Combination of chemocatalysis and biocatalysis in flow

With increased efforts towards enzyme engineering and chemo-catalysis in milder conditions, the combination of chemo- and bio-catalysis has seen a significant rise in interest. Continuous flow methods have also provided advantages to many catalytic processes, which have been increasingly explored by both academics and industry. This review highlights the different approaches for the combination of chemo- and bio-catalysis in continuous flow, together with the main advantages and challenges facing the development of this relatively new research area.

[1]  Steven V. Ley,et al.  An Orthogonal Biocatalytic Approach for the Safe Generation and Use of HCN in a Multistep Continuous Preparation of Chiral O-Acetylcyanohydrins , 2015, Synlett.

[2]  J. G. Vries,et al.  Why Does Industry Not Use Immobilized Transition Metal Complexes as Catalysts , 2016 .

[3]  D. Vos,et al.  Heterogeneous vanadium catalysts for racemization and chemoenzymatic dynamic kinetic resolution of benzylic alcohols , 2007 .

[4]  Florian Rudroff,et al.  Opportunities and challenges for combining chemo- and biocatalysis , 2018, Nature Catalysis.

[5]  Jurriaan Huskens,et al.  Supported Catalysis in Continuous-Flow Microreactors , 2015 .

[6]  L. Poppe,et al.  Chemoenzymatic Dynamic Kinetic Resolution of Amines in Fully Continuous-Flow Mode. , 2018, Organic letters.

[7]  Nikil Kapur,et al.  Simple and Versatile Laboratory Scale CSTR for Multiphasic Continuous-Flow Chemistry and Long Residence Times , 2017 .

[8]  S. Ley,et al.  Rapid, selective and stable HaloTag- Lb ADH immobilization directly from crude cell extract for the continuous biocatalytic production of chiral alcohols and epoxides , 2018 .

[9]  Joerg H. Schrittwieser,et al.  Artificial Biocatalytic Linear Cascades for Preparation of Organic Molecules. , 2018, Chemical reviews.

[10]  Diána Weiser,et al.  A Continuous‐Flow Cascade Reactor System for Subtilisin A‐ Catalyzed Dynamic Kinetic Resolution of N‐tert‐Butyloxycarbonylphenylalanine Ethyl Thioester with Benzylamine , 2016 .

[11]  E. García‐Verdugo,et al.  Dimethyl carbonate as a non-innocent benign solvent for the multistep continuous flow synthesis of amino alcohols , 2018 .

[12]  R. Kourist,et al.  A chemo-enzymatic tandem reaction in a mixture of deep eutectic solvent and water in continuous flow , 2020, Reaction Chemistry & Engineering.

[13]  Raquel A. C. Leão,et al.  Continuous flow dynamic kinetic resolution of rac-1-phenylethanol using a single packed-bed containing immobilized CAL-B lipase and VOSO4 as racemization catalysts , 2017 .

[14]  M. Farah,et al.  Selective amine cross-coupling using iridium-catalyzed "borrowing hydrogen" methodology. , 2009, Angewandte Chemie.

[15]  J. V. van Hest,et al.  Chemoenzymatic flow cascade for the synthesis of protected mandelonitrile derivatives. , 2015, Organic & biomolecular chemistry.

[16]  Joshua Britton,et al.  Continuous flow biocatalysis. , 2018, Chemical Society reviews.