After Reaching Retirement Age Physical Activity Sustains Cerebral Perfusion and Cognition

Among neurologically normal volunteers approaching age 65 with an option for retirement, a four‐year prospective longitudinal study was designed to examine effects of different levels of physical activity on cerebral perfusion by between‐group comparisons. After the fourth year, cognitive performance was also tested. Three groups were compared, each composed of 30 elderly volunteers, assigned as follows: Group 1, who continued to work; Group 2, who retired but participated in regular physical activities; and Group 3, who retired but did not participate in regular, planned physical activities. Retirees who elected to become physically inactive exhibited significant declines in cerebral blood flow (CBF) throughout four years of follow‐up. Those who continued to work or retirees who elected to participate in regular activities sustained more constant CBF levels. Active retirees and those who continued to work also scored better on cognitive testing after the fourth year of follow‐up compared to inactive retirees.

[1]  R. L. Rogers,et al.  Reducing Hypertriglyceridemia in Elderly Patients with Cerebrovascular Disease Stabilizes or Improves Cognition and Cerebral Perfusion , 1989, Angiology.

[2]  P. Welling,et al.  The Clinical Pharmacokinetics of Quinapril , 1989, Angiology.

[3]  L. Hershey,et al.  Validation of Cognitive and Functional Assessment Instruments in Vascular Dementia , 1988, International journal of psychiatry in medicine.

[4]  R. L. Rogers,et al.  Cognition and cerebral blood flow fluctuate together in multi-infarct dementia. , 1988, Stroke.

[5]  Juha Pekkanen,et al.  REDUCTION OF PREMATURE MORTALITY BY HIGH PHYSICAL ACTIVITY: A 20-YEAR FOLLOW-UP OF MIDDLE-AGED FINNISH MEN , 1987, The Lancet.

[6]  R. L. Rogers,et al.  Hyperlipidemia is a risk factor for decreased cerebral perfusion and stroke. , 1987, Archives of neurology.

[7]  R. L. Rogers,et al.  Additional predisposing risk factors for atherothrombotic cerebrovascular disease among treated hypertensive volunteers. , 1987, Stroke.

[8]  R. Rauramaa,et al.  Inhibition of platelet aggregability by moderate-intensity physical exercise: a randomized clinical trial in overweight men. , 1986, Circulation.

[9]  P. Korner,et al.  EFFECT OF CHANGING LEVELS OF PHYSICAL ACTIVITY ON BLOOD-PRESSURE AND HAEMODYNAMICS IN ESSENTIAL HYPERTENSION , 1986, The Lancet.

[10]  R. Paffenbarger,et al.  Physical activity, all-cause mortality, and longevity of college alumni. , 1986, The New England journal of medicine.

[11]  R. L. Rogers,et al.  Decreased cerebral blood flow precedes multi‐infarct dementia, but follows senile dementia of Alzheimer type , 1986, Neurology.

[12]  R. L. Rogers,et al.  Prospective analysis of long term control of mild hypertension on cerebral blood flow. , 1985, Stroke.

[13]  L. Thal,et al.  Dementia and motor neuron disease: Morphometric, biochemical, and Golgi studies , 1984, Annals of neurology.

[14]  R. L. Rogers,et al.  Cerebral blood flow changes in benign aging and cerebrovascular disease , 1984, Neurology.

[15]  R. L. Rogers,et al.  Cigarette smoking decreases cerebral blood flow suggesting increased risk for stroke. , 1983, JAMA.

[16]  F. Sakai,et al.  Narcolepsy , 1979, Neurology.

[17]  R. Paffenbarger,et al.  Physical activity as an index of heart attack risk in college alumni. , 1978, American journal of epidemiology.

[18]  F. Sakai,et al.  Improved Method for Noninvasive Measurement of Regional Cerebral Blood Flow by 133Xenon Inhalation Part I: Description of Method and Normal Values Obtained in Healthy Volunteers , 1978, Stroke.

[19]  W. Obrist,et al.  Regional cerebral blood flow estimated by 133-xenon inhalation. , 1975, Stroke.

[20]  J. Durnin,et al.  Human energy expenditure. , 1955, Physiological reviews.

[21]  M. Karvonen Physical activity in work and leisure time in relation to cardiovascular diseases. , 1982, Annals of clinical research.

[22]  J. Strain,et al.  Screening for organic mental syndromes in the medically ill. , 1977, Annals of internal medicine.

[23]  W. Zung A SELF-RATING DEPRESSION SCALE. , 1965, Archives of general psychiatry.