Mitochondria as biological targets for stem cell and organismal senescence.

[1]  A. Branco,et al.  Leucine and Arginine Availability Modulate Mouse Embryonic Stem Cell Proliferation and Metabolism , 2022, International journal of molecular sciences.

[2]  Wei Liu,et al.  Multi-omics analysis of an in vitro photoaging model and protective effect of umbilical cord mesenchymal stem cell-conditioned medium , 2022, Stem cell research & therapy.

[3]  Hongqin Zhang,et al.  hUCMSCs reduce theca interstitial cells apoptosis and restore ovarian function in premature ovarian insufficiency rats through regulating NR4A1-mediated mitochondrial mechanisms , 2022, Reproductive Biology and Endocrinology.

[4]  X. Cheng,et al.  Human umbilical cord-derived mesenchymal stromal cells ameliorate aging-associated skeletal muscle atrophy and dysfunction by modulating apoptosis and mitochondrial damage in SAMP10 mice , 2022, Stem Cell Research & Therapy.

[5]  Lisha Li,et al.  RNA sequencing profiles reveal dynamic signaling and glucose metabolic features during bone marrow mesenchymal stem cell senescence , 2022, Cell & bioscience.

[6]  Xiaona Wang,et al.  Menstrual blood-derived stem cells and its mitochondrial treatment improve the ovarian condition of aged mice , 2022, Aging.

[7]  Rui Guo,et al.  Treatment of Pelvic Organ Prolapse by the Downregulation of the Expression of Mitofusin 2 in Uterosacral Ligament Tissue via Mesenchymal Stem Cells , 2022, Genes.

[8]  A. Branco,et al.  Differential Oxygen Exposure Modulates Mesenchymal Stem Cell Metabolism and Proliferation through mTOR Signaling , 2022, International journal of molecular sciences.

[9]  J. Sweedler,et al.  Development of a cell‐free strategy to recover aged skeletal muscle after disuse , 2022, The Journal of physiology.

[10]  Guangju Ji,et al.  Mesenchymal stem cells alleviate aging in vitro and in vivo , 2022, Annals of translational medicine.

[11]  Kezhen Li,et al.  A comparative study of Mesenchymal Stem Cells transplantation approach to antagonize age-associated ovarian hypofunction with consideration of safety and efficiency , 2021, Journal of advanced research.

[12]  Sónia Sá Santos,et al.  The Mitochondrial Antioxidant Sirtuin3 Cooperates with Lipid Metabolism to Safeguard Neurogenesis in Aging and Depression , 2021, Cells.

[13]  T. Evans,et al.  Sirt1 promotes tissue regeneration in zebrafish through regulating the mitochondrial unfolded protein response , 2021, iScience.

[14]  K. Man,et al.  Automated Optical Tweezers Manipulation to Transfer Mitochondria from Fetal to Adult MSCs to Improve Antiaging Gene Expressions. , 2021, Small.

[15]  Xingyu Gao,et al.  Analysis of Age-Related Circular RNA Expression Profiles in Mesenchymal Stem Cells of Rat Bone Marrow , 2021, Frontiers in Genetics.

[16]  Quanguang Zhang,et al.  Photobiomodulation has rejuvenating effects on aged bone marrow mesenchymal stem cells , 2021, Scientific Reports.

[17]  Liu Cao,et al.  Adipose‐derived stem cells regulate metabolic homeostasis and delay aging by promoting mitophagy , 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[18]  Xingyu Gao,et al.  MiR-34a suppression targets Nampt to ameliorate bone marrow mesenchymal stem cell senescence by regulating NAD+-Sirt1 pathway , 2021, Stem cell research & therapy.

[19]  M. Kaeberlein,et al.  An energetics perspective on geroscience: mitochondrial protonmotive force and aging , 2021, GeroScience.

[20]  A. Rizvanov,et al.  Mitochondria Donation by Mesenchymal Stem Cells: Current Understanding and Mitochondria Transplantation Strategies , 2021, Frontiers in Cell and Developmental Biology.

[21]  Young Shin Kim,et al.  The mitochondrial-derived peptide MOTS-c promotes homeostasis in aged human placenta-derived mesenchymal stem cells in vitro. , 2021, Mitochondrion.

[22]  Minjian Kong,et al.  SRT1720 Pretreatment Promotes Mitochondrial Biogenesis of Aged Human Mesenchymal Stem Cells and Improves Their Engraftment in Post-infarct Non-Human Primate Hearts. , 2021, Stem cells and development.

[23]  F. Chen,et al.  Human amnion-derived mesenchymal stem cells improved the reproductive function of age-related diminished ovarian reserve in mice through Ampk/FoxO3a signaling pathway , 2021, Stem Cell Research & Therapy.

[24]  Apekshya Panda,et al.  MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations , 2020, Nucleic Acids Res..

[25]  T. Almeida-Santos,et al.  Does supplementation with mitochondria improve oocyte competence? A systematic review. , 2020, Reproduction.

[26]  Ying-ai Shi,et al.  Sirt3 Attenuates Oxidative Stress Damage and Rescues Cellular Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Superoxide Dismutase 2 , 2020, Frontiers in Cell and Developmental Biology.

[27]  Y. Wan,et al.  The mitochondria regulation of stem cell aging , 2020, Mechanisms of Ageing and Development.

[28]  Xiaolong Liu,et al.  Mesenchymal stromal cell therapies: immunomodulatory properties and clinical progress , 2020, Stem Cell Research & Therapy.

[29]  W. Kuo,et al.  Epigallocatechin-3-gallate preconditioned Adipose-derived Stem Cells confer Neuroprotection in aging rat brain , 2020, International journal of medical sciences.

[30]  Chi-Hung Lin,et al.  Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss , 2020, Aging cell.

[31]  H. Ghanbarian,et al.  Inhibition of miR-34a reduces cellular senescence in human adipose tissue-derived mesenchymal stem cells through the activation of SIRT1. , 2020, Life sciences.

[32]  T. Tong,et al.  Sirtuins and their Biological Relevance in Aging and Age-Related Diseases , 2020, Aging and disease.

[33]  Xuliang Deng,et al.  Mitochondria transfer enhances proliferation, migration, and osteogenic differentiation of bone marrow mesenchymal stem cell and promotes bone defect healing , 2020, Stem Cell Research & Therapy.

[34]  Zhongmin Liu,et al.  Senescence in Mesenchymal Stem Cells: Functional Alterations, Molecular Mechanisms, and Rejuvenation Strategies , 2020, Frontiers in Cell and Developmental Biology.

[35]  Lu Sun,et al.  SIRT3 Transfection of Aged Human Bone Marrow-derived Mesenchymal Stem Cells Improves Cell Therapy-mediated Myocardial Repair. , 2020, Rejuvenation research.

[36]  T. von Zglinicki,et al.  Senescence in Post-Mitotic Cells: A Driver of Aging? , 2020, Antioxidants & redox signaling.

[37]  C. Jorgensen,et al.  Mesenchymal Stem Cell Derived Extracellular Vesicles in Aging , 2020, Frontiers in Cell and Developmental Biology.

[38]  R. Borzì,et al.  Molecular Mechanisms Contributing to Mesenchymal Stromal Cell Aging , 2020, Biomolecules.

[39]  S. Berger,et al.  Mitochondria-to-nucleus retrograde signaling drives formation of cytoplasmic chromatin and inflammation in senescence , 2020, Genes & development.

[40]  Byung-Chul Lee,et al.  Impact of mesenchymal stem cell senescence on inflammaging , 2020, BMB reports.

[41]  M. Jeschke,et al.  Allogeneic mesenchymal stem cells for treatment of severe burn injury , 2019, Stem Cell Research & Therapy.

[42]  Yanbo Zhang,et al.  Mesenchymal Stem Cells for Regenerative Medicine , 2019, Cells.

[43]  R. Perona,et al.  Downregulation of mTOR Signaling Increases Stem Cell Population Telomere Length during Starvation of Immortal Planarians , 2019, Stem cell reports.

[44]  V. Popov,et al.  Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways , 2019, Front. Genet..

[45]  Farshad Zarei,et al.  Application of Cell Therapy for Anti-Aging Facial Skin. , 2019, Current stem cell research & therapy.

[46]  T. Betsuyaku,et al.  Calorie restriction enhances adult mouse lung stem cells function and reverses several ageing‐induced changes , 2019, Journal of tissue engineering and regenerative medicine.

[47]  Shou‐Tung Chen,et al.  Mitochondrial transplantation regulates antitumour activity, chemoresistance and mitochondrial dynamics in breast cancer , 2019, Journal of experimental & clinical cancer research : CR.

[48]  K. Marycz,et al.  5‐Azacytydine and resveratrol reverse senescence and ageing of adipose stem cells via modulation of mitochondrial dynamics and autophagy , 2018, Journal of cellular and molecular medicine.

[49]  C. Plass,et al.  LaminA/C regulates epigenetic and chromatin architecture changes upon aging of hematopoietic stem cells , 2018, Genome Biology.

[50]  M. Schuliga,et al.  Mitochondrial dysfunction contributes to the senescent phenotype of IPF lung fibroblasts , 2018, Journal of cellular and molecular medicine.

[51]  M. Rojas,et al.  Senescence of bone marrow-derived mesenchymal stem cells from patients with idiopathic pulmonary fibrosis , 2018, Stem Cell Research & Therapy.

[52]  Yongchun Wang,et al.  CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells. , 2018, International journal of molecular medicine.

[53]  R. Donahue,et al.  Effects of Mitochondrial Transplantation on Bioenergetics, Cellular Incorporation, and Functional Recovery after Spinal Cord Injury. , 2018, Journal of neurotrauma.

[54]  A. Hoffman,et al.  Mitochondrial peptides modulate mitochondrial function during cellular senescence , 2018, Aging.

[55]  A. Whitworth,et al.  The NAD+ Precursor Nicotinamide Riboside Rescues Mitochondrial Defects and Neuronal Loss in iPSC and Fly Models of Parkinson's Disease. , 2018, Cell reports.

[56]  Baptiste N. Jaeger,et al.  Mitochondrial Aging Defects Emerge in Directly Reprogrammed Human Neurons due to Their Metabolic Profile. , 2018, Cell reports.

[57]  D. Sinclair,et al.  Therapeutic Potential of NAD-Boosting Molecules: The In Vivo Evidence. , 2018, Cell metabolism.

[58]  M. J. Kim,et al.  Delivery of exogenous mitochondria via centrifugation enhances cellular metabolic function , 2018, Scientific Reports.

[59]  Cole M. Haynes,et al.  The mitochondrial UPR: mechanisms, physiological functions and implications in ageing , 2017, Nature Reviews Molecular Cell Biology.

[60]  Richie Poulton,et al.  Eleven Telomere, Epigenetic Clock, and Biomarker-Composite Quantifications of Biological Aging: Do They Measure the Same Thing? , 2017, American journal of epidemiology.

[61]  William B. Mair,et al.  Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. , 2017, Cell metabolism.

[62]  E. K. Cunningham,et al.  Mesenchymal Stromal Cells Modulate Macrophages in Clinically Relevant Lung Injury Models by Extracellular Vesicle Mitochondrial Transfer , 2017, American journal of respiratory and critical care medicine.

[63]  H. Han,et al.  EphB2 signaling‐mediated Sirt3 expression reduces MSC senescence by maintaining mitochondrial ROS homeostasis , 2017, Free radical biology & medicine.

[64]  A. Heldman,et al.  Allogeneic Mesenchymal Stem Cells Ameliorate Aging Frailty: A Phase II Randomized, Double-Blind, Placebo-Controlled Clinical Trial , 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

[65]  Caroline L. Wilson,et al.  Cellular senescence drives age-dependent hepatic steatosis , 2017, Nature Communications.

[66]  Yulin Li,et al.  Nampt Expression Decreases Age-Related Senescence in Rat Bone Marrow Mesenchymal Stem Cells by Targeting Sirt1 , 2017, PloS one.

[67]  K. Marycz,et al.  The effects of the DNA methyltranfserases inhibitor 5‐Azacitidine on ageing, oxidative stress and DNA methylation of adipose derived stem cells , 2016, Journal of cellular and molecular medicine.

[68]  B. Huppertz,et al.  Magnetomitotransfer: An efficient way for direct mitochondria transfer into cultured human cells , 2016, Scientific Reports.

[69]  Keisuke Ito,et al.  Metabolism and the Control of Cell Fate Decisions and Stem Cell Renewal. , 2016, Annual review of cell and developmental biology.

[70]  R. Aebersold,et al.  NAD+ repletion improves mitochondrial and stem cell function and enhances life span in mice , 2016, Science.

[71]  Ruiyan Zhang,et al.  Bone marrow-derived mesenchymal stem cells rescue injured H9c2 cells via transferring intact mitochondria through tunneling nanotubes in an in vitro simulated ischemia/reperfusion model , 2015, Molecular medicine reports.

[72]  T. Rando,et al.  Stem cells and healthy aging , 2015, Science.

[73]  Bo Yu,et al.  Roles of microRNA-34a targeting SIRT1 in mesenchymal stem cells , 2015, Stem Cell Research & Therapy.

[74]  K. S. Bhullar,et al.  Lifespan and healthspan extension by resveratrol. , 2015, Biochimica et biophysica acta.

[75]  Danica Chen,et al.  A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging , 2015, Science.

[76]  S. Kuo,et al.  Delivering healthy mitochondria for the therapy of mitochondrial diseases and beyond. , 2014, The international journal of biochemistry & cell biology.

[77]  D. Kami,et al.  Internalization of isolated functional mitochondria: involvement of macropinocytosis , 2014, Journal of cellular and molecular medicine.

[78]  Manuel Serrano,et al.  The Hallmarks of Aging , 2013, Cell.

[79]  Robert W. Williams,et al.  Mitonuclear protein imbalance as a conserved longevity mechanism , 2013, Nature.

[80]  D. Rowlands,et al.  Mitochondrial transfer from bone-marrow–derived stromal cells to pulmonary alveoli protects against acute lung injury , 2012, Nature Medicine.

[81]  S. Gygi,et al.  Succinate Dehydrogenase Is a Direct Target of Sirtuin 3 Deacetylase Activity , 2011, PloS one.

[82]  Wei Yu,et al.  Sirt3 Mediates Reduction of Oxidative Damage and Prevention of Age-Related Hearing Loss under Caloric Restriction , 2010, Cell.

[83]  Sterling C. Johnson,et al.  Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys , 2009, Science.

[84]  Shiwei Song,et al.  A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis , 2008, Proceedings of the National Academy of Sciences.

[85]  A. Uccelli,et al.  Mesenchymal stem cells in health and disease , 2008, Nature Reviews Immunology.

[86]  Ronald A. DePinho,et al.  How stem cells age and why this makes us grow old , 2007, Nature Reviews Molecular Cell Biology.

[87]  Lindolfo da Silva Meirelles,et al.  Mesenchymal stem cells reside in virtually all post-natal organs and tissues , 2006, Journal of Cell Science.

[88]  Ardeshir Ghavamzadeh,et al.  BMC Cell Biology BioMed Central Research article Aging of mesenchymal stem cell in vitro , 2005 .

[89]  Denham Harman,et al.  The Biologic Clock: The Mitochondria? , 1972, Journal of the American Geriatrics Society.