Direct Measurement of the Intracellular Concentration of 8-Oxo-2'-Deoxyguanosine-5'-Triphosphate by LC-MS/MS
暂无分享,去创建一个
K. Schwartz | A. Ray | Ting Wang | E. Murakami | A. Kashishian | P. Fan | Michael O. Ports | G. Notte | Julie Far
[1] S. Viatchenko‐Karpinski,et al. Discovery of Potent and Selective MTH1 Inhibitors for Oncology: Enabling Rapid Target (In)Validation. , 2019, ACS medicinal chemistry letters.
[2] E. Kool,et al. The Existence of MTH1-independent 8-oxodGTPase Activity in Cancer Cells as a Compensatory Mechanism against On-target Effects of MTH1 Inhibitors , 2019, Molecular Cancer Therapeutics.
[3] S. Sasaki,et al. Luminescent europium sensors for specific detection of 8-oxo-dGTP by time-gated fluorescence. , 2018, Bioorganic & medicinal chemistry.
[4] (S)-crizotinib induces apoptosis in human non-small cell lung cancer cells by activating ROS independent of MTH1 , 2017, Journal of experimental & clinical cancer research : CR.
[5] Samuel H. Wilson,et al. Oxidized nucleotide insertion by pol β confounds ligation during base excision repair , 2017, Nature Communications.
[6] G. Papeo. MutT Homolog 1 (MTH1): The Silencing of a Target. , 2016, Journal of medicinal chemistry.
[7] Graeme Walker,et al. Potent and Selective Inhibitors of MTH1 Probe Its Role in Cancer Cell Survival. , 2016, Journal of medicinal chemistry.
[8] F. Mseeh,et al. Identification of potent and selective MTH1 inhibitors. , 2005, Bioorganic & medicinal chemistry letters.
[9] T. Helleday,et al. Crystal structure, biochemical and cellular activities demonstrate separate functions of MTH1 and MTH2 , 2015, Nature Communications.
[10] Richard Svensson,et al. MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool , 2014, Nature.
[11] G. Superti-Furga,et al. Stereospecific targeting of MTH1 by (S)-crizotinib as anticancer strategy , 2014, Nature.
[12] Chin Wee Tan,et al. Wnt Signalling Pathway Parameters for Mammalian Cells , 2012, PloS one.
[13] N. Kieffer,et al. Redox control of the survival of healthy and diseased cells. , 2011, Antioxidants & redox signaling.
[14] M. Georgiadis,et al. Redox regulation of DNA repair: implications for human health and cancer therapeutic development. , 2010, Antioxidants & redox signaling.
[15] J. Tyson McDonald,et al. Trace amounts of 8-oxo-dGTP in mitochondrial dNTP pools reduce DNA polymerase γ replication fidelity , 2008, Nucleic acids research.
[16] A. Ray,et al. Simultaneous quantitation of the nucleotide analog adefovir, its phosphorylated anabolites and 2'-deoxyadenosine triphosphate by ion-pairing LC/MS/MS. , 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.
[17] Zucai Suo,et al. Single-turnover kinetic analysis of the mutagenic potential of 8-oxo-7,8-dihydro-2'-deoxyguanosine during gap-filling synthesis catalyzed by human DNA polymerases lambda and beta. , 2007, Journal of molecular biology.
[18] M. Valko,et al. Free radicals, metals and antioxidants in oxidative stress-induced cancer. , 2006, Chemico-biological interactions.
[19] S. Pochet,et al. Probing the substrate recognition mechanism of the human MTH1 protein by nucleotide analogs. , 2004, Journal of molecular biology.
[20] T. Traut,et al. Physiological concentrations of purines and pyrimidines , 1994, Molecular and Cellular Biochemistry.
[21] N. Van Larebeke,et al. Endogenous DNA damage in humans: a review of quantitative data. , 2004, Mutagenesis.
[22] C. Mathews,et al. Assessing the Metabolic Function of the MutT 8-Oxodeoxyguanosine Triphosphatase in Escherichia coli by Nucleotide Pool Analysis* , 2002, The Journal of Biological Chemistry.
[23] R. L. Claire,et al. Positive ion electrospray ionization tandem mass spectrometry coupled to ion-pairing high-performance liquid chromatography with a phosphate buffer for the quantitative analysis of intracellular nucleotides. , 2000, Rapid communications in mass spectrometry : RCM.
[24] Y. Nakabeppu,et al. Metabolic fate of oxidized guanine ribonucleotides in mammalian cells. , 1999, Biochemistry.
[25] Karol Bialkowski,et al. A novel assay of 8-oxo-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase (8-oxo-dGTPase) activity in cultured cells and its use for evaluation of cadmium(II) inhibition of this activity , 1998, Nucleic Acids Res..
[26] J. Cadet,et al. Repair and mutagenic potency of 8-oxoG:A and 8-oxoG:C base pairs in mammalian cells. , 1998, Nucleic acids research.
[27] L. Loeb,et al. Incorporation of the Guanosine Triphosphate Analogs 8-Oxo-dGTP and 8-NH2-dGTP by Reverse Transcriptases and Mammalian DNA Polymerases* , 1997, The Journal of Biological Chemistry.
[28] H. Maki,et al. MutT protein specifically hydrolyses a potent mutagenic substrate for DNA synthesis , 1992, Nature.
[29] L. Loeb,et al. 8-Hydroxyguanine, an abundant form of oxidative DNA damage, causes G----T and A----C substitutions. , 1992, The Journal of biological chemistry.
[30] C. Yanofsky,et al. The unusual mutagenic specificity of an E. Coli mutator gene. , 1966, Proceedings of the National Academy of Sciences of the United States of America.