Multiple symmetric lipomatosis (Madelung's disease) with symptoms and signs of hypertension, lipodystrophy, and dyspnea: A case report and literature review

Madelung's disease generally refers to a benign symmetrical lipomatosis of the neck, but its presentation can vary. It is treated surgically and different approaches can be implemented. In cases of a threatened airway, a tracheostomy can be performed.

[1]  U. Wollina,et al.  Madelung’s Disease – Case Series and Treatment by Tumescent Liposuction or Lipectomy , 2017, Open access Macedonian journal of medical sciences.

[2]  W. Colangeli,et al.  A case of symmetrical lipomatosis of the tongue presenting as macroglossia. , 2016, Annali italiani di chirurgia.

[3]  G. Sergi,et al.  Multiple symmetric lipomatosis: a rare disease and its possible links to brown adipose tissue. , 2015, Nutrition, metabolism, and cardiovascular diseases : NMCD.

[4]  S. Berkovic,et al.  Multiple Symmetrical Lipomatosis--a mitochondrial disorder of brown fat. , 2013, Mitochondrion.

[5]  G. Ferrandina,et al.  Malignant transformation of Madelung’s disease in a patient with a coincidental diagnosis of breast cancer: a case report , 2012, Diagnostic Pathology.

[6]  D. Lacroix,et al.  How to diagnose a lipodystrophy syndrome. , 2012, Annales d'endocrinologie.

[7]  Zheng Shen,et al.  MicroRNA-217 Promotes Ethanol-induced Fat Accumulation in Hepatocytes by Down-regulating SIRT1* , 2012, The Journal of Biological Chemistry.

[8]  Min You,et al.  Regulation of hepatic lipin‐1 by ethanol: Role of AMP‐activated protein kinase/sterol regulatory element‐binding protein 1 signaling in mice , 2012, Hepatology.

[9]  R. González-García,et al.  Benign Symmetric Lipomatosis (Madelung’s Disease): Case Reports and Current Management , 2004, Aesthetic Plastic Surgery.

[10]  J. Constantinidis,et al.  COMBINED SURGICAL LIPECTOMY AND LIPOSUCTION IN THE TREATMENT OF BENIGN SYMMETRICAL LIPOMATOSIS OF THE HEAD AND NECK , 2003, Scandinavian journal of plastic and reconstructive surgery and hand surgery.

[11]  R. Ng,et al.  AESTHETIC CONSIDERATIONS IN THE CERVICOFACIAL MANAGEMENT OF MADELUNG SYNDROME , 2003, Scandinavian journal of plastic and reconstructive surgery and hand surgery.

[12]  G. Enzi,et al.  Multiple symmetric lipomatosis: clinical aspects and outcome in a long-term longitudinal study , 2002, International Journal of Obesity.

[13]  J. Wohlrab,et al.  Intralesional injection of enoxaparin in benign symmetrical lipomatosis: an alternative to surgery? , 2001, The British journal of dermatology.

[14]  A. Federico,et al.  Mitochondrial G8363A mutation presenting as cerebellar ataxia and lipomas in an Italian family , 1999, Neurology.

[15]  A. King,et al.  Madelung disease: distribution of cervical fat and preoperative findings at sonography, MR, and CT. , 1998, AJNR. American journal of neuroradiology.

[16]  J. Arenas,et al.  Single large-scale mitochondrial DNA deletion in a patient with mitochondrial myopathy associated with multiple symmetric lipomatosis , 1996, Neurology.

[17]  E. Holme,et al.  Multiple symmetric lipomas with high levels of mtDNA with the tRNA(Lys) A-->G(8344) mutation as the only manifestation of disease in a carrier of myoclonus epilepsy and ragged-red fibers (MERRF) syndrome. , 1993, American journal of human genetics.

[18]  E. Shoubridge,et al.  Mitochondrial dysfunction in multiple symmetrical lipomatosis , 1991, Annals of neurology.

[19]  O. Braun-falco,et al.  [Benign symmetric Launois-Bensaude type III lipomatosis and Bureau-Barrière syndrome]. , 1991, Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete.

[20]  K. Mills,et al.  Familial multiple symmetric lipomatosis with peripheral neuropathy , 1990, Neurology.

[21]  M. Pollock,et al.  NEUROPATHY IN MULTIPLE SYMMETRIC LIPOMATOSIS , 1988 .

[22]  M. Pollock,et al.  Neuropathy in multiple symmetric lipomatosis. Madelung's disease. , 1988, Brain : a journal of neurology.

[23]  T. Peters,et al.  MULTIPLE SYMMETRIC LIPOMATOSIS (LAUNOIS‐BENSAUDE SYNDROME): EFFECT OF ORAL SALBUTAMOL , 1987, Clinical endocrinology.

[24]  G. Enzi.  Multiple Symmetric Lipomatosis: An Updated Clinical Report , 1984, Medicine.

[25]  K. Vykoupil,et al.  Malignant degeneration in Madelung's disease (benign lipomatosis of the neck): case report. , 1983, British journal of plastic surgery.

[26]  H. Stähelin,et al.  [Benign symmetric lipomatosis: a symptom of alcoholic liver disease?]. , 1977, Schweizerische medizinische Wochenschrift. Supplementum.

[27]  M. Prosdocimi,et al.  Multiple symmetric lipomatosis: a defect in adrenergic-stimulated lipolysis. , 1977, The Journal of clinical investigation.

[28]  B. Brodie.  Lectures Illustrative of Various Subjects on Pathology and Surgery , 1846, The Medico-chirurgical review.