ABO Genotype and Blood Type Are Associated with Otitis Media.

Aim: To determine if there is an association between ABO variants or blood types and otitis media. Methods: DNA samples from 214 probands from Finnish families with recurrent acute (RAOM) and/or chronic otitis media with effusion (COME) were submitted for exome sequencing. Fisher exact tests were performed when (a) comparing frequencies of ABO genotypes in the Finnish probands with otitis media vs. counts in gnomAD Finnish, and (b) within the Finnish family cohort, comparing occurrence of RAOM vs. COME according to ABO genotype/haplotype and predicted blood type. Results: Female sex is protective against having both RAOM and COME. The wildtype genotype for the ABO c.260insG (p.Val87_Thr88fs*) variant resulting in blood type O was protective against RAOM. On the other hand, type A was associated with increased risk for COME. These findings remained significant after adjustment for age and sex. Conclusions: Within the Finnish family cohort, the wildtype genotype for the ABO c.260insG (p.Val87_Thr88fs*) variant and type O are protective against RAOM while type A increases risk for COME. This suggests that the association between the ABO locus and otitis media is specific to blood type, otitis media type and cohort.

[1]  Ivana V. Yang,et al.  FUT2 Variants Confer Susceptibility to Familial Otitis Media. , 2018, American journal of human genetics.

[2]  I. Fraser,et al.  Systematic Investigation of Multi-TLR Sensing Identifies Regulators of Sustained Gene Activation in Macrophages. , 2017, Cell systems.

[3]  H. Kiyono,et al.  Epithelial glycosylation in gut homeostasis and inflammation , 2016, Nature Immunology.

[4]  J. Kere,et al.  Genome-wide association analysis reveals variants on chromosome 19 that contribute to childhood risk of chronic otitis media with effusion , 2016, Scientific Reports.

[5]  S. Leal,et al.  Genetic and Environmental Determinants of Otitis Media in an Indigenous Filipino Population , 2016, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[6]  Lisa L Hunter,et al.  Clinical Practice Guideline , 2016, Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery.

[7]  Joseph K. Pickrell,et al.  Detection and interpretation of shared genetic influences on 42 human traits , 2015, Nature Genetics.

[8]  D. Swanepoel,et al.  Prevalence and risk factors for parent‐reported recurrent otitis media during early childhood in the Western Australian Pregnancy Cohort (Raine) Study , 2014, Journal of paediatrics and child health.

[9]  M. Bhutta.  Epidemiology and Pathogenesis of Otitis Media: Construction of a Phenotype Landscape , 2014, Audiology and Neurotology.

[10]  M. DePristo,et al.  The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. , 2010, Genome research.

[11]  H. Nevanlinna.  The Finnish population structure. A genetic and genealogical study. , 2009, Hereditas.

[12]  Tadao Saito,et al.  Lactobacilli binding human A-antigen expressed in intestinal mucosa. , 2006, Research in microbiology.

[13]  D. Passali,et al.  Quality of life and psycho-social development in children with otitis media with effusion. , 2005, Acta otorhinolaryngologica Italica : organo ufficiale della Societa italiana di otorinolaringologia e chirurgia cervico-facciale.

[14]  E. Ferekidis,et al.  Blood Group in Otitis media with Effusion , 2002, ORL.

[15]  H. Rockette,et al.  The heritability of otitis media: a twin and triplet study. , 1999, JAMA.

[16]  C. Svanborg,et al.  The receptor repertoire defines the host range for attaching Escherichia coli strains that recognize globo-A , 1991, Infection and immunity.

[17]  T. Lildholdt,et al.  Distribution of ABO blood groups in secretory otitis media and cholesteatoma. , 1983, Clinical otolaryngology and allied sciences.

[18]  S. Esposito,et al.  Acute otitis media with spontaneous tympanic membrane perforation , 2016, European Journal of Clinical Microbiology & Infectious Diseases.

[19]  J. Kere,et al.  Genetic background and the risk of otitis media. , 2012, International journal of pediatric otorhinolaryngology.

[20]  Claude-Alain H. Roten,et al.  Fast and accurate short read alignment with Burrows–Wheeler transform , 2009, Bioinform..