Functional properties of coffee and coffee by-products

Coffee, one of the most popular beverages, is consumed by millions of people every day. Traditionally, coffee beneficial effects have been attributed solely to its most intriguing and investigated ingredient, caffeine, but it is now known that other compounds also contribute to the valuable properties of this beverage. The role of coffee brew consumption in preventing some severe and prevalent diseases justifies its classification as a functional beverage. These properties are determined directly by the composition of the green beans and the changes that occur during roasting. On the other hand, by-products of coffee fruit and bean processing can also be considered as potential functional ingredients for the food industry. The coffee husks, peel and pulp, which comprises nearly 45% of the cherry, are one of the main by-products of coffee agro-industry and might be a valuable material for several purposes, including extraction of caffeine and polyphenols. Other by-products of coffee processing have been less studied, such as the mucilage and the parchment; however, they might have a high potential as a source of important ingredients as well. Furthermore, the use of the roasted coffee silverskin as a dietary fiber rich ingredient and for its antioxidative properties has also been evaluated. Finally, spent beans have been studied mainly for their antioxidative properties. The aim of this paper is to compile recent information on the functional properties of coffee, coffee beans and by-products in terms of the associated potential health benefits. The data in this review have been organized in sections according to the coffee product or by-product.

[1]  M. M. Naidu,et al.  Production of α-amylase under solid-state fermentation utilizing coffee waste. , 2009 .

[2]  J. J. Pis,et al.  Evidence of self-gasification during the microwave-induced pyrolysis of coffee hulls , 2007 .

[3]  Mohan,et al.  Biotechnological potential of coffee pulp and coffee husk for bioprocesses. , 2000, Biochemical engineering journal.

[4]  Leandro S. Oliveira,et al.  Kinetics and equilibrium studies of methylene blue adsorption by spent coffee grounds. , 2009 .

[5]  H. Reinhardt,et al.  Fibers of coffee husk and hulls for the production of particleboard , 2010 .

[6]  M. Glória,et al.  Profile and levels of bioactive amines in instant coffee , 2007 .

[7]  Leandro S. Oliveira,et al.  A preliminary evaluation of the effect of processing temperature on coffee roasting degree assessment , 2009 .

[8]  Harriet de Wit,et al.  Genetics of caffeine consumption and responses to caffeine , 2010, Psychopharmacology.

[9]  M. Dietrich,et al.  Coffee and cigarette consumption and perceived effects in recovering alcoholics participating in Alcoholics Anonymous in Nashville, Tennessee, USA. , 2008, Alcoholism, clinical and experimental research.

[10]  E. A. Huisman,et al.  Biological treatments affect the chemical composition of coffee pulp. , 2003, Bioresource technology.

[11]  M. Serafini,et al.  Redox ingredients for oxidative stress prevention: the unexplored potentiality of coffee. , 2009, Clinics in dermatology.

[12]  A. S. Franca,et al.  Untreated coffee husks as biosorbents for the removal of heavy metals from aqueous solutions. , 2008, Journal of hazardous materials.

[13]  Susana Casal,et al.  Tocopherols in coffee brews: Influence of coffee species, roast degree and brewing procedure , 2010 .

[14]  V. Brezová,et al.  Coffee as a source of antioxidants: An EPR study , 2009 .

[15]  P. Mazzafera,et al.  Extraction of green coffee oil using supercritical carbon dioxide , 2008 .

[16]  M. Clifford,et al.  Tannins in wet-processed coffee beans and coffee pulp , 1991 .

[17]  Leandro S. Oliveira,et al.  Physical and chemical attributes of defective crude and roasted coffee beans , 2005 .

[18]  Elena Verzelloni,et al.  Antiglycative and antioxidative properties of coffee fractions , 2011 .

[19]  M. Clifford Chemical and Physical Aspects of Green Coffee and Coffee Products , 1985 .

[20]  B. Fredholm,et al.  Caffeine--an atypical drug of dependence. , 1998, Drug and alcohol dependence.

[21]  D. Selmar,et al.  Influence of processing on the content of sugars in green Arabica coffee beans , 2006 .

[22]  B. Frei,et al.  Coffee and Health: A Review of Recent Human Research , 2006, Critical reviews in food science and nutrition.

[23]  J. Brillouet,et al.  Microbiological and Biochemical Study of Coffee Fermentation , 2001, Current Microbiology.

[24]  R. Wildman,et al.  Handbook of Nutraceuticals and Functional Foods , 2019 .

[25]  M. Clifford,et al.  Analysis of proanthocyanidins in coffee pulp , 1994 .

[26]  T. Shibamoto,et al.  Quantitation of volatiles and nonvolatile acids in an extract from coffee beverages: correlation with antioxidant activity. , 2006, Journal of agricultural and food chemistry.

[27]  Eugeniusz Molga,et al.  CFD modelling and divergence criterion for safety of chemical reactors , 2005 .

[28]  K. Mochida,et al.  In vitro antioxidative effects and tyrosinase inhibitory activities of seven hydroxycinnamoyl derivatives in green coffee beans. , 2004, Journal of agricultural and food chemistry.

[29]  T. Ogihara,et al.  Green coffee bean extract improves human vasoreactivity. , 2004, Hypertension Research.

[30]  F. Morales,et al.  Peroxyl radical scavenging activity of melanoidins in aqueous systems , 2004 .

[31]  M. A. Cirillo,et al.  Ochratoxin A in coffee beans (Coffea arabica L.) processed by dry and wet methods , 2009 .

[32]  M. Eberlin,et al.  Brazilian roasted coffee oil obtained by mechanical expelling: compositional analysis by GC-MS , 2005 .

[33]  T. Hase,et al.  Antihypertensive Effect of Green Coffee Bean Extract on Mildly Hypertensive Subjects , 2005, Hypertension Research.

[34]  J. Brillouet,et al.  Involvement of pectolytic micro‐organisms in coffee fermentation , 2002 .

[35]  J. Dórea,et al.  Is coffee a functional food? , 2005, British Journal of Nutrition.

[36]  J W Purseglove,et al.  Tropical crops: dicotyledons , 1969 .

[37]  H. Shimoda,et al.  Inhibitory effect of green coffee bean extract on fat accumulation and body weight gain in mice , 2006, BMC complementary and alternative medicine.

[38]  A. S. Franca,et al.  Correlation between cup quality and chemical attributes of Brazilian coffee , 2006 .

[39]  L. Rao,et al.  Antioxidant potential of low-grade coffee beans , 2008 .

[40]  M. Glade,et al.  Caffeine-Not just a stimulant. , 2010, Nutrition.

[41]  M. Goto,et al.  Bioactivities of low-grade green coffee and spent coffee in different in vitro model systems , 2009 .

[42]  J. Werther,et al.  Combustion of coffee husks , 2001 .

[43]  C. Torres,et al.  Feasibility of ethanol production from coffee husks , 2008, Biotechnology Letters.

[44]  K Ramalakshmi,et al.  Physicochemical characteristics of green coffee: comparison of graded and defective beans. , 2007, Journal of food science.

[45]  V. Fogliano,et al.  Natural occurrence of ochratoxin A and antioxidant activities of green and roasted coffees and corresponding byproducts. , 2007, Journal of agricultural and food chemistry.

[46]  Soccol,et al.  Biological detoxification of coffee husk by filamentous fungi using a solid state fermentation system. , 2000, Enzyme and microbial technology.

[47]  P. Farris Idebenone, green tea, and Coffeeberry® extract: new and innovative antioxidants , 2007, Dermatologic therapy.

[48]  A. Constable,et al.  Cafestol and kahweol, two coffee specific diterpenes with anticarcinogenic activity. , 2002, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[49]  G. Budryn,et al.  Antioxidant properties of Arabica and Robusta coffee extracts prepared under different conditions , 2008 .

[50]  M. León-Camacho,et al.  HPLC analysis of tocopherols and triglycerides in coffee and their use as authentication parameters , 2001 .

[51]  J. R. Ramírez-Martínez Phenolic compounds in coffee pulp: Quantitative determination by HPLC , 1988 .

[52]  S. Yoshida,et al.  Determination of Biologically Active Substances in Roasted Coffees Using a Diode-Array HPLC System , 2004, Analytical sciences : the international journal of the Japan Society for Analytical Chemistry.

[53]  To whom correspondence should be addressed; , 2022 .

[54]  C. R. Soccol,et al.  Packed Bed Column Fermenter and Kinetic Modeling for Upgrading the Nutritional Quality of Coffee Husk in Solid‐State Fermentation , 2001, Biotechnology progress.

[55]  Ashok Pandey,et al.  Gibberellic acid production by solid-state fermentation in coffee husk , 2002, Applied biochemistry and biotechnology.

[56]  Rita C. Alves,et al.  Benefícios do café na saúde: mito ou realidade? , 2009 .

[57]  P. Lashermes,et al.  Genomics of Coffee One of the World’s Largest Traded Commodities , 2008 .

[58]  R. Bibiloni,et al.  Impact of coffee consumption on the gut microbiota: a human volunteer study. , 2009, International journal of food microbiology.

[59]  Masood Sadiq Butt,et al.  Coffee and its Consumption: Benefits and Risks , 2011, Critical reviews in food science and nutrition.

[60]  M. Clifford,et al.  Coffee: Botany, Biochemistry and Production of Beans and Beverage , 2012 .

[61]  Emille Rocha Bernardino de Almeida Prata,et al.  Fresh coffee husks as potential sources of anthocyanins , 2007 .

[62]  M. Clifford,et al.  Phenols and caffeine in wet-processed coffee beans and coffee pulp , 1991 .

[63]  S. Doulbeau,et al.  Influence of environmental factors, wet processing and their interactions on the biochemical composition of green Arabica coffee beans , 2010 .

[64]  P. Schieberle,et al.  Influence of processing on the generation of γ-aminobutyric acid in green coffee beans , 2005 .

[65]  Abebe Belay,et al.  Measurement of caffeine in coffee beans with UV/vis spectrometer , 2008 .

[66]  A. S. Franca,et al.  Microwave assisted thermal treatment of defective coffee beans press cake for the production of adsorbents. , 2010, Bioresource technology.

[67]  M. Génard,et al.  Fruit thinning and shade improve bean characteristics and beverage quality of coffee (Coffea arabica L.) under optimal conditions , 2006 .

[68]  P. A. Berbert,et al.  PH—Postharvest Technology: Dielectric Properties of Parchment Coffee , 2001 .

[69]  I. Lantz,et al.  Studies on acrylamide levels in roasting, storage and brewing of coffee. , 2006, Molecular nutrition & food research.

[70]  Roberto A. Buffo,et al.  Coffee flavour: an overview , 2004 .

[71]  P. Pittia,et al.  Effect of roasting degree, equivalent thermal effect and coffee type on the radical scavenging activity of coffee brews and their phenolic fraction , 2009 .

[72]  F. Ravera,et al.  Interfacial properties of coffee oils , 2010 .

[73]  I. Saito,et al.  The Blood Pressure-Lowering Effect and Safety of Chlorogenic Acid from Green Coffee Bean Extract in Essential Hypertension , 2006, Clinical and experimental hypertension.

[74]  R. Boulanger,et al.  Impact of “ecological” post-harvest processing on the volatile fraction of coffee beans: I. Green coffee , 2007 .

[75]  G. Sulochanamma,et al.  Studies on extraction and antioxidant potential of green coffee , 2008 .

[76]  Alan Crozier,et al.  On-line HPLC analysis of the antioxidant activity of phenolic compounds in brewed, paper-filtered coffee , 2006 .

[77]  M. Labuschagne,et al.  Genetic diversity and correlation of bean caffeine content with cup quality and green bean physical characteristics in coffee (Coffea arabica L.) , 2008 .

[78]  M. Daglia,et al.  Isolation, identification, and quantification of roasted coffee antibacterial compounds. , 2007, Journal of agricultural and food chemistry.

[79]  K. Ramalakshmi,et al.  A Perception on Health Benefits of Coffee , 2008, Critical reviews in food science and nutrition.

[80]  Leandro S. Oliveira,et al.  Evaluation of untreated coffee husks as potential biosorbents for treatment of dye contaminated waters. , 2008, Journal of hazardous materials.

[81]  C. Guillou,et al.  Liquid chromatography coupled with ultraviolet absorbance detection, electrospray ionization, collision-induced dissociation and tandem mass spectrometry on a triple quadrupole for the on-line characterization of polyphenols and methylxanthines in green coffee beans. , 2009, Rapid communications in mass spectrometry : RCM.

[82]  Adriana Farah,et al.  Phenolic compounds in coffee , 2006 .

[83]  A. Farah,et al.  Chlorogenic acids and other relevant compounds in Brazilian coffees processed by semi-dry and wet post-harvesting methods , 2010 .

[84]  M. Murkovic,et al.  Determination of acrylamide during roasting of coffee. , 2008, Journal of agricultural and food chemistry.

[85]  E. A. Huisman,et al.  Effect of different chemical treatments on nutritional and antinutritional properties of coffee pulp , 2002 .

[86]  M. Daglia,et al.  Antiadhesive effect of green and roasted coffee on Streptococcus mutans' adhesive properties on saliva-coated hydroxyapatite beads. , 2002, Journal of agricultural and food chemistry.

[87]  J. Rufián‐Henares,et al.  Functional properties of melanoidins: In vitro antioxidant, antimicrobial and antihypertensive activities , 2007 .

[88]  Christopher Doctor Coffee–Functional Food and Medicinal Herb , 2006 .

[89]  E. Thom The Effect of Chlorogenic Acid Enriched Coffee on Glucose Absorption in Healthy Volunteers and Its Effect on Body Mass When Used Long-term in Overweight and Obese People , 2007, The Journal of international medical research.

[90]  J. Brillouet,et al.  Polysaccharide Constituents of Coffee‐Bean Mucilage , 2000 .

[91]  Károly Héberger,et al.  Botanical and geographical characterization of green coffee (Coffea arabica and Coffea canephora): chemometric evaluation of phenolic and methylxanthine contents. , 2009, Journal of agricultural and food chemistry.

[92]  M. Ichinose,et al.  Antiviral activities of coffee extracts in vitro. , 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[93]  F. Saura-calixto,et al.  Conceptual study on maillardized dietary fiber in coffee. , 2010, Journal of agricultural and food chemistry.

[94]  S. Guyot,et al.  Characterization and estimation of proanthocyanidins and other phenolics in coffee pulp (Coffea arabica) by thiolysis-high-performance liquid chromatography. , 2004, Journal of agricultural and food chemistry.

[95]  H. Kaur,et al.  Antibacterial Activity of Tea and Coffee: Their Extracts and Preparations , 2009 .

[96]  Yukiko Koshiro,et al.  Changes in content and biosynthetic activity of caffeine and trigonelline during growth and ripening of Coffea arabica and Coffea canephora fruits , 2006 .

[97]  R. Souza Plant-Parasitic Nematodes of Coffee , 2008 .

[98]  K. Speer,et al.  The lipid fraction of the coffee bean , 2006 .

[99]  P. Mazzafera,et al.  Caffeine content variation in single green Arabica coffee seeds , 2010, Seed Science Research.

[100]  Liliana Jiménez,et al.  Polyphenols: food sources and bioavailability. , 2004, The American journal of clinical nutrition.

[101]  A. Nkondjock Coffee consumption and the risk of cancer: an overview. , 2009, Cancer letters.

[102]  H. Vieira Coffee: The Plant and its Cultivation , 2008 .

[103]  M. Gordon,et al.  Effect of roasting on the antioxidant activity of coffee brews. , 2002, Journal of agricultural and food chemistry.

[104]  M. Benassi,et al.  Antioxidant activity, polyphenols, caffeine and melanoidins in soluble coffee: The influence of processing conditions and raw material , 2011 .

[105]  P. Moore,et al.  Genomics of Tropical Crop Plants , 2008 .

[106]  M. Glória,et al.  Changes on the levels of serotonin precursors – tryptophan and 5-hydroxytryptophan – during roasting of Arabica and Robusta coffee , 2010 .

[107]  Chi-Tang Ho,et al.  Polyphenolic chemistry of tea and coffee: a century of progress. , 2009, Journal of agricultural and food chemistry.

[108]  J. Rufián‐Henares,et al.  Antimicrobial activity of coffee melanoidins-a study of their metal-chelating properties. , 2009, Journal of agricultural and food chemistry.

[109]  L. Rao,et al.  An Impression of Coffee Carbohydrates , 2007, Critical reviews in food science and nutrition.

[110]  I. Saito,et al.  Green coffee bean extract and its metabolites have a hypotensive effect in spontaneously hypertensive rats. , 2002, Hypertension research : official journal of the Japanese Society of Hypertension.

[111]  J. Graafland,et al.  Concepts of Price Fairness: Empirical Research into the Dutch Coffee Market , 2009 .

[112]  S. Sisodia,et al.  Coffea arabica: A wonder gift to medical science , 2010 .

[113]  Mitsuru Sugawara,et al.  In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid. , 2011, International journal of pharmaceutics.

[114]  T. Shibamoto,et al.  Role of roasting conditions in the level of chlorogenic acid content in coffee beans: correlation with coffee acidity. , 2009, Journal of agricultural and food chemistry.

[115]  M. Daglia,et al.  Isolation of high molecular weight components and contribution to the protective activity of coffee against lipid peroxidation in a rat liver microsome system. , 2008, Journal of agricultural and food chemistry.

[116]  E. Gonzalez de Mejia,et al.  Caffeine (1, 3, 7-trimethylxanthine) in foods: a comprehensive review on consumption, functionality, safety, and regulatory matters. , 2010, Journal of food science.

[117]  Sheng-Xi Wu,et al.  The multifaceted mechanisms for coffee's anti-tumorigenic effect on liver. , 2008, Medical hypotheses.

[118]  B. Bertrand,et al.  Impact of the Coffea canephora gene introgression on beverage quality of C. arabica , 2003, Theoretical and Applied Genetics.

[119]  R. M. Filho,et al.  Rate-Based Modeling Approach and Simulation for Molecular Distillation of Green Coffee Oil , 2010 .

[120]  M. Arias,et al.  Biotechnological enhancement of coffee pulp residues by solid-state fermentation with Streptomyces. Py–GC/MS analysis , 2008 .

[121]  Mano Misra,et al.  Spent coffee grounds as a versatile source of green energy. , 2008, Journal of agricultural and food chemistry.

[122]  Santino Orecchio,et al.  Polycyclic aromatic hydrocarbons (PAHs) in coffee brew samples: analytical method by GC-MS, profile, levels and sources. , 2009, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[123]  S. Lafay,et al.  Chlorogenic acids from green coffee extract are highly bioavailable in humans. , 2008, The Journal of nutrition.

[124]  Cássia Regina Limonta Carvalho,et al.  Sun protection factor, content and composition of lipid fraction of green coffee beans , 2011 .

[125]  J. Heimbach,et al.  Safety studies on products from whole coffee fruit. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[126]  J. M. Araújo,et al.  Extraction of coffee diterpenes and coffee oil using supercritical carbon dioxide , 2007 .

[127]  F. Saura-calixto,et al.  Dietary fiber in brewed coffee. , 2007, Journal of agricultural and food chemistry.

[128]  P. Mazzafera,et al.  Plant biochemistry: A naturally decaffeinated arabica coffee , 2004, Nature.

[129]  Susana Casal,et al.  Isoflavones in coffee: influence of species, roast degree, and brewing method. , 2010, Journal of agricultural and food chemistry.

[130]  G. Smit,et al.  Electron spin resonance (ESR) studies on the formation of roasting-induced antioxidative structures in coffee brews at different degrees of roast. , 2008, Journal of agricultural and food chemistry.

[131]  R. Bressani,et al.  Coffee pulp : composition, technology, and utilization , 1979 .

[132]  Marc Meurens,et al.  Chemical discrimination of arabica and robusta coffees by Fourier transform Raman spectroscopy. , 2005, Journal of agricultural and food chemistry.

[133]  C. Delgado-Andrade,et al.  Unraveling the contribution of melanoidins to the antioxidant activity of coffee brews. , 2005, Journal of agricultural and food chemistry.

[134]  J. Brillouet,et al.  Fate of mucilage cell wall polysaccharides during coffee fermentation. , 2001, Journal of agricultural and food chemistry.

[135]  M. Glória,et al.  Antibacterial activity of coffee extracts and selected coffee chemical compounds against enterobacteria. , 2006, Journal of agricultural and food chemistry.

[136]  Alberto Ritieni,et al.  Characterization of a new potential functional ingredient: coffee silverskin. , 2004, Journal of agricultural and food chemistry.

[137]  M. Gordon,et al.  Peroxyl radical-scavenging activity of coffee brews , 2005 .

[138]  J. Vinson,et al.  Coffee and cardiovascular disease: in vitro, cellular, animal, and human studies. , 2007, Pharmacological research.