Route-Dependent Metabolism of Morphine in the Vascularly Perfused Rat Small Intestine Preparation
暂无分享,去创建一个
[1] K. Pang,et al. A new physiologically based, segregated-flow model to explain route-dependent intestinal metabolism. , 2000, Drug metabolism and disposition: the biological fate of chemicals.
[2] K. Brouwer,et al. P-glycoprotein-mediated transport of morphine in brain capillary endothelial cells. , 1999, Biochemical pharmacology.
[3] T. Baillie,et al. Is the role of the small intestine in first-pass metabolism overemphasized? , 1999, Pharmacological reviews.
[4] R. Fontana,et al. Molecular and physical mechanisms of first-pass extraction. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[5] Y Zhang,et al. Role of P-glycoprotein and cytochrome P450 3A in limiting oral absorption of peptides and peptidomimetics. , 1998, Journal of pharmaceutical sciences.
[6] U. Christians,et al. Metabolism and transport of the macrolide immunosuppressant sirolimus in the small intestine. , 1998, The Journal of pharmacology and experimental therapeutics.
[7] K. Brouwer,et al. Effect of GF120918, a Potent P-glycoprotein Inhibitor, on Morphine Pharmacokinetics and Pharmacodynamics in the Rat , 1998, Pharmaceutical Research.
[8] D. Meijer,et al. Contribution of the murine mdr1a P‐glycoprotein to hepatobiliary and intestinal elimination of cationic drugs as measured in mice with an mdr1a gene disruption , 1998, Hepatology.
[9] D. Shen,et al. Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism. , 1997, The Journal of pharmacology and experimental therapeutics.
[10] K. Pang,et al. First-pass effect: significance of the intestine for absorption and metabolism. , 1997, Drug and chemical toxicology.
[11] Morton B. Brown,et al. Role of intestinal P‐glycoprotein (mdr1) in interpatient variation in the oral bioavailability of cyclosporine , 1997, Clinical pharmacology and therapeutics.
[12] Akira Tsuji,et al. Carrier-Mediated Intestinal Transport of Drugs , 1996, Pharmaceutical Research.
[13] D. Shen,et al. First‐pass metabolism of midazolam by the human intestine , 1996, Clinical pharmacology and therapeutics.
[14] M Rowland,et al. Differentiation of absorption and first‐pass gut and hepatic metabolism in humans: Studies with cyclosporine , 1995, Clinical pharmacology and therapeutics.
[15] P. Borst,et al. Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A. , 1995, The Journal of clinical investigation.
[16] H. Saitoh,et al. Possible Involvement of Multiple P-Glycoprotein-Mediated Efflux Systems in the Transport of Verapamil and Other Organic Cations Across Rat Intestine , 1995, Pharmaceutical Research.
[17] J. Kolars,et al. Interpatient heterogeneity in expression of CYP3A4 and CYP3A5 in small bowel. Lack of prediction by the erythromycin breath test. , 1994, Drug metabolism and disposition: the biological fate of chemicals.
[18] J. Riordan,et al. Synthetic and natural opiates interact with P-glycoprotein in multidrug-resistant cells. , 1993, The Journal of biological chemistry.
[19] E. Calabrese,et al. Extent and implications of interspecies differences in the intestinal hydrolysis of certain glucuronide conjugates. , 1993, Xenobiotica; the fate of foreign compounds in biological systems.
[20] B. Lacarelle,et al. 3'-azido-3'-deoxythymidine drug interactions. Screening for inhibitors in human liver microsomes. , 1992, Drug metabolism and disposition: the biological fate of chemicals.
[21] H. Hirayama,et al. Viability of the vascularly perfused, recirculating rat intestine and intestine-liver preparations. , 1989, The American journal of physiology.
[22] P. Watkins,et al. Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients. , 1989, The Journal of clinical investigation.
[23] R. Dubey,et al. Localization and characterization of drug-metabolizing enzymes along the villus-crypt surface of the rat small intestine--II. Conjugases. , 1988, Biochemical pharmacology.
[24] P. Watkins,et al. Identification of glucocorticoid-inducible cytochromes P-450 in the intestinal mucosa of rats and man. , 1987, The Journal of clinical investigation.
[25] J. Houston,et al. Glucuronidation in vitro and in vivo. Comparison of intestinal and hepatic conjugation of morphine, naloxone, and buprenorphine. , 1987, Drug metabolism and disposition: the biological fate of chemicals.
[26] K S Pang,et al. Disposition of enalapril in the perfused rat intestine-liver preparation: absorption, metabolism and first-pass effect. , 1985, The Journal of pharmacology and experimental therapeutics.
[27] J. Noordhoek,et al. Glucuronidation of morphine and six beta 2-sympathomimetics in isolated rat intestinal epithelial cells. , 1985, Drug metabolism and disposition: the biological fate of chemicals.
[28] J. Noordhoek,et al. Glucuronidation in isolated perfused rat intestinal segments after mucosal and serosal administration of 1-naphthol. , 1983, The Journal of pharmacology and experimental therapeutics.
[29] A. Rane,et al. Determination of morphine, morphine-3-glucuronide and (tentatively) morphine-6-glucuronide in plasma and urine using ion-pair high-performance liquid chromatography. , 1982, Journal of chromatography.
[30] T. Tsuruo,et al. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity of vincristine and vinblastine by verapamil. , 1981, Cancer research.
[31] M. Gibaldi,et al. Physiologically based pharmacokinetic model for digoxin distribution and elimination in the rat. , 1977, Journal of pharmaceutical sciences.
[32] C. T. Walsh,et al. Studies of the enterohepatic circulation of morphine in the rat. , 1975, The Journal of pharmacology and experimental therapeutics.
[33] T. Tephly,et al. Morphine metabolism. II. Studies on morphine glucuronyltransferase activity in intestinal microsomes of rats. , 1974, Drug metabolism and disposition: the biological fate of chemicals.
[34] S. Brunk,et al. Morphine metabolism in man , 1974 .
[35] Oliver H. Lowry,et al. Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.
[36] R. Remmel,et al. First-pass disposition of (-)-6-aminocarbovir in rats. I. Prodrug activation may be limited by access to enzyme. , 1999, Drug metabolism and disposition: the biological fate of chemicals.
[37] R. Kawai. PHYSIOLOGICALLY-BASED PHARMACOKINETIC MODELING OF CYCLOSPORINE DERIVATIVES IV , 1994 .
[38] R. Minchin,et al. Metabolism of drugs and other xenobiotics in the gut lumen and wall. , 1990, Pharmacology & therapeutics.
[39] G. Mulder,et al. Absorption and metabolism of acetaminophen by the in situ perfused rat small intestine preparation. , 1986, Drug metabolism and disposition: the biological fate of chemicals.