Changing Form and Function through Carotenoids and Synthetic Biology1[OPEN]

The diverse structures and multifaceted roles of carotenoids make these colorful pigments attractive targets for synthetic biology.

[1]  P. Nabity,et al.  Phylloxerids share ancestral carotenoid biosynthesis genes of fungal origin with aphids and adelgids , 2017, PloS one.

[2]  A. Aharoni,et al.  Efficient in planta gene targeting in tomato using geminiviral replicons and the CRISPR/Cas9 system. , 2018, The Plant journal : for cell and molecular biology.

[3]  P. He,et al.  A tomato B-box protein SlBBX20 modulates carotenoid biosynthesis by directly activating PHYTOENE SYNTHASE 1, and is targeted for 26S proteasome-mediated degradation. , 2018, The New phytologist.

[4]  Ratnakar Vallabhaneni,et al.  Maize Provitamin A Carotenoids, Current Resources, and Future Metabolic Engineering Challenges , 2012, Front. Plant Sci..

[5]  Pooja Singh,et al.  Prospects and progress in the production of valuable carotenoids: Insights from metabolic engineering, synthetic biology, and computational approaches. , 2018, Journal of biotechnology.

[6]  R. Monaco,et al.  Plastid Localization of the Key Carotenoid Enzyme Phytoene Synthase Is Altered by Isozyme, Allelic Variation, and Activity[W] , 2012, Plant Cell.

[7]  A. Weber,et al.  Surveying the Oligomeric State of Arabidopsis thaliana Chloroplasts. , 2017, Molecular plant.

[8]  O. Köster,et al.  β-Cyclocitral, a Grazer Defence Signal Unique to the Cyanobacterium Microcystis , 2010, Journal of Chemical Ecology.

[9]  Jian-Ren Shen,et al.  Structural basis for energy transfer pathways in the plant PSI-LHCI supercomplex , 2015, Science.

[10]  S. Al‐Babili,et al.  Mechanistic aspects of carotenoid biosynthesis. , 2014, Chemical reviews.

[11]  S. Danoun,et al.  Carotenoid accumulation during tomato fruit ripening is modulated by the auxin-ethylene balance , 2015, BMC Plant Biology.

[12]  E. Majer,et al.  Rewiring carotenoid biosynthesis in plants using a viral vector , 2017, Scientific Reports.

[13]  Scott A. Taylor,et al.  The Evolution and Genetics of Carotenoid Processing in Animals. , 2017, Trends in genetics : TIG.

[14]  Y. Kamiya,et al.  Inhibition of shoot branching by new terpenoid plant hormones , 2008, Nature.

[15]  P. Beyer,et al.  Phytoene Desaturase from Oryza sativa: Oligomeric Assembly, Membrane Association and Preliminary 3D-Analysis , 2015, PloS one.

[16]  M. Zubko,et al.  Unique chromoplast organisation and carotenoid gene expression in carotenoid-rich carrot callus , 2018, Planta.

[17]  Changfu Zhu,et al.  A global perspective on carotenoids: Metabolism, biotechnology, and benefits for nutrition and health. , 2018, Progress in lipid research.

[18]  P. Beyer,et al.  Transcription Factor RAP 2 . 2 and Its Interacting Partner SINAT 2 : Stable Elements in the Carotenogenesis of Arabidopsis Leaves 1 [ W ] , 2007 .

[19]  S. Al‐Babili,et al.  3-Hydroxycarlactone, a Novel Product of the Strigolactone Biosynthesis Core Pathway. , 2018, Molecular plant.

[20]  Tobias Kretzschmar,et al.  The importance of strigolactone transport regulation for symbiotic signaling and shoot branching , 2016, Planta.

[21]  J. Timlin,et al.  Localizing and Quantifying Carotenoids in Intact Cells and Tissues , 2017 .

[22]  P. Fraser,et al.  Carotenoid profiling of yams: Clarity, comparisons and diversity. , 2018, Food chemistry.

[23]  Oliver Rübel,et al.  Dirigent Protein-Mediated Lignan and Cyanogenic Glucoside Formation in Flax Seed: Integrated Omics and MALDI Mass Spectrometry Imaging. , 2015, Journal of natural products.

[24]  Ratnakar Vallabhaneni,et al.  Timing and Biosynthetic Potential for Carotenoid Accumulation in Genetically Diverse Germplasm of Maize1[C][W][OA] , 2009, Plant Physiology.

[25]  P. Fraser,et al.  Subchromoplast Sequestration of Carotenoids Affects Regulatory Mechanisms in Tomato Lines Expressing Different Carotenoid Gene Combinations[C][W] , 2013, Plant Cell.

[26]  H. Bouwmeester,et al.  A petunia ABC protein controls strigolactone-dependent symbiotic signalling and branching , 2012, Nature.

[27]  A. Wyss,et al.  Carotenoids in human nutrition and health. , 2018, Archives of biochemistry and biophysics.

[28]  Johannes Pfeifer,et al.  Changes in the allocation of endogenous strigolactone improve plant biomass production on phosphate‐poor soils , 2017, The New phytologist.

[29]  J. Dawson,et al.  Control of carotenoid biosynthesis through a heme-based cis-trans isomerase , 2015, Nature chemical biology.

[30]  Peter A. Crisp,et al.  Learning the Languages of the Chloroplast: Retrograde Signaling and Beyond. , 2016, Annual review of plant biology.

[31]  A. Ross,et al.  Metabolic Effects of Inflammation on Vitamin A and Carotenoids in Humans and Animal Models. , 2017, Advances in nutrition.

[32]  Eleanore T. Wurtzel,et al.  A transcriptional analysis of carotenoid, chlorophyll and plastidial isoprenoid biosynthesis genes during development and osmotic stress responses in Arabidopsis thaliana , 2011, BMC Systems Biology.

[33]  Walter Sanseverino,et al.  A high-quality carrot genome assembly provides new insights into carotenoid accumulation and asterid genome evolution , 2016, Nature Genetics.

[34]  J. A. Teixeira da Silva,et al.  The biotechnology (genetic transformation and molecular biology) of Bixa orellana L. (achiote) , 2018, Planta.

[35]  P. León,et al.  An Uncharacterized Apocarotenoid-Derived Signal Generated in ζ-Carotene Desaturase Mutants Regulates Leaf Development and the Expression of Chloroplast and Nuclear Genes in Arabidopsis[C][W] , 2014, Plant Cell.

[36]  I. Wheeldon,et al.  Host and Pathway Engineering for Enhanced Lycopene Biosynthesis in Yarrowia lipolytica , 2017, Front. Microbiol..

[37]  Qiang Xu,et al.  The Citrus Transcription Factor CsMADS6 Modulates Carotenoid Metabolism by Directly Regulating Carotenogenic Genes1 , 2018, Plant Physiology.

[38]  R. McQuinn,et al.  AtPDS overexpression in tomato: exposing unique patterns of carotenoid self‐regulation and an alternative strategy for the enhancement of fruit carotenoid content , 2017, Plant biotechnology journal.

[39]  S. Katsumura,et al.  Strategies to enhance the excitation energy-transfer efficiency in a light-harvesting system using the intra-molecular charge transfer character of carotenoids. , 2017, Faraday discussions.

[40]  O. Tzfadia,et al.  The phytoene synthase gene family in the Grasses , 2009, Plant signaling & behavior.

[41]  M. W. Butler,et al.  Ancient origins and multiple appearances of carotenoid-pigmented feathers in birds , 2014, Proceedings of the Royal Society B: Biological Sciences.

[42]  A. Allan,et al.  A kiwifruit (Actinidia deliciosa) R2R3‐MYB transcription factor modulates chlorophyll and carotenoid accumulation , 2018, The New phytologist.

[43]  P. Fraser,et al.  The regulation of carotenoid formation in tomato fruit , 2017, The Plant journal : for cell and molecular biology.

[44]  Q. Xia,et al.  CRISPR/Cas9-Mediated Mutagenesis of Carotenoid Cleavage Dioxygenase 8 (CCD8) in Tobacco Affects Shoot and Root Architecture , 2018, International journal of molecular sciences.

[45]  R. McQuinn,et al.  Integrative Transcript and Metabolite Analysis of Nutritionally Enhanced DE-ETIOLATED1 Downregulated Tomato Fruit[W] , 2010, Plant Cell.

[46]  Ratnakar Vallabhaneni,et al.  From epoxycarotenoids to ABA: the role of ABA 8'-hydroxylases in drought-stressed maize roots. , 2010, Archives of biochemistry and biophysics.

[47]  Vangelis Daskalakis.  Protein-protein interactions within photosystem II under photoprotection: the synergy between CP29 minor antenna, subunit S (PsbS) and zeaxanthin at all-atom resolution. , 2018, Physical chemistry chemical physics : PCCP.

[48]  Jianbing Yan,et al.  Natural Genetic Variation in Lycopene Epsilon Cyclase Tapped for Maize Biofortification , 2008, Science.

[49]  M. Rodríguez-Concepcíon,et al.  Illuminating colors: regulation of carotenoid biosynthesis and accumulation by light. , 2017, Current opinion in plant biology.

[50]  R. Shamir,et al.  The MORPH Algorithm: Ranking Candidate Genes for Membership in Arabidopsis and Tomato Pathways[C][W] , 2012, Plant Cell.

[51]  E. Wurtzel,et al.  The carotenoid biosynthetic pathway: thinking in all dimensions. , 2013, Plant science : an international journal of experimental plant biology.

[52]  T. Thannhauser,et al.  Arabidopsis OR proteins are the major posttranscriptional regulators of phytoene synthase in controlling carotenoid biosynthesis , 2015, Proceedings of the National Academy of Sciences.

[53]  P. Fraser,et al.  Engineering of tomato for the sustainable production of ketocarotenoids and its evaluation in aquaculture feed , 2017, Proceedings of the National Academy of Sciences.

[54]  E. Harrison,et al.  Apocarotenoids: Emerging Roles in Mammals. , 2018, Annual review of nutrition.

[55]  P. Beyer,et al.  Enzyme Fusion Removes Competition for Geranylgeranyl Diphosphate in Carotenogenesis1[OPEN] , 2018, Plant Physiology.

[56]  Mauricio S. Antunes,et al.  Engineering synthetic regulatory circuits in plants. , 2018, Plant science : an international journal of experimental plant biology.

[57]  G. Aprea,et al.  Candidate Enzymes for Saffron Crocin Biosynthesis Are Localized in Multiple Cellular Compartments1[OPEN] , 2018, Plant Physiology.

[58]  W. Kohlen,et al.  Strigolactone Levels in Dicot Roots Are Determined by an Ancestral Symbiosis-Regulated Clade of the PHYTOENE SYNTHASE Gene Family , 2018, Front. Plant Sci..

[59]  H. Ernst,et al.  Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system. , 2009, Free radical biology & medicine.

[60]  P. Christou,et al.  Combined transcript, proteome, and metabolite analysis of transgenic maize seeds engineered for enhanced carotenoid synthesis reveals pleotropic effects in core metabolism , 2015, Journal of experimental botany.

[61]  Carla C. C. R. de Carvalho,et al.  Carotenoids in Aquatic Ecosystems and Aquaculture: A Colorful Business with Implications for Human Health , 2017, Front. Mar. Sci..

[62]  M. Christodoulou,et al.  Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis , 2015, International journal of molecular sciences.

[63]  S. Al‐Babili,et al.  From carotenoids to strigolactones. , 2018, Journal of experimental botany.

[64]  Marcel Fuciman,et al.  Zeaxanthin Protects Plant Photosynthesis by Modulating Chlorophyll Triplet Yield in Specific Light-harvesting Antenna Subunits* , 2012, The Journal of Biological Chemistry.

[65]  R. Reski,et al.  Strigolactone biosynthesis is evolutionarily conserved, regulated by phosphate starvation and contributes to resistance against phytopathogenic fungi in a moss, Physcomitrella patens. , 2017, The New phytologist.

[66]  Broome,et al.  Literature cited , 1924, A Guide to the Carnivores of Central America.

[67]  S. Sawayama,et al.  Overexpression of DnaJ-Like Chaperone Enhances Carotenoid Synthesis in Chlamydomonas reinhardtii , 2017, Applied Biochemistry and Biotechnology.

[68]  Jordan A. Greco,et al.  High Efficiency Light Harvesting by Carotenoids in the LH2 Complex from Photosynthetic Bacteria: Unique Adaptation to Growth under Low-Light Conditions , 2014, The journal of physical chemistry. B.

[69]  L. Gómez-Gómez,et al.  Carotenoid Cleavage Oxygenases from Microbes and Photosynthetic Organisms: Features and Functions , 2016, International journal of molecular sciences.

[70]  Faqiang Li,et al.  Maize Y9 encodes a product essential for 15-cis-zeta-carotene isomerization. , 2007, Plant physiology.

[71]  Tal Isaacson,et al.  Epistasis in tomato color mutations involves regulation of phytoene synthase 1 expression by cis-carotenoids , 2012, Proceedings of the National Academy of Sciences.

[72]  D. Robertson,et al.  The Genetics of Vivipary in Maize. , 1955, Genetics.

[73]  P. Benfey,et al.  β-Cyclocitral is a conserved root growth regulator , 2019, Proceedings of the National Academy of Sciences.

[74]  K. Niyogi,et al.  Engineering the lutein epoxide cycle into Arabidopsis thaliana , 2017, Proceedings of the National Academy of Sciences.

[75]  G. Britton,et al.  Protein‐chromophore interactions in α‐crustacyanin, the major blue carotenoprotein from the carapace of the lobster, Homarus gammarus a study by 13C magic angle spinning NMR , 1995, FEBS letters.

[76]  P. Beyer,et al.  Transgenic rice (Oryza sativa) endosperm expressing daffodil (Narcissus pseudonarcissus) phytoene synthase accumulates phytoene, a key intermediate of provitamin A biosynthesis. , 1997, The Plant journal : for cell and molecular biology.

[77]  D. Schemske,et al.  Allele substitution at a flower colour locus produces a pollinator shift in monkeyflowers , 2003, Nature.

[78]  Dong Zhang,et al.  Genome-wide analysis of carotenoid cleavage oxygenase genes and their responses to various phytohormones and abiotic stresses in apple (Malus domestica). , 2018, Plant physiology and biochemistry : PPB.

[79]  L. Tian.  Recent advances in understanding carotenoid-derived signaling molecules in regulating plant growth and development , 2015, Front. Plant Sci..

[80]  Eleanore T. Wurtzel,et al.  Plant metabolism, the diverse chemistry set of the future , 2016, Science.

[81]  E. Kennelly,et al.  Synergistic Interactions between Carotene Ring Hydroxylases Drive Lutein Formation in Plant Carotenoid Biosynthesis1[W][OA] , 2012, Plant Physiology.

[82]  Yuehua Xiao,et al.  Specific Upregulation of a Cotton Phytoene Synthase Gene Produces Golden Cottonseeds with Enhanced Provitamin A , 2018, Scientific Reports.

[83]  Faqiang Li,et al.  Maize Y9 Encodes a Product Essential for 15-cis-ζ-Carotene Isomerization1[OA] , 2007, Plant Physiology.

[84]  P. Beyer,et al.  Engineering the provitamin A (beta-carotene) biosynthetic pathway into (carotenoid-free) rice endosperm. , 2000, Science.

[85]  Yifan Cheng,et al.  Single-particle cryo-EM—How did it get here and where will it go , 2018, Science.

[86]  M. Fernández,et al.  Potential of Dietary Non-Provitamin A Carotenoids in the Prevention and Treatment of Diabetic Microvascular Complications. , 2016, Advances in nutrition.

[87]  N. Nagata,et al.  Digalactosyldiacylglycerol Is Essential for Organization of the Membrane Structure in Etioplasts1 , 2018, Plant Physiology.

[88]  R. Cogdell,et al.  Carotenoids and Photosynthesis. , 2016, Sub-cellular biochemistry.

[89]  N. Misawa,et al.  Elucidation of the Erwinia uredovora carotenoid biosynthetic pathway by functional analysis of gene products expressed in Escherichia coli , 1990, Journal of bacteriology.

[90]  H. Klee,et al.  The Carotenoid Cleavage Dioxygenase 1 Enzyme Has Broad Substrate Specificity, Cleaving Multiple Carotenoids at Two Different Bond Positions* , 2008, Journal of Biological Chemistry.

[91]  G. Giuliano.  Provitamin A biofortification of crop plants: a gold rush with many miners. , 2017, Current opinion in biotechnology.

[92]  F. Chen,et al.  Molecular mechanisms of the coordination between astaxanthin and fatty acid biosynthesis in Haematococcus pluvialis (Chlorophyceae). , 2015, The Plant journal : for cell and molecular biology.

[93]  M. Morgante,et al.  Long-range patterns of diversity and linkage disequilibrium surrounding the maize Y1 gene are indicative of an asymmetric selective sweep. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[94]  P. Beyer,et al.  On the Structure and Function of the Phytoene Desaturase CRTI from Pantoea ananatis, a Membrane-Peripheral and FAD-Dependent Oxidase/Isomerase , 2012, PloS one.

[95]  P. Fraser,et al.  Creating plant molecular factories for industrial and nutritional isoprenoid production. , 2018, Current opinion in biotechnology.

[96]  D. Hornero-Méndez,et al.  Xanthophyll esterification accompanying carotenoid overaccumulation in chromoplast of Capsicum annuum ripening fruits is a constitutive process and useful for ripeness index. , 2000, Journal of agricultural and food chemistry.

[97]  Andrew R. Korte,et al.  Spatial Mapping of Lipids at Cellular Resolution in Embryos of Cotton[W][OA] , 2012, Plant Cell.

[98]  Yixiong Tang,et al.  Metabolic engineering of gossypol in cotton , 2013, Applied Microbiology and Biotechnology.

[99]  Huimin Zhao,et al.  A plug‐and‐play pathway refactoring workflow for natural product research in Escherichia coli and Saccharomyces cerevisiae , 2017, Biotechnology and bioengineering.

[100]  Yutaka Suzuki,et al.  Identification of the carotenoid modifying gene PALE YELLOW PETAL 1 as an essential factor in xanthophyll esterification and yellow flower pigmentation in tomato (Solanum lycopersicum). , 2014, The Plant journal : for cell and molecular biology.

[101]  P. Beyer,et al.  Regulation and activation of phytoene synthase, a key enzyme in carotenoid biosynthesis, during photomorphogenesis , 2000, Planta.

[102]  P. Beyer,et al.  Structure of Phytoene Desaturase Provides Insights into Herbicide Binding and Reaction Mechanisms Involved in Carotene Desaturation. , 2017, Structure.

[103]  P. Matthews,et al.  Maize phytoene desaturase and zeta-carotene desaturase catalyse a poly-Z desaturation pathway: implications for genetic engineering of carotenoid content among cereal crops. , 2003, Journal of experimental botany.

[104]  R. McQuinn,et al.  Synthesis and Function of Apocarotenoid Signals in Plants. , 2016, Trends in plant science.

[105]  D. Robertson,et al.  Role of Carotenoids in Protecting Chlorophyll From Photodestruction. , 1960, Plant physiology.

[106]  Di Liu,et al.  Dynamic metabolic control: towards precision engineering of metabolism , 2018, Journal of Industrial Microbiology & Biotechnology.

[107]  S. Al‐Babili,et al.  Strigolactones, a novel carotenoid-derived plant hormone. , 2015, Annual review of plant biology.

[108]  R. Rivera-Madrid,et al.  Carotenoid Derivates in Achiote (Bixa orellana) Seeds: Synthesis and Health Promoting Properties , 2016, Front. Plant Sci..

[109]  M. Rodriguez-Franco,et al.  Establishment of an Arabidopsis callus system to study the interrelations of biosynthesis, degradation and accumulation of carotenoids , 2018, PloS one.

[110]  A. Allan,et al.  The Phytoene synthase gene family of apple (Malus x domestica) and its role in controlling fruit carotenoid content , 2015, BMC Plant Biology.

[111]  P. Beyer,et al.  Why Is Golden Rice Golden (Yellow) Instead of Red?1[w] , 2005, Plant Physiology.

[112]  B. Wang,et al.  Nuclear Receptor Regulation of Aquaporin-2 in the Kidney , 2016, International journal of molecular sciences.

[113]  T. Rocheford,et al.  The Maize Phytoene Synthase Gene Family: Overlapping Roles for Carotenogenesis in Endosperm, Photomorphogenesis, and Thermal Stress Tolerance1[C][W][OA] , 2008, Plant Physiology.

[114]  Michelle D. Miller,et al.  Association between Malnutrition and 28-Day Mortality and Intensive Care Length-of-Stay in the Critically ill: A Prospective Cohort Study , 2017, Nutrients.

[115]  D. Xing,et al.  β-cyclocitral upregulates salicylic acid signalling to enhance excess light acclimation in Arabidopsis. , 2015, Journal of experimental botany.

[116]  Seon-Won Kim,et al.  Synthetic Biology and Metabolic Engineering for Marine Carotenoids: New Opportunities and Future Prospects , 2014, Marine drugs.

[117]  P. Beyer,et al.  Phytoene synthase from Narcissus pseudonarcissus: functional expression, galactolipid requirement, topological distribution in chromoplasts and induction during flowering. , 1996, The Plant journal : for cell and molecular biology.

[118]  T. Thannhauser,et al.  Clp Protease and OR Directly Control the Proteostasis of Phytoene Synthase, the Crucial Enzyme for Carotenoid Biosynthesis in Arabidopsis. , 2018, Molecular plant.

[119]  Louis M. T. Bradbury,et al.  The carotenoid dioxygenase gene family in maize, sorghum, and rice. , 2010, Archives of biochemistry and biophysics.

[120]  Li Li,et al.  Carotenoid Metabolism in Plants: The Role of Plastids. , 2018, Molecular plant.

[121]  Z. Fei,et al.  Distinct Mechanisms of the ORANGE Protein in Controlling Carotenoid Flux1[OPEN] , 2016, Plant Physiology.

[122]  Hilla Peretz,et al.  Ju n 20 03 Schrödinger ’ s Cat : The rules of engagement , 2003 .

[123]  G. Giuliano.  Plant carotenoids: genomics meets multi-gene engineering. , 2014, Current opinion in plant biology.

[124]  G. Giuliano,et al.  Molecular and biochemical characterization of a potato collection with contrasting tuber carotenoid content , 2017, PloS one.

[125]  Ratnakar Vallabhaneni,et al.  Metabolite Sorting of a Germplasm Collection Reveals the Hydroxylase3 Locus as a New Target for Maize Provitamin A Biofortification1[C][W][OA] , 2009, Plant Physiology.

[126]  Xixian Chen,et al.  A “plug‐n‐play” modular metabolic system for the production of apocarotenoids , 2018, Biotechnology and bioengineering.

[127]  M. Madigan,et al.  Probing structure–function relationships in early events in photosynthesis using a chimeric photocomplex , 2017, Proceedings of the National Academy of Sciences.

[128]  W. Eyster.  Vivipary in Maize. , 1931, Genetics.

[129]  Je-Gun Joung,et al.  Combined transcriptome, genetic diversity and metabolite profiling in tomato fruit reveals that the ethylene response factor SlERF6 plays an important role in ripening and carotenoid accumulation. , 2012, The Plant journal : for cell and molecular biology.

[130]  W. Gruszecki,et al.  Carotenoids as modulators of lipid membrane physical properties. , 2005, Biochimica et biophysica acta.

[131]  E. Kennelly,et al.  Lycopene cyclase paralog CruP protects against reactive oxygen species in oxygenic photosynthetic organisms , 2012, Proceedings of the National Academy of Sciences.

[132]  T. Friedrich,et al.  The photocycle of orange carotenoid protein conceals distinct intermediates and asynchronous changes in the carotenoid and protein components , 2017, bioRxiv.

[133]  Faqiang Li,et al.  PSY3, a New Member of the Phytoene Synthase Gene Family Conserved in the Poaceae and Regulator of Abiotic Stress-Induced Root Carotenogenesis1[W][OA] , 2007, Plant Physiology.

[134]  M. Smulders,et al.  Genome-Wide Association Analysis of the Anthocyanin and Carotenoid Contents of Rose Petals , 2016, Front. Plant Sci..

[135]  P. Benfey,et al.  β-cyclocitral is a conserved root growth regulator , 2018, bioRxiv.

[136]  Naiman A. Khan,et al.  The Macular Carotenoids are Associated with Cognitive Function in Preadolescent Children , 2018, Nutrients.

[137]  Zhenfeng Liu,et al.  Structure of spinach photosystem II–LHCII supercomplex at 3.2 Å resolution , 2016, Nature.

[138]  R. Efremov,et al.  Lipid Nanodiscs as a Tool for High-Resolution Structure Determination of Membrane Proteins by Single-Particle Cryo-EM. , 2017, Methods in enzymology.

[139]  Denis S. Willett,et al.  Maize w3 disrupts homogentisate solanesyl transferase (ZmHst) and reveals a plastoquinone-9 independent path for phytoene desaturation and tocopherol accumulation in kernels. , 2018, The Plant journal : for cell and molecular biology.

[140]  J. Friml,et al.  Asymmetric Localizations of the ABC Transporter PaPDR1 Trace Paths of Directional Strigolactone Transport , 2015, Current Biology.

[141]  K. Niyogi,et al.  Evolution of an atypical de-epoxidase for photoprotection in the green lineage , 2016, Nature Plants.

[142]  P. Benfey,et al.  Periodic root branching in Arabidopsis requires synthesis of an uncharacterized carotenoid derivative , 2014, Proceedings of the National Academy of Sciences.

[143]  P. Beyer,et al.  Tissue-Specific Apocarotenoid Glycosylation Contributes to Carotenoid Homeostasis in Arabidopsis Leaves1 , 2015, Plant Physiology.

[144]  A. Ross,et al.  Metabolic Effects of In fl ammation on Vitamin A and Carotenoids in Humans and Animal Models 1 – 3 , 2017 .

[145]  A. Plagge,et al.  Assessing the Effectiveness of a Far-Red Fluorescent Reporter for Tracking Stem Cells In Vivo , 2017, International journal of molecular sciences.

[146]  H. Frank,et al.  Molecular factors controlling photosynthetic light harvesting by carotenoids. , 2010, Accounts of chemical research.

[147]  Sanwen Huang,et al.  A chemical genetic roadmap to improved tomato flavor , 2017, Science.

[148]  K. V. van Wijk,et al.  Plastoglobuli: Plastid Microcompartments with Integrated Functions in Metabolism, Plastid Developmental Transitions, and Environmental Adaptation. , 2017, Annual review of plant biology.

[149]  K. Niyogi,et al.  Dissecting and modeling zeaxanthin- and lutein-dependent nonphotochemical quenching in Arabidopsis thaliana , 2017, Proceedings of the National Academy of Sciences.

[150]  G. Sandmann,et al.  Combinatorial Biosynthesis of Novel Multi-Hydroxy Carotenoids in the Red Yeast Xanthophyllomyces dendrorhous , 2017, Journal of fungi.

[151]  P. Beyer,et al.  Novel carotenoid cleavage dioxygenase catalyzes the first dedicated step in saffron crocin biosynthesis , 2014, Proceedings of the National Academy of Sciences.

[152]  P. Beyer,et al.  Transcription Factor RAP2.2 and Its Interacting Partner SINAT2: Stable Elements in the Carotenogenesis of Arabidopsis Leaves1[W] , 2007, Plant Physiology.

[153]  Jean-Charles Portais,et al.  Strigolactone inhibition of shoot branching , 2008, Nature.

[154]  M. Havaux.  Carotenoid oxidation products as stress signals in plants. , 2014, The Plant journal : for cell and molecular biology.

[155]  J. Zeevaart,et al.  The 9-cis-epoxycarotenoid cleavage reaction is the key regulatory step of abscisic acid biosynthesis in water-stressed bean. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[156]  Faqiang Li,et al.  Isolation and Characterization of the Z-ISO Gene Encoding a Missing Component of Carotenoid Biosynthesis in Plants1[C][W][OA] , 2010, Plant Physiology.

[157]  C. Valon,et al.  An Update on Abscisic Acid Signaling in Plants and More , 2022 .

[158]  M. Morgante,et al.  Contrasting Effects of Selection on Sequence Diversity and Linkage Disequilibrium at Two Phytoene Synthase Loci Online version contains Web-only data. Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.012526. , 2003, The Plant Cell Online.

[159]  K. Chapman,et al.  Lipidomics in situ: insights into plant lipid metabolism from high resolution spatial maps of metabolites. , 2014, Progress in lipid research.

[160]  Sriram Subramaniam,et al.  Single-particle cryo-EM structure of a voltage-activated potassium channel in lipid nanodiscs , 2018, eLife.

[161]  Z. Fei,et al.  Ectopic expression of ORANGE promotes carotenoid accumulation and fruit development in tomato , 2018, Plant biotechnology journal.

[162]  M. Rodríguez-Concepcíon,et al.  A role for &bgr;,&bgr;-xanthophylls in Arabidopsis UV-B photoprotection , 2018, Journal of experimental botany.

[163]  R. Finkelstein,et al.  Abscisic Acid Synthesis and Response , 2013, The arabidopsis book.

[164]  Faqiang Li,et al.  PSY 3 , a New Member of the Phytoene Synthase Gene Family Conserved in the Poaceae and Regulator of Abiotic Stress-Induced Root Carotenogenesis 1 [ W ] [ OA ] , 2008 .

[165]  P. Beyer,et al.  Tissue-Speci fi c Apocarotenoid Glycosylation Contributes to Carotenoid Homeostasis in Arabidopsis Leaves 1 , 2015 .

[166]  L. Soubigou-Taconnat,et al.  Carotenoid oxidation products are stress signals that mediate gene responses to singlet oxygen in plants , 2012, Proceedings of the National Academy of Sciences.