Abnormalities at 14q32.1 in T cell malignancies involve two oncogenes.

The TCL1 oncogene on human chromosome 14q32.1 is involved in the development of T cell leukemia in humans. Its expression in these leukemias is activated by chromosomal translocations and inversions at 14q32.1. Here we report the isolation and characterization of a new member of the TCL1 gene family, TCL1b, located approximately 16 kb centromeric of TCL1. The 1.2-kb TCL1b cDNA encodes a 14-kDa protein of 128 aa and shows 60% similarity to Tcl1. Expression profiles of TCL1 and TCL1b genes are very similar: both genes are expressed at very low levels in normal bone marrow and peripheral lymphocytes but are activated in T cell leukemia by rearrangements of the 14q32.1 region. Thus, translocations and inversions at 14q32. 1 in T cell malignancies involve two oncogenes.

[1]  J. Seigneurin,et al.  Characteristics of Epstein-Barr virus transformed B cell lines from patients with Alzheimer's disease and age-matched controls , 1992, Mechanisms of Ageing and Development.

[2]  M. Isobe,et al.  Chromosome walking on the TCL1 locus involved in T-cell neoplasia. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[3]  M. Isobe,et al.  Identification of the TCL1 gene involved in T-cell malignancies. , 1994, Proceedings of the National Academy of Sciences of the United States of America.

[4]  F. Sigaux,et al.  The MTCP-1/c6.1B gene encodes for a cytoplasmic 8 kD protein overexpressed in T cell leukemia bearing a t(X;14) translocation. , 1994, Oncogene.

[5]  G. Russo,et al.  TCL1 is overexpressed in patients affected by adult T-cell leukemias. , 1997, Cancer research.

[6]  F. Sigaux,et al.  Transgenic mice for MTCP1 develop T-cell prolymphocytic leukemia. , 1998, Blood.

[7]  Y. Pekarsky,et al.  Nitrilase and Fhit homologs are encoded as fusion proteins in Drosophila melanogaster and Caenorhabditis elegans. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[8]  Masao Seto,et al.  Expression of the TCL1 Gene at 14q32 in B‐Cell Malignancies but Not in Adult T‐Cell Leukemia , 1998, Japanese journal of cancer research : Gann.

[9]  Y. Pekarsky,et al.  The murine Fhit locus: isolation, characterization, and expression in normal and tumor cells. , 1998, Cancer research.

[10]  C. Croce,et al.  Crystal structure of MTCP-1: implications for role of TCL-1 and MTCP-1 in T cell malignancies. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[11]  G. Russo,et al.  Deregulated expression of TCL1 causes T cell leukemia in mice. , 1998, Proceedings of the National Academy of Sciences of the United States of America.

[12]  M. Isobe,et al.  Amplification of the TCL1 flanking region at 14q32.1 with no TCL1 gene transcription in a patient with peripheral T cell lymphoma , 1998, Leukemia.