Brca1 is expressed in human microglia and is dysregulated in human and animal model of ALS

[1]  K. Savage,et al.  BRCA1, a ‘complex’ protein involved in the maintenance of genomic stability , 2015, The FEBS journal.

[2]  Y. Kitagishi,et al.  BRCA1 and p53 Tumor Suppressor Molecules in Alzheimer’s Disease , 2015, International journal of molecular sciences.

[3]  G. Rouleau,et al.  Dissection of genetic factors associated with amyotrophic lateral sclerosis , 2014, Experimental Neurology.

[4]  D. Brites,et al.  Microglia centered pathogenesis in ALS: insights in cell interconnectivity , 2014, Front. Cell. Neurosci..

[5]  G. Tell,et al.  A short review on the implications of base excision repair pathway for neurons: relevance to neurodegenerative diseases. , 2014, Mitochondrion.

[6]  F. Gage,et al.  Role of BRCA1 in brain development , 2014, Proceedings of the National Academy of Sciences.

[7]  Da Li,et al.  BRCA1 regulates insulin-like growth factor 1 receptor levels in ovarian cancer , 2014, Oncology letters.

[8]  Toshiro K. Ohsumi,et al.  The Microglial Sensome Revealed by Direct RNA Sequencing , 2013, Nature Neuroscience.

[9]  J. Watters,et al.  Microglia express distinct M1 and M2 phenotypic markers in the postnatal and adult central nervous system in male and female mice , 2013, Journal of neuroscience research.

[10]  R. Myers,et al.  A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. , 2013, Cell reports.

[11]  G. R. Van de Walle,et al.  The role of BRCA1 in DNA double-strand repair: past and present. , 2013, Experimental cell research.

[12]  H. Werner,et al.  IGF-1 and BRCA1 signalling pathways in familial cancer. , 2012, The Lancet. Oncology.

[13]  J. Hugnot,et al.  Unlike Physical Exercise, Modified Environment Increases the Lifespan of SOD1G93A Mice However Both Conditions Induce Cellular Changes , 2012, PloS one.

[14]  S. Appel,et al.  Transformation from a neuroprotective to a neurotoxic microglial phenotype in a mouse model of ALS , 2012, Experimental Neurology.

[15]  Mutsuko Ouchi,et al.  Deregulation of BRCA1 Leads to Impaired Spatiotemporal Dynamics of γ-H2AX and DNA Damage Responses in Huntington’s Disease , 2012, Molecular Neurobiology.

[16]  M. Vivanco,et al.  Early Functional Deficit and Microglial Disturbances in a Mouse Model of Amyotrophic Lateral Sclerosis , 2012, PloS one.

[17]  F. Coppedè.  An Overview of DNA Repair in Amyotrophic Lateral Sclerosis , 2011, TheScientificWorldJournal.

[18]  S. Appel,et al.  Neuroinflammation modulates distinct regional and temporal clinical responses in ALS mice , 2011, Brain, Behavior, and Immunity.

[19]  S. David,et al.  Repertoire of microglial and macrophage responses after spinal cord injury , 2011, Nature Reviews Neuroscience.

[20]  J. Lasiene,et al.  Glial Cells in Amyotrophic Lateral Sclerosis , 2011, Neurology research international.

[21]  Jose Julio Rodriguez,et al.  Serotonin fibre sprouting and increase in serotonin transporter immunoreactivity in the CA1 area of hippocampus in a triple transgenic mouse model of Alzheimer’s disease , 2010, The European journal of neuroscience.

[22]  D. Cleveland,et al.  Non–cell autonomous toxicity in neurodegenerative disorders: ALS and beyond , 2009, The Journal of cell biology.

[23]  Weihua Zhao,et al.  Microglia in ALS: The Good, The Bad, and The Resting , 2009, Journal of Neuroimmune Pharmacology.

[24]  W. Huttner,et al.  Brca1 is required for embryonic development of the mouse cerebral cortex to normal size by preventing apoptosis of early neural progenitors , 2009, Development.

[25]  A. Michelucci,et al.  Characterization of the microglial phenotype under specific pro-inflammatory and anti-inflammatory conditions: Effects of oligomeric and fibrillar amyloid-β , 2009, Journal of Neuroimmunology.

[26]  E. Thiel,et al.  Prediction of qualitative outcome of oligonucleotide microarray hybridization by measurement of RNA integrity using the 2100 Bioanalyzer™ capillary electrophoresis system , 2009, Annals of Hematology.

[27]  I. Ellis,et al.  Expression of BRCA1 protein in breast cancer and its prognostic significance. , 2008, Human pathology.

[28]  J. Fletcher,et al.  The Impact of BRCA1 on Spina Bifida Meningomyelocele Lesions , 2007, Annals of human genetics.

[29]  Hyoung-Gon Lee,et al.  BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease , 2007, International journal of medical sciences.

[30]  F. Viader,et al.  Breast cancer and motor neuron disease: Clinical study of seven cases , 2007, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

[31]  F. Perrin,et al.  Cell death pathways differ in several mouse models with motoneurone disease: analysis of pure motoneurone populations at a presymptomatic age , 2006, Journal of neurochemistry.

[32]  M. Docquier,et al.  No widespread induction of cell death genes occurs in pure motoneurons in an amyotrophic lateral sclerosis mouse model. , 2005, Human molecular genetics.

[33]  E. Rosen,et al.  BRCA1 Induces Antioxidant Gene Expression and Resistance to Oxidative Stress , 2004, Cancer Research.

[34]  I. Rojas-Marcos,et al.  Spectrum of Paraneoplastic Neurologic Disorders in Women with Breast and Gynecologic Cancer , 2003, Medicine.

[35]  K. Somasundaram.  Breast cancer gene 1 (BRCA1): Role in cell cycle regulation and DNA repair—perhaps through transcription , 2003, Journal of cellular biochemistry.

[36]  D. Lindholm,et al.  Tumor suppressor gene BRCA‐1 is expressed by embryonic and adult neural stem cells and involved in cell proliferation , 2003, Journal of neuroscience research.

[37]  Wei-Min Liu,et al.  Analysis of high density expression microarrays with signed-rank call algorithms , 2002, Bioinform..

[38]  Wei-Min Liu,et al.  Robust estimators for expression analysis , 2002, Bioinform..

[39]  P. De Camilli,et al.  Autoimmunity to βIV spectrin in paraneoplastic lower motor neuron syndrome , 2001, Proceedings of the National Academy of Sciences of the United States of America.

[40]  M. D. De Latour,et al.  Brca1 and Brca2 protein expression patterns in different tissues of murine origin. , 2001, International journal of oncology.

[41]  D. Forman,et al.  A reversible cause of hypercapnic respiratory failure: lower motor neuronopathy associated with renal cell carcinoma. , 1999, Chest.

[42]  M. Rosenblum,et al.  Motor neuron syndromes in cancer patients , 1997, Annals of neurology.

[43]  B. Koller,et al.  Brca1 deficiency results in early embryonic lethality characterized by neuroepithelial abnormalities , 1996, Nature Genetics.

[44]  M. Gurney,et al.  Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation. , 1994, Science.

[45]  S. Oh,et al.  Paraneoplastic motor neuron disease and renal cell carcinoma , 1990, Neurology.

[46]  A. Chiò,et al.  Motor neuron disease and malignancies: results of a population-based study , 1988, Journal of Neurology.

[47]  L. Brain,et al.  Motor neurone disease as a manifestation of neoplasm (with a note on the course of classical motor neurone disease). , 1965, Brain : a journal of neurology.

[48]  G. Poli,et al.  Tumor suppressor genes and ROS: complex networks of interactions. , 2012, Free radical biology & medicine.