Pancreatic cancers suppress negative feedback of glucose transport to reprogram chromatin for metastasis

[1]  L. Wood,et al.  A unifying paradigm for transcriptional heterogeneity and squamous features in pancreatic ductal adenocarcinoma , 2020, Nature Cancer.

[2]  D. Schadendorf,et al.  Metabolic heterogeneity confers differences in melanoma metastatic potential , 2019, Nature.

[3]  S. Sleijfer,et al.  Pan-cancer whole-genome analyses of metastatic solid tumours , 2019, Nature.

[4]  G. G. Galli,et al.  The landscape of cancer cell line metabolism , 2019, Nature Medicine.

[5]  G. Koh,et al.  Tumor metastasis to lymph nodes requires YAP-dependent metabolic adaptation , 2019, Science.

[6]  D. Merico,et al.  Integration of Genomic and Transcriptional Features in Pancreatic Cancer Reveals Increased Cell Cycle Progression in Metastases. , 2019, Cancer cell.

[7]  D. Tuveson,et al.  TP63-Mediated Enhancer Reprogramming Drives the Squamous Subtype of Pancreatic Ductal Adenocarcinoma , 2018, Cell reports.

[8]  Johannes G. Reiter,et al.  Minimal functional driver gene heterogeneity among untreated metastases , 2018, Science.

[9]  O. McDonald,et al.  Pentose conversions support the tumorigenesis of pancreatic cancer distant metastases , 2018, Oncogene.

[10]  Charles M. Perou,et al.  Asparagine bioavailability governs metastasis in a model of breast cancer , 2018, Nature.

[11]  R. White,et al.  As Extracellular Glutamine Levels Decline, Asparagine Becomes an Essential Amino Acid. , 2018, Cell metabolism.

[12]  Mathias J Friedrich,et al.  Evolutionary routes and KRAS dosage define pancreatic cancer phenotypes , 2018, Nature.

[13]  Brandon Da Silva,et al.  Enhancer Reprogramming Promotes Pancreatic Cancer Metastasis , 2017, Cell.

[14]  Steven J. M. Jones,et al.  Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma. , 2017, Cancer cell.

[15]  L. Cantley,et al.  Phosphorylation of TXNIP by AKT Mediates Acute Influx of Glucose in Response to Insulin. , 2017, Cell reports.

[16]  A. Maitra,et al.  Pancreatic Cancer Genomics 2.0: Profiling Metastases. , 2017, Cancer cell.

[17]  D. Tuveson,et al.  Untangling the genetics from the epigenetics in pancreatic cancer metastasis , 2017, Nature Genetics.

[18]  R. Weinberg,et al.  Emerging Biological Principles of Metastasis , 2017, Cell.

[19]  Krishnendu Chatterjee,et al.  Reconstructing metastatic seeding patterns of human cancers , 2017, Nature Communications.

[20]  Wenbing Xie,et al.  Acetylation Enhances TET2 Function in Protecting against Abnormal DNA Methylation during Oxidative Stress. , 2017, Molecular cell.

[21]  Alexei Vazquez,et al.  Acetate Recapturing by Nuclear Acetyl-CoA Synthetase 2 Prevents Loss of Histone Acetylation during Oxygen and Serum Limitation , 2017, Cell reports.

[22]  A. Feinberg,et al.  Epigenomic reprogramming during pancreatic cancer progression links anabolic glucose metabolism to distant metastasis , 2017, Nature Genetics.

[23]  Johannes G. Reiter,et al.  Limited heterogeneity of known driver gene mutations among the metastases of individual patients with pancreatic cancer , 2017, Nature Genetics.

[24]  C. Lyssiotis,et al.  Employing Metabolism to Improve the Diagnosis and Treatment of Pancreatic Cancer. , 2017, Cancer cell.

[25]  R. Naftalin Faculty Opinions recommendation of Identification and Optimization of the First Highly Selective GLUT1 Inhibitor BAY-876. , 2017 .

[26]  Scott B. Crown,et al.  Lipids Reprogram Metabolism to Become a Major Carbon Source for Histone Acetylation. , 2016, Cell reports.

[27]  D. Hayes,et al.  LKB1 loss links serine metabolism to DNA methylation and tumorigenesis , 2016, Nature.

[28]  Christian M. Metallo,et al.  ATP-Citrate Lyase Controls a Glucose-to-Acetate Metabolic Switch. , 2016, Cell reports.

[29]  Gun Ho Jang,et al.  A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns , 2016, Nature.

[30]  L. Cope,et al.  Mutant p53 Together with TGFβ Signaling Influence Organ-Specific Hematogenous Colonization Patterns of Pancreatic Cancer , 2016, Clinical Cancer Research.

[31]  Toby C. Cornish,et al.  Metastatic progression is associated with dynamic changes in the local microenvironment , 2016, Nature Communications.

[32]  Emanuel J. V. Gonçalves,et al.  Fumarate is an epigenetic modifier that elicits epithelial-to-mesenchymal transition , 2016, Nature.

[33]  Charles Swanton,et al.  Metastasis as an evolutionary process , 2016, Science.

[34]  Travis M. Drucker,et al.  Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease. , 2016, Cancer research.

[35]  J. Massagué,et al.  Metastatic colonization by circulating tumour cells , 2016, Nature.

[36]  Yingming Zhao,et al.  The rate of glycolysis quantitatively mediates specific histone acetylation sites , 2015, Cancer & metabolism.

[37]  R. Deberardinis,et al.  Oxidative stress inhibits distant metastasis by human melanoma cells , 2015, Nature.

[38]  J. Debnath,et al.  Autophagy at the crossroads of catabolism and anabolism , 2015, Nature Reviews Molecular Cell Biology.

[39]  J. Kench,et al.  Whole genomes redefine the mutational landscape of pancreatic cancer , 2015, Nature.

[40]  S. Inoue,et al.  Glutathione and thioredoxin antioxidant pathways synergize to drive cancer initiation and progression. , 2015, Cancer cell.

[41]  R. Deberardinis,et al.  Acetate Is a Bioenergetic Substrate for Human Glioblastoma and Brain Metastases , 2014, Cell.

[42]  Lei Zheng,et al.  A preclinical murine model of hepatic metastases. , 2014, Journal of visualized experiments : JoVE.

[43]  Jing Chen,et al.  Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. , 2014, Molecular cell.

[44]  Stephen A. Sastra,et al.  Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma. , 2014, Cancer cell.

[45]  Channing J Der,et al.  KRAS: feeding pancreatic cancer proliferation. , 2014, Trends in biochemical sciences.

[46]  Amy Y. M. Au,et al.  p53 status determines the role of autophagy in pancreatic tumour development , 2013, Nature.

[47]  J. Massagué,et al.  Review Origins of Metastatic Traits , 2022 .

[48]  A. Shaywitz,et al.  AMPK-dependent degradation of TXNIP upon energy stress leads to enhanced glucose uptake via GLUT1. , 2013, Molecular cell.

[49]  Trent Su,et al.  Histone acetylation regulates intracellular pH. , 2013, Molecular cell.

[50]  Lincoln D. Stein,et al.  Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes , 2012, Nature.

[51]  Gerald C. Chu,et al.  Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism , 2012, Cell.

[52]  Bond-Smith Giles,et al.  Only women with symptoms need to have their breast implants removed, says government , 2012 .

[53]  C. Iacobuzio-Donahue,et al.  Computational Modeling of Pancreatic Cancer Reveals Kinetics of Metastasis Suggesting Optimum Treatment Strategies , 2012, Cell.

[54]  Maximilian Reichert,et al.  EMT and Dissemination Precede Pancreatic Tumor Formation , 2012, Cell.

[55]  R. Hruban,et al.  Disruption of p16 and Activation of Kras in Pancreas Increase Ductal Adenocarcinoma Formation and Metastasis in vivo , 2011, Oncotarget.

[56]  Andrew Menzies,et al.  The patterns and dynamics of genomic instability in metastatic pancreatic cancer , 2010, Nature.

[57]  M. Nowak,et al.  Distant Metastasis Occurs Late during the Genetic Evolution of Pancreatic Cancer , 2010, Nature.

[58]  D. Ayer,et al.  Glucose Controls Nuclear Accumulation, Promoter Binding, and Transcriptional Activity of the MondoA-Mlx Heterodimer , 2010, Molecular and Cellular Biology.

[59]  Paul Timpson,et al.  Mutant p53 drives metastasis and overcomes growth arrest/senescence in pancreatic cancer , 2010, Proceedings of the National Academy of Sciences.

[60]  Hanna Y. Irie,et al.  Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment , 2009, Nature.

[61]  Justin R. Cross,et al.  ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation , 2009, Science.

[62]  Alison P. Klein,et al.  DPC4 gene status of the primary carcinoma correlates with patterns of failure in patients with pancreatic cancer. , 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[63]  G. Parmigiani,et al.  Core Signaling Pathways in Human Pancreatic Cancers Revealed by Global Genomic Analyses , 2008, Science.

[64]  D. Ayer,et al.  Glucose sensing by MondoA:Mlx complexes: A role for hexokinases and direct regulation of thioredoxin-interacting protein expression , 2008, Proceedings of the National Academy of Sciences.

[65]  R. Hruban,et al.  Development and characterization of a cytokine-secreting pancreatic adenocarcinoma vaccine from primary tumors for use in clinical trials. , 1998, The cancer journal from Scientific American.

[66]  H. Barrach,et al.  Inhibition of NADP dependent oxidoreductases by the 6‐aminonicotinamide analogue of NADP , 1970, FEBS letters.

[67]  N. Bardeesy,et al.  Pancreatic adenocarcinoma. , 2014, The New England journal of medicine.

[68]  Wolfgang Schima,et al.  Pancreatic adenocarcinoma , 2006, European Radiology.