Rationally designed chemical modulators convert a bacterial channel protein into a pH-sensory valve.

[1]  Ben L Feringa,et al.  A Light-Actuated Nanovalve Derived from a Channel Protein , 2005, Science.

[2]  S. Sukharev,et al.  Gain-of-function Mutations Reveal Expanded Intermediate States and a Sequential Action of Two Gates in MscL , 2005, The Journal of general physiology.

[3]  R. Wray,et al.  Defining the physical gate of a mechanosensitive channel, MscL, by engineering metal-binding sites. , 2004, Biophysical journal.

[4]  P. Blount,et al.  An in vivo assay identifies changes in residue accessibility on mechanosensitive channel gating. , 2004, Proceedings of the National Academy of Sciences of the United States of America.

[5]  P. Blount,et al.  Cysteine scanning of MscL transmembrane domains reveals residues critical for mechanosensitive channel gating. , 2004, Biophysical journal.

[6]  K. Ulbrich,et al.  Polymeric anticancer drugs with pH-controlled activation. , 2004, Advanced drug delivery reviews.

[7]  C Kung,et al.  Chemically charging the pore constriction opens the mechanosensitive channel MscL. , 2001, Biophysical journal.

[8]  C Kung,et al.  Hydrophilicity of a single residue within MscL correlates with increased channel mechanosensitivity. , 1999, Biophysical journal.

[9]  I. Booth,et al.  Protection of Escherichia coli cells against extreme turgor by activation of MscS and MscL mechanosensitive channels: identification of genes required for MscS activity , 1999, The EMBO journal.

[10]  D C Rees,et al.  Structure of the MscL homolog from Mycobacterium tuberculosis: a gated mechanosensitive ion channel. , 1998, Science.

[11]  M. Besnard,et al.  Release of Thioredoxin via the Mechanosensitive Channel MscL during Osmotic Downshock of Escherichia coli Cells* , 1998, The Journal of Biological Chemistry.

[12]  R. Minchin,et al.  Estimation of the pore size of the large-conductance mechanosensitive ion channel of Escherichia coli. , 1997, Biophysical journal.

[13]  H. Guy,et al.  Membrane topology and multimeric structure of a mechanosensitive channel protein of Escherichia coli. , 1996, The EMBO journal.

[14]  B. Pitard,et al.  Reconstitution of membrane proteins into liposomes: application to energy-transducing membrane proteins. , 1995, Biochimica et biophysica acta.

[15]  B. Martinac,et al.  Purification and Functional Reconstitution of the Recombinant Large Mechanosensitive Ion Channel (MscL) of Escherichia coli(*) , 1995, The Journal of Biological Chemistry.

[16]  Boris Martinac,et al.  A large-conductance mechanosensitive channel in E. coli encoded by mscL alone , 1994, Nature.

[17]  C. Houssin,et al.  A patch‐clamp study of ion channels of inner and outer membranes and of contact zones of E. coli, fused into giant liposomes , 1989, FEBS letters.

[18]  F. P. Robinson,et al.  Inductive substituent constants from dissociation of methyl-substituted 4-picolinium ions , 1978 .

[19]  J. Hine,et al.  Internal catalysis in the reaction of N,N,N'-trimethylethylenediamine with phenylglyoxal hydrate to give N-(2-dimethylaminoethyl)-N-methylmandelamide , 1975 .

[20]  J. Hine,et al.  Catalysis of .alpha.-hydrogen exchange. XV. Bifunctional catalysis of the dedeuteration of acetone-d6 by 3-dimethylaminopropylamine, 2-(dimethylaminomethyl)cyclopentylamines, and polyethylenimines , 1974 .

[21]  E. Kornfeld.  Lithium Aluminum Hydride Reduction of Diethyl 2,6-Dimethyl-3,4-pyridinedicarboxylate , 1955 .

[22]  Boris Martinac,et al.  Physical principles underlying the transduction of bilayer deformation forces during mechanosensitive channel gating , 2002, Nature Structural Biology.

[23]  R. Méndez,et al.  Studies on clavulanic acid. Part 1. Stability of clavulanic acid in aqueous solutions of amines containing hydroxy groups , 1989 .

[24]  E. F. Hammel,et al.  Physico-Chemical Studies of the Simpler Polypeptides. I. The Dissociation Constants of Mono-, Di-, Tri-, Tetra-, Penta-, Hexa- and Hepta-glycine and their Esters1 , 1941 .