003, Progress in cell cycle research.

[17]  E. Hamel,et al.  A novel palladium-mediated coupling approach to 2,3-disubstituted benzo(b)thiophenes and its application to the synthesis of tubulin binding agents. , 2001, Organic letters.

[18]  C. Walczak Microtubule dynamics and tubulin interacting proteins. , 2000, Current opinion in cell biology.

[19]  A. Bounds,et al.  A new anti-tubulin agent containing the benzo[b]thiophene ring system. , 1999, Bioorganic & medicinal chemistry letters.

[20]  W. Gerwick,et al.  Structure-activity analysis of the interaction of curacin A, the potent colchicine site antimitotic agent, with tubulin and effects of analogs on the growth of MCF-7 breast cancer cells. , 1998, Molecular pharmacology.

[21]  T. Mitchison,et al.  Dynamics of microtubule assembly in vivo , 1994 .

[22]  E. Hamel,et al.  Antimitotic natural products combretastatin A-4 and combretastatin A-2: studies on the mechanism of their inhibition of the binding of colchicine to tubulin. , 1989, Biochemistry.

[23]  E. Hamel,et al.  Separation of active tubulin and microtubule-associated proteins by ultracentrifugation and isolation of a component causing the formation of microtubule bundles. , 1984, Biochemistry.

[24]  J. R. Beck A facile synthesis of 2-phenylbenzo[b]thiophene-3-amine and the corresponding S-oxides , 1978 .

[25]  C. Lozzio,et al.  Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome. , 1975, Blood.