Alleviation of Sleep Maintenance Insomnia with Timed Exposure to Bright Light

Objective: Half of the population over 65 suffers from chronic sleep disturbance. As a consequence, almost 40% of hypnotic medications are prescribed to people over age 60. Yet, hypnotics are often of little benefit in this population. As such, an effective non‐drug alternative could prove important in the management of age‐related sleep maintenance insomnia. The current study sought to evaluate the efficacy of bright light exposure in the treatment of sleep maintenance insomnia.

[1]  H. Agnew,et al.  Stage 4 Sleep: Influence of Time Course Variables , 1971, Science.

[2]  A. Borbély.  A two process model of sleep regulation. , 1982, Human neurobiology.

[3]  David J. Kupfer,et al.  EEG sleep in elderly depressed, demented, and healthy subjects , 1985, Biological Psychiatry.

[4]  Domien G. M. Beersma,et al.  All night spectral analysis of EEG sleep in young adult and middle-aged male subjects , 1989, Neurobiology of Aging.

[5]  Kripke Df.  Why we need a tax on sleeping pills. , 1983 .

[6]  H. Zepelin,et al.  Age differences in autonomic variables during sleep. , 1987, Journal of gerontology.

[7]  W. B. Webb,et al.  A modified method for scoring slow wave sleep of older subjects. , 1982, Sleep.

[8]  T. Roth,et al.  Daytime sleepiness and daytime wakefulness: the effect of instruction. , 1982, Sleep.

[9]  D. Ingram,et al.  Circadian rhythmicity and sleep: Effects of aging in laboratory animals , 1982, Neurobiology of Aging.

[10]  S. Daan,et al.  Reduction of human sleep duration after bright light exposure in the morning , 1987, Neuroscience Letters.

[11]  T. Åkerstedt,et al.  Body temperature and sleep at different times of day. , 1982, Sleep.

[12]  D. Dawson,et al.  Sleep-onset insomniacs have delayed temperature rhythms. , 1990, Sleep.

[13]  V. R. Carlson,et al.  Sleep Variables as a Function of Age in Man , 1968 .

[14]  D. Dawson,et al.  Aging young sleep: a test of the phase advance hypothesis of sleep disturbance in the elderly , 1992, Journal of sleep research.

[15]  A. Lewy.  Effects of light on human melatonin production and the human circadian system , 1983, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

[16]  T. Åkerstedt,et al.  Sleepiness as a consequence of shift work. , 1988, Sleep.

[17]  J. Edinger,et al.  Treatment of sleep-maintenance insomnia in older adults: sleep period reduction, sleep education, and modified stimulus control. , 1988, Psychology and aging.

[18]  S. Campbell,et al.  Evidence for circadian influence on human slow wave sleep during daytime sleep episodes. , 1989, Psychophysiology.

[19]  E. C. Hammond,et al.  Short and long sleep and sleeping pills. Is increased mortality associated? , 1979, Archives of general psychiatry.

[20]  Daniel F. Kripke,et al.  Natural light exposure of young adults , 1986, Physiology & Behavior.

[21]  J. C. Zimmerman,et al.  Chronobiology of aging: Temperature, sleep-wake rhythms and entrainment , 1982, Neurobiology of Aging.

[22]  A. Winfree,et al.  Biological Rhythms , 1972, Nature.

[23]  D. Greenblatt,et al.  Daytime carryover of triazolam and flurazepam in elderly insomniacs. , 1982, Sleep.

[24]  N. Azrin,et al.  Behavioral and cognitive treatments of geriatric insomnia. , 1988, Journal of consulting and clinical psychology.

[25]  P N Prinz,et al.  Geriatrics: sleep disorders and aging. , 1996, The New England journal of medicine.

[26]  S. Daan,et al.  Timing of human sleep: recovery process gated by a circadian pacemaker. , 1984, The American journal of physiology.

[27]  W. B. Webb.  Sleep in older persons: sleep structures of 50- to 60-year-old men and women. , 1982, Journal of gerontology.

[28]  J. Yesavage,et al.  A preliminary study comparing sleep restriction and relaxation treatments for insomnia in older adults. , 1991, Journal of gerontology.

[29]  M. Thorpy,et al.  Treatment of chronic insomnia by restriction of time in bed. , 1987, Sleep.

[30]  W. B. Webb,et al.  Awakenings and the return to sleep in an older population. , 1980, Sleep.

[31]  I Feinberg,et al.  EEG sleep patterns as a function of normal and pathological aging in man. , 1967, Journal of psychiatric research.

[32]  T. Roth,et al.  Efficacy of a reduced triazolam dose in elderly insomniacs , 1985, Neurobiology of Aging.

[33]  Myrna I. Baker,et al.  The Use of Benzodiazepine Hypnotics in the Elderly , 1988, Pharmacotherapy.

[34]  D Dawson,et al.  Timed exposure to bright light improves sleep and alertness during simulated night shifts. , 1991, Sleep.

[35]  J. Waterhouse,et al.  Adaptation to abrupt time shifts of the oscillator(s) controlling human circadian rhythms. , 1978, The Journal of physiology.

[36]  D. Kupfer,et al.  Effects of age on delta and REM sleep parameters. , 1989, Electroencephalography and clinical neurophysiology.

[37]  Bright light treatment: are we keeping our subjects in the dark? , 1990, Sleep.

[38]  R. Kronauer,et al.  Bright light induction of strong (type 0) resetting of the human circadian pacemaker. , 1989, Science.

[39]  D. Kripke,et al.  Gender differences in the circadian temperature rhythms of healthy elderly subjects: relationships to sleep quality. , 1989, Sleep.

[40]  Scott S. Campbell,et al.  Exposure to light in healthy elderly subjects and alzheimer's patients , 1988, Physiology & Behavior.

[41]  W C Dement,et al.  “White Paper” on Sleep and Aging , 1982, Journal of the American Geriatrics Society.

[42]  C A Czeisler,et al.  Human sleep: its duration and organization depend on its circadian phase. , 1980, Science.

[43]  G. Gottlieb,et al.  Sleep disorders and their management. Special considerations in the elderly. , 1990, The American journal of medicine.

[44]  M. Carskadon,et al.  Sleep fragmentation in the elderly: Relationship to daytime sleep tendency , 1982, Neurobiology of Aging.

[45]  M. Vitiello,et al.  Healthy Elderly Women and Men Have Different Entrained Circadian Temperature Rhythms , 1991, Journal of the American Geriatrics Society.