Route-Dependent Metabolism of Morphine in the Vascularly Perfused Rat Small Intestine Preparation

[1]  K. Pang,et al.  A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism. , 2000, Drug metabolism and disposition: the biological fate of chemicals.

[2]  K. Brouwer,et al.  P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells. , 1999, Biochemical pharmacology.

[3]  T. Baillie,et al.  Is the role of the small intestine in first-pass metabolism overemphasized? , 1999, Pharmacological reviews.

[4]  R. Fontana,et al.  Molecular and physical mechanisms of first-pass extraction. , 1999, Drug metabolism and disposition: the biological fate of chemicals.

[5]  Y Zhang,et al.  Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. , 1998, Journal of pharmaceutical sciences.

[6]  U. Christians,et al.  Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. , 1998, The Journal of pharmacology and experimental therapeutics.

[7]  K. Brouwer,et al.  Effect of GF120918, a Potent P-glycoprotein Inhibitor, on Morphine Pharmacokinetics and Pharmacodynamics in the Rat , 1998, Pharmaceutical Research.

[8]  D. Meijer,et al.  Contribution of the murine mdr1a P‐glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption , 1998, Hepatology.

[9]  D. Shen,et al.  Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. , 1997, The Journal of pharmacology and experimental therapeutics.

[10]  K. Pang,et al.  First-pass effect: significance of the intestine for absorption and metabolism. , 1997, Drug and chemical toxicology.

[11]  Morton B. Brown,et al.  Role of intestinal P‐glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine , 1997, Clinical pharmacology and therapeutics.

[12]  Akira Tsuji,et al.  Carrier-Mediated Intestinal Transport of Drugs , 1996, Pharmaceutical Research.

[13]  D. Shen,et al.  First‐pass metabolism of midazolam by the human intestine , 1996, Clinical pharmacology and therapeutics.

[14]  M Rowland,et al.  Differentiation of absorption and first‐pass gut and hepatic metabolism in humans: Studies with cyclosporine , 1995, Clinical pharmacology and therapeutics.

[15]  P. Borst,et al.  Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. , 1995, The Journal of clinical investigation.

[16]  H. Saitoh,et al.  Possible Involvement of Multiple P-Glycoprotein-Mediated Efflux Systems in the Transport of Verapamil and Other Organic Cations Across Rat Intestine , 1995, Pharmaceutical Research.

[17]  J. Kolars,et al.  Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test. , 1994, Drug metabolism and disposition: the biological fate of chemicals.

[18]  J. Riordan,et al.  Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells. , 1993, The Journal of biological chemistry.

[19]  E. Calabrese,et al.  Extent and implications of interspecies differences in the intestinal hydrolysis of certain glucuronide conjugates. , 1993, Xenobiotica; the fate of foreign compounds in biological systems.

[20]  B. Lacarelle,et al.  3'-azido-3'-deoxythymidine drug interactions. Screening for inhibitors in human liver microsomes. , 1992, Drug metabolism and disposition: the biological fate of chemicals.

[21]  H. Hirayama,et al.  Viability of the vascularly perfused, recirculating rat intestine and intestine-liver preparations. , 1989, The American journal of physiology.

[22]  P. Watkins,et al.  Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. , 1989, The Journal of clinical investigation.

[23]  R. Dubey,et al.  Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--II. Conjugases. , 1988, Biochemical pharmacology.

[24]  P. Watkins,et al.  Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. , 1987, The Journal of clinical investigation.

[25]  J. Houston,et al.  Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine. , 1987, Drug metabolism and disposition: the biological fate of chemicals.

[26]  K S Pang,et al.  Disposition of enalapril in the perfused rat intestine-liver preparation: absorption, metabolism and first-pass effect. , 1985, The Journal of pharmacology and experimental therapeutics.

[27]  J. Noordhoek,et al.  Glucuronidation of morphine and six beta 2-sympathomimetics in isolated rat intestinal epithelial cells. , 1985, Drug metabolism and disposition: the biological fate of chemicals.

[28]  J. Noordhoek,et al.  Glucuronidation in isolated perfused rat intestinal segments after mucosal and serosal administration of 1-naphthol. , 1983, The Journal of pharmacology and experimental therapeutics.

[29]  A. Rane,et al.  Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography. , 1982, Journal of chromatography.

[30]  T. Tsuruo,et al.  Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. , 1981, Cancer research.

[31]  M. Gibaldi,et al.  Physiologically based pharmacokinetic model for digoxin distribution and elimination in the rat. , 1977, Journal of pharmaceutical sciences.

[32]  C. T. Walsh,et al.  Studies of the enterohepatic circulation of morphine in the rat. , 1975, The Journal of pharmacology and experimental therapeutics.

[33]  T. Tephly,et al.  Morphine metabolism. II. Studies on morphine glucuronyltransferase activity in intestinal microsomes of rats. , 1974, Drug metabolism and disposition: the biological fate of chemicals.

[34]  S. Brunk,et al.  Morphine metabolism in man , 1974 .

[35]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[36]  R. Remmel,et al.  First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme. , 1999, Drug metabolism and disposition: the biological fate of chemicals.

[37]  R. Kawai PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING OF CYCLOSPORINE DERIVATIVES IV , 1994 .

[38]  R. Minchin,et al.  Metabolism of drugs and other xenobiotics in the gut lumen and wall. , 1990, Pharmacology & therapeutics.

[39]  G. Mulder,et al.  Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation. , 1986, Drug metabolism and disposition: the biological fate of chemicals.