A novel micro-fabricated thruster for drug release in remote controlled capsule

Abstract A novel solid propellant microthruster has been developed and used as the actuation assembly of a patented remote controlled capsule (RCC). It produces sufficient gas pressure to empty the drug reservoir within the RCC. A MEMS-based microigniter works as the critical component of the miniaturized thruster that houses the detonating agent – diazodintrophenol (DDNP) and the propellant – black powder. Ignition and combustion tests were performed to justify its feasibility and reliability. Results demonstrated that 166 mW power consumption led to one successful combustion and that complete and rapid drug release was achieved when the propellant ranged from 16 mg to 20 mg. The RCC integrated with the microthruster could provide a promising alternative for site-specific drug delivery in human GI tract.

[1]  Danick Briand,et al.  Reliability of freestanding polysilicon microheaters to be used as igniters in solid propellant microthrusters , 2007 .

[2]  Carole Rossi,et al.  Design, fabrication and modelling of MEMS-based microthrusters for space application , 2001 .

[3]  Leland Weiss,et al.  Characterization and modeling of the dynamic behavior of a liquid-vapor phase change actuator , 2009 .

[4]  Pierre Temple-Boyer,et al.  Realization and performance of thin SiO2/SiNx membrane for microheater applications , 1998 .

[5]  Edgar Y. Choueiri,et al.  MEMS Mega-pixel Micro-thruster Arrays for Small Satellite Stationkeeping , 2000 .

[6]  Wen Zhiyu,et al.  Design of site specific delivery capsule based on MEMS , 2008, 2008 3rd IEEE International Conference on Nano/Micro Engineered and Molecular Systems.

[7]  David V. Prior,et al.  Remote controlled capsules in human drug absorption (HDA) studies. , 2003, Critical reviews in therapeutic drug carrier systems.

[8]  R. B. Cohen,et al.  Digital MicroPropulsion , 1999, Technical Digest. IEEE International MEMS 99 Conference. Twelfth IEEE International Conference on Micro Electro Mechanical Systems (Cat. No.99CH36291).

[9]  Ren Dahai,et al.  Study on MEMS Micro-Thruster Technology , 2004 .

[10]  Alan F. Parr,et al.  Use of the InteliSite® Capsule to Study Ranitidine Absorption from Various Sites Within the Human Intestinal Tract , 1998, Pharmaceutical Research.

[11]  Abdul W Basit,et al.  The use of the InteliSite companion device to deliver mucoadhesive polymers to the dog colon. , 2009, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

[12]  J. Castracane,et al.  High-voltage, electric field-driven micro/nanofabrication for polymeric drug delivery systems , 2009, IEEE Engineering in Medicine and Biology Magazine.

[13]  Carole Rossi,et al.  Design, fabrication and modeling of solid propellant microrocket-application to micropropulsion , 2002 .

[14]  Zhaoying Zhou,et al.  Development of a MEMS based colloid thruster with sandwich structure , 2005 .

[15]  Matthias E. Bellemann,et al.  Rotating magnetic macrospheres as heating mechanism for remote controlled drug release , 2007 .

[16]  Karen Twomey,et al.  Swallowable-Capsule Technology , 2008, IEEE Pervasive Computing.

[17]  I. Wilding.  Site-specific drug delivery in the gastrointestinal tract. , 2000, Critical reviews in therapeutic drug carrier systems.

[18]  S. Lai,et al.  Design of a Self-Regulated Drug Delivery Device , 2001 .

[19]  Zhang Gaofei,et al.  MEMS-based propulsion arrays with solid propellant , 2004 .

[20]  R Gröning,et al.  Control of drug release from capsules using high frequency energy transmission systems. , 2008, International journal of pharmaceutics.

[21]  Hirst,et al.  Development of a new engineering-based capsule for human drug absorption studies. , 2000, Pharmaceutical science & technology today.

[22]  Peng Chenglin,et al.  A Novel Remote Controlled Capsule for Human Drug Absorption studies. , 2005, Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference.

[23]  Siaw Kiang Chou,et al.  Development of a solid propellant microthruster with chamber and nozzle etched on a wafer surface , 2004 .