Language Changes in Dementia of the Alzheimer Type

In 1907 Alzheimer described a demented woman who "frequently used perplexing phrases ... some paraphrastic expressions" (milk-pourer instead of cup) and suffered from a significant languag<: comprehension deficit.' Language disorders continue to be one of the most obvious and well-stUdied symptoms of dementia and are particularly pronounced in dementia of the Alzheimer type (OAT). The incidence oflanguage impairment in dementia is estimated to be between 88 and 95 percent, and is close w 100 percent in DAT. ~.127 This chapter will (1) describe the language disorder associated with various stages of OAT; (2) review sevetal prominent research questions about the origin and interprecation of these languag<: disorders; (3) discuss clinical implications of this research for diagnosis and treatment of language disorders in OAT; and (4) sketch out important areas of future resean:h.

[1]  Kathryn A. Bayles,et al.  Language function in senile dementia , 1982, Brain and Language.

[2]  J. Cummings The dementias of Parkinson's disease: prevalence, characteristics, neurobiology, and comparison with dementia of the Alzheimer type. , 1988, European neurology.

[3]  A. Wechsler Presenile dementia presenting as aphasia. , 1977, Journal of neurology, neurosurgery, and psychiatry.

[4]  H. Kirshner,et al.  The naming disorder of dementia , 1984, Neuropsychologia.

[5]  M. Mesulam Primary progressive aphasia—differentiation from Alzheimer's disease , 1987, Annals of neurology.

[6]  Michael P. Alexander,et al.  Creutzfeldt‐Jakob disease presenting as isolated aphasia , 1989, Neurology.

[7]  J. Morris,et al.  Aphasia, family history, and the longitudinal course of senile dementia of the alzheimer type , 1985, Psychiatry Research.

[8]  G. Rochford A study of naming errors in dysphasic and in demented patients. , 1971, Neuropsychologia.

[9]  J. Illes,et al.  Neurolinguistic characteristics of language production in Huntington's disease: A preliminary report , 1987, Brain and Language.

[10]  A. Kertesz,et al.  A study of language functioning in Alzheimer patients , 1982, Brain and Language.

[11]  N. helm-estabrooks,et al.  Visual action therapy for global aphasia. , 1982, The Journal of speech and hearing disorders.

[12]  F. Sakai,et al.  Noninvasive regional cerebral blood flow measurements in dementia. , 1980, Archives of neurology.

[13]  D. Benson,et al.  Neurologic Correlates of Anomia , 1979 .

[14]  C. Marsden,et al.  Outcome of Investigation of Patients with Presenile Dementia , 1972, British medical journal.

[15]  J T Becker,et al.  Neuropsychological function in Alzheimer's disease. Pattern of impairment and rates of progression. , 1988, Archives of neurology.

[16]  B. Seltzer,et al.  A comparison of clinical features in early- and late-onset primary degenerative dementia. One entity or two? , 1983, Archives of neurology.

[17]  M. Albert,et al.  Semantic processing in patients with Alzheimer's disease , 1989, Brain and Language.

[18]  R. S. Williams,et al.  Alzheimer's disease presenting as slowly progressive aphasia. , 1984, Rhode Island medical journal.

[19]  D. Benson,et al.  Angular gyrus syndrome simulating Alzheimer's disease. , 1982, Archives of neurology.

[20]  B. Rovner,et al.  Language dysfunction in early‐ and late‐onset possible Alzheimer's disease , 1988, Neurology.

[21]  Luigi Mansi,et al.  Regional cortical dysfunction in Alzheimer's disease as determined by positron emission tomography , 1984, Annals of neurology.

[22]  R. Nebes,et al.  Use of semantic context by patients with Alzheimer's disease. , 1986, Psychology and aging.

[23]  Mark S. Seidenberg,et al.  Priming and semantic memory loss in Alzheimer's disease , 1989, Brain and Language.

[24]  R. Kuttner Language in Dementia , 1985, British Journal of Psychiatry.

[25]  R. Katzman.,et al.  Pathological verification of ischemic score in differentiation of dementias , 1980, Annals of neurology.

[26]  J. Morris,et al.  Hereditary dysphasic dementia and the Pick‐Alzheimer spectrum , 1984, Annals of neurology.

[27]  M. Albert,et al.  The `subcortical dementia' of progressive supranuclear palsy , 1974, Journal of neurology, neurosurgery, and psychiatry.

[28]  E. Andersen,et al.  Naming consistency in Alzheimer's disease , 1990, Brain and Language.

[29]  N L Foster,et al.  Towards a behavioral typology of Alzheimer's patients. , 1986, Journal of clinical and experimental neuropsychology.

[30]  Language and Brain Dysfunction in Dementia , 1983 .

[31]  H. Chui Dementia. A review emphasizing clinicopathologic correlation and brain-behavior relationships. , 1989, Archives of neurology.

[32]  Myrna F. Schwartz,et al.  Sensitivity to grammatical structure in so-called agrammatic aphasics , 1983, Cognition.

[33]  M. Schwartz,et al.  Dissociations of language function in dementia: A case study , 1979, Brain and Language.

[34]  D. Delis,et al.  Retrieval from semantic memory in Alzheimer-type dementia. , 1986, Journal of clinical and experimental neuropsychology.

[35]  J. D. Wit,et al.  The International Society for the Study of Behavioral Development , 1978 .

[36]  Suzanne Corkin,et al.  Semantic impairment and anomia in Alzheimer's disease , 1986, Brain and Language.

[37]  Anthony F Jorm,et al.  Controlled and automatic information processing in senile dementia: a review , 1986, Psychological Medicine.

[38]  R. Nebes,et al.  Sparing of semantic memory in Alzheimer's disease. , 1984, Journal of abnormal psychology.

[39]  E. Miller,et al.  Language impairment in Alzheimer type dementia , 1989 .

[40]  J. Moossy,et al.  The dissolution of language in Pick's disease with neurofibrillary tangles: A case study , 1985, Brain and Language.

[41]  J. Haxby,et al.  Brain metabolism as measured with positron emission tomography , 1985, Neurology.

[42]  A. Heyman,et al.  The relationship of agraphia to the severity of dementia in Alzheimer's disease. , 1988, Archives of neurology.

[43]  E. Metter,et al.  Subcortical structures in aphasia. An analysis based on (F-18)-fluorodeoxyglucose, positron emission tomography, and computed tomography. , 1988, Archives of neurology.

[44]  Walter Schneider,et al.  Controlled and Automatic Human Information Processing: 1. Detection, Search, and Attention. , 1977 .

[45]  N. Butters,et al.  Comparison of the neuropsychological deficits associated with early and advanced Huntington's disease. , 1978, Archives of neurology.

[46]  Hanna K. Ulatowska,et al.  Discourse Performance in Subjects with Dementia of the Alzheimer Type , 1988 .

[47]  J. Growdon,et al.  Single photon emission computed tomography in Alzheimer's disease. Abnormal iofetamine I 123 uptake reflects dementia severity. , 1988, Archives of neurology.

[48]  D. Kimura,et al.  Motor functions of the left hemisphere. , 1974, Brain : a journal of neurology.

[49]  A. Burns Clinical diagnosis of Alzheimer's disease , 1991 .

[50]  H. Kirshner,et al.  Progressive aphasia without dementia: Two cases with focal spongiform degeneration , 1987, Annals of neurology.

[51]  L. Bäckman Compensation and recoding: a framework for aging and memory research. , 1985, Scandinavian journal of psychology.

[52]  Mark Byrd,et al.  Patterns of memory loss in three elderly samples. , 1987, Psychology and aging.

[53]  A. Wingfield,et al.  Speed of processing in normal aging: effects of speech rate, linguistic structure, and processing time. , 1985, Journal of gerontology.

[54]  R. Shiffrin,et al.  Controlled and automatic human information processing: I , 1977 .

[55]  B. Wulfeck,et al.  Grammaticality judgments and sentence comprehension in agrammatic aphasia. , 1988, Journal of speech and hearing research.

[56]  M. Mesulam,et al.  Slowly progressive aphasia without generalized dementia , 1982, Annals of neurology.

[57]  J. Fox,et al.  Use of computerized tomography in senile dementia. , 1975, Journal of neurology, neurosurgery, and psychiatry.

[58]  H. Whitaker A Case of the Isolation of the Language Function , 1976 .

[59]  R. Nebes,et al.  Automatic and attentional mechanisms of semantic priming in Alzheimer's disease. , 1989, Journal of Clinical and Experimental Neuropsychology.