Diagnostic value of IgG and IgM antibodies to capsid antigen of Epstein-Barr virus in infectious mononucleosis.

IgM antibodies were detected in 34 (89.5%) of the 38 cases of infectious mononucleosis tested, whereas the diagnosis could be established by seroconversion or fourfold increase in titer of IgG in only 24 (63.2%). Apart from the considerable value of IgM antibodies in the identification of primary infections in cases of infectious mononucleosis that are negative for heterophile antibodies, detection of IgM antibodies may be of diagnostic value for patients in whom heterophile antibodypositive results are doubtful or not compatible with clinical and/or hematological findings.

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